OV and VO variation in code-switching

This monograph is intended as a contribution to the field of bilingualism from a generative syntax perspective at a variety of levels. It investigates code-switching between Korean and English and also between Japanese and English, which exhibit several interesting features. Due to their canonical word order differences, Korean and Japanese being SOV (Subject-Object-Verb) and English SVO (Subject-Verb-Object), a code-switched sentence between Korean/Japanese and English can take, in principle, either OV or VO order, to which little attention has been paid in the literature. On the contrary, word order is one of the most extensively discussed topics in generative syntax, especially in the Principles and Parameter’s approach (P&P) where various proposals have been made to account of various order patterns of different languages. By taking the generative view that linguistic variation is due to variation in the domain of functional categories rather than lexical roots (e.g. Borer 1984; Chomsky 1995), this monograph investigates word order variation in Korean-English and Japanese-English code-switching, with particular attention to the relative placement of the predicate (verb) and its complement (object) in two contrasting word orders, OV and VO, which was tested against Korean-English and Japanese-English bilingual speakers’ introspective judgments. The results provide strong evidence indicating that the distinction between functional and lexical verbs plays a major role in deriving different word orders (OV and VO, respectively) in Korean-English and Japanese-English code-switching, which supports the hypothesis that parametric variation is attributed to differences in the features of a functional category in the lexicon, as assumed in minimalist syntax. In particular, the explanation pursued in this monograph is based on feature inheritance, a syntactic derivational process, which was proposed in recent developments the Minimalist Program. The monograph shows that by studying diverse and creative word order patterns of code-switching, we are at a better disposal to understand how languages are parameterized similarly or differently in a given domain, which is the very topic that generative linguists have pursued for a long time

Problematic Autoethnographic Research: Researcher’s Failure in Positioning

This article problematizes and discusses the “auto”ethnographical approach, which has recently become pervasive in research-oriented writings, to “tell the story of self and subject” in order to analyze wider cultural and social conditions. This method can be found in the remarkable array of a variety of disciplines in which scholars have explicitly and implicitly highlighted identity-related issues. One problem with this approach is its failure to recognize the ideological generalization in identifying the researcher’s position, with the risk of eventually becoming a neutral “truth through the researcher’s reality.” This paper focuses on the crisis between history and memory in contextualizing a researcher’s collective identity, and the crisis between insiderness and outsiderness in research. As a researcher and writer, I apply my examples to the conceptual framework built in this study on the identity crisis of my life, struggles, and conflicts. Considering researchers’ struggles and conflicts in determining self with regard to the identity established in research, my impetus for writing this paper is to provide a roadmap that critically examines the contexts that should be considered when a researcher positions self in the study and writing

OV and VO variation in code-switching

This monograph is intended as a contribution to the field of bilingualism from a generative syntax perspective at a variety of levels. It investigates code-switching between Korean and English and also between Japanese and English, which exhibit several interesting features. Due to their canonical word order differences, Korean and Japanese being SOV (Subject-Object-Verb) and English SVO (Subject-Verb-Object), a code-switched sentence between Korean/Japanese and English can take, in principle, either OV or VO order, to which little attention has been paid in the literature. On the contrary, word order is one of the most extensively discussed topics in generative syntax, especially in the Principles and Parameter’s approach (P&P) where various proposals have been made to account of various order patterns of different languages. By taking the generative view that linguistic variation is due to variation in the domain of functional categories rather than lexical roots (e.g. Borer 1984; Chomsky 1995), this monograph investigates word order variation in Korean-English and Japanese-English code-switching, with particular attention to the relative placement of the predicate (verb) and its complement (object) in two contrasting word orders, OV and VO, which was tested against Korean-English and Japanese-English bilingual speakers’ introspective judgments. The results provide strong evidence indicating that the distinction between functional and lexical verbs plays a major role in deriving different word orders (OV and VO, respectively) in Korean-English and Japanese-English code-switching, which supports the hypothesis that parametric variation is attributed to differences in the features of a functional category in the lexicon, as assumed in minimalist syntax. In particular, the explanation pursued in this monograph is based on feature inheritance, a syntactic derivational process, which was proposed in recent developments the Minimalist Program. The monograph shows that by studying diverse and creative word order patterns of code-switching, we are at a better disposal to understand how languages are parameterized similarly or differently in a given domain, which is the very topic that generative linguists have pursued for a long time

