Flow Fair Sampling Based on Multistage Bloom Filters

Network traffic distribution is heavy-tailed. Most of network flows are short and carry very few packets, and the number of large flows is small. Traditional random sampling tends to sample more large flows than short ones. However, many applications depend on per-flow traffic other than just large flows. A flow fair sampling based on multistage Bloom filters is proposed. The total measurement interval is divided into n child time intervals. In each child time interval, employ multistage Bloom filters to query the incoming packet’s flow whether exists in flow information table or not, if exists, sample the packet with static sampling rate which is inversely proportional to the estimation flow traffic up to the previous time interval. If it is a new flow’s first packet, create its flow information and insert it into the multistage Bloom filters. The results show that the proposed algorithm is accurate especially for short flows and easy to extend

Two-directional simultaneous inference for high-dimensional models

This paper proposes a general two directional simultaneous inference (TOSI) framework for high-dimensional models with a manifest variable or latent variable structure, for example, high-dimensional mean models, high-dimensional sparse regression models, and high-dimensional latent factors models. TOSI performs simultaneous inference on a set of parameters from two directions, one to test whether the assumed zero parameters indeed are zeros and one to test whether exist zeros in the parameter set of nonzeros. As a result, we can exactly identify whether the parameters are zeros, thereby keeping the data structure fully and parsimoniously expressed. We theoretically prove that the proposed TOSI method asymptotically controls the Type I error at the prespecified significance level and that the testing power converges to one. Simulations are conducted to examine the performance of the proposed method in finite sample situations and two real datasets are analyzed. The results show that the TOSI method is more predictive and has more interpretable estimators than existing methods

N-(2,3-Dimeth­oxy­benzyl­idene)naphthalen-1-amine

The title compound, C19H17NO2, represents a trans isomer with respect to the C=N bond. The dihedral angle between the planes of the naphthyl ring system and the benzene ring is 71.70 (3)°. In the crystal, weak C—H⋯O hydrogen bonding is present

High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis

Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration

High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis

Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration

Abiotic Conversion of Extracellular NH2OH Contributes to N2O Emission during Ammonia Oxidation

The authors wish to thank Holger Wissel for his assistance with 15N isotope analysis, Franz Leistner for his assistance in gas chromatography and Kerim Dimitri Kits for helpful discussions. We would like to thank Andreas Pommerening-Röser (University of Hamburg, Germany) for providing us with AOB strains. SL was supported by the Chinese Scholarship Council (scholarship no. 201206760007). MW and PH were supported by an ERC Advanced Grant (NITRICARE, 294343). LH is funded through the Nitrous Oxide Research Alliance (NORA), a Marie Skłodowska-Curie ITN and research project under the EU's seventh framework program (FP7).Peer reviewedPostprin