In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy

Idiopathic central serous chorioretinopathy (CSCR) is a relatively common ophthalmic disorder characterized by the development of a serous detachment of the sensory retina. Psychophysiological factors may trigger or maintain CSCR, though, surprisingly, the association between CSCR and anxiety has yet to be studied. The aims of the present study were threefold: to determine whether 1) Iranian patients with CSCR have higher scores for anxiety, 2) anxiety is lower, if CSCR has been experienced twice, and whether 3) anxiety scores differ between sexes.; A total of 30 patients with CSCR and 30 healthy age-and sex-matched controls took part in the study. A brief face-to-face interview was conducted covering demographic variables and history and occurrence of CSCR and assessing anxiety.; Compared to healthy controls, anxiety was significantly higher in both first-time and second-time CSCR patients. In CSCR patients, anxiety scores did not differ between sexes.; Higher anxiety scores were observed in Iranian patients with CSCR, irrespective of whether this was the first or second occurrence of CSCR. This suggests there is no psychological adaptation in terms of reduced anxiety among patients with repeated CSCR

In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy

INTRODUCTION: Idiopathic central serous chorioretinopathy (CSCR) is a relatively common ophthalmic disorder characterized by the development of a serous detachment of the sensory retina. Psychophysiological factors may trigger or maintain CSCR, though, surprisingly, the association between CSCR and anxiety has yet to be studied. The aims of the present study were threefold: to determine whether 1) Iranian patients with CSCR have higher scores for anxiety, 2) anxiety is lower, if CSCR has been experienced twice, and whether 3) anxiety scores differ between sexes. METHODS: A total of 30 patients with CSCR and 30 healthy age-and sex-matched controls took part in the study. A brief face-to-face interview was conducted covering demographic variables and history and occurrence of CSCR and assessing anxiety. RESULTS: Compared to healthy controls, anxiety was significantly higher in both first-time and second-time CSCR patients. In CSCR patients, anxiety scores did not differ between sexes. CONCLUSION: Higher anxiety scores were observed in Iranian patients with CSCR, irrespective of whether this was the first or second occurrence of CSCR. This suggests there is no psychological adaptation in terms of reduced anxiety among patients with repeated CSCR

Feasibility study on development of artificial reefs in the Persian Gulf (Hormuzgan province)

Persian Gulf waters (areas of Hormuzgan province) in order to determine the best location for installation of Artificial reefs were studied seasonally from December 2006 to March 2007. Distribution of fauna and flora and estimation of deposit depth by SCUBA diving method, density and frequency of macrobenthose communities, frequency of ichthyoplankton communities, determination of organic carbon (OC) and Grain size and measurement of water physical factors including salinity, saturation oxygen, dissolved oxygen, temperature, chlorophyll a, in transect and subtransect was studied for recognizing the best placement to installation of artificial reefs. All areas of Shipping, military areas, around of Islands, natural habitats and entrance to jetty were introduced for excluding areas. South of Qeshm Island (transects of Bahman jetty, Bandar Masen and Bandar Salakh) are catching area for small pelagic (sardine and anchovy fishes), therefore in these areas installation of artificial reefs have confined with this restriction. Also entrance to Bahman jetty, sea plant habitats (sea grass and algae) in transects of Bahman jetty and Bandar Masen were considered as restricted areas. In this area, suitable areas for installation of artificial reefs was determined based on distribution of Ichthyoplankton societies for every transect, for macrobenthose enrichment Bahman jetty transect was calculated middle, but transects of Bandar Masen, Hengam island and Bandar Salakh was done good indicator. The deposition depth in transects of Bandar Masen and Hengam island was determined as good factor but this index was known as average factor for transects of Bahman jetty and Bandar Masen. Also, two another indicators, primary production and bottom sturdiness, were calculated as middle factor for Bahman jetty transect, but these indicators were known as good factors for other transects in this area (Bandar Masen, Hengam island and Bandar Salakh). The results of these indicators in transects of Bandar Kong and Bandar Bostaneh in Bandar Lengeh area was indicated that T. O. C and bottom sturdiness indices had no significant difference (p>0. 05) and the whole of these transects had average priority. Bottom sturdiness, primary productions and macrobenthose communities indices had difference in Bandar Lengeh area (p<0. 05) and these indices had average priority in Bandar Kong transect and had good priority in transects of Bandar Bostaneh and Bandar Hasineh. Ichthyoplankton community had average priority for Bandar Bostaneh transect, and had good priority for transects of Bandar Kong and Bandar Hasineh. The good priority has obtained for transects of Bandar Charak, Bandar Gorzeh and Bandar Chiroeyah. Also Macrobenthose community, primary production, water physical factors and bottom sturdiness were known as good, good, average and weakness priority respectively for transects of Bandar Charak, Bandar Gorzeh, but primary production, bottom sturdiness, water physical factors and macrobenthose community were resulted as average, good, good and average priority respectively for Bandar Chiroeyah transect . T.O.C index was determined as average priority for transects of Bandar Gorzeh and Bandar Chiroeyah and good priority for Bandar Charak transect. Finally, excluded areas maps, suitability areas maps and feasibility areas maps were drawn by Arc GIS software. In this survey, layers between 10 to 20 meters depth were recognized as the best position for installation of artificial reefs

