Research on WASH sector, environment and water resources in the Central Rift Valley of Ethiopia

Peer ReviewedPostprint (published version

Comparative clinico-haematological analysis in young Zebu cattle experimentally infected with Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia

Background: Ethiopia, particularly in the Northwest region, is affected by both tsetse and non-tsetse fly transmitted trypanosomosis, with significant impact on livestock productivity. The aim of this study was to determine and compare clinical findings and haematological values between experimental infections induced by Trypanosoma vivax isolates from areas of either transmission mode. Sixteen young (aged between 6 and 12 months) Zebu cattle (Bos indicus), purchased from a trypanosome-free area and confirmed to be trypanosome-negative, were randomly assigned into four groups of four animals. Groups 1, 2 and 3 were infected with an isolate from a tsetse infested or one of two isolates from a non-tsetse infested area, and group 4 was a non-infected control. All animals in the infected groups were inoculated intravenously with 2 × 106 trypanosomes from donor animals. The experimental animals were monitored for eight consecutive weeks post infection for clinical signs, parasitaemia and haematological changes in packed cell volume (PCV), haemoglobin concentration (Hgb), total red blood cell (RBC) and white blood cell (WBC) counts, differential WBC count and blood indices (mean corpuscular volume [MCV], mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration).<p></p> Results: Infection was characterized by reduced feed intake, weakness, pyrexia, parasitaemia, rough hair coat, enlarged prescapular lymph nodes, lacrimation, weight loss, pallor mucus membrane and dehydration. Body weight loss in all infected groups was significantly higher than in the non-infected control. Similarly, body weight loss was higher (P < 0.001) in animals infected with the tsetse infested isolate than with the non-tsetse infested isolates. The mean PCV, Hgb, total RBC and WBC counts were lower (P < 0.001), and mean MCV was higher (P = 0.01) in all infected groups than in non-infected control animals at different time points during the study period. Except for minor variations in haematological values, the overall changes were similar in all infected groups.<p></p> Conclusion: Clinical signs and significant reduction in haematological values in the infected groups indicated the pathogenicity of the T. vivax parasites. Pathogenicity of T. vivax from the non-tsetse infested area can be considered as nearly as important as that of its counterpart derived from the tsetse infested area

Harnessing social media for promoting tourism in Africa: an exploratory analysis of tweets

Tourism has the potential to be the engine of a country’s economic development. Some developing countries, especially those in Africa, rely on tourism for their citizens’ employment. Consequently, the rise and fall of their unemployment rates are closely associated with that of tourist numbers. Hence, they need to constantly find ways to promote their cultural heritage in order to attract more tourists. Some of the key promotion tools are social media such as Twitter and an investigation to understand the nature of tweets about cultural heritage institutions is an important undertaking. However, investigations into the nature of tweets about African cultural heritage are non-existent. Our research aims to shed some light on the broad characteristics of tweets about African cultural heritage. We also identify possible implications and suggest potential strategies for tourism organizations, operators, and other stakeholders in their use of Social Media in general and Twitter in particular

Northern leaf blight response of elite maize inbred lines adapted to the mid-altitude sub-humid tropics

Productivity of maize (Zea mays L.) is curtailed by a number of stress factors, predominantly by diseases and insect pests. The Northern leaf blight disease of maize caused by Exserohilum turcicum (Pass.) Leonard and Suggs inflict significant yield losses in the humid tropical regions. The objectives of this study were to determine the leaf blight response of 50 elite maize inbred lines developed for the mid-altitude, sub-humid tropics and to select promising parents for resistance breeding. Inbred lines were evaluated in the field using a 5 × 10 alpha lattice design with three replications. Plants were artificially inoculated at the 4–6 leaf stages during 2011 and 2012. Data on disease severity and incidence, AUDPC and yields were recorded. Inbred lines had significant differences for E. turcicum reactions, and were classified into resistant, intermediate or susceptible categories. The mean disease severity ranged from 2.04% for the inbred line 136-a to 3.25% (Kuleni-C1-101-1-1-1). The upper leaf area infection of inbred lines 143-5-I and 136-a was 3.3%, while the line Kuleni-C1-101-1-1-1 displayed 100% infection. Further, 136-a developed the lowest AUDPC score at 238, whereas Kuleni-C1-101-1-1-1 had the maximum at 700. Overall, inbred lines CML202, 144-7-b, 139-5-j, 136-a, 30H83-7-1-1-1-2-1, ILoo’E-1-9-1-1-1-1-1 and 142-1-e, were identified as promising sources of resistance against E. turcicum. The selected elite inbred lines would be recommended for use in general varietal development, disease management and to enhance maize productivity, in the mid-altitude sub-humid tropics

The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study.

