‘We didn’t see it coming': the Conservatives

This contribution to the ‘Britain Votes 2017’ special issue of Parliamentary Affairs focuses on the Conservative Party’s campaign. It was a campaign at which everything that could go wrong for the Conservatives did go wrong. The manifesto, which May’s Chief of Staff Nick Timothy believed would be an asset, turned into a liability, confirming the belief of her campaign consultant Lynton Crosby that the contest between the parties needed to be framed in terms of leadership. Unfortunately, however, Theresa May simply wasn’t the kind of presidential politician who could carry that kind of campaign. Nor did Brexit do her or her party as much of a favour as everyone had expected. For one thing, she seemed to think she could get away with mouthing mantras and platitudes about leaving the EU, opening up a vacuum that other issues rushed in to fill. For another, the number of UKIP, older, poorly-educated and working-class voters that the party gained as a result of the government’s tough talk on Europe seems to have been outweighed by the number of younger, better-educated, middle-class, Remain voters who were alienated and infuriated by it. More generally, the Tories suffered because they were unable or unwilling, ideologically or otherwise, to respond convincingly to increasing voter concern about ongoing cuts to key public services

Emotions, cognitions and moderation : understanding losers’ consent in the 2016 Brexit referendum

Why do some voters accept their defeat and agree to a democratic verdict while some do not? This distinction between “graceful” and “sore” losers is essential for the stability of democratic regimes. This paper focuses on the phenomenon of losers’ consent in the 2016 Brexit referendum using original public opinion data. Extant studies suggest that post-electoral reactions are mainly outcome-driven, consider winners and losers as homogeneous groups, and neglect the individual-level profile and motivations of graceful losers. Using an innovative and direct question to measure losers’ consent, this research finds that voters’ reaction to the outcome is also process-driven. Graceful losers are politically involved and principled citizens who are more inclined to judge the merits of democracy in procedural terms. They are also more politically sophisticated, less emotionally engaged in the electoral decision, hold more moderate views on the object of the vote, and are torn between the options until the end of the campaign. These findings have important implications for democratic theory. The stability of democracies depends not only on sophisticated voters capable of prioritizing the benefits of the democratic process over disappointing outcomes but also on voters who are indecisive, hesitant, and above all, moderate

Rheumatoid arthritis - clinical aspects: 134. Predictors of Joint Damage in South Africans with Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) causes progressive joint damage and functional disability. Studies on factors affecting joint damage as clinical outcome are lacking in Africa. The aim of the present study was to identify predictors of joint damage in adult South Africans with established RA. Methods: A cross-sectional study of 100 black patients with RA of >5 years were assessed for joint damage using a validated clinical method, the RA articular damage (RAAD) score. Potential predictors of joint damage that were documented included socio-demographics, smoking, body mass index (BMI), disease duration, delay in disease modifying antirheumatic drug (DMARD) initiation, global disease activity as measured by the disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and autoantibody status. The predictive value of variables was assessed by univariate and stepwise multivariate regression analyses. A p value <0.05 was considered significant. Results: The mean (SD) age was 56 (9.8) years, disease duration 17.5 (8.5) years, educational level 7.5 (3.5) years and DMARD lag was 9 (8.8) years. Female to male ratio was 10:1. The mean (SD) DAS28 was 4.9 (1.5) and total RAAD score was 28.3 (12.8). The mean (SD) BMI was 27.2 kg/m2 (6.2) and 93% of patients were rheumatoid factor (RF) positive. More than 90% of patients received between 2 to 3 DMARDs. Significant univariate predictors of a poor RAAD score were increasing age (p = 0.001), lower education level (p = 0.019), longer disease duration (p < 0.001), longer DMARD lag (p = 0.014), lower BMI (p = 0.025), high RF titre (p < 0.001) and high ESR (p = 0.008). The multivariate regression analysis showed that the only independent significant predictors of a higher mean RAAD score were older age at disease onset (p = 0.04), disease duration (p < 0.001) and RF titre (p < 0.001). There was also a negative association between BMI and the mean total RAAD score (p = 0.049). Conclusions: Patients with longstanding established RA have more severe irreversible joint damage as measured by the clinical RAAD score, contrary to other studies in Africa. This is largely reflected by a delay in the initiation of early effective treatment. Independent of disease duration, older age at disease onset and a higher RF titre are strongly associated with more joint damage. The inverse association between BMI and articular damage in RA has been observed in several studies using radiographic damage scores. The mechanisms underlying this paradoxical association are still widely unknown but adipokines have recently been suggested to play a role. Disclosure statement: C.I. has received a research grant from the Connective Tissue Diseases Research Fund, University of the Witwatersrand. All other authors have declared no conflicts of interes

High performance RDMA protocols in HPC

Abstract. Modern network interconnects that leverage Remote Directory Memory Access (RDMA) and OS bypass, such as Infiniband [2], Myrinet [9], and iWARP over TCP [3], can offer significant performance advantages over conventional send/receive network semantics. However, the high performance of RDMA often comes with hidden costs. RDMA based interconnects generally fail to provide true one-sided semantics, requiring an exchange of information prior to initiating a one-sided RDMA operation. In addition, both the initiator and target must typically preserve the physical to virtual memory mappings during the RDMA operation. This paper describes a unique user-level ‘pipeline ’ protocol that addresses these constraints while avoiding some of the pitfalls of existing techniques. By effectively overlapping the cost of memory registration with RDMA operations this protocol provides good performance even in the absence of memory buffer reuse. This protocol may also take advantage of memory buffers that have already been used in RDMA operations by avoiding the cost of memory registration. Through this approach, bandwidth may be increased up to 67 % when memory buffers are not effectively reused while providing performance equal to that of existing techniques as demonstrated by both Linpack and NPB benchmark results. Several user level protocols are explored using Open MPI’s PML (Point to point messaging layer) and compared/contrasted to this ‘pipeline ’ protocol.

The application of histomorphometry and Fourier Transform Infrared Spectroscopy to the analysis of early Anglo-Saxon burned bone

Macroscopic examination, histomorphometry and Fourier Transform Infrared Spectroscopy (FTIR) are applied to the analysis of burned bones from the early Anglo-Saxon cemetery at Elsham in Lincolnshire, UK. These methods were undertaken to gain a greater understanding of pyre conditions from an archaeological context and the effects of burning on bone microstructure. Sixteen samples were employed for thin-section analysis while eight samples were used with FTIR. The results suggest that these methods correspond well with macroscopic examination, though anomalies did occur. The techniques employed in this paper have demonstrated that the temperatures reached on the funerary pyres at Elsham ranged from 600 degrees C to over 900 degrees C under oxidizing conditions. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved