Effect of percutaneous mitral vavuloplasty on pregnant mother and foetus--a tertiary care hospital experience from a developing country

This study evaluated the short and long-term consequences of Percutaneous Mitral Valvuloplasty (PMV) in pregnant patients and their offspring, in a tertiary care setting, Karachi, Pakistan. The hospital database was used to retrieve all patients who underwent PMV during pregnancy in the period 1998-2007. The follow up data of the patients and the born children were obtained from the hospital records and also by contacting the patients via phone. Six patients underwent PMV but follow-up was available for 5 patients only. All 5 patients were admitted due to severe mitral stenosis with symptoms of dyspnea and palpitation. Mean age was 27 +/- 5.3 years with a mean gestational age at the time of procedure of 22.20 +/- 1.6 weeks. The mean valve area increased from 0.94 +/- 0.22 cm2 preoperatively to 1.62 +/- 0.50 cm2 post-operatively. The ejection fraction changed from a mean of 50 +/- 11.7% to 56 +/- 2.2%. There were no maternal deaths, abortions or stillbirths. Developmental milestones were achieved at the appropriate ages in all babies. PMV appears to be a safe and effective intervention for patients with severe MS during pregnancy. Keywords: Mitral stenosis, Percutaneous Mitra

Kashmir: The Major Source of Conflict between Pakistan and India

Kashmir is the most serious dispute between Pakistan and India that originated with the British decision to give independence to British India that later divided into two states i.e. Pakistan and India. Being a Muslim majority princely state, the people wanted to join Pakistan. However the non-Muslim ruler of Kashmir opted India. The people of Kashmir revolted against this decision which set the stage for the first Kashmir war between Pakistan and India. Since then India has maintained its control over Kashmir by use of force and a heavy presence of Indian security forces. India and Pakistan fought another war on Kashmir in 1965. Despite India’s coercive policies, Kashmiris continued to resist Indian domination. The current uprising in Kashmir is the latest manifestation of Kashmiri revolt against India. Pakistan and India need to hold talks for a peaceful resolution of Kashmir which is also acceptable to the Kashmiris. They do not want to live under Indian rule and want to decide about the future of Kashmir through plebiscite, as promised in the UN resolutions of 1948-4

Comparison of nutrients uptake in different varieties of rice in Pakistan

The objective of this research was to determine the uptake of different elements (K, Mg, Ca, Na, Fe, Co, Mn, Pb, Cu, Zn and Ni) which are used as nutrients by the rice crop. Different types of rice seeds KSK-282, KSK-134, BAS-515, IR6, BAS-2000, KSK-133 and super-BAS were collected from National Agricultural Research Centre (NARC) Islamabad Pakistan and grown in different plastic pots containing soil under the same condition. Ten days old immature plants of different varieties of rice were dried and their roots were separated from the whole plants. The dried roots were ground into fine powder followed by acid digestion (HNO , H SO and 3 2 4 HClO ) solution in a ratio of (5:1:0.1) individually. After digestion the solutions were filtered and the filtrates 4 were diluted by adding distilled water. The diluted solutions of all the above mentioned varieties of rice were analyzed by Atomic Absorption Spectrophotometer (AAS) for nutrients (K, Mg, Ca, Na, Fe, Co, Mn, Pb, Cu, Zn and Ni) concentration. The different values obtained from AAS had shown that some rice varieties had taken up nutrients (elements) in large amount (e.g., KSK-134 had taken up maximum Fe while KSK-133 had taken up minimum) as compared to other varieties. Similarly, several verities absorbed comparatively minimum concentration of elements. The results obtained in this research work clearly indicated that the absorption of these elements from the soil was dependent on the rice variety (e.g., BAS-2000 absorbed maximum Mg while minimum Super-BAS). Interestingly most of the rice vaities had absorbed the beneficial elements in large quantity as compared to other toxic elements

Recent advances and role of melatonin in post-harvest quality preservation of shiitake (Lentinula edodes)

