Reliability handbook for silicon monolithic microcircuits. Volume 2 - Failure mechanisms of monolithic microcircuits

Reliability handbook for silicon monolithic microcircuits - failure mechanism

Sushi in the United States, 1945-1970

Sushi first achieved widespread popularity in the United States in the mid-1960s. Many accounts of sushi’s US establishment foreground the role of a small number of key actors, yet underplay the role of a complex web of large-scale factors that provided the context in which sushi was able to flourish. This article critically reviews existing literature, arguing that sushi’s US popularity arose from contingent, long-term, and gradual processes. It examines US newspaper accounts of sushi during 1945–1970, which suggest the discursive context for US acceptance of sushi was considerably more propitious than generally acknowledged. Using California as a case study, the analysis also explains conducive social and material factors, and directs attention to the interplay of supply- and demand-side forces in the favorable positioning of this “new” food. The article argues that the US establishment of sushi can be understood as part of broader public acceptance of Japanese cuisine

RNA delivery by extracellular vesicles in mammalian cells and its applications.

The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of cellular origin that derive either from the endosomal compartment (exosomes) or as a result of shedding from the plasma membrane (microvesicles, oncosomes and apoptotic bodies). Extracellular vesicles carry a variety of cargo, including RNAs, proteins, lipids and DNA, which can be taken up by other cells, both in the direct vicinity of the source cell and at distant sites in the body via biofluids, and elicit a variety of phenotypic responses. Owing to their unique biology and roles in cell-cell communication, extracellular vesicles have attracted strong interest, which is further enhanced by their potential clinical utility. Because extracellular vesicles derive their cargo from the contents of the cells that produce them, they are attractive sources of biomarkers for a variety of diseases. Furthermore, studies demonstrating phenotypic effects of specific extracellular vesicle-associated cargo on target cells have stoked interest in extracellular vesicles as therapeutic vehicles. There is particularly strong evidence that the RNA cargo of extracellular vesicles can alter recipient cell gene expression and function. During the past decade, extracellular vesicles and their RNA cargo have become better defined, but many aspects of extracellular vesicle biology remain to be elucidated. These include selective cargo loading resulting in substantial differences between the composition of extracellular vesicles and source cells; heterogeneity in extracellular vesicle size and composition; and undefined mechanisms for the uptake of extracellular vesicles into recipient cells and the fates of their cargo. Further progress in unravelling the basic mechanisms of extracellular vesicle biogenesis, transport, and cargo delivery and function is needed for successful clinical implementation. This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications

Plant fibre reinforced polymers: where do we stand in terms of tensile properties?

Plant fibres have a unique set of properties ranging from being stiff and brittle, such as hemp and flax, to more ductile, such as coir, c ombining these properties with their cost and availability makes them attractive alternative reinforcements for the production of greener composites . This article reviews the tensile properties of various plant fibre or plant based natural fibre - reinforced polymer s reported in the literature . We critically discuss the use of plant fibres as reinforcement for the production of bio - based , renewable or green polymer composites , showing t he evolution of the properties of plant fibre composites. The reported tensile properties of plant fibre - reinforced polymer composites are compared against various renewable and n on - renewable engineering/commodity polymers as well as the tensile properties of commercially available randomly oriented glass fibre - reinforced polymers (GFRP). G reen composites containing random short plant fibres do have similar properties to randomly oriented GFRP at a lower overall part weight. U nidirectional plant fibre - reinf orced polymers offer better performance than randomly oriented GFRP and could have the potential to be adapted in applications requiring even higher mechanical performance, especially in areas where the use of costly synthetic fibres might be less attracti ve . Furthermore, plant fibres can also be regarded as effective fillers to replace more expensive polymer s and improve the green credential s of final composite parts. These features may motivate the industry to introduce more plant fibre - based products to the market