Understanding Governance Structures in Shaping Greenway Implementation in City-Regions: A Case Study in Central Zhejiang Province, China

Greenway implementation in city-regions is a collective action involving a complex range of relations between regional and local agencies, between government departments at the same administrative level, and between adjacent jurisdictions. This paper explores how greenway implementation governance is structured, and why different governance structures result in different greenway implementation processes and outcomes in a city-region. We use a case study approach to a greenway project in central Zhejiang Province (CCCZ), where data are collected through field reconnaissance, in-depth interviews, and document analysis. Preliminary findings reveal that the central Zhejiang Greenway Project has experienced a development from ‘territorially-specialized governance’ to ‘cross-scale governance’. ‘Double-hatted’ agencies comprising government leaders and professional representatives from different agencies can create cross-scale institutional linkages both vertically (across levels of governments) and horizontally (across jurisdictions an

الأخطاء النحوية في الكتابة العربية لطلاب الفصل الثالث في مدرسة معهد فضل الله الإسلامية المتوسطة تامباك سومور وارو سيدوارجو

Bahasa arab merupakan bahasa target dalam pembelajaran di fakultas adab jurusan bahasa dan sastra arah, dan bahasa arab adalah alat komunikasi orang arab yang memiliki berbagai aturan bahasa sehingga ada kemungkinan terjadinya kesalahan dalam pembelajarannya. Dalam skripsi ini penulis ingin mengetah ui kemampuan dan kekurangan pelajar pondok Fadhlil lah dalam berbahasa arab. Penulis memil ih pondok Fadhlillah Tambak Sumur Waru Sidoarjo karena pondok Fadhlillah merupakan salah satu pondok yang komunikasi sehari­ harinya menggunakan bahasa arab dan bahasa inggris, dan pelajaran bahasa arab adalah bahasa target utama di pondok tersebut. Permasalahannya adalah : A. Apa sajakah bentuk kesalahan nahwu dalam tulisan arab milik pelajar kelas 3 tsanawiyah di pondok Fadhlillah?. B. Apa sebab-seba b kesalahannya?. C. dan apa solusi untuk menghindari terjadinya kesalahan dalam tu1isan arab? Skripsi in i meru pakan penel itian bersifat deskriptif yakni memaparkan anal isis kesalahan berbahasa se11a sebab-sebab terjadinya kesalahan. OJeh karena i tu, agar dapat membahas lebih jauh tentang analisis kesalahan berbahasa ini pen ulis menggunakan metode deduktif dan induktif. Penulis memaparkan kesalahan-kesalahan yang terjadi dalam tulisan arab milik pelajar kelas 3 tsanawiyah di pondok Fadhlillah kemudian mencari sebab dan solusinya. Hasil penelitian ini menyebutkan bahwa bentuk kesalahan dalam tulisan bahasa arab milik pelajar kelas 3 tsanawiyah di pondok Fadhlillah adalah m u rn i kesalahan analisa bahasa secara sistematis bukan kesalahan yang disengaja u ntuk merubah suatu sistem bahasa tertentu (kaidah bahasa), karena pelajar kelas 3 tsanawiyah belum memaham i dengan benar kaidah-kaidah bahasa arab dan khususnya pelajaran nahwu

The role of 245 phase in alkaline iron selenide superconductors revealed by high pressure studies

Here we show that a pressure of about 8 GPa suppresses both the vacancy order and the insulating phase, and a further increase of the pressure to about 18 GPa induces a second transition or crossover. No superconductivity has been found in compressed insulating 245 phase. The metallic phase in the intermediate pressure range has a distinct behavior in the transport property, which is also observed in the superconducting sample. We interpret this intermediate metal as an orbital selective Mott phase (OSMP). Our results suggest that the OSMP provides the physical pathway connecting the insulating and superconducting phases of these iron selenide materials.Comment: 32 pages, 4 figure

Ticagrelor reduces doxorubicin-induced pyroptosis of rat cardiomyocytes by targeting GSK-3β/caspase-1

Doxorubicin (Dox) is a widely used clinical drug whose cardiotoxicity cannot be ignored. Pyroptosis (inflammatory cell death) has gradually gained attention in the context of Dox-induced cardiotoxicity. In addition to the inhibition of platelet activation by ticagrelor, little is known about its other pharmacological effects. Glycogen synthase kinase 3β (GSK-3β) has been shown to contribute to the pathological process of pyroptosis, but whether it is related to the potential role of ticagrelor is unclear. In this study, we investigated the effects of ticagrelor on Dox-induced pyroptosis in cardiomyocytes. Rats were treated with ticagrelor (7.5 mg/kg, i.g.) 1 h before intravenous injection of Dox (2.5 mg/kg), once every 3 days, six times in total. Hearts were collected for histochemical analysis and western blot detection 8 weeks after the last administration. Ticagrelor was shown to significantly improve cardiac function by inhibiting GSK-3β/caspase-1/GSDMD activation. In vitro experiments were conducted using rat cardiac myocytes (RCMs) and rat embryonic cardiac-derived H9c2 cells. Pretreatment with ticagrelor (10 μm) significantly inhibited Dox (1 μm)-induced hypertrophy and reversed the upregulation of GSDMD-NT expression. We showed that ticagrelor suppressed the activation of Akt caused by Dox in the heart tissue as well as in RCMs/H9c2 cells caused by Dox. When GSK-3β expression was absent in H9c2 cells, the inhibitory effect of ticagrelor on Dox-induced caspase-1/GSDMD activation was weakened. These data showed that ticagrelor reduced Dox-induced pyroptosis in rat cardiomyocytes by targeting GSK-3β/caspase-1

