Tracking and Resisting Backlash Against Equality Gains in Sexual Offence Law

The authors document feminist efforts to expose, challenge, and eliminate direct, indirect, and systemic inequality in the substantive, evidentiary, and procedural laws proscribing sexual offences and in the enforcement and application of those laws have not only been consistently resisted by police, lawyers, judges, and juries, but have also consistently generated backlash against those responsible for and/or supportive of such egalitarian change. Actual and imagined social, economic, political and legal equality gains by women as a class-however unevenly distributed- have triggered a variety of types of backlash, including an escalation in actual or threatened violence against women accompanied by new equality-resistant strains of legal doctrine that effectively offset or bypass earlier reforms. The authors illustrate these forms of backlash by examining three decades of feminist reforms to sexual assault laws

Father Involvement with Children with Developmental Delays

Children with developmental delays (DD) pose unique caregiving challenges, given their developmental problems and risks for behavior problems (Baker, McIntyre, Blacher, Crnic, Edelbrock, & Low, 2003). Most of the studies involving caregivers of children with DD have highlighted the role of mothers, with very few studies focusing specifically on fathers. Studies on father involvement in home and school settings provide a theoretical rationale for increasing father involvement to support positive outcomes in children with DD. Synthesizing research on father involvement can further contribute to and shape legislation that ensures equitable access to education for young children with disabilities (i.e., the Individuals with Disabilities Education Act). This paper summarizes findings from a systematic literature review of father involvement across home and school settings in families of preschool-aged children with or at risk for DD

Father Involvement with Children with Developmental Delays

Children with developmental delays (DD) pose unique caregiving challenges, given their developmental problems and risks for behavior problems (Baker, McIntyre, Blacher, Crnic, Edelbrock, & Low, 2003). Most of the studies involving caregivers of children with DD have highlighted the role of mothers, with very few studies focusing specifically on fathers. Studies on father involvement in home and school settings provide a theoretical rationale for increasing father involvement to support positive outcomes in children with DD. Synthesizing research on father involvement can further contribute to and shape legislation that ensures equitable access to education for young children with disabilities (i.e., the Individuals with Disabilities Education Act). This paper summarizes findings from a systematic literature review of father involvement across home and school settings in families of preschool-aged children with or at risk for DD

Ozone loss derived from balloon-borne tracer measurements and the SLIMCAT CTM

Balloon-borne measurements of CFC-11 (on flights of the DIRAC in situ gas chromatograph and the DESCARTES grab sampler), ClO and O3 were made during the 1999/2000 winter as part of the SOLVE-THESEO 2000 campaign. Here we present the CFC-11 data from nine flights and compare them first with data from other instruments which flew during the campaign and then with the vertical distributions calculated by the SLIMCAT 3-D CTM. We calculate ozone loss inside the Arctic vortex between late January and early March using the relation between CFC-11 and O3 measured on the flights, the peak ozone loss (1200 ppbv) occurs in the 440–470 K region in early March in reasonable agreement with other published empirical estimates. There is also a good agreement between ozone losses derived from three independent balloon tracer data sets used here. The magnitude and vertical distribution of the loss derived from the measurements is in good agreement with the loss calculated from SLIMCAT over Kiruna for the same days

Supply Chain Based Solution to Prevent Fuel Tax Evasion: Proof of Concept Final Report

The goal of this research was to provide a proof-of-concept (POC) system for preventing non-taxable (non-highway diesel use) or low-taxable (jet fuel) petrochemical products from being blended with taxable fuel products and preventing taxable fuel products from cross-jurisdiction evasion. The research worked to fill the need to validate the legitimacy of individual loads, offloads, and movements by integrating and validating, on a near-real-time basis, information from global positioning system (GPS), valve sensors, level sensors, and fuel-marker sensors

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci

The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pathway of macrophage apoptosis. Pharmacological inhibition or knockout of cathepsin D during pneumococcal infection blocked macrophage apoptosis. As a result of cathepsin D activation, Mcl-1 interacted with its ubiquitin ligase Mule and expression declined. Inhibition of cathepsin D had no effect on early bacterial killing but inhibited the late phase of apoptosis-associated killing of pneumococci in vitro. Mice bearing a cathepsin D-/- hematopoietic system demonstrated reduced macrophage apoptosis in vivo, with decreased clearance of pneumococci and enhanced recruitment of neutrophils to control pulmonary infection. These findings establish an unexpected role for a cathepsin D-mediated lysosomal pathway of apoptosis in pulmonary host defense and underscore the importance of apoptosis-associated microbial killing to macrophage function

Supply Chain Based Solution to Prevent Fuel Tax Evasion: Proof of Concept Final Report

The goal of this research was to provide a proof-of-concept (POC) system for preventing non-taxable (non-highway diesel use) or low-taxable (jet fuel) petrochemical products from being blended with taxable fuel products and preventing taxable fuel products from cross-jurisdiction evasion. The research worked to fill the need to validate the legitimacy of individual loads, offloads, and movements by integrating and validating, on a near-real-time basis, information from global positioning system (GPS), valve sensors, level sensors, and fuel-marker sensors

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57