361 research outputs found
Correlation between chemical composition, EHGE and TME of corn for ducks
Correlations between chemical composition, enzymatic hydrolysate gross energy (EHGE), and true metabolizable energy (TME) of corn for ducks were investigated. Twenty-two corn samples were collected from various regions in 11 provinces of China. The crude protein (CP), ether extract (EE), neutral detergent fibre (NDF), Ash, gross energy (GE), dry matter (DM), amylopectin (AP), amylose (AM), total starch (TS), and AP/AM were determined for each sample. Five of the samples of corn were chosen at the mean, mean Β± 1 standard deviation (SD), and mean Β± 2 SD based on AP/AM. The EHGE of these samples was analysed using the pepsin-artificial small intestinal fluid enzymatic method. These five samples were also force-fed to male Cherry Valley ducks to assay their TME. Finally, correlation analyses were performed, and regression equations were established. Ash content, GE, and TS were highly related to EHGE. Univariate prediction equations were EHGE = 11.8566Ash-0.0421 (P <0.05), EHGE = 0.1535GE1.5642 (P <0.05), and EHGE = 0.1020TS1.1561 (P <0.05). The total starch, AP/AM, and ash of the chemical compositions were highly related to TME. The corresponding univariate regression equations were TME = 21.9355TS-0.0910 (P <0.05), TME = 15.6590AP/AM-0.0559 (P <0.05), and TME = 15.0778Ash0.0442 (P <0.05). The mean EHGE was equivalent to 78.5% of TME, but their correlation coefficient was low. In conclusion, chemical composition was predictive of EHGE and TME of corn samples for ducks, but the correlation of EHGE and TME was low
Keywords: Cherry Valley duck, amylopectin, amylose, true metabolizable energ
Relationship between HPV16/18 E6 and Ρ53, Ρ21waf1, MDM2, Ki67 and cyclin D1 expression in esophageal squamous cell carcinoma: comparative study by using tissue microarray technology
Aim: To investigate the role of human papillomavirus (HPV) HPV16/18 E6 oncogene in the carcinogenesis of esophageal cell carcinoma (ESCC). Materials and Methods: Tissue microarray (TMA) block was constructed from 60 cases of paraffin-embedded ESCC tissues and pair-matched controls (adjacent normal epithelium). Immunohistochemistry (IHC) methods were applied to detect the expression of HPV16/18 E6, p53, p21Waf1, MDM2, Ki67 and cyclin D1 proteins on TMA slides. In situ hybridization (ISH) targeting HPV gene was also used. Results: In ESCC samples, 18.3% (11/60) were revealed HPV16/18 E6 positive by IHC, while 40.0% (24/60) HPV positive by ISH; HPV16/18 E6 expression was significantly higher than that of control samples. In ESCC samples, the expressions of p53, p21Waf1, Cyclin D1, MDM2 and Ki67 were recorded in 60.0% (36/60), 40.0% (24/60), 51.7% (31/60), 65.0% (39/60) and 88.3% (53/60) cases respectively, In ESCC samples, p53, MDM2 and Ki67 expression correlated with the HPV16/18 E6 expression (p < 0.01), p21Waf1 expression β with these of MDM2 and cyclin D1 (p < 0.01) whilst expression of Ki67 β with ESCC grade (p < 0.01). Conclusion: HPV might be one of etiological factor of esophageal carcinoma in Shantou, China. p53, MDM2 proteins may play important roles in the pathogenesis of HPV-associated ESCC.Π¦Π΅Π»Ρ: ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ ΡΠΎΠ»Ρ ΠΎΠ½ΠΊΠΎΠ³Π΅Π½Π° HPV16/18 E6 Π²ΠΈΡΡΡΠ° ΠΏΠ°ΠΏΠΈΠ»Π»ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (HPV) Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ
ΠΏΠΈΡΠ΅Π²ΠΎΠ΄Π° (ESCC). ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 60 ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ESCC ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΠ΅ ΠΎΠ±ΡΠ°Π·ΡΡ Π½Π΅ΡΡΠ°Π½ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ
ΡΠΊΠ°Π½ΠΈ (ΠΏΠ°ΡΠ°ΡΠΈΠ½ΠΎΠ²ΡΠ΅ Π±Π»ΠΎΠΊΠΈ). ΠΠ»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π±Π΅Π»ΠΊΠΎΠ² HPV16/18 E6, p53, p21Waf1, MDM2, Ki67 ΠΈ ΡΠΈΠΊΠ»ΠΈΠ½Π° D1 Π² ΡΡΠ΅Π·Π°Ρ
Π΄Π»Ρ ΡΠΊΠ°Π½Π΅Π²ΡΡ
ΠΌΠΈΠΊΡΠΎΡΠΈΠΏΠΎΠ² (tissue microarray, TMA) ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ ΠΌΠ΅ΡΠΎΠ΄ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΠΈ (IHC), Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ
Π³Π΅Π½ΠΎΠ² HPV ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΡ in situ (ISH). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ IHC, ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ HPV16/18 E6 Π²ΡΡΠ²Π»Π΅Π½Π° Π² 18,3%
(11/60) ΡΠ»ΡΡΠ°Π΅Π² ESCC, Π² ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΌΠ΅ΡΠΎΠ΄Π° ISH, 40,0% (24/60) ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΏΡΠΈΠ·Π½Π°Π½Ρ HPV-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΠΌΠΈ.