Locality in Movement and Scope Interpretation of In-Situ Wh-Phrases

The dissertation investigates syntactic distributions and interpretations of wh-phrases in Korean and other languages from a minimalist perspective, and reveals patterns of similarities and differences between wh-in-situ languages and wh-movement languages. First, this dissertation examines Korean long distance wh-scrambling with respect to anti-radical reconstruction and semantic effects, arguing that Korean long distance whscrambling is motivated by discourse properties such as contrastive focus; hence long distance scrambling in Korean is not a purely optional movement but follows Scope Economy. This dissertation notes that left periphery movement of a wh-phrase in Korean is not a unitary construction: there is movement of a wh-phrase by an agreeing question morpheme, and movement of a wh-phrase by a non-agreeing question morpheme. This dissertation suggests that both wh-movement and wh-scrambling uniformly are motivated by an optional edge feature (Chomsky 2005) that marks specificity or definiteness when present. Second, this dissertation explores the correlation between superiority effects in whmovement and head movement in head-final languages (e.g. Korean and Japanese), headinitial languages (e.g. English), and V2 languages (e.g. German and Spanish). Based on crosslinguistics data, the dissertation considers that in head-final languages such as Korean and Japanese, head movement may not occur at narrow syntax, whereas in other languages it obligatorily takes place, hence V-to-C is very closely related with the presence or absence of superiority, offering an analysis of the presence and absence of superiority effects in whmovement in Korean (and Japanese): movement from a nonphase-edge to a phase-edge gives rise to superiority effects, but movement from a phase-edge to a phase-edge overrides superiority effects. Third, this disserttaion focuses on wh-scope interpretations between in-situ wh-phrases and the licensing heads (i.e, Q-morpheme) in Korean, proposing a local modeling of a nonlocal dependency that establishes a long distance wh-scope agreement relationship, a mechanism of indirect Agree mediating between a licensing head and wh-elements in an embedded clause. The dissertation argues that, in Korean, both wh- phrasal movement and wh-scope interpretations are constrained by local operations that the Minimalist Program takes to be one of the vital properties of the faculty of language

Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

DA-9701 is a new botanical drug composed of the extracts of Corydalis tuber and Pharbitidis semen, and it is used as an oral therapy for the treatment of functional dyspepsia in Korea. The inhibitory potentials of DA-9701 and its component herbs, Corydalis tuber and Pharbitidis semen, on the activities of seven major human cytochrome P450 (CYP) enzymes and four UDP-glucuronosyltransferase (UGT) enzymes in human liver microsomes were investigated using liquid chromatography-tandem mass spectrometry. DA-9701 and Corydalis tuber extract slightly inhibited UGT1A1-mediated etoposide glucuronidation, with 50% inhibitory concentration (IC50) values of 188 and 290 μg/mL, respectively. DA-9701 inhibited CYP2D6-catalyzed bufuralol 1′-hydroxylation with an inhibition constant (Ki) value of 6.3 μg/mL in a noncompetitive manner. Corydalis tuber extract competitively inhibited CYP2D6-mediated bufuralol 1′-hydroxylation, with a Ki value of 3.7 μg/mL, whereas Pharbitidis semen extract showed no inhibition. The volume in which the dose could be diluted to generate an IC50 equivalent concentration (volume per dose index) value of DA-9701 for inhibition of CYP2D6 activity was 1.16 L/dose, indicating that DA-9701 may not be a potent CYP2D6 inhibitor. Further clinical studies are warranted to evaluate the in vivo extent of the observed in vitro interactions

The uncalibrated pulse contour cardiac output during off-pump coronary bypass surgery: performance in patients with a low cardiac output status and a reduced left ventricular function

