Approaches to interdisciplinary mixed methods research in land change science and environmental management

Combining qualitative and quantitative methods and data is crucial to understanding the complex dynamics and often interdisciplinary nature of conservation. Many conservation scientists use mixed methods, but there are a variety of mixed methods approaches, a lack of shared vocabulary, and few methodological frameworks. We reviewed articles from 2 conservation-related fields that often incorporate qualitative and quantitative methods: land-change science (n= 16) and environmental management (n= 16). We examined how authors of these studies approached mixed-methods research by coding key methodological characteristics, including relationships between method objectives, extent of integration, iterative interactions between methods, and justification for use of mixed methods. Using these characteristics, we created a typology with the goal of improving understanding of how researchers studying land-change science and environmental management approach interdisciplinary mixed methods research. We found 5 types of mixed methods approaches, which we termed simple nested, informed nested, simple parallel, unidirectional synthesis, and bidirectional synthesis. Methods and data sources were often used to address different research questions within a project, and only around half of the reviewed papers methodologically integrated different forms of data. Most authors used one method to inform the other rather than both informing one another. Very few articles used methodological iteration. Each methodological type has certain epistemological implications, such as the disciplinary reach of the research and the capacity for knowledge creation through the exchange of information between distinct methodologies. To exemplify a research design that can lead to multi-dimensional knowledge production, we provide a methodological framework that bidirectionally integrates and iterates qualitative and quantitative methods

The Lantern Vol. 4, No. 3, June 1936

• Dr. Omwake as his Friends See Him: A Letter from Dr. James M. Anders ; An Interview with Dean Kline • George Leslie Omwake, Educator and Churchman • The Story of Ursinus • Way Back When • Editorial: We Look Before and After • Reminiscences of an Ex-Storekeeper\u27s Daughter • The Tale of a Toper, or How the Little Stone Went Rolling • Book Review: May I Present? • Time Out, Please • Youth at the Crossroads • Of Candy Bars and Tears • Reflections • To a Star • It Takes Two to Study the Moonhttps://digitalcommons.ursinus.edu/lantern/1008/thumbnail.jp

The Lantern Vol. 4, No. 3, June 1936

• Dr. Omwake as his Friends See Him: A Letter from Dr. James M. Anders ; An Interview with Dean Kline • George Leslie Omwake, Educator and Churchman • The Story of Ursinus • Way Back When • Editorial: We Look Before and After • Reminiscences of an Ex-Storekeeper\u27s Daughter • The Tale of a Toper, or How the Little Stone Went Rolling • Book Review: May I Present? • Time Out, Please • Youth at the Crossroads • Of Candy Bars and Tears • Reflections • To a Star • It Takes Two to Study the Moonhttps://digitalcommons.ursinus.edu/lantern/1008/thumbnail.jp

Editorial: Implementing the Teacher Education Initiative

Representatives from ten specialty professional associations affiliated with the National Technology Leadership Coalition (NTLC) are collaborating with Microsoft Corporation to develop an innovative professional development opportunity for teacher educators—the Teacher Education Initiative (TEI). The goal of the initiative is to enhance preparation of future teachers to use technology in effective ways to teach students across grades and academic disciplines. This effort builds upon initiatives such as Preparing Tomorrow’s Teachers to Use Technology (PT3) and Microsoft’s Partners in Learning (PIL) program. The goals of TEI are described in more detail in a previously published overview, “Preparing Teachers for Tomorrow’s Technologies” (Dilworth et al., 2012). The current article describes planned implementation strategies designed to advance more effective integration of technology in teacher preparation. TEI is grounded in the framework of technology, pedagogy, and content knowledge (TPACK; referred to as technological pedagogical content knowledge in Mishra & Koehler, 2006). Representatives of teacher education associations from a number of academic disciplines have assumed responsibility for the development of teacher education resources for each discipline. Representatives from associations related to special education, instructional technology, and teacher education at large are developing resources for non-discipline-specific teacher educators. In order to facilitate a systematic, coordinated approach within each TEI college or university representatives from the American Association of Colleges for Teacher Education (AACTE) are developing related materials for the leaders of schools, colleges and departments of teacher education

Expert Panel Curation of 113 Primary Mitochondrial Disease Genes for the Leigh Syndrome Spectrum

