Enhancing Gearbox Fault Diagnosis through Advanced Feature Engineering and Data Segmentation Techniques

Efficient gearbox fault diagnosis is crucial for the cost-effective maintenance and reliable operation of rotating machinery. Despite extensive research, effective fault diagnosis remains challenging due to the multitude of features available for classification. Traditional feature selection methods often fail to achieve optimal performance in fault classification tasks. This study introduces diverse ranking methods for selecting the relevant features and utilizes data segmentation techniques such as sliding, windowing, and bootstrapping to strengthen predictive model performance and scalability. A comparative analysis of these methods was conducted to identify the potential causes and future solutions. An evaluation of the impact of enhanced feature engineering and data segmentation on predictive maintenance in gearboxes revealed promising outcomes, with decision trees, SVM, and KNN models outperforming others. Additionally, within a fully connected network, windowing emerged as a more robust and efficient segmentation method compared to bootstrapping. Further research is necessary to assess the performance of these techniques across diverse datasets and applications, offering comprehensive insights for future studies in fault diagnosis and predictive maintenance

Rational Mutational Analysis of a Multidrug MFS Transporter CaMdr1p of Candida albicans by Employing a Membrane Environment Based Computational Approach

CaMdr1p is a multidrug MFS transporter of pathogenic Candida albicans. An over-expression of the gene encoding this protein is linked to clinically encountered azole resistance. In-depth knowledge of the structure and function of CaMdr1p is necessary for an effective design of modulators or inhibitors of this efflux transporter. Towards this goal, in this study, we have employed a membrane environment based computational approach to predict the functionally critical residues of CaMdr1p. For this, information theoretic scores which are variants of Relative Entropy (Modified Relative Entropy REM) were calculated from Multiple Sequence Alignment (MSA) by separately considering distinct physico-chemical properties of transmembrane (TM) and inter-TM regions. The residues of CaMdr1p with high REM which were predicted to be significantly important were subjected to site-directed mutational analysis. Interestingly, heterologous host Saccharomyces cerevisiae, over-expressing these mutant variants of CaMdr1p wherein these high REM residues were replaced by either alanine or leucine, demonstrated increased susceptibility to tested drugs. The hypersensitivity to drugs was supported by abrogated substrate efflux mediated by mutant variant proteins and was not attributed to their poor expression or surface localization. Additionally, by employing a distance plot from a 3D deduced model of CaMdr1p, we could also predict the role of these functionally critical residues in maintaining apparent inter-helical interactions to provide the desired fold for the proper functioning of CaMdr1p. Residues predicted to be critical for function across the family were also found to be vital from other previously published studies, implying its wider application to other membrane protein families

Recyclable Polymer Supported DMAP Catalyzed Cascade Synthesis of α‑Pyrones

Polymer-supported catalysts have emerged as one of the sustainable and cost-effective alternatives in organic synthetic chemistry. We have developed the first polymer-supported DMAP catalyzed one-pot synthesis of diversely substituted α-pyrones. The cascade approach involves C5 conjugate addition of 5H-oxazol-4-ones to α,β-unsaturated-β-ketoesters followed by lactonization/elimination

Recyclable Polymer Supported DMAP Catalyzed Cascade Synthesis of α‑Pyrones

Polymer-supported catalysts have emerged as one of the sustainable and cost-effective alternatives in organic synthetic chemistry. We have developed the first polymer-supported DMAP catalyzed one-pot synthesis of diversely substituted α-pyrones. The cascade approach involves C5 conjugate addition of 5H-oxazol-4-ones to α,β-unsaturated-β-ketoesters followed by lactonization/elimination