Reliability of the tools used to examine psychological distress, fear of COVID-19 and coping amongst migrants and non-migrants in Australia

Study tools examining psychological distress, fear of COVID-19 and coping amongst migrants and non-migrants in Australia are very limited. The aim of this research was to assess the psychometric properties and correlation of the English version of Kessler Psychological Distress Scale (K-10), Fear of COVID-19 Scale (FCSV-19S), and Brief Resilient Coping Scale (BRCS) tools during the COVID-19 pandemic situation in Australia. Data from a cross-sectional survey (n = 516) were utilized to examine reliability; 299 (57.9%) were migrants. High internal consistency, as evidenced by Cronbach’s alpha, was found for the K-10 (0.92), FCV-19S (0.87) and BRCS (0.66) tools. The corresponding values for migrants and non-migrants were (0.92, 0.87, 0.67) and (0.92, 0.86, 0.63), respectively. Item-total correlations ranged 0.57-0.78 for K-10, 0.62–0.69 for FCV-19S, and 0.39–0.50 for BRCS tools. EFA retained a single factor for each tool with adequate factor loadings. The scoring of K-10 was significantly predicted by the scoring of FCV-19S (r = 0.284, P < 0.001) and BRCS tool (r = 0.132, P < 0.01). Therefore, these tools can be used reliably amongst both migrant and non-migrant population in Australia. © 2021 John Wiley & Sons Australia, Ltd. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Muhammad Aziz Rahman and Wendy Cross" is provided in this record*

Synthesis, Antimicrobial, and DFT Studies of Some Benzyl 4-O-Acyl-α-L-rhamnopyranosides

Application of carbohydrate fatty acid (CFA) esters in food and beverage industries has increased their interest in other fields. Especially rhamnopyranoside esters having both the hydrophilic and lipophilic nature had broader applications including anticancer activities. Benzyl α-L-rhamnopyranoside, prepared from L-rhamnose, on 2,3-O-isopropylidene protection with 2,2-dimethoxypropane followed by acylation at C-4 hydroxyl position with different acylating agents furnished the corresponding 4-O-acyl-α-L-rhamnopyranosides in good yields. All the compounds were well characterized by spectroscopic techniques.&nbsp;In vitro&nbsp;antimicrobial activities against eight bacterial and two fungal pathogens indicated that these 2,3-O-isopropylidene protected rhamnopyranosides had weak to moderate inhibitory properties. To rationalize such moderate activities structural (conformational) distortion of these monoacetonide protected CFA esters were studied from the density functional theory (DFT) optimized structures. In addition, thermodynamic properties including frontier molecular orbitals of the synthesized rhamnopyranosides were calculated and discussed. Corroboration of all the studies signifies that the moderate antimicrobial efficacy of the isopropylidene protected rhamnopyranosides might be due to their distorted conformations, lower softness and smaller dipole moments. DOI:&nbsp;http://dx.doi.org/10.17807/orbital.v13i3.161

Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy.

Morusin, a water-insoluble prenylated flavonoid is known for its numerous medicinal properties. It manifests its anticancer potential by suppression of genes involved in tumor progression. However, poor solubility of the drug results in low bioavailability and rapid degradation thus hindering its clinical utilization. In order to overcome this, we have synthesized a niosome system composed of non-ionic surfactant span 60 and cholesterol using a thin-layer evaporation technique to improve the aqueous-phase solubility of the drug. Highly cytocompatible niosomes of 479 nm average size with smooth and uniform spherical morphology were synthesized in a facile manner. Unlike free morusin, nanomorusin was found to be freely dispersible in aqueous media. Having an extremely high drug entrapment efficiency (97%), controlled and sustained release of morusin resulting in enhanced therapeutic efficacy was observed in cancer cell lines of 4 different lineages. The results demonstrate that the morusin-niosome system is a promising strategy for enhanced anti-cancer activity against multiple cancer types and could be an indispensable tool for future targeted chemotherapeutic strategies

Petrographic Study of Sedimentary Iron Ore in Shendi-Atbara Basin,River Nile State, Sudan

