Roles of Pro- and Anti-Inflammatory Cytokines in the Pathogenesis of SLE

SLE is an autoimmune inflammatory disease in which various pro- and anti-inflammatory cytokines, including TGF-β, IL-10, BAFF, IL-6, IFN-α, IFN-γ, IL-17, and IL-23, play crucial pathogenic roles. Virtually, all these cytokines can be generated by both innate and adaptive immune cells and exert different effects depending on specific local microenvironment. They can also interact with each other, forming a complex network to maintain delicate immune homeostasis. In this paper, we elaborate on the abnormal secretion and functions of these cytokines in SLE, analyze their potential pathogenic roles, and probe into the possibility of them being utilized as targets for therapy

Angiotensin-converting enzyme gene 2350 G/A polymorphism and susceptibility to atrial fibrillation in Han Chinese patients with essential hypertension

OBJECTIVE: The angiotensin-converting enzyme gene is one of the most studied candidate genes related to atrial fibrillation. Among the polymorphisms of the angiotensin-converting enzyme gene, the 2350 G/A polymorphism (rs4343) is known to have the most significant effects on the plasma angiotensin-converting enzyme concentration. The aim of the present study was to investigate the association of the angiotensin-converting enzyme 2350 G/A polymorphism with atrial fibrillation in Han Chinese patients with essential hypertension. METHODS: A total of 169 hypertensive patients were eligible for this study. Patients with atrial fibrillation (n = 75) were allocated to the atrial fibrillation group, and 94 subjects without atrial fibrillation were allocated to the control group. The PCR-based restriction fragment length polymorphism technique was used to assess the genotype frequencies. RESULTS: The distributions of the angiotensin-converting enzyme 2350 G/A genotypes (GG, GA, and AA, respectively) were 40.43%, 41.49%, and 18.08% in the controls and 18.67%, 46.67%, and 34.66% in the atrial fibrillation subjects (p = 0.037). The frequency of the A allele in the atrial fibrillation group was significantly greater than in the control group (58.00% vs. 38.83%, p = 0.0007). Compared with the wild-type GG genotype, the GA and AA genotypes had an increased risk for atrial fibrillation. Additionally, atrial fibrillation patients with the AA genotype had greater left atrial dimensions than the patients with the GG or GA genotypes (

Ustekinumab treats psoriasis by suppressing RORC and T-box but its suppression of GATA restrains its efficacy

Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, a fully human monoclonal antibody targeting the p40 subunit of both IL-12 and IL-23, has proven to be efficient and safe for treating patients with psoriasis. Yet, there have been no reports with human skin/blood samples that would elucidate the molecular mechanisms by which ustekinumab calms psoriasis skin lesions. To investigate the efficacy and molecular pathway (RORC, t-BOX and GATA) of ustekinumab in treating patients with psoriasis skin lesions. A total of 30 patients with psoriasis were randomized into placebo group and treatment group. PASI of each patient was calculated at 0, 12 and 24 weeks post-treatment. The mRNA levels of RORC, t-BOX and GATA in peripheral blood mononuclear cells separated from patients’ whole blood were analyzed using qPCR. Decreased mRNA of RORC, t-BOX and GATA were observed after continuous injections, indicating that ustekinumab exerts its effect by interacting with these molecules; while no significant difference in foxp3 mRNA levels were found between placebo group and treatment group

Intense duskside lower band chorus waves observed by Van Allen Probes: Generation and potential acceleration effect on radiation belt electrons

Abstract Local acceleration driven by whistler mode chorus waves largely accounts for the enhancement of radiation belt relativistic electron fluxes, whose favored region is usually considered to be the plasmatrough with magnetic local time approximately from midnight through dawn to noon. On 2 October 2013, the Van Allen Probes recorded a rarely reported event of intense duskside lower band chorus waves (with power spectral density up to 10-3nT 2/Hz) in the low-latitude region outside of L=5. Such chorus waves are found to be generated by the substorm-injected anisotropic suprathermal electrons and have a potentially strong acceleration effect on the radiation belt energetic electrons. This event study demonstrates the possibility of broader spatial regions with effective electron acceleration by chorus waves than previously expected. For such intense duskside chorus waves, the occurrence probability, the preferential excitation conditions, the time duration, and the accurate contribution to the long-term evolution of radiation belt electron fluxes may need further investigations in future

A User-Centered Mapping Design for Geomorphological Hazard Thematic Map

Numerous studies have concentrated on developing user-centered designs for hazard zone maps but rarely for hazard-oriented geomorphological maps, named as Geomorphological Hazard Thematic Maps (GHTMs) in this study, which provide more detailed information about natural hazards. This study developed a user-centered mapping design for GHTMs for nonexperts in geomorphology. We invited civil engineers and high school educators to evaluate a sample GHTM\u27s design in group and focus group panel interviews. The civil engineers preferred maps with more geomorphological features, whereas the educators preferred simple designs. Both groups indicated that the inclusion of essential facilities and road networks is essential. The map was also adjusted by adding hillshade layer and by changing the symbology for mass wasting, fault scarps, and fluvial features to increase clarity and simplicity. This case study is the first step toward developing user-centered mapping designs for hazard communication that will deepen their understanding of natural hazards

Nonstorm time dynamics of electron radiation belts observed by the Van Allen Probes

Abstract Storm time electron radiation belt dynamics have been widely investigated for many years. Here we present a rarely reported nonstorm time event of electron radiation belt evolution observed by the Van Allen Probes during 21-24 February 2013. Within 2 days, a new belt centering around L=5.8 formed and gradually merged with the original outer belt, with the enhancement of relativistic electron fluxes by a factor of up to 50. Strong chorus waves (with power spectral density up to 10-4nT2/Hz) occurred in the region L\u3e5. Taking into account the local acceleration driven by these chorus waves, the two-dimensional STEERB can approximately reproduce the observed energy spectrums at the center of the new belt. These results clearly illustrate the complexity of electron radiation belt behaviors and the importance of chorus-driven local acceleration even during the nonstorm times

Discovery of six high-redshift quasars with the Lijiang 2.4m telescope and the Multiple Mirror Telescope

Quasars with redshifts greater than 4 are rare, and can be used to probe the structure and evolution of the early universe. Here we report the discovery of six new quasars with $i$-band magnitudes brighter than 19.5 and redshifts between 2.4 and 4.6 from the YFOSC spectroscopy of the Lijiang 2.4m telescope in February, 2012. These quasars are in the list of $z>3.6$ quasar candidates selected by using our proposed $J-K/i-Y$ criterion and the photometric redshift estimations from the SDSS optical and UKIDSS near-IR photometric data. Nine candidates were observed by YFOSC, and five among six new quasars were identified as $z>3.6$ quasars. One of the other three objects was identified as a star and the other two were unidentified due to the lower signal-to-noise ratio of their spectra. This is the first time that $z>4$ quasars have been discovered using a telescope in China. Thanks to the Chinese Telescope Access Program (TAP), the redshift of 4.6 for one of these quasars was confirmed by the Multiple Mirror Telescope (MMT) Red Channel spectroscopy. The continuum and emission line properties of these six quasars, as well as their central black hole masses and Eddington ratios, were obtained.Comment: 7 pages, 2 figures, published in Research in Astronomy and Astrophysics (RAA) as a lette