529 research outputs found
Chasing Perfection: Collateral Indications and Ambiguous Debtor Names on Financing Statements Under Article 9
Article 9 of the Uniform Commercial Code sought to create consistent commercial laws governing secured transactions across the United States. One of its principal tenets is that secured lenders must provide notice to other lenders of their stake in a debtor’s personal property or fixtures. Secured lenders do so by filing a financing statement, a form that third parties can access to see who has a security interest in what. Two important aspects of the financing statement are the collateral indication and the debtor name. This Note will explore the nuances of the collateral indication and debtor name in light of In re Financial Oversight and Management Board for Puerto Rico and In re I80 Equipment, LLC, cases arising out of the First and Seventh Circuits, respectively. This Note argues that Article 9’s collateral indication requirements on the financing statement must not be construed to require third parties to search outside a secured lender’s filings to determine what collateral may be subject to a security interest. Requiring would-be creditors to do so is against the express purposes of the Uniform Commercial Code and creates uncertainty and an unnecessary burden for such creditors when conducting their diligence. This Note further argues that the First Circuit was wrong in its determination that the financing statement did refer to the debtor in question because when a novel issue arises under Article 9, an interpretation that promotes one or more of the Code’s stated purposes should be preferred
A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry
A novel bunyavirus was recently found to cause severe febrile illness with high mortality in agricultural regions of China, Japan, and South Korea. This virus, named severe fever with thrombocytopenia syndrome virus (SFTSV), represents a new group within the Phlebovirus genus of the Bunyaviridae. Little is known about the viral entry requirements beyond showing dependence on dynamin and endosomal acidification. A haploid forward genetic screen was performed to identify host cell requirements for SFTSV entry. The screen identified dependence on glucosylceramide synthase (ugcg), the enzyme responsible for initiating de novo glycosphingolipid biosynthesis. Genetic and pharmacological approaches confirmed that UGCG expression and enzymatic activity were required for efficient SFTSV entry. Furthermore, inhibition of UGCG affected a post-internalization stage of SFTSV entry, leading to the accumulation of virus particles in enlarged cytoplasmic structures, suggesting impaired trafficking and/or fusion of viral and host membranes. These findings specify a role for glucosylceramide in SFTSV entry and provide a novel target for antiviral therapies
Gold as an inflation hedge?
This paper attempts to reconcile an apparent contradiction between short-run and long-run movements in the price of gold. The theoretical model suggests a set of conditions under which the price of gold rises over time at the general rate of inflation and hence be an effective hedge against inflation. The model also demonstrates that short-run changes in the gold lease rate, the real interest rate, convenience yield, default risk, the covariance of gold returns with other assets and the dollar/world exchange rate can disturb this equilibrium relationship and generate short-run price volatility. Using monthly gold price data (1976-1999), and cointegration regression techniques, an empirical analysis confirms the central hypotheses of the theoretical model
The ACS Virgo Cluster Survey IV: Data Reduction Procedures for Surface Brightness Fluctuation Measurements with the Advanced Camera for Surveys
The Advanced Camera for Surveys (ACS) Virgo Cluster Survey is a large program
to image 100 early-type Virgo galaxies using the F475W and F850LP bandpasses of
the Wide Field Channel of the ACS instrument on the Hubble Space Telescope
(HST). The scientific goals of this survey include an exploration of the
three-dimensional structure of the Virgo Cluster and a critical examination of
the usefulness of the globular cluster luminosity function as a distance
indicator. Both of these issues require accurate distances for the full sample
of 100 program galaxies. In this paper, we describe our data reduction
procedures and examine the feasibility of accurate distance measurements using
the method of surface brightness fluctuations (SBF) applied to the ACS Virgo
Cluster Survey F850LP imaging. The ACS exhibits significant geometrical
distortions due to its off-axis location in the HST focal plane; correcting for
these distortions by resampling the pixel values onto an undistorted frame
results in pixel correlations that depend on the nature of the interpolation
kernel used for the resampling. This poses a major challenge for the SBF
technique, which normally assumes a flat power spectrum for the noise. We
investigate a number of different interpolation kernels and show through an
analysis of simulated galaxy images having realistic noise properties that it
is possible, depending on the kernel, to measure SBF distances using
distortion-corrected ACS images without introducing significant additional
error from the resampling. We conclude by showing examples of real image power
spectra from our survey.Comment: ApJS, in press, complete version of the paper at the link:
http://www.physics.rutgers.edu/~pcote/acs/publications.htm
Effects of linker flexibility on phase behavior and structure of linked colloidal gels
Colloidal nanocrystal gels can be assembled using a difunctional "linker"
molecule to mediate bonding between nanocrystals. The conditions for gelation
and the structure of the gel are controlled macroscopically by the linker
concentration and microscopically by the linker's molecular characteristics.