BACKGROUND: Erythema nodosum leprosum (ENL) is a debilitating multisystem disorder which complicates leprosy. It is characterised by fever, malaise and painful erythematous cutaneous nodules. ENL is often recurrent or chronic in nature and frequently severe. Patients often require prolonged treatment with high doses of oral corticosteroids. There are no data on the mortality associated with treated ENL. METHODOLOGY: The notes of patients who were admitted, discharged, transferred to another facility or died with a diagnosis of leprosy or a leprosy-related complication for a five year period were reviewed. RESULT/DISCUSSION: 414 individuals were identified from the ward database. 312 (75.4%) patient records were located and reviewed. Ninety-nine individuals had ENL and 145 had a Type 1 reaction. The median age of individuals with ENLwas 25 years. Eight patients with erythema nodosum leprosum died compared with two diagnosed with Type 1 reaction. This difference is statistically significant (p = 0.0168, Fisher's Exact Test). There is a significant mortality and morbidity associated with ENL in this Ethiopian cohort. The adverse outcomes seen are largely attributable to the chronic administration of oral corticosteroids used to control the inflammatory and debilitating symptoms of the condition

A Randomized Controlled Double Blind Trial of Ciclosporin versus Prednisolone in the Management of Leprosy Patients with New Type 1 Reaction, in Ethiopia.

BACKGROUND: Leprosy Type 1 (T1R) reactions are immune-mediated events leading to nerve damage and preventable disability affecting hands, feet and eyes. Type 1 Reactions are treated with oral corticosteroids. There is little evidence on alternative treatments for patients who do not respond to steroids or experience steroid adverse effects. We report the results of a randomized controlled trial testing the efficacy and adverse effect profile of ciclosporin and prednisolone (CnP) in comparison to prednisolone only (P) in patients with new T1R in Ethiopia. Ciclosporin is a potent immunosuppressant. Outcomes were measured using a clinical severity score, recurrence rate, adverse events and quality of life. RESULTS: Seventy three patients with new T1R were randomized to receive CnP or P for 20 weeks. Recovery rates in skin signs was similar in both groups (91% vs 88%). Improvements in nerve function both, new and old, sensory (66% vs 49%) and motor (75% vs 74%) loss were higher (but not significantly so) in the patients on CnP. Recurrences rates of T1R (85%) were high in both groups, and recurrences occurred significantly earlier (8 weeks) in patients CnP, who needed 10% more additional prednisolone. Serious major and minor adverse events rates were similar in patients in the two treatment arms of the study. Both groups had a significant improvement in their quality of life after the study, measured by the SF-36. CONCLUSIONS: This is the first double-blind RCT assessing ciclosporin, in the management of T1R in Africa. Ciclosporin could be a safe alternative second-line drug for patients with T1R who are not improving with prednisolone or are experiencing adverse events related to prednisolone. This study illustrates the difficulty in switching off leprosy inflammation. Better treatment agents for leprosy patients with reactions and nerve damage are needed

Prevalence of Induced Abortion and Associated Factors among Wachamo University Regular Female Students, Southern Ethiopia, 2015.

Background: All over the world, women experience unwanted pregnancy and some of them seek to terminate the pregnancy and undergo induced abortion. In Ethiopia, abortion is still common and it is one of the contributing factors for maternal death. In 2008 it was estimated that, there were 382,000 induced abortions in Ethiopia and 52,600 women were treated for complications of abortion. Most of these women who tend to experience induced abortion are adolescents and youth with age below 25 years. The aim of this study was, to assess the magnitude of induced abortion and associated factors among Wachamo University regular female students. Methods: A cross sectional study design was used. Data were collected from 461 randomly selected female students of Wachamo University by using pre-tested structured questionnaire from January to March, 2015. The collected data were entered using EPI info Version 3.5.1 and analyzed by SPSS version 16. Descriptive statistics was computed and odds ratio along with the 95% confidence interval was estimated to identify factors associated with induced abortion using multivariate logistic regression. Level of statistical significance was declared at P- value less or equal to 0.05. Results: In this study the prevalence of induced abortion was 5.9% (95% CI 3.8-8.0%), from which 9(33.3%) were conducted in an unsafe conditions. A total of 180(39 %) female students had sex and 58 (12.58%) of them get pregnant. Out of the total pregnancies, 53(91.4%) were unwanted. Based on the results from multivariate logistic regression, living out of campus [AOR= 6.78, 95% CI: (1.44, 31.97)], Substance use [AOR= 4.75, 95% CI: (1.12, 20.16)], and earning enough pocket money [AOR= 6.91, 95% CI: (1.62, 29.50)] were significantly associated factors with induced abortion. Conclusion and Recommendation: A significant proportion of pregnancies among students in higher educational institution are terminated with induced abortion. Living out of campus, substance use and pocket money have significant association with induced abortion. The university and local health bodies should work together to address for prevention of unintended pregnancy and induced abortion. Keywords: Induced abortion, Abortion, Adolescent and yout

