The asteroseismological potential of the pulsating DB white dwarf stars CBS 114 and PG 1456+103

We have acquired 65 h of single-site time-resolved CCD photometry of the pulsating DB white dwarf star CBS 114 and 62 h of two-site high-speed CCD photometry of another DBV, PG 1456+103. The pulsation spectrum of PG 1456+103 is complicated and variable on time scales of about one week and could only partly be deciphered with our measurements. The modes of CBS 114 are more stable in time and we were able to arrive at a frequency solution somewhat affected by aliasing, but still satisfactory, involving seven independent modes and two combination frequencies. These frequencies also explain the discovery data of the star, taken 13 years earlier. We find a mean period spacing of 37.1 +/- 0.7 s significant at the 98% level between the independent modes of CBS 114 and argue that they are due to nonradial g-mode pulsations of spherical degree l=1. We performed a global search for asteroseismological models of CBS 114 using a genetic algorithm, and we examined the susceptibility of the results to the uncertainties of the observational frequency determinations and mode identifications (we could not provide m values). The families of possible solutions are identified correctly even without knowledge of m. Our optimal model suggests Teff = 21,000 K and M_* = 0.730 M_sun as well as log(M_He/M_*) = -6.66, X_O = 0.61. This measurement of the central oxygen mass fraction implies a rate for the ^12C(alpha,gamma)^16O nuclear reaction near S_300=180 keV b, consistent with laboratory measurements.Comment: 10 pages, 10 embedded figures, 3 embedded tables. Accepted for publication in MNRA

So You Discovered a Potential Glycan-Based Biomarker; Now What? We Developed a High-Throughput Method for Quantitative Clinical Glycan Biomarker Validation

Glycomic-based approaches to discover potential biomarkers have shown great promise in their ability to distinguish between healthy and diseased individuals; these methods can identify when aberrant glycosylation is significant, but they cannot practically be adapted into widely implemented diagnostic assays because they are too complex, expensive, and low-throughput. We have developed a new strategy that addresses challenges associated with sample preparation, sample throughput, instrumentation needs, and data analysis to transfer the valuable knowledge provided by protein glycosylation into a clinical environment. Notably, the detection limits of the assay are in the single-digit picomole range. Proof of principle is demonstrated by quantifying the changes in the sialic acid content in fetuin. As the sialic acid content in proteins varies in a number of disease states, this example demonstrates the utility of the method for biomarker analysis. Furthermore, the developed method can be adapted to other biologically important saccharides, affording a broad array of quantitative glycomic analyses that are accessible in a high-throughput, plate-reader format. These studies enable glycomic-based biomarker discovery efforts to transition through the difficult landscape of developing a potential biomarker into a clinical assay

Spectroscopic characterization and detection of Ethyl Mercaptan in Orion

New laboratory data of ethyl mercaptan, CH$_{3}$CH$_{2}$SH, in the millimeter and submillimeter-wave domains (up to 880 GHz) provided very precise values of the spectroscopic constants that allowed the detection of $gauche$-CH$_3$CH$_2$SH towards Orion KL. 77 unblended or slightly blended lines plus no missing transitions in the range 80-280 GHz support this identification. A detection of methyl mercaptan, CH$_{3}$SH, in the spectral survey of Orion KL is reported as well. Our column density results indicate that methyl mercaptan is $\simeq$ 5 times more abundant than ethyl mercaptan in the hot core of Orion KL.Comment: Accepted for publication in ApJL (30 January 2014)/ submitted (8 January 2014

Open Systems Viewed Through Their Conservative Extensions

A typical linear open system is often defined as a component of a larger conservative one. For instance, a dielectric medium, defined by its frequency dependent electric permittivity and magnetic permeability is a part of a conservative system which includes the matter with all its atomic complexity. A finite slab of a lattice array of coupled oscillators modelling a solid is another example. Assuming that such an open system is all one wants to observe, we ask how big a part of the original conservative system (possibly very complex) is relevant to the observations, or, in other words, how big a part of it is coupled to the open system? We study here the structure of the system coupling and its coupled and decoupled components, showing, in particular, that it is only the system's unique minimal extension that is relevant to its dynamics, and this extension often is tiny part of the original conservative system. We also give a scenario explaining why certain degrees of freedom of a solid do not contribute to its specific heat.Comment: 51 page

Buckling of swelling gels

The patterns arising from the differential swelling of gels are investigated experimentally and theoretically as a model for the differential growth of living tissues. Two geometries are considered: a thin strip of soft gel clamped to a stiff gel, and a thin corona of soft gel clamped to a disk of stiff gel. When the structure is immersed in water, the soft gel swells and bends out of plane leading to a wavy periodic pattern which wavelength is measured. The linear stability of the flat state is studied in the framework of linear elasticity using the equations for thin plates. The flat state is shown to become unstable to oscillations above a critical swelling rate and the computed wavelengths are in quantitative agreement with the experiment

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages

Tumor-associated macrophages can account for up to 50% of the tumor mass in breast cancer patients and high TAM density is associated with poor clinical prognosis. Because TAMs enhance tumor growth, development, and metastatic potential, redirection of TAM activation may have significant therapeutic benefit. Our studies in primary human macrophages and murine breast TAMs suggest that the synthetic oleanane triterpenoid CDDO-methyl ester (CDDO-Me) reprograms the activation profile of TAMs from tumor-promoting to tumor-inhibiting. We show that CDDO-Me treatment inhibits expression of IL-10 and VEGF in stimulated human M2 macrophages and TAMs but increases expression of TNF-α and IL-6. Surface expression of CD206 and CD163, which are characteristic of M2 activation, is significantly attenuated by CDDO-Me. In contrast, CDDO-Me up-regulates surface expression of HLA-DR and CD80, which are markers of M1 activation, and importantly potentiates macrophage activation of autologous T cells but inhibits endothelial cell vascularization. These results show for the first time that CDDO-Me redirects activation of M2 macrophages and TAMs from immune-suppressive to immune-stimulatory, and implicate a role for CDDO-Me as an immunotherapeutic in the treatment of breast and potentially other types of cancer

Perceived Realism of Pedestrian Crowds Trajectories in VR

Crowd simulation algorithms play an essential role in populating Virtual Reality (VR) environments with multiple autonomous humanoid agents. The generation of plausible trajectories can be a significant computational cost for real-time graphics engines, especially in untethered and mobile devices such as portable VR devices. Previous research explores the plausibility and realism of crowd simulations on desktop computers but fails to account the impact it has on immersion. This study explores how the realism of crowd trajectories affects the perceived immersion in VR. We do so by running a psychophysical experiment in which participants rate the realism of real/synthetic trajectories data, showing similar level of perceived realism

The nested games of the UK’s EU referendum: ruptures, reconfigurations and lessons for Europe

The 2016 decision by the United Kingdom to withdraw from the European Union was a seminal one for both parties. In this special issue, we consider the extent to which the inter-penetration of the national and the European arenas produced significant opportunities for recasting political action. The nesting of these two levels matters firstly in allowing for the politicisation and mobilisation of domestic actors around European issues and secondly in explaining why seemingly sub-optimal or counter-productive actions are taken. The tensions this generated reached a critical juncture with the referendum, a rupture that highlights the extent to which a nominally second-order vote can have fundamental impacts on the first order’s structure and preferences. Bringing together scholars from a wide range of approaches and covering various aspects of the Brexit process, this special issue offers a significant contribution to improving our understanding of an event that will shape British and European politics for a generation