Anti-hyperuricemia effect of hesperetin is mediated by inhibiting the activity of xanthine oxidase and promoting excretion of uric acid

Hesperetin is a natural flavonoid with many biological activities. In view of hyperuricemia treatment, the effects of hesperetin in vivo and in vitro, and the underlying mechanisms, were explored. Hyperuricemia models induced by yeast extract (YE) or potassium oxonate (PO) in mice were created, as were models based on hypoxanthine and xanthine oxidase (XOD) in L-O2 cells and sodium urate in HEK293T cells. Serum level of uric acid (UA), creatinine (CRE), and urea nitrogen (BUN) were reduced significantly after hesperetin treatment in vivo. Hesperetin provided hepatoprotective effects and inhibited xanthine oxidase activity markedly, altered the level of malondialdehyde (MDA), glutathione peroxidase (GSH-PX) and catalase (CAT), downregulated the XOD protein expression, toll-like receptor (TLR)4, nucleotide binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, interleukin-18 (IL-18), upregulated forkhead box O3a (FOXO3a), manganese superoxide dismutase (MnSOD) in a uric acid-synthesis model in mice. Protein expression of organic anion transporter 1 (OAT1), OAT3, organic cationic transporter 1 (OCT1), and OCT2 was upregulated by hesperetin intervention in a uric acid excretion model in mice. Our results proposal that hesperetin exerts a uric acid-lowering effect through inhibiting xanthine oxidase activity and protein expression, intervening in the TLR4-NLRP3 inflammasome signaling pathway, and up-regulating expression of FOXO3a, MnSOD, OAT1, OAT3, OCT1, and OCT2 proteins. Thus, hesperetin could be a promising therapeutic agent against hyperuricemia

Differences in neuroanatomy and functional connectivity between motor subtypes of Parkinson’s disease

BackgroundThe “postural instability/gait difficulty” (PIGD) and “tremor-dominant” (TD) motor subtypes of Parkinson’s disease (PD) differ in their clinical manifestations. The neurological basis of these differences is unclear.MethodsWe performed voxel-based morphometric analysis and measured amplitudes of low-frequency fluctuation (ALFF) on 87 PIGD patients and 51 TD patients. We complemented this neuroanatomical comparison with seed-to-voxel analysis to explore differences in functional connectivity.ResultsThe PIGD group showed significantly smaller gray matter volume in the medial frontal gyrus (mainly on the right side) than the TD group. Across all patients, gray matter volume in the medial frontal gyrus correlated negatively with severity of PIGD symptoms after controlling for age (r = −0.250, p = 0.003), but this correlation was not observed in separate analyses of only PIGD or TD patients. The PIGD group showed greater functional connectivity of the right superior frontal gyrus with the left lingual gyrus, right lateral occipital cortex, and right lingual gyrus. ALFF did not differ significantly between the two groups.ConclusionPostural instability/gait difficulty may be associated with smaller gray matter volume in medial frontal gyrus than TD, as well as with greater functional connectivity between the right superior frontal gyrus and occipital cortex. These results may help explain the clinical differences between the two motor subtypes of PD

Probing high-momentum component in nucleon momentum distribution by neutron-proton bremsstrahlung {\gamma}-rays in heavy ion reactions

The high momentum tail (HMT) of nucleons, as a signature of the short-range correlations in nuclei, has been investigated by the high-energy bremsstrahlung $\gamma$ rays produced in $^{86}$Kr + $^{124}$Sn at 25 MeV/u. The energetic photons are measured by a CsI(Tl) hodoscope mounted on the spectrometer CSHINE. The energy spectrum above 30 MeV can be reproduced by the IBUU model calculations incorporating the photon production channel from $np$ process in which the HMTs of nucleons is considered. A non-zero HMT ratio of about $15\%$ is favored by the data. The effect of the capture channel $np \to d\gamma$ is demonstrated

In Situ Construction of an Ultrarobust and Lithiophilic Li-Enriched Li–N Nanoshield for High-Performance Ge-Based Anode Materials

Alloy-based materials are promising anodes for rechargeable batteries because of their higher theoretical capacities in comparison to graphite. Unfortunately, the huge volume changes during cycling cause serious structural degradation and undesired parasitic reactions with electrolytes, resulting in fragile solid-electrolyte interphase formation and serious capacity decay. This work proposes to mitigate the volume changes and suppress the interfacial reactivity of Ge anodes without sacrificing the interfacial Li+ transport, through in situ construction of an ultrarobust and lithiophilic Li-enriched Li–N nanoshield, which demonstrated improved chemical, electrochemical, mechanical, and environmental stability. Therefore, it can serve as a versatile interlayer to facilitate Li+ transport and effectively block the attack of electrolyte solvents, thus boosting the long-term cycle stability and fast charging capability of Ge anodes. This work offers an alternative methodology to tune the interfaces of other electrode materials as well by screening for more N-containing compounds that can react with Li+ during battery operation