Here, we demonstrate using a toy model for a colloid-linker mixture that linker
flexibility plays a key role in determining both phase behavior and structure
of the mixture. We fix the linker length and systematically vary its bending
stiffness to span the flexible, semiflexible, and rigid regimes. At fixed
linker concentration, flexible-linker and rigid-linker mixtures phase separate
at low colloid volume fractions in agreement with predictions of first-order
thermodynamic perturbation theory, but the semiflexible-linker mixtures do not.
We correlate and attribute this qualitatively different behavior to undesirable
"loop" linking motifs that are predicted to be more prevalent for linkers with
end-to-end distances commensurate with the locations of chemical bonding sites
on the colloids. Linker flexibility also influences the spacing between linked
colloids, suggesting strategies to design gels with desired phase behavior,
structure, and by extension, structure-dependent properties.Comment: 11 pages, 8 figures, supplementary materia
The Embryonic Transcriptome Of The Red-Eared Slider Turtle (Trachemys Scripta)
The bony shell of the turtle is an evolutionary novelty not found in any other group of animals, however, research into its formation has suggested that it has evolved through modification of conserved developmental mechanisms. Although these mechanisms have been extensively characterized in model organisms, the tools for characterizing them in non-model organisms such as turtles have been limited by a lack of genomic resources. We have used a next generation sequencing approach to generate and assemble a transcriptome from stage 14 and 17 Trachemys scripta embryos, stages during which important events in shell development are known to take place. The transcriptome consists of 231,876 sequences with an N-50 of 1,166 bp. GO terms and EC codes were assigned to the 61,643 unique predicted proteins identified in the transcriptome sequences. All major GO categories and metabolic pathways are represented in the transcriptome. Transcriptome sequences were used to amplify several cDNA fragments designed for use as RNA in situ probes. One of these, BMP5, was hybridized to a T. scripta embryo and exhibits both conserved and novel expression patterns. The transcriptome sequences should be of broad use for understanding the evolution and development of the turtle shell and for annotating any future T. scripta genome sequences
Outcomes of surgery and postoperative radiation therapy in managing medullary thyroid carcinoma
Background and Objectives We evaluated the outcomes of surgery with or without postoperative radiation therapy (PORT) in the management of medullary thyroid carcinoma (MTC). Methods From two tertiary cancer centers, 297 consecutive patients with MTC treated with PORT (n = 46) between 1990 and 2016 or surgery alone (n = 251) between 2000 and 2016 were reviewed. Results Ten-year cumulative incidences of locoregional and distant failure were 30.2% and 24.9% in the surgery cohort, and 16.9% and 55.2% in the PORT cohort. In the surgery alone cohort, T4 disease, extrathyroidal extension, N1 disease, extranodal extension (ENE), and residual disease after surgery were associated with local failure. The PORT cohort had significantly higher proportions of patients with T4 disease, N1 disease, ENE, and residual disease. Conclusions High-risk clinical features can help identify patients with MTC at high-risk for local failure after surgery alone. Patients with high-risk clinical features had effective locoregional control after PORT
Colorimetric quantification of linking in thermoreversible nanocrystal gel assemblies
Nanocrystal gels can be responsive, tunable materials, but designing their structure and properties is challenging.