Faba Bean (Vicia faba L.) Variety Adaptation Trial in Alicho Wuriro and Anlemo Districts of Southern Ethiopia

Faba bean (Vicia faba L.) is a major food and feed legume. The trial consisting of 10 varieties and a local check were evaluated for adaptation in Alicho Wuriro and Anlemo districts of Southern, Ethiopia using a randomized complete block design with three replications during 2013. Data on some agronomical traits were recorded. Highly significant difference at (P<0.01) Table 4 were between days to flowering x varieties, plat height x locations, days to maturity x locations, hundred seed weight x varieties, yield x locations. And significantly different at (p<0.05) were between days to flowering x locations, plant height x locations x varieties, pods per plant x locations, number of pods per plants x locations x varieties, number of seeds per plants x locations x varieties, days to maturity x varieties, 100 seed weight x locations x varieties. The top mean grain yield (Table 2 and Graph 1), (4.62 ton ha-1) over locations was achieved by variety Dosha followed by Shallo (4.58 ton ha-1), Obse (4.48 ton ha-1), Gabelcho (4.44 ton ha-1) and Moti (4.37 ton ha-1). Among the tested locations maximum mean yield was at Anlemo (4.46 ton ha-1) followed by Alicho Wuriro (3.92 ton ha-1). Yield over locations were highly significant differences at (P<0.01). From Anlemo district Shallo variety with mean yield (5.42 ton ha-1); followed by varieties Dosha (5.07ton ha-1), Moti (4.86 ton ha-1), Gabelcho (4.79 ton ha-1), Degaga (4.79 ton ha-1) and Obse (4.58 ton ha-1) which were higher than location mean but not significantly different (Table 2 and Graph 1).  From Alicho Wuriro district there was no varieties significantly difference on yield, but Tumsa (4.58 ton ha-1), Obse (4.38 ton ha-1), Dosha (4.17 ton ha-1) and Gabelcho (4.10 ton ha-1) to be used as variety option (Table 2 and Graph 1). Dosha variety was the highest and stable in grain yield across locations. But Tumssa variety was not stable; the highest grain yield in Alicho Wuriro district but the lowest garin yield in Anlemo district. Variable diseases chocolate spot and rust severity scores (1-9) scale were recorded for all tested varieties. Almost all the varieties tested across locations in 2013 cropping season were exhibited immune to moderately susceptible (2-5) reactions to important diseases indicating that they could be used as a source of gene for resistance in breeding programs Table 3. Different severity scores were recorded for both diseases reactions on the same varieties in different environments but both did not show significant differences Table 4. But rust positively highly correlated to grain yield. Keywords: Faba bean, disease reaction, fungal pathogens

Morphometric Analysis of Lake Langano Watershed using Geographic Information System

An understanding of watershed characteristics like areal, linear and relief aspect has paramount significance for watershed planning and management. An automatic extraction of these characteristics from digital elevation model is so effective and efficient. The main objective of this research work was Morphometric analysis of Lake Langano watershed characteristics from Digital Elevation model using GIS. This research work employs an automatic extraction of hydrological characteristics using Geographical Information system. The results of finding show that the watershed has highly permeable soil type which absorbs the water passing over the soil. Drainage texture of the watershed is very coarse and the watershed is less affected by erosion. There is high runoff in the watershed due to large number of overland flow length. The shape of the watershed is elongated shape and experiences low peak flow over longer duration of time. Circulatory value of the watershed indicates that lake Langano watershed is not under flood risk. Relief characteristics of the watershed indicate that most part of the watershed is characterized by gentle slope and the peak of south eastern part is characterized by steep slope. Keywords: DEM (digital elevation model), GIS (Geographic Information system), Morphometric analysis, Watershed characteristics. DOI: 10.7176/JEES/10-11-03 Publication date: November 30th 202