Como sonhar grande, mas não implementar tanto assim: Coordenação de Desenvolvimento do Ministério do Trabalho da Jordânia

O caso versa sobre a cooperação entre o Canadá e a Jordânia no desenvolvimento de uma estratégia denominada “Educação para o Emprego e Capacitação Técnica e Vocacional (E-TVET)”. Dentro do Ministério do Trabalho jordaniano, órgão que liderava a ação, foi criada uma unidade de coordenação, para qual foi disponibilizada pela cooperação canadense uma assessora com expertise em educação, Brenda Cooke. Sua tarefa era apoiar o estabelecimento e a operacionalização dessa unidade, conforme termo de referência. Contando com a boa assistência técnica da consultora, o projeto deu certo e gerou lições importantes que são descritas no caso, como a administração adequada das expectativas dos atores envolvidos, abordagem participativa para estabelecer as regras de funcionamento da unidade etc. O caso presta-se ao ensino de temas como cooperação internacional, liderança, gestão de projetos e outrosNúmero de páginas: 8 p.LiderançaInovaçãoLeslie Shimotakahara era diretora da Divisão de Programas Internacionais do Instituto de Administração Pública do Canadá quando redigiu este cas

Techniques of biliary reconstruction following bile duct resection (with video)

In several clinical situations, including resection of malignant or benign biliary lesions, reconstruction of the biliary system using the Roux-en-Y jejunum limb has been adopted as the standard procedure. The basic technique and the procedural knowledge essential for most gastroenterological surgeons are described in this article, along with a video supplement. Low complication rates involving anastomotic insufficiency or stricture can be achieved by using proper surgical techniques, even following small bile duct reconstruction. Using the ropeway method to stabilize the bile duct and jejunal limb allows precise mucosa-to-mucosa anastomosis with interrupted sutures of the posterior row of the anastomosis. Placement of a transanastomotic stent tube is the second step. The final step involves suturing the anterior row of the anastomosis. In contrast to the lower extrahepatic bile duct, the wall of the hilar or intrahepatic bile duct can be recognized within the fibrous connective tissue in the Glissonean pedicle. The portal side of the duct should be selected for the posterior wall during anastomosis owing to its thickness. Meticulous inspection to avoid overlooking small bile ducts could decrease the chance of postoperative intractable bile leakage. In reconstruction of small or fragile branches, a transanastomotic stent tube could work as an anchor for the anastomosis

Management Strategy for Congenital Choledochal Cyst with Co-existing Intrahepatic Dilation and Aberrant Bile Duct As Well As Other Complicated Biliary Anomalies

The purpose of this study was to investigate and discuss imaging methods and management strategies for congenital choledochal cyst with co-existing intrahepatic dilation and aberrant bile duct as well as other complicated biliary anomalies. In this study we reviewed and analyzed 72 patients with congenital choledochal cyst, ranging in age from 15 days to 12 years old and who were seen at our hospital during the past 12 years, from January 1993 to October 2005. The image manifestation and clinical significance of patients with coxisting intrahepatic biliary dilation and aberrant bile duct were carefully examined during operation via MRCP, cholangiography and choledochoscope. Twenty-two cases (30.1%) presented with intrahepatic bile duct dilation and 12 of these were of the cystic type. That is, the orifice of the dilated intrahepatic tract that converged into the common hepatic duct showed membrane or septum-like stenosis. In 10 cases the dilation tapered off from the porta hepatis to the initiating terminals of the intra-hepatic bile ducts and was not accompanied by stenosis. An aberrant bile duct was observed in 2 of the cases. In 3 cases, the right and left hepatic ducts converged at the choledochal cyst. In conclusion, the imaging methods for intrahepatic bile duct dilation possess important clinical significance. Further, for hepatojejunostomy with radical excision of a choledochal cyst, additional operative procedures for intrahepatic stenosis, possible bile duct malformation and pancreaticobiliary common duct calculi can potentially reduce postoperative complications

Folding of small disulfide-rich proteins : clarifying the puzzle

Premi a l'excel·lència investigadora. Àmbit de les Ciències Experimentals. 2008The process by which small proteins fold to their native conformations has been intensively studied over the last few decades. In this field, the particular chemistry of disulfide bond formation has facilitated the characterization of the oxidative folding of numerous small, disulfide-rich proteins with results that illustrate a high diversity of folding mechanisms, differing in the heterogeneity and disulfide pairing nativeness of their intermediates. In this review, we combine information on the folding of different protein models together with the recent structural determinations of major intermediates to provide new molecular clues in oxidative folding. Also, we turn to analyze the role of disulfide bonds in misfolding and protein aggregation and their implications in amyloidosis and conformational diseases

CASA: An Efficient Automated Assignment of Protein Mainchain NMR Data Using an Ordered Tree Search Algorithm

Rapid analysis of protein structure, interaction, and dynamics requires fast and automated assignments of 3D protein backbone triple-resonance NMR spectra. We introduce a new depth-first ordered tree search method of automated assignment, CASA, which uses hand-edited peak-pick lists of a flexible number of triple resonance experiments. The computer program was tested on 13 artificially simulated peak lists for proteins up to 723 residues, as well as on the experimental data for four proteins. Under reasonable tolerances, it generated assignments that correspond to the ones reported in the literature within a few minutes of CPU time. The program was also tested on the proteins analyzed by other methods, with both simulated and experimental peaklists, and it could generate good assignments in all relevant cases. The robustness was further tested under various situations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43050/1/10858_2005_Article_4079.pd

Como sonhar grande, mas não implementar tanto assim: Coordenação de Desenvolvimento do Ministério do Trabalho da Jordânia

The case deals with the cooperation between Canada and Jordan to develop a strategy called "Technical and Vocational Education and Training strategy (E-TVET)". Within the Jordanian Ministry of Labour, the public body that led the action, a coordination unit was set up for which, by the canadian cooperation, was provided an advisor with expertise in education, Brenda Cooke. Her task was to support the establishment and operation of this unit, according to the term of reference. Relying on the good technical assistance of the consultant, the project worked well and generated important lessons that are described in the case, such as the proper administration of the stakeholders’ expectations, participatory approach to establishing the unit's operating rules, etc.Número de páginas: 6 p.Administração PúblicaGestão de Projetos. Gestão de ProgramasInovaçãoLiderançaEstudo de caso traduzido do original "Como sonhar grande, mas não implementar tanto assim: Coordenação de Desenvolvimento do Ministério do Trabalho da Jordânia"