Assessment of dominant species food relation in habitats of commercial shrimp in Hormuzgan Province waters (Persian Gulf)

Shrimp is one of the most important aquatic animals,that have decreased their stocks in Hormozgan province, especially the eastern province . Evalution of food interaction in shrimp habitats (Estuaries of Tyab, Yek shabeh, Laft and Khouran) was studied with Ecopaht with Ecosim software (ver. 6.5) in Hormuzgan province. After entering the input components (Biomass,P/B and Q/B), model was balanced and outputs were extracted. Results of trophic levels, was close to previous research in these areas for all species in estuaries. Maximum of ecotrophic efficiency was belonged to phytoplankton and other preys that were observed in predator stomachs. Biological future of food web estimated to be threatened based on omnivore index of planktonivore groups. Maximum food competition between the four food models was estimated in detritivores communities in Laft estuary, that may be related to the low density of mangrove in this region. Khamir estuary ecosystem could be more stable, because each impacting group had its own separate ecological niche and special predation territory. key indices in each of four food models were related to phytoplankton communities, this key role has been demonstrated much better in Yek Shovy estuary than others. Future of commercial shrimp stocks will be expected to be in better condition in Khoran estuary compared to other three ones, due to selection of separate ecological niche by predators and High biomass of detritus in this estuary

Monitoring of fisheries resources in artificial reefs in east of Kish Island waters

Artificial reefs are manmade materials deployed under water in order to improve environment and increase the exploitation of fishing area. Usage of artificial technic has developed due to increase of world population and need to supply of protein, aim to restoring of natural specially rehabilitation of demersal fishes. It has effected to increase the production in order sustainable exploitation. Coasts and Islands have destruction due to over harvesting from ecosystems and other activities by humans and natural, these caused many aquatic as demersal fishes has endangered in Persian Gulf and Oman Sea. The artificial reef is one way or method that can improve the environment and restore the aquatic. Iranian fisheries has established an artificial reefs area in west of Kish Island. This area has studied during one year, Data of assembled fishes and physical sampling were collected in seasonal during spring, summer, autumn and wintered. There were tow treatment for sampling as artificial reefs site and a control site. Collected data has analyzed and evaluated by SPSS and Exel. The results showed that there was significant difference between the sites and assembled fishes in artificial reefs were more than control site. Consequently the artificial reefs can be a tool and technic to improve the marine environment and increase the production of fishes, especially the demersal fishes

The unfinished agenda of communicable diseases among children and adolescents before the COVID-19 pandemic, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019

BACKGROUND: Communicable disease control has long been a focus of global health policy. There have been substantial reductions in the burden and mortality of communicable diseases among children younger than 5 years, but we know less about this burden in older children and adolescents, and it is unclear whether current programmes and policies remain aligned with targets for intervention. This knowledge is especially important for policy and programmes in the context of the COVID-19 pandemic. We aimed to use the Global Burden of Disease (GBD) Study 2019 to systematically characterise the burden of communicable diseases across childhood and adolescence. METHODS: In this systematic analysis of the GBD study from 1990 to 2019, all communicable diseases and their manifestations as modelled within GBD 2019 were included, categorised as 16 subgroups of common diseases or presentations. Data were reported for absolute count, prevalence, and incidence across measures of cause-specific mortality (deaths and years of life lost), disability (years lived with disability [YLDs]), and disease burden (disability-adjusted life-years [DALYs]) for children and adolescents aged 0-24 years. Data were reported across the Socio-demographic Index (SDI) and across time (1990-2019), and for 204 countries and territories. For HIV, we reported the mortality-to-incidence ratio (MIR) as a measure of health system performance. FINDINGS: In 2019, there were 3·0 million deaths and 30·0 million years of healthy life lost to disability (as measured by YLDs), corresponding to 288·4 million DALYs from communicable diseases among children and adolescents globally (57·3% of total communicable disease burden across all ages). Over time, there has been a shift in communicable disease burden from young children to older children and adolescents (largely driven by the considerable reductions in children younger than 5 years and slower progress elsewhere), although children younger than 5 years still accounted for most of the communicable disease burden in 2019. Disease burden and mortality were predominantly in low-SDI settings, with high and high-middle SDI settings also having an appreciable burden of communicable disease morbidity (4·0 million YLDs in 2019 alone). Three cause groups (enteric infections, lower-respiratory-tract infections, and malaria) accounted for 59·8% of the global communicable disease burden in children and adolescents, with tuberculosis and HIV both emerging as important causes during adolescence. HIV was the only cause for which disease burden increased over time, particularly in children and adolescents older than 5 years, and especially in females. Excess MIRs for HIV were observed for males aged 15-19 years in low-SDI settings. INTERPRETATION: Our analysis supports continued policy focus on enteric infections and lower-respiratory-tract infections, with orientation to children younger than 5 years in settings of low socioeconomic development. However, efforts should also be targeted to other conditions, particularly HIV, given its increased burden in older children and adolescents. Older children and adolescents also experience a large burden of communicable disease, further highlighting the need for efforts to extend beyond the first 5 years of life. Our analysis also identified substantial morbidity caused by communicable diseases affecting child and adolescent health across the world. FUNDING: The Australian National Health and Medical Research Council Centre for Research Excellence for Driving Investment in Global Adolescent Health and the Bill & Melinda Gates Foundation