This paper presents the results of petrographic study of sedimentary iron ore from surface strata of the Shendi-Atbara Basin, River Nile State, Sudan. The aims of this study are to investigate the geological behavior and geological conditions affecting precipitation of sedimentary iron ore. The methodologies have been used to realize the objectives of this study include field work, office work and laboratory work including thin sections and polished sections analysis. According to field observation sedimentary iron ore can broadly be considered as occurring in three major classes:Ferribands iron, ferricrete iron and oolitic iron ores. The modes of occurrence of iron ore were described at the outcrops and vertical sedimentary profiles revealed that the iron occurred in the study area at different types in stratigraphic sequence such as cap, bedded and interbedded conformable with Shendi Formation. Petrographic study of iron ore in collected samples using polarized microscope and ore microscope includes study of the textures and structures of ores to obtain ore history. The main types of textures and structures in studied samples are oolitic, granular, lamellar and bands.According to these results the origin of iron ore is formed by chemical precipitation during chemical weathering of surrounding areas in continental lacustrine environment. The iron ore in study area is potential for future mining works and steel industr

Phylogenic analysis of serotype Asia1 foot-and-mouth disease virus from Sulaimani/Iraq using VP1 protein: heterogeneity with vaccine strain As1/Shamir/89

Foot-and-mouth disease virus (FMDV) serotypes O, A and Asia1 are responsible for a significant number of disease outbreaks in Iraq. The current study can be considered as the first molecular characterization of serotype Asia1 in Iraq. The present investigation reports the detection of serotype FMDV Asia1 from local farms in Sulaimani districts in 2012 and 2014 outbreaks. Phylogenetic analysis of the complete VP1 gene has shown that FMDV Asia1 field isolates were under genetic novel variant Sindh-08 (group VII) including PAK/iso/11 and TUR/13 strains. The VP1 protein sequence of circulatory FMDV Asia1 genotype showed heterogeneity of nine amino acid substitutions within the G-H loop with the vaccine strain As1/Shamir/89 (JF739177) that is currently used in vaccination program in Iraq. Our result indicated that differences in VP1 protein at G-H loop of the locally circulated FMDV serotype Asia1 strain may be a reason for current vaccination failure

TPPSO: A Novel Two-Phase Particle Swarm Optimization

Particle swarm optimization (PSO) is a stout and rapid searching algorithm that has been used in various applications. Nevertheless, its major drawback is the stagnation problem that arises in the later phases of the search process. To solve this problem, a proper balance between investigation and manipulation throughout the search process should be maintained. This article proposes a new PSO variant named two-phases PSO (TPPSO). The concept of TPPSO is to split the search process into two phases. The first phase performs the original PSO operations with linearly decreasing inertia weight, and its objective is to focus on exploration. The second phase focuses on exploitation by generating two random positions in each iteration that are close to the global best position. The two generated positions are compared with the global best position sequentially. If a generated position performs better than the global best position, then it replaces the global best position. To prove the effectiveness of the proposed algorithm, sixteen popular unimodal, multimodal, shifted, and rotated benchmarking functions have been used to compare its performance with other existing well-known PSO variants and non-PSO algorithms. Simulation results show that TPPSO outperforms the other modified and hybrid PSO variants regarding solution quality, convergence speed, and robustness. The convergence speed of TPPSO is extremely fast, making it a suitable optimizer for real-world optimization problems

Serum lipid profile and its association with hypertension in Bangladesh

BACKGROUND: Hypertension and dyslipidemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the Bangladeshi population. The objective of this study was to determine the association between serum lipid profiles in hypertensive patients with normotensive control subjects in Bangladesh. METHODS: A cross-sectional study was carried out among 234 participants including 159 hypertensive patients and 75 normotensive controls from January to December 2012 in the National Centre for Control of Rheumatic Fever and Heart Disease in Dhaka, Bangladesh. Data were collected on sociodemographic factors, anthropometric measurements, blood pressure, and lipid profile including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL). RESULTS: The mean (± standard deviation) systolic blood pressure and diastolic blood pressure of the participants were 137.94±9.58 and 94.42±8.81, respectively, which were higher in the hypertensive patients (P<0.001). The serum levels of TC, TG, and LDL were higher while HDL levels were lower in hypertensive subjects compared to normotensives, which was statistically significant (P<0.001). Age, waist circumference, and body mass index showed significant association with hypertensive patients (P<0.001) but not with normotensives. The logistic regression analysis showed that hypertensive patients had 1.1 times higher TC and TG, 1.2 times higher LDL, and 1.1 times lower HDL than normotensives, which was statistically significant (P<0.05). CONCLUSION: Hypertensive patients in Bangladesh have a close association with dyslipidemia and need measurement of blood pressure and lipid profile at regular intervals to prevent cardiovascular disease, stroke, and other comorbidities

Structural Features of Patients with Drusen-like Deposits and Systemic Lupus Erythematosus