By using reversibly bonded molecular linkers, gelation can be realized under conditions predicted by thermody-
namics. However, simulations have offered the only microscopic insights, with no experimental means to monitor
linking leading to gelation. We introduce a metal coordination linkage with a distinct optical signature allowing
us to quantify linking in situ and establish structural and thermodynamic bases for assembly. Because of coupling
between linked indium tin oxide nanocrystals, their infrared absorption shifts abruptly at a chemically tunable
gelation temperature. We quantify bonding spectroscopically and use molecular simulation to understand
temperature-dependent bonding motifs, revealing that gel formation is governed by reaching a critical number of
effective links that extend the nanocrystal network. Microscopic insights from our colorimetric linking chemistry
enable switchable gels based on thermodynamic principles, opening the door to rational design of programmable
nanocrystal networks.We would like to thank the University of Texas at Austin Mass Spectrometry and NMR Facility
for the use of the Bruker AVANCE III 500: NIH grant number 1 S10 OD021508-01 and the Texas
Materials Institute for the use of the SAXSLAB Ganesha, acquired using an NSF MRI grant
CBET-1624659. We thank the Texas Advanced Computing Center (TACC) at the University
of Texas at Austin for HPC resources. Funding: This research was primarily supported by the
National Science Foundation through the Center for Dynamics and Control of Materials: an
NSF Materials Research Science and Engineering Center (NSF MRSEC) under Cooperative
Agreement DMR-1720595. E.V.A. acknowledges support from the Welch Regents Chair
(F-0046). D.J.M. and T.M.T. also acknowledge support by the Welch Foundation (F-1696
and F-1848). This work was also supported by an NSF Graduate Research Fellowships
(DGE-1610403) to S.A.V. and Arnold O. Beckman Postdoctoral Fellowship to Z.M.S.Center for Dynamics and Control of Material
Demographic, criminal and psychiatric factors related to inmate suicide
A review of 19 studies suggests that it may be feasible to identify prisoners with suicide risk on the basis of demographic, psychiatric, and criminal characteristics. The present study aimed to identify combinations of characteristics that are capable of identifying potential suicide victims. Characteristics of 95 suicide victims in the Dutch prison system were compared with those of a random sample of 247 inmates in ten jails. Combinations of indicators for suicide risk were also tested for their capability of identifying 209 suicides in U.S. jails and 279 prison suicides in England and Wales. A combination of six characteristics (age 40+, homelessness, history of psychiatric care, history of drug abuse, one prior incarceration, violent offence) was capable of correctly classifying 82% of the Dutch suicide victims (82% specificity). Less powerful combinations correctly classified 53% of the U.S. suicides and 47% of the U.K. suicides. It is concluded that a set of demographic and criminal characteristics and indicators of psychiatric problems is useful for the identification of suicide risk in jails and prisons
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Ancient Lowland Maya neighborhoods: Average Nearest Neighbor analysis and kernel density models, environments, and urban scale
Many humans live in large, complex political centers, composed of multi-scalar communities including neighborhoods and districts. Both today and in the past, neighborhoods form a fundamental part of cities and are defined by their spatial, architectural, and material elements. Neighborhoods existed in ancient centers of various scales, and multiple methods have been employed to identify ancient neighborhoods in archaeological contexts. However, the use of different methods for neighborhood identification within the same spatiotemporal setting results in challenges for comparisons within and between ancient societies. Here, we focus on using a single method—combining Average Nearest Neighbor (ANN) and Kernel Density (KD) analyses of household groups—to identify potential neighborhoods based on clusters of households at 23 ancient centers across the Maya Lowlands. While a one-size-fits all model does not work for neighborhood identification everywhere, the ANN/KD method provides quantifiable data on the clustering of ancient households, which can be linked to environmental zones and urban scale. We found that centers in river valleys exhibited greater household clustering compared to centers in upland and escarpment environments. Settlement patterns on flat plains were more dispersed, with little discrete spatial clustering of households. Furthermore, we categorized the ancient Maya centers into discrete urban scales, finding that larger centers had greater variation in household spacing compared to medium-sized and smaller centers. Many larger political centers possess heterogeneity in household clustering between their civic-ceremonial cores, immediate hinterlands, and far peripheries. Smaller centers exhibit greater household clustering compared to larger ones. This paper quantitatively assesses household clustering among nearly two dozen centers across the Maya Lowlands, linking environment and urban scale to settlement patterns. The findings are applicable to ancient societies and modern cities alike; understanding how humans form multi-scalar social groupings, such as neighborhoods, is fundamental to human experience and social organization
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