Π ΠΎΠ±ΡΠ°Π·ΒΡΠ°Ρ
ESCC ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ p53, p21Waf1, ΡΠΈΠΊΠ»ΠΈΠ½Π° D1, MDM2 ΠΈ Ki67 Π²ΡΡΠ²Π»Π΅Π½Π° Π² 60,0% (36/60), 40,0% (24/60), 51,7% (31/60),
65,0% (39/60) ΠΈ 88,3% (53/60) ΡΠ»ΡΡΠ°Π΅Π² ΡΠΎΠΎΡΠ²Π΅ΡΒΡΡΠ²Π΅Π½Π½ΠΎ, ΠΏΡΠΈΡΠ΅ΠΌ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ p53, MDM2 ΠΈ Ki67 ΠΊΠΎΡΡΠ΅Π»ΠΈΡΠΎΠ²Π°Π»Π° Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ
HPV16/18 E6 (p < 0,01), ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ p21Waf1 β Ρ ΡΠ°ΠΊΠΎΠ²ΠΎΠΉ MDM2 ΠΈ ΡΠΈΠΊΠ»ΠΈΠ½Π° D1, Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Ki67 β ΡΠΎ ΡΡΠ°Π΄ΠΈΠ΅ΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ
ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ (p < 0.01). ΠΡΠ²ΠΎΠ΄Ρ: HPV ΠΌΠΎΠΆΠ΅Ρ ΡΠ²Π»ΡΡΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ°ΠΊΠ° ΠΏΠΈΡΠ΅Π²ΠΎΠ΄Π° Π² ΠΏΡΠΎΠ²ΠΈΠ½ΡΠΈΠΈ
Π¨Π°Π½ΡΡ, ΠΠΈΡΠ°ΠΉ. ΠΠ΅Π»ΠΊΠΈ p53 ΠΈ MDM2 ΠΌΠΎΠ³ΡΡ ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΡ ΡΡΠ°ΡΡΠΈΠ΅ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΏΠΈΡΠ΅Π²ΠΎΠ΄Π°, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ
Ρ Π²ΠΈΡΡΡΠΎΠΌ ΠΏΠ°ΠΏΠΈΠ»Π»ΠΎΠΌΠ°ΡΠΎΠ·Π°
Blended self-management interventions to reduce disease burden in patients with chronic obstructive pulmonary disease and asthma: systematic review and meta-analysis
Background: Chronic obstructive pulmonary disease (COPD) and asthma have a high prevalence and disease burden. Blended self-management interventions, which combine eHealth with face-to-face interventions, can help reduce the disease burden.Objective: This systematic review and meta-analysis aims to examine the effectiveness of blended self-management interventions on health-related effectiveness and process outcomes for people with COPD or asthma. Methods: PubMed, Web of Science, COCHRANE Library, Emcare, and Embase were searched in December 2018 and updated in November 2020. Study quality was assessed using the Cochrane risk of bias (ROB) 2 tool and the Grading of Recommendations, Assessment, Development, and Evaluation.Results: A total of 15 COPD and 7 asthma randomized controlled trials were included in this study. The meta-analysis of COPD studies found that the blended intervention showed a small improvement in exercise capacity (standardized mean difference [SMD] 0.48; 95% CI 0.10-0.85) and a significant improvement in the quality of life (QoL; SMD 0.81; 95% CI 0.11-1.51). Blended intervention also reduced the admission rate (relative ratio [RR] 0.61; 95% CI 0.38-0.97). In the COPD systematic review, regarding the exacerbation frequency, both studies found that the intervention reduced exacerbation frequency (RR 0.38; 95% CI 0.26-0.56). A large effect was found on BMI (d=0.81; 95% CI 0.25-1.34); however, the effect was inconclusive because only 1 study was included. Regarding medication adherence, 2 of 3 studies found a moderate effect (d=0.73; 95% CI 0.50-0.96), and 1 study reported a mixed effect. Regarding self-management ability, 1 study reported a large effect (d=1.15; 95% CI 0.66-1.62), and no effect was reported in that study. No effect was found on other process outcomes. The meta-analysis of asthma studies found that blended intervention had a small improvement in lung function (SMD 0.40; 95% CI 0.18-0.62) and QoL (SMD 0.36; 95% CI 0.21-0.50) and a moderate improvement in asthma control (SMD 0.67; 95% CI 0.40-0.93). A large effect was found on BMI (d=1.42; 95% CI 0.28-2.42) and exercise capacity (d=1.50; 95% CI 0.35-2.50); however, 1 study was included per outcome. There was no effect on other outcomes. Furthermore, the majority of the 22 studies showed some concerns about the ROB, and the