VIRTUAL SCREENING, PHARMACOPHORE MODELING, AND QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES ON HISTAMINE 4 RECEPTOR

  Objective: To find out novel inhibitors for histamine 4 receptor (H4R), the target for various allergic and inflammatory pathophysiological conditions.Methods: Homology modeling of H4R was performed using easy modeler and validated using structure analysis and verification server, and with the modeled structure, virtual screening, pharmacophore modeling, and quantitative structure activity relationship (QSAR) studies were performed using the Schrodinger 9.3 software.Results: Among all the synthetic and natural ligands, hesperidin, vitexin, and diosmin were found to have the highest dock score, and with that, a five-point pharmacophore model was developed consisting of two hydrogen bond acceptor and three ring atoms, and the pharmacophore hypothesis yielded a statistically significant three-dimensional QSAR (3D-QSAR) model with a correlation coefficient of r2=0.8962 as well as good predictive power.Conclusion: The pharmacophore-based 3D-QSAR model generated from natural antihistamines can provide intricate structural knowledge about a new class of anti-allergic and anti-inflammatory drug research

JOB SATISFACTION IN THE TEXTILE INDUSTRY EMPLOYEES IN TIRPUR, INDIA

Indian Textile industry is playing a major role in the development of the Indian Economy. Tamil Nadu state provides more revenue through the Textile industry in this state. Tirupur contributes more revenue collection of the Tamilnadu state. Tirupur is the "knitwear capital" of India. It has spurred up the textile industry in India for the past three decades. Jab satisfaction is one of the factors of Quality to Work Life (QWL). Better quality of QWL ultimately improves production and gets more satisfaction among the employee. Job satisfaction indicates the positive affective responses of employees to their job environment. Nowadays textile industry employees are dissatisfied with job viz., absenteeism, annoyances, anxiety, reduction in efficiency, physical pains and this is evident through many earlier types of research on several aspects of human resources in the textile industry. Hence, the researcher wants to know the job satisfaction position of textile industry employee who is working in Tirupu

Curvelet and Ridgelet-based Multimodal Biometric Recognition System using Weighted Similarity Approach

Biometric security artifacts for establishing the identity of a person with high confidence have evoked enormous interest in security and access control applications for the past few years. Biometric systems based solely on unimodal biometrics often suffer from problems such as noise, intra-class variations and spoof attacks. This paper presents a novel multimodal biometric recognition system by integrating three biometric traits namely iris, fingerprint and face using weighted similarity approach. In this work, the multi-resolution features are extracted independently from query images using curvelet and ridgelet transforms, and are then compared to the enrolled templates stored in the database containing features of each biometric trait. The final decision is made by normalizing the feature vectors, assigning different weights to the modalities and fusing the computed scores using score combination techniques. This system is tested with the public unimodal databases such as CASIA–Iris-V3-Interval, FVC2004, ORL and self-built multimodal databases. Experimental results obtained shows that the designed system achieves an excellent recognition rate of 98.75 per cent and 100 per cent for the public and self-built databases respectively and provides ultra high security than unimodal biometric systems.Defence Science Journal, 2014, 64(2), pp. 106-114. DOI: http://dx.doi.org/10.14429/dsj.64.346

Effectiveness of flutter mucus clearance device on lung function in COPD subjects with retained secretion.

INTRODUCTION : Chronic obstructive pulmonary disease is the most common lung disease and major causes of disability and death in the world population. WHO estimates that by 2000, 2.74 million COPD people died, world wide. Copd is the most common disorder, affiliating 10-15% of adults over the age of 40 Yrs and prevalence is increasing. Flutter a positive expiratory pressure technique eliminates mucus from the bronchial airway and thus improves bronchial hygiene in chronic bronchitis patients. By using flutter device there was a statistically significant improvement in FEV1 and FVC, whether patients were pretreated with mucus clearance device there was a significant improvement in lung function compared to baseline with combined bronchodilator therapy. AIM : The aim of the study is to analyze the effectiveness of flutter mucous clearance device on lung function in COPD subjects with retained secretion. OBJECTIVES : • To study the effectiveness of flutter device on mucous clearance in copd subjects and retained secretion. • To study the effectiveness of lung function in COPD with retained secretion. MATERIALS AND METHODS : MATERIALS - Personal data, Flutter device, Stethoscope, Computerized Spirometer, Sputum box. METHODOLOGY : Study Design - Quasi experimenta study. Study Setting - The study was conducted at the outpatient department in JKKMMRF College of physiotherapy, and District Head Quarters Hospital, Erode, under the supervision of concerned authority. Study sampling - A total of 30 subject were selected by purposive random sampling method after due consideration to the inclusion and exclusion criteria. They were divided into Group A and Group B, with 15 subjects in each group. CONCLUSION : As the incidence of stress and chronic illness increase the challenge to the physiotherapist to treat Bronchitis (COPD) Patients. Flutter device increases the Lung function and reduce mucous retention. This study concluded that there was a significant effect of flutter Mucus clearance device on Lung function in COPD subjects with retained secretion