BACKGROUND: We compared the continuous cardiac index measured by the FloTrac/Vigileo™ system (FCI) to that measured by a pulmonary artery catheter (CCI) with emphasis on the accuracy of the FCI in patients with a decreased left ventricular ejection fraction (LVEF) and a low cardiac output status during off-pump coronary bypass surgery (OPCAB). We also assessed the influence of several factors affecting the pulse contour, such as the mean arterial pressure (MAP), the systemic vascular resistance index (SVRI) and the use of norepinephrine. METHODS: Fifty patients who were undergoing OPCAB (30 patients with a LVEF ≥ 40%, 20 patients with a LVEF < 40%) were enrolled. The FCI and CCI were measured and we performed a Bland-Altman analysis. Subgroup analyses were done according to the LVEF (< 40%), the CCI (≤ 2.4 L/min/m), the MAP (60-80 mmHg), the SVRI (1,600-2,600 dyne/s/cm(5)/m(2)) and the use of norepinephrine. RESULTS: The FCI was reliable at all the time points of measurement with an overall bias and limit of agreement of -0.07 and 0.67 L/min/m(2), respectively, resulting in a percentage error of 26.9%. The percentage errors in the patients with a decreased LVEF and in a low cardiac output status were 28.2% and 22.3%, respectively. However, the percentage error in the 91 data pairs outside the normal range of the SVRI was 40.2%. CONCLUSIONS: The cardiac output measured by the FloTrac/Vigileo™ system was reliable even in patients with a decreased LVEF and in a low cardiac output status during OPCAB. Acceptable agreement was also noted during the period of heart displacement and grafting of the obtuse marginalis branch.ope

Physician Compliance with Nutrition Support Team Recommendations: Effects on the Outcome of Treatment for Critically Ill Patients

Purpose Attending physicians in Korea are aware of the existence of the Nutrition Support Team (NST), but even when the NST are consulted, compliance with their recommendations may be low. This study was performed to identify physicians’ compliance with the NST advice and how this affected the outcome of treatment for critically ill patients. Methods This study was a retrospective observational study. Critically ill patients who were older than 18 years, younger than 90 years, and had been admitted and managed in the intensive care unit were selected for this study. Patients were assigned to either the compliance group or the non-compliance group according to physician compliance with the NST advice. Each group were compared using variables such as calorie supply, protein supply, laboratory findings, hospital stay, 30-day mortality, and survival rate. Results The compliance group (81% of cases) was supplied with a significantly higher energy (1,146.36 ± 473.45 kcal vs. 832.45 ± 364.28 kcal, p < 0.01) and a significantly higher protein (55.00 ± 22.30 g/day vs. 42.98 ± 24.46 g/day, p = 0.04) compared with the non-compliance group. There was no significant difference in the basic demographics between groups, although the compliance group had a better outcome in the 30-day mortality rate (8% vs. 26%, p = 0.02), and in survival beyond 1 year (Crude model, hazard ratio: 2.42, CI: 1.11–5.29). Conclusion Critically ill patients whose attending physician complied with the NST advice, received an increased energy intake and supply of protein which was positively associated with survival

Determination of Risk Factors for Predicting Bladder-Urethra Injury in Cases of Pelvic Bone Fracture: A Retrospective Single Center Study

Purpose Pelvis fractures are associated with bladder and urethral injury (BUI). The purpose of this study was to identify risk factors associated with BUI in patients with pelvic fracture. Methods Patients (> 18 years) with pelvic injury (N = 314) at our hospital between January 2015 and June 2020 were retrospectively analyzed for age, sex, cause of injury, initial vital signs, urine red blood cell (RBC) count, Glasgow Coma Scale and Abbreviated Injury Scale score, Injury Severity Score, preperitoneal pelvic packing, and femur, lumbar spine, and pelvic fractures. Results Compared with the BUI-absent group, the BUI-present group had a greater percentage of patients who were male (79.2% vs. 55.9%; p = 0.026), had a urine RBC count/high power field (HPF) ≥ 30 (94.4% vs. 38.8%; p < 0.001), underwent preperitoneal pelvic packing (37.5% vs. 18.6%; p = 0.035), had symphysis pubis diastasis (33.3% vs. 11.7%; p = 0.008), and had sacroiliac joint dislocation (54.2% vs. 23.4%; p = 0.001). Independent risk factors associated with BUI were symphysis pubis diastasis [odds ratio (OR) was 3.958 (95% confidence interval: 1.191–13.154); p = 0.025] and a urine RBC count/HPF ≥ 30 [OR = 25.415 (95% confidence interval: 3.252–198.637); p = 0.006]. Of those with BUI, 15 patients were diagnosed at the trauma bay, and 9 had a delayed diagnosis. Conclusion Patients with pelvic injury who display symphysis pubis diastasis or have a urine RBC count/HPF ≥ 30 are at higher risk of BUI, therefore, further BUI investigations should be considered