Seven HCI Grand Challenges

This article aims to investigate the Grand Challenges which arise in the current and emerging landscape of rapid technological evolution towards more intelligent interactive technologies, coupled with increased and widened societal needs, as well as individual and collective expectations that HCI, as a discipline, is called upon to address. A perspective oriented to humane and social values is adopted, formulating the challenges in terms of the impact of emerging intelligent interactive technologies on human life both at the individual and societal levels. Seven Grand Challenges are identified and presented in this article: Human-Technology Symbiosis; Human-Environment Interactions; Ethics, Privacy and Security; Well-being, Health and Eudaimonia; Accessibility and Universal Access; Learning and Creativity; and Social Organization and Democracy. Although not exhaustive, they summarize the views and research priorities of an international interdisciplinary group of experts, reflecting different scientific perspectives, methodological approaches and application domains. Each identified Grand Challenge is analyzed in terms of: concept and problem definition; main research issues involved and state of the art; and associated emerging requirements

A brain-computer interface based cognitive training system for healthy elderly: A randomized control pilot study for usability and preliminary efficacy

10.1371/journal.pone.0079419PLoS ONE811-POLN

Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model

Background: Clinically protective malaria vaccines consistently fail to protect adults and children in endemic settings, and at best only partially protect infants. Methodology/Principal Findings: We identify and evaluate 1916 immunization studies between 1965-February 2010, and exclude partially or nonprotective results to find 177 completely protective immunization experiments. Detailed reexamination reveals an unexpectedly mundane basis for selective vaccine failure: live malaria parasites in the skin inhibit vaccine function. We next show published molecular and cellular data support a testable, novel model where parasite-host interactions in the skin induce malaria-specific regulatory T cells, and subvert early antigen-specific immunity to parasite-specific immunotolerance. This ensures infection and tolerance to reinfection. Exposure to Plasmodium-infected mosquito bites therefore systematically triggers immunosuppression of endemic vaccine-elicited responses. The extensive vaccine trial data solidly substantiate this model experimentally. Conclusions/Significance: We conclude skinstage-initiated immunosuppression, unassociated with bloodstage parasites, systematically blocks vaccine function in the field. Our model exposes novel molecular and procedural strategies to significantly and quickly increase protective efficacy in both pipeline and currently ineffective malaria vaccines, and forces fundamental reassessment of central precepts determining vaccine development. This has major implications fo

Enantioselective organocatalytic synthesis of medicinally privileged 2-amino-4H-chromene-3-carbonitriles via a cascade process

10.1016/j.tetlet.2011.09.030Tetrahedron Letters52466137-6141TELE

Asymmetric organocatalytic cascade Michael/hemiketalization/retro-Henry reaction of β,γ-unsaturated ketoesters with α-nitroketones

10.1039/c1cc11124hChemical Communications47205819-5821CHCO

Expeditious assembly of a 2-Amino-4H-chromene skeleton by using an enantioselective Mannich intramolecular ring cyclization-tautomerization cascade sequence

10.1002/chem.201100927Chemistry - A European Journal17287781-7785CEUJ

COVID-19 Pandemic: A Usability Study on Platforms to Support eLearning

With the COVID-19 pandemic, the higher education communities throughout almost the entire world have moved from traditional face-to-face teaching to remote learning by using video conferencing software and online learning applications and platforms. With social distancing requirements, it is expected that eLearning will be part of the delivery modalities at least until an effective vaccine is widely available. Even after the pandemic is over, it is expected that remote learning and online education will be part of the new or next normal. Such online and remote learning modalities are not simply restricted to academic institutions. Businesses are using online and remote learning to re-train, re-tool, and re-educate their employees. The students, in general, are not enthusiastic about the virtual classroom. Niche.com surveyed 14,000 undergraduate and graduate students in April 2020 and found that more than 2/3 of them thought online classes are not as effective as in-person and teacher-centered classes. This unplanned change in teaching modes caused by COVID-19 and the negative feedback from students creates some serious concerns for educators and universities. How to enhance the eLearning experience for students? How to choose from many eLearning platforms on the market? Which eLearning platform is the most user friendly and the best suited for online classes? Which eLearning platforms enable the best class participation and student involvement? In this research, we apply the eLearning usability heuristics to evaluate the major video conferencing platforms (e.g., Cisco Webex, Microsoft Teams, and Zoom)