OBJECTIVE: Primary mitochondrial diseases (PMDs) are heterogeneous disorders caused by inherited mitochondrial dysfunction. Classically defined neuropathologically as subacute necrotizing encephalomyelopathy, Leigh syndrome spectrum (LSS) is the most frequent manifestation of PMD in children, but may also present in adults. A major challenge for accurate diagnosis of LSS in the genomic medicine era is establishing gene-disease relationships (GDRs) for this syndrome with >100 monogenic causes across both nuclear and mitochondrial genomes. METHODS: The Clinical Genome Resource (ClinGen) Mitochondrial Disease Gene Curation Expert Panel (GCEP), comprising 40 international PMD experts, met monthly for 4 years to review GDRs for LSS. The GCEP standardized gene curation for LSS by refining the phenotypic definition, modifying the ClinGen Gene-Disease Clinical Validity Curation Framework to improve interpretation for LSS, and establishing a scoring rubric for LSS. RESULTS: The GDR with LSS across the nuclear and mitochondrial genomes was classified as definitive for 31/114 gene-disease relationships curated (27%); moderate for 38 (33%); limited for 43 (38%); and 2 as disputed (2%). Ninety genes were associated with autosomal recessive inheritance, 16 were maternally inherited, 5 autosomal dominant, and 3 X-linked. INTERPRETATION: GDRs for LSS were established for genes across both nuclear and mitochondrial genomes. Establishing these GDRs will allow accurate variant interpretation, expedite genetic diagnosis of LSS, and facilitate precision medicine, multi-system organ surveillance, recurrence risk counselling, reproductive choice, natural history studies and eligibility for interventional clinical trials. This article is protected by copyright. All rights reserved

Relational Conservation Territories: Racialized Property Regimes, Negotiated Rights and Environmental Management in the Selva Misionera

Thesis (Ph.D.)--University of Washington, 2023This dissertation examines the intersection of the often-unrealized rights of Latin America’s ‘territorial turn’ and the shifting political economy of Misiones, Argentina, as the selva misionera subtropical forest is revalorized as an object of conservation. I analyze the making of conservation territories through an ethnography of ‘Lote 8’, a nearly 4000-hectare lot in the Yabotí Biosphere Reserve, purchased for conservation and titled to three Mbya Guarani communities following over a decade of struggle for their land. First, I explore how Lote 8 is produced and stabilized as a discursive object through a multi-scalar network of actors, institutions, and infrastructures, which extract political, social and material value through its representation. Then, I trace the relationship among property, indigeneity and the selva though the creation of the Yabotí Biosphere Reserve in the early 1990s, the dispute over Lote 8 between the Mbya Guarani and a logging company at the turn of the century, and the negotiated conservation land purchase and titling agreement. I show how claims to ‘conservation citizenship’ produce new spaces to contest histories of racialized dispossession and negotiate rights otherwise foreclosed through legal avenues, as conservation networks become an audience for the enunciation of rights claims and a non-state arbiter of the recognition of Indigenous communities. Problematically however, where rights claims made to the state require legibility of land as Indigenous territory, recognition by conservation actors requires that Indigenous communities demonstrate their legitimacy as conservation subjects, making ‘negotiated rights’ contingent, imbricated with the political economy of conservation and always susceptible to being undermined. Finally, I examine the effects of (re)producing the selva misionera as an object of environmental management in the Yabotí Biosphere Reserve and its area of influence. I show how provincial parks are socially produced through the embodied labor of park rangers, which extends through (b)ordering practices for managing the overlapping borderlands of the Yabotí Biosphere Reserve and the national border with Brazil. I argue that accessing land titles through conservation entangles Indigenous rights with environmental management as it operates as a mode of extending settler colonial territorial control through the everyday enactment of conservation territories

Biases and limitations of Global Forest Change and author-generated land cover maps in detecting deforestation in the Amazon.

Studying land use change in protected areas (PAs) located in tropical forests is a major conservation priority due to high conservation value (e.g., species richness and carbon storage) here, coupled with generally high deforestation rates. Land use change researchers use a variety of land cover products to track deforestation trends, including maps they produce themselves and readily available products, such as the Global Forest Change (GFC) dataset. However, all land cover maps should be critically assessed for limitations and biases to accurately communicate and interpret results. In this study, we assess deforestation in PA complexes located in agricultural frontiers in the Amazon Basin. We studied three specific sites: Amboró and Carrasco National Parks in Bolivia, Jamanxim National Forest in Brazil, and Tambopata National Reserve and Bahuaja-Sonene National Park in Peru. Within and in 20km buffer areas around each complex, we generated land cover maps using composites of Landsat imagery and supervised classification, and compared deforestation trends to data from the GFC dataset. We then performed a dissimilarity analysis to explore the discrepancies between the two remote sensing products. Both the GFC and our supervised classification showed that deforestation rates were higher in the 20km buffer than inside the PAs and that Jamanxim National Forest had the highest deforestation rate of the PAs we studied. However, GFC maps showed consistently higher rates of deforestation than our maps. Through a dissimilarity analysis, we found that many of the inconsistencies between these datasets arise from different treatment of mixed pixels or different parameters in map creation (for example, GFC does not detect reforestation after 2012). We found that our maps underestimated deforestation while GFC overestimated deforestation, and that true deforestation rates likely fall between our two estimates. We encourage users to consider limitations and biases when using or interpreting our maps, which we make publicly available, and GFC's maps

Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1)

Congenital fibrosis of the extraocular muscles type 1 (CFEOM1; OMIM #135700) is an autosomal dominant strabismus disorder associated with defects of the oculomotor nerve. We show that individuals with CFEOM1 harbor heterozygous missense mutations in a kinesin motor protein encoded by KIF21A. We identified six different mutations in 44 of 45 probands. The primary mutational hotspots are in the stalk domain, highlighting an important new role for KIF21A and its stalk in the formation of the oculomotor axis