quality of evidence varied.Conclusions: In patients with COPD, the blended self-management interventions had mixed effects on health-related outcomes, with the strongest evidence found for exercise capacity, QoL, and admission rate. Furthermore, the review suggested that the interventions resulted in small effects on lung function and QoL and a moderate effect on asthma control in patients with asthma. There is some evidence for the effectiveness of blended self-management interventions for patients with COPD and asthma; however, more research is needed.Prevention, Population and Disease management (PrePoD)Public Health and primary car
Generalized Holographic Dark Energy Model
In this paper, the model of holographic Chaplygin gas has been extended to
two general cases: first is the case of modified variable Chaplygin gas and
secondly of the viscous generalized Chaplygin gas. The dynamics of the model
are expressed by the use of scalar fields and the scalar potentials.Comment: 12 pages, to appear in Eur. Phys. J.
Partial wave analysis of J/\psi \to \gamma \phi \phi
Using events collected in the BESII detector, the
radiative decay is
studied. The invariant mass distribution exhibits a near-threshold
enhancement that peaks around 2.24 GeV/.
A partial wave analysis shows that the structure is dominated by a
state () with a mass of
GeV/ and a width of GeV/. The
product branching fraction is: .Comment: 11 pages, 4 figures. corrected proof for journa
Measurements of the observed cross sections for exclusive light hadrons containing at , 3.650 and 3.6648 GeV
By analyzing the data sets of 17.3, 6.5 and 1.0 pb taken,
respectively, at , 3.650 and 3.6648 GeV with the BES-II
detector at the BEPC collider, we measure the observed cross sections for
, , ,
and at the three energy
points. Based on these cross sections we set the upper limits on the observed
cross sections and the branching fractions for decay into these
final states at 90% C.L..Comment: 7 pages, 2 figure
Direct Measurements of Absolute Branching Fractions for D0 and D+ Inclusive Semimuonic Decays
By analyzing about 33 data sample collected at and around 3.773
GeV with the BES-II detector at the BEPC collider, we directly measure the
branching fractions for the neutral and charged inclusive semimuonic decays
to be and , and determine the ratio of the two branching
fractions to be
A study of charged kappa in
Based on events collected by BESII, the decay
is studied. In the invariant mass
spectrum recoiling against the charged , the charged
particle is found as a low mass enhancement. If a Breit-Wigner function of
constant width is used to parameterize the kappa, its pole locates at MeV/. Also in this channel,
the decay is observed for the first time.
Its branching ratio is .Comment: 14 pages, 4 figure
Holographic Dark Energy in Brans-Dicke Theory
In this paper, the holographic dark energy model is considered in Brans-Dicke
theory where the holographic dark energy density is replaced with . Here
is a time variable Newton constant. With this
replacement, it is found that no accelerated expansion universe will be
achieved when the Hubble horizon is taken as the role of IR cut-off. When the
event horizon is adopted as the IR cut-off, an accelerated expansion universe
is obtained. In this case, the equation of state of holographic dark energy
takes a modified form
. In the limit , the 'standard' holographic dark energy is recovered. In the holographic
dark energy dominated epoch, power-law and de Sitter time-space solutions are
obtained.Comment: 7 pages, 1 figure, match the published versio
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