M2M Security Technology of CPS Based on Blockchains

As the core of intelligent manufacturing, cyber-physical systems (CPS) have serious security issues, especially for the communication security of their terminal machine-to-machine (M2M) communications. In this paper, blockchain technology is introduced to address such a security problem of communications between different types of machines in the CPS. According to the principles of blockchain technology, we designed a blockchain for secure M2M communications. As a communication system, M2M consists of public network areas, device areas, and private areas, and we designed a sophisticated blockchain structure between the public area and private area. For validating our design, we took cotton spinning production as a case study to demonstrate our solution to M2M communication problems under the CPS framework. We have demonstrated that the blockchain technology can effectively solve the safety of expansion of machines in the production process and the communication data between the machines cannot be tampered with

Modulation of ovine SBD-1 expression by 17beta-estradiol in ovine oviduct epithelial cells

Abstract Background Mucosal epithelia, including those of the oviduct, secrete antimicrobial innate immune molecules (AIIMS). These have bactericidal/bacteriostatic functions against a variety of pathogens. Among the AIIMs, sheep β-defensin-1 (SBD-1) is one of the most potent. Even though the SBD-1 is an important AIIM and it is regulated closely by estrogenic hormone, the regulation mechanism of 17β-estradiol has not been clearly established. We investigated the effects of E2 and agonist or inhibitor on ovine oviduct epithelial cells in regard to SBD-1 expression using reverse transcription quantitative PCR (RT-qPCR). In addition, three different pathways were inhibited separately or simultaneously to confirm the effect of different inhibitors in the regulation mechanism. Results 17beta-estradiol (E2) induced release of SBD-1 in ovine oviduct epithelial cells. SBD-1 expression was mediated through G-protein-coupled receptor 30 (GPR30) and Estrogen Receptors (ERs) activation in ovine oviduct epithelial cell. Inhibition of gene expression of protein kinase A (PKA), protein kinase C (PKC), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) led to a decreased SBD-1 expression. Conclusions Taken together, E2-induced up-regulation of SBD-1 expressions were GPR30-dependent during prophase and ERs-dependent during later-stage in ovine oviduct epithelial cells, and we assume that the effect was completed by the PKA, PKC, and NF-κB pathways simultaneous.</p

Association of high sensitivity C-reactive protein and abdominal aortic aneurysm: a meta-analysis and systematic review

<p><b>Objective:</b> To evaluate the association of high sensitivity C-reactive protein (hsCRP) with the presence of abdominal aortic aneurysm (AAA).</p> <p><b>Methods:</b> Medline, Cochrane, Embase, and Google Scholar databases were searched until 22 June 2016 using the keywords predictive factors, biomarkers, abdominal aortic aneurysm, prediction, high sensitivity C-reactive protein, and hsCRP. Prospective studies, retrospective studies, and cohort studies were included.</p> <p><b>Results:</b> Twelve case–control studies were included in the meta-analysis with a total of 8345 patients (1977 in the AAA group and 6368 in the control group). The pooled results showed that AAA patients had higher hsCRP value than the control group (difference in means = 1.827, 95% CI = 0.010 to 3.645, <i>p</i> = .049). Subgroup analysis found AAA patients with medium or small aortic diameter (<50 mm) had higher hsCRP plasma levels than the control group (difference in means = 1.301, 95% CI = 0.821 to 1.781, <i>p</i> < .001). In patients with large aortic diameter (≥50 mm), no difference was observed in hsCRP levels between the AAA and control groups (difference in means = 1.769, 95% CI = −1.387 to 4.925, <i>p</i> = .272). Multi-regression analysis found the difference in means of hsCRP plasma levels between AAA and control groups decreased as aortic diameter increased (slope = −0.04, <i>p</i> < .001), suggesting that hsCRP levels may be inversely associated with increasing aneurysm size.</p> <p><b>Conclusions:</b> Our findings suggest that hsCRP levels may possibly be used as a diagnostic biomarker for AAA patients with medium or small aortic diameter but not for AAA patients with large aortic diameter. The correlation between serum hsCRP level and AAA aneurysm is not conclusive due to the small number of included articles and between-study heterogeneity.</p