484 research outputs found
Some Observations on the Construct Marker -a in Classical Ethiopic
This contribution offers a discussion of the Classical Ethiopic use of the marker -a to indicate both the direct object and the construct state of nouns. Following a critical evaluation of the explanation of the phenomenon given by Josef Tropper, a few observations are made here which seem to lend support to the idea that the use of the marker in the construct state is in fact a generalization of the accusative ending
The Confounding Effect of Population Structure on Bayesian Skyline Plot Inferences of Demographic History
Many coalescent-based methods aiming to infer the demographic history of populations assume a single, isolated and panmictic population (i.e. a Wright-Fisher model). While this assumption may be reasonable under many conditions, several recent studies have shown that the results can be misleading when it is violated. Among the most widely applied demographic inference methods are Bayesian skyline plots (BSPs), which are used across a range of biological fields. Violations of the panmixia assumption are to be expected in many biological systems, but the consequences for skyline plot inferences have so far not been addressed and quantified. We simulated DNA sequence data under a variety of scenarios involving structured populations with variable levels of gene flow and analysed them using BSPs as implemented in the software package BEAST. Results revealed that BSPs can show false signals of population decline under biologically plausible combinations of population structure and sampling strategy, suggesting that the interpretation of several previous studies may need to be re-evaluated. We found that a balanced sampling strategy whereby samples are distributed on several populations provides the best scheme for inferring demographic change over a typical time scale. Analyses of data from a structured African buffalo population demonstrate how BSP results can be strengthened by simulations. We recommend that sample selection should be carefully considered in relation to population structure previous to BSP analyses, and that alternative scenarios should be evaluated when interpreting signals of population size change.Danish Council for Independent Research, Laboratoire d’Excellence (LABEX) grant: (ANR-10-LABX-41)
Poetisk verbalbrug og sproglig datering af gammeltestamentlige tekster
This article includes a short introduction to the general issueof linguistic dating of Old Testament texts as well as an appraisal ofthe alternative, non-chronological view of linguistic variation that hasrecently been put forward by Young, Rezetko and Ehrensvärd. Two poeticaltexts that are generally considered arch aic (Exodus 15 and Judges5), are examined using an approach to the verbal system in Biblical Hebrewpoetry inspired by Alviero Niccacci. In this way it is demonstratedthat supposedly archaic preterital use of yiqtol can be explained in otherways – which means that this feature is not a conclusive argument forearly dating
Learning Channel Importance for High Content Imaging with Interpretable Deep Input Channel Mixing
Uncovering novel drug candidates for treating complex diseases remain one of
the most challenging tasks in early discovery research. To tackle this
challenge, biopharma research established a standardized high content imaging
protocol that tags different cellular compartments per image channel. In order
to judge the experimental outcome, the scientist requires knowledge about the
channel importance with respect to a certain phenotype for decoding the
underlying biology. In contrast to traditional image analysis approaches, such
experiments are nowadays preferably analyzed by deep learning based approaches
which, however, lack crucial information about the channel importance. To
overcome this limitation, we present a novel approach which utilizes
multi-spectral information of high content images to interpret a certain aspect
of cellular biology. To this end, we base our method on image blending concepts
with alpha compositing for an arbitrary number of channels. More specifically,
we introduce DCMIX, a lightweight, scaleable and end-to-end trainable mixing
layer which enables interpretable predictions in high content imaging while
retaining the benefits of deep learning based methods. We employ an extensive
set of experiments on both MNIST and RXRX1 datasets, demonstrating that DCMIX
learns the biologically relevant channel importance without scarifying
prediction performance.Comment: Accepted @ DAGM German Conference on Pattern Recognition (GCPR) 202
Surface wind variability on seasonal and interannual scales over RĂO de la Plata area
Previous works show that wind forcing is the main source of circulation seasonal variability in the RĂo de la Plata estuary, located on the southeastern coast of South America. Wind forcing exceeds by far the role of fresh water discharges. However, due to a lack of enough observations, the features and causes of surface wind variability are not well understood yet. Therefore this paper presents a comprehensive study of surface wind variability over the RĂo de la Plata estuary using the National Center for Environmental Prediction-National Center for Atmospheric Research (NCEP/NCAR) reanalysis data between 1948 and 1997. It is expected that this study contributes to better understand, model and thus predict the estuary circulation. An onshore to offshore rotation characterizes the seasonal variations of the surface winds from summer to winter. A linear trend analysis shows a displacement of the summer-winter seasonal features to earlier months. On interannual time-scales, the first leading pattern describes east-west changes of surface winds that seems to be forced by the quasibiennial tropospheric oscillation excited in the western tropical Pacific and previously identified by many authors. The conditions over the South Atlantic and in particular the RĂo de la Plata are influenced by such oscillation through an atmospheric Rossby wave train propagating out of the tropics. This result is very important for its implication on the predictability levels in the region. The second leading mode is associated with anticyclonic/cyclonic wind rotations off the estuary on interannual times scales which are related with changes in both atmospheric and oceanic surface conditions at Southern Hemispher high-latitudes.Fil: Simionato, Claudia Gloria. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la AtmĂłsfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la AtmĂłsfera; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la AtmĂłsfera; ArgentinaFil: Vera, Carolina Susana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la AtmĂłsfera; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la AtmĂłsfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la AtmĂłsfera; ArgentinaFil: Siegismund, Frank. Universitat Hamburg; Alemani
Det er jo min elskede Salomon – eller er det? Om Højsangen, fortolkning og Bibelen 2020
The new Bible translation, Bibelen 2020, makes biblical books accessible to readers with little prior knowledge of the Bible, in idiomatic, contemporary Danish. However, the article argues that the attempt to make the texts accessible may have problematic consequences when the translation directly reflects one specific interpretation. This is particularly the case in the Song of Songs. Bibelen 2020 indicates the speaker of each passage, and the introduction identifies one female speaker (“Sulamit”) and one male (her beloved “Salomon”). In a very problematic way, this interpretation and the idea that the beloved is “Salomon”, referred to as “king”, have been built into the translation. The article discusses the once popular interpretation of the book as a drama including one woman and two men and argues that elements of such an approach can illuminate important aspects of the text. It is argued that these aspects are largely lost in the translation in Bibelen 2020
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