Shiitake mushrooms are renowned for their popularity and robust nutritional value, are susceptible to spoilage due to their inherent biodegradability. Nevertheless, because of their lack of protection, these mushrooms have a short shelf life. Throughout the post-harvest phase, mushrooms experience a persistent decline in quality. This is evidenced by changes such as discoloration, reduced moisture content, texture changes, an increase in microbial count, and the depletion of nutrients and flavor. Ensuring postharvest quality preservation and prolonging mushroom shelf life necessitates the utilization of post-harvest preservation techniques, including physical, chemical, and thermal processes. This review provides a comprehensive overview of the deterioration processes affecting mushroom quality, covering elements such as moisture loss, discoloration, texture alterations, increased microbial count, and the depletion of nutrients and flavor. It also explores the key factors influencing these processes, such as temperature, relative humidity, water activity, and respiration rate. Furthermore, the review delves into recent progress in preserving mushrooms through techniques such as drying, cooling, packaging, irradiation, washing, and coating

Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir

Using a repeat-exposure macaque model, Walid Heneine and colleagues find that pre-exposure prophylaxis with combination antiretroviral drugs provides protection against rectal challenge with a SHIV virus

کرنل فضلِ اکبر کمالؔ اور میجر نورالحسن رضوی کے شعری مجموعوں کا جائزہ

This article has presented the services of Army's two great poets. They continued military service as well as Urdu. Colonel Fazl-e-Akbar Kamal is the author of "Hareem o Hijab". Their poetry has fascinating trend and reality factor. And the rays of hope are obvious. His poetry covers various writings of Urdu literature. Maj. Syed Noor-ul-Hassan is the author of "Aks e Noor". In this book, he has tested many principles of Urdu literature. Your poetry has been tested on love virtual and glimpse of dream. you think Western Civilization greatly damaged Islamic civilization and culture. your poetry can be included in Urdu literature

Weed flora of Sugarcane (Saccharum officinarum L.) Crop Cultivated on High Fertile Soil of District Charsadda-Pakistan

Sugarcane is the major crop of district Charsadda-Pakistan and weeds infestation is the most problematic factor responsible for low yield in sugarcane. For the purpose a field experiment was conducted to find out the important and most problematic weeds of Sugarcane crop using quadrate method in different sugarcane fields at DistrictCharsadda, Khyber Pakhtunkhwa, Pakistan. The data was collected during summer season,2021. Based on spatial data it is concluded that Cyperus rotundus L., Parthenium hysterophorus L., Trianthema portulacastrum L., Euphorbia helioscopia  L., Convolvulus arvensis  L., Brachianreptans (L.)., Amaranthus viridusL., Physalis minima  L., Dactydocteniumaegyptium(L)., Amaranthus spinosusL., Portulaca  oleracea  L.,CynodondactylonL. and  Solanum nigrum  L., were the most abundant weeds of the studied fields. The relative weed densities (%) and relative frequencies (%) of all these weeds were calculated to quantify their importance values in descending order of their percentages as following: P.hysterophorus, T.portulacasrum, C.rotundus,  E. helioscopia. C. arvensis, B.reptans, A.viridus, and S. nigrum. Similarly, the highest (35.1%) importance value recorded for C. rotundus and declared the most competitive weed of sugarcane at district Charsadda. The control of C. rotundus recommended for the farmers of the area for the outmost yield of sugarcane

Unraveling the genetic variations underlying virulence disparities among SARS-CoV-2 strains across global regions: insights from Pakistan