Qualitative And Quantitative Analysis of Cinnamomum Tamala Leaf Extract

Objective: The purpose of the study is to assess the properties and bioactive components of Cinnamomum tamala leaves. Methods: The leaves of Cinnamomum tamala were extracted. Different experimental methods have been used to study the phytochemicals (qualitative and quantitative). The phytochemical screening was evaluated in different extractions such as aqueous, hexane, ethanol, petroleum ether and hydroethanolic to compare the solubility of various bioactive components. Further, high performance liquid chromatography (HPLC) and gas chromatography mass spectrometry (GC-MS) were also performed to study the presence of flavonoids and secondary metabolites respectively. Results: The Qualitative analysis showed the presence of phytochemical compounds in higher concentration in hydroethanolic extract of the leaves of Cinnamomum tamala. In comparison with other extracts, hydroethanolic extract had larger yields of flavonoids (186.42 ± 13.04 mg/g QE), phenols (226.34 ± 15.84 mg/g GAE), saponins (112.10 ± 7.84 mg/g) and steroids (161.30 ± 11.29 mg/g CL). HPLC analysis revealed the presence of flavonoids in hydroethanolic extracts of the leaves of Cinnamomum tamala. GC-MS analysis proved the presence of various bioactive compounds in the hydroethanolic extract of the leaves of Cinnamomum tamala. Conclusion: The results of this study demonstrated the significance of the leaves of Cinnamomum tamala. We concluded that Cinnamomum tamala leaves have various biological activities which can treat diseases.

Indolicidin – Antibacterial activity against bacterial pathogens isolated from ocular infections

Indolicidin is a novel/ promising antimicrobial peptide (a 13 amino acid cationic antimicrobial residue present in the form of cytoplasmic granules of bovine neutrophils) and observed with a broad spectrum of antimicrobial activity against bacteria, fungi, protozoa & even viruses. In the present study, Escherichia coli was transformed with pET 21a+ plasmid carrying indolicidin gene and was expressed. The crude extracts of indolicidin samples induced with varying IPTG concentrations (5mM and 20 mM/ ml of the medium) in Min A medium were checked for antibacterial activities against clinically important ocular bacterial pathogens such as E. coli, Klebsiella sp,, Pseudomonas sp., Acenitobacter sp., Staphylococcus aureus, coagulase negative Staphylococcus aureus, Streptococcus viridans, S. pneumoniae and S. pyogens and its activity was evaluated.&nbsp

A study on customer satisfaction on online marketing in india

Marketing of products or services over the internet. Online Marketing is the marketing of products or services over the internet & it ties together creative and technical aspects of the internet, including design, development, advertising, and sale. Online marketing is used by companies selling goods and services directly to consumers as well as those who operate on a business to business. Online marketing, it refers to the techniques which are available to a business market, promote and advertise their products, services or brand to the World Wide Web

Effect of the valine-threonine constraint on the dynamics of the proline helix -A molecular dynamics study

Al~traet. Proline residues in helices play an important role in the structure of proteins. The proline residue introduces a kink in the helix which varies from about 5 ~ to 50 ~ The presence of other residues such as threonine or valine near the proline region can influence the flexibility exhibited by the kinked helix, which can have an important biological role. In the present paper, the constraint introduced by threonine and valine on a proline helix is investigated by molecular dynamics studies. The systems considered are (1) a poly-alanine helix with threonine-proline residues (TP) and (2) a poly-alanine helix with valine-threonineproline residues (VTP), in the middle. Molecular dynamics simulations are carried out on these two systems for 500ps. The results are analyzed in terms of structural transitions, bend-related parameters and sidechain orientations

Effect of the valine-threonine constraint on the dynamics of the proline helix- A molecular dynamics study

Proline residues in helices play an important role in the structure of proteins. The proline residue introduces a kink in the helix which varies from about 5° to 50°. The presence of other residues such as threonine or valine near the proline region can influence the flexibility exhibited by the kinked helix, which can have an important biological role. In the present paper, the constraint introduced by threonine and valine on a proline helix is investigated by molecular dynamics studies. The systems considered are (1) a poly-alanine helix with threonine-proline residues (TP) and (2) a poly-alanine helix with valine-threonineproline residues (VTP), in the middle. Molecular dynamics simulations are carried out on these two systems for 500 ps. The results are analyzed in terms of structural transitions, bend-related parameters and sidechain orientations