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Relationship of Retinal Nerve Fibers Layer Thickness with Mild Cognitive Impairment and Alzheimer\'s Dementia

Background and Objective: In this study, the thickness of the retinal nerve fibers layer(RNFL) was compared among patients with mild cognitive impairment, Alzheimer's dementia, and healthy individuals (controls) using Optical Coherence Tomography (OCT) device. Materials and Methods: This case-control study was conducted on 30 patients diagnosed with mild cognitive impairment and 31 healthy subjects undergoing neurological examination. The examinations included minimal mental state examination a comprehensive assessment of ophthalmology and performance of OCT using a Spectralis device. Both eyes were selected for analysis, and the differences in the thickness of retinal nerve fibers layer between patients with mild cognitive impairment and healthy subjects were investigated. Results: In this study, the mean age scores of the patients and healthy individuals were 66.00±8.56 and 60.25±7.50 years, respectively. According to the results of the ordinal logistic regression model, after controlling the effects of other variables, the severity of cognitive impairment increased by 1.26 times in the right eye and by 1.30 times in the left eye (P<0.001). Similarly, for each micrometer increase in the thickness of the retinal nerve layer in the superior quadrant of the right and left eyes, the severity of the cognitive impairment decreased by 4% and 5%, respectively. Conclusion: These results indicated that superior and inferior retinal nerve fiberslayer thickness was reduced in patients with mild cognitive impairment and Alzheimer's dementia, compared to the healthy subjects, and it can be an element to detect and track this pathology

Study of phytoplankton community in coastal waters of Hormozgan province, Qeshm and Leangeh Islands

The study of spatial and temporal variability of distribution of phytoplankton communities in Northern part of the Persian Gulf (Qeshm andLengeh Islands) was studied. In this study, five groups (47 genera) of phytoplankton include Bacillariophyceae, Dinophyceae, Cyanophyceae, Crysophyceae and Euglenophyceae were identified. The results showed that Diatoms group (79.6 %) and Rhizosolenia genus (45.5 %), contributed more towards the percentage composition of different groups and genera of phytoplankton during the study. The annual changes in relative abundance and Margalef, Shannon, pielu and simpson indices were estimated, 0.58-2.56 , 0.08-0.97, 0.23-2.6, 0.09-0.93 respectively. Multivariate analysis of variance showed that during the sudy, density and biological indicators of phytoplankton were significant between seasons (P<0.05). The spatial cluster analysis based on similarity coefficients obtained twoclustersin theareasstudied. The results of the current study suggested that the ​​ecological conditions ofboth Islandsin ranks are instead moderate. Moreover, Phytoplankton of diversity and richness is good

Adjoint-based Calibration of Inlet Boundary Condition for Atmospheric CFD Solvers

An adjoint solver is developed for optimization of inlet velocity boundary condition for incompressible atmospheric boundary layer (ABL) CFD simulations. Using the wind speed observations in the interior domain, the solver computes the gradient of the calibration objective function with respect to inlet velocity components as design variables. The algorithm is implemented in the open source CFD package OpenFOAM. Further, the DAKOTA optimization package is coupled with OpenFOAM and numerical studies are carried out to determine the inlet velocity profile of a 3D domain with a cosine shaped hill. The CFD simulation with optimized inlet velocty profile shows good agreement with experimental study