Abstract Over the course of the COVID-19 pandemic, several SARS-CoV-2 variants have emerged that may exhibit different etiological effects such as enhanced transmissibility and infectivity. However, genetic variations that reduce virulence and deteriorate viral fitness have not yet been thoroughly investigated. The present study sought to evaluate the effects of viral genetic makeup on COVID-19 epidemiology in Pakistan, where the infectivity and mortality rate was comparatively lower than other countries during the first pandemic wave. For this purpose, we focused on the comparative analyses of 7096 amino-acid long polyprotein pp1ab. Comparative sequence analysis of 203 SARS-CoV-2 genomes, sampled from Pakistan during the first wave of the pandemic revealed 179 amino acid substitutions in pp1ab. Within this set, 38 substitutions were identified within the Nsp3 region of the pp1ab polyprotein. Structural and biophysical analysis of proteins revealed that amino acid variations within Nsp3’s macrodomains induced conformational changes and modified protein-ligand interactions, consequently diminishing the virulence and fitness of SARS-CoV-2. Additionally, the epistatic effects resulting from evolutionary substitutions in SARS-CoV-2 proteins may have unnoticed implications for reducing disease burden. In light of these findings, further characterization of such deleterious SARS-CoV-2 mutations will not only aid in identifying potential therapeutic targets but will also provide a roadmap for maintaining vigilance against the genetic variability of diverse SARS-CoV-2 strains circulating globally. Furthermore, these insights empower us to more effectively manage and respond to potential viral-based pandemic outbreaks of a similar nature in the future

The influence of incisor inclination and anterior vertical facial height on facial attractiveness in an Asian woman

Introduction: Orthodontic treatment can help improve facial attractiveness through the modification of factors affecting the soft tissue profile. The objectives of this study were to determine the impact of different maxillary incisal inclinations and lower anterior facial heights (at rest and with a smile) on the facial attractiveness of an Asian woman, as perceived by different panels of raters using visual analog scale (VAS) scores.Methods: A cross-sectional study was performed with 66 raters equally divided into 3 panels that consisted of general dentists, orthodontic residents, and laypersons. Raters assessed modified photographs of a subject with various incisor inclinations and lower anterior facial height/total anterior facial height (LAFH/TAFH) on lateral profile view. Modifications were made using Photoshop software (Adobe, San Jose, Calif). Subjective evaluations of facial attractiveness were performed by raters using VAS. Kruskal-Wallis test was used to compare VAS scores among raters. Mann-Whitney U test was applied to compare VAS scores between groups.Results: Significant differences in VAS scores were found among raters for -10° (P = 0.004) and -15° (P = 0.021) incisal inclinations. Significant differences were found in VAS scores for -8% LAFH/TAFH (P = 0.044) and 4% LAFH/TAFH with smile (P = 0.002).Conclusions: Professionals preferred normal incisal inclinations to be the most attractive. General dentists found reduced facial height to be unattractive. Orthodontic residents and laypersons considered increased LAFH/TAFH to be most unattractive. Smile had a negative impact on VAS scores at extreme anterior facial height modifications

Influence of incisor inclination and anterior vertical facial height on facial attractiveness in an adult Asian male

Introduction: Balanced facial proportions and hard tissue relationships are important factors in facial attractiveness. The objective of this study was to determine the most pleasing maxillary incisal inclination (MII) on the lateral profile and the impact of various lower anterior facial height (LAFH) ratios (at rest and with a smile) on facial attractiveness.Methods: This cross-sectional study was performed with 66 raters equally divided into 3 panels: general dentists (GD), orthodontic residents (OR), and laypersons (LP). Lateral profile view photographs of an Asian man were modified using Photoshop software (Adobe Systems, San Jose, Calif) to show altered MII and LAFH ratios at rest and when smiling. Subjective evaluations of facial attractiveness were performed by raters using a visual analog scale. Kruskal-Wallis test was used to compare esthetic scores among raters, and the Mann-Whitney U test was applied to compare ES between groups.Results: Kruskal-Wallis test showed significant differences in esthetic scores among raters for -10° (P = 0.028) and -15° MII (P = 0.030). Similarly, significant differences were found in ES for 8% LAFH ratio (P = 0.022), and 4% LAFH ratio (P = 0.035) at rest. Mann-Whitney U test showed significant differences between raters for -10° and -15° MII and between 8% and 4% LAFH ratio at rest.Conclusions: All groups rated -5° inclinations to be most attractive. General dentists and orthodontic residents found normal LAFH to be the most attractive, whereas long facial height was less attractive with smile. In addition, smile had a camouflaging effect on LAFH