Background: The relevance of drusen-like deposits (DLD) in patients with systemic lupus erythematosus (SLE) is to a large extent uncertain. Their genesis is proposed to be correlated to immune-complex and complement depositions in the framework of SLE. The intention of this study was to determine potential morphological differences in the choroid and retina as well as potential microvascular changes comparing two cohorts of SLE patients divergent in the presence or absence of DLD using multimodal imaging. Methods: Both eyes of 16 SLE patients with DLD were compared to an age- and sex-matched control-group consisting of 16 SLE patients without detectable DLD. Both cohorts were treated with hydroxychloroquine (HCQ) and did not differ in the treatment duration or dosage. Using spectral-domain optical coherence tomography (SD-OCT) choroidal volume measures, choroidal vascularity indices (CVI) and retinal layer segmentation was performed and compared. In addition, by the exploitation of optical coherence tomography angiography vascular density, perfusion density of superficial and deep retinal capillary plexuses and the choriocapillaris were analyzed. For the choroidal OCT-scans, a subset of 51 healthy individuals served as a reference-group. Results: CVI measures revealed a significant reduction in eyes with DLD compared to healthy controls (0.56 (0.54–0.59) versus 0.58 (0.57–0.59) (p = 0.018) and 0.56 (0.54–0.58) versus 0.58 (0.57–0.60) (p < 0.001)). The photoreceptor cell layer presented significant thinning in both eyes of subjects with DLD compared to control subjects without DLD (68.8 ± 7.7 µm vs. 77.1 ± 7.3 µm for right eyes, p = 0.008, and 66.5 ± 10.5 µm vs. 76.1 ± 6.3 µm for left eyes, p = 0.011). OCTA scans revealed no significant changes, yet there could be observed numerically lower values in the capillary plexuses of the retina in eyes with DLD than in eyes without DLD. Conclusions: Our results illustrated significant alterations in the choroidal and retinal analyzes, suggesting a correlation between DLD and the progression of inflammatory processes in the course of SLE leading to retinal degeneration. For this reason, DLD could serve as a biomarker for a more active state of disease

Weight loss surgery for obstructive sleep apnoea with obesity in adults: a systematic review and meta-analysis protocol

Introduction Obstructive sleep apnoea (OSA) is causedby complete or partial obstruction of the upper airwayresulting in repeated episodes of interrupted or shallowbreaths. OSA is associated with significant morbidity andmortality. The prevalence is estimated to range from 3%to 7% in the general population but may be much higher.Several studies show that weight loss or bariatric surgerymay have a role in treating OSA. The aim of this systematicreview is to assess the safety and efficacy of randomisedcontrolled trials (RCTs) of weight loss surgery for adultswith OSA and comorbid obesity.Methods and analysis A search of the Cochrane CentralRegister of Controlled Trials, PubMed, EMBASE and twomajor Chinese biomedical databases will be performedto identify related trials published as of October 2018.This study will include RCTs, comparing different typesof weight loss surgery for OSA with obesity or weightloss surgery for OSA with obesity with other upper airwaysurgeries. The primary outcomes that will be measuredare apnoea&ndash;hypopnoea index, excess weight loss andin-hospital mortality. The secondary outcomes willinclude duration of hospital stay, neck circumference,reoperation, waist circumference, body mass index,Epworth Sleepiness Scale score, overt complications(eg, gastric fistula, bleeding, delayed gastric emptying,wound infection), quality of life, quality of sleep and/orfunctionality. The systematic review will be conductedaccording to the recommendations as outlined by theCochrane collaboration.Ethics and dissemination The systematic review andmeta-analysis will include published data available onlineand thus ethics approval will not be required. The findingswill be disseminated and published in a peer-reviewedjournal. Review updates will be conducted if there isnew evidence that may cause any change in reviewconclusions. Any changes to the study protocol will beupdated in the PROSPERO trial registry accordingly

Religio-ethical discussions on organ donation among Muslims in Europe: an example of transnational Islamic bioethics

This article analyzes the religio-ethical discussions of Muslim religious scholars, which took place in Europe specifically in the UK and the Netherlands, on organ donation. After introductory notes on fatwas (Islamic religious guidelines) relevant to biomedical ethics and the socio-political context in which discussions on organ donation took place, the article studies three specific fatwas issued in Europe whose analysis has escaped the attention of modern academic researchers. In 2000 the European Council for Fatwa and Research (ECFR) issued a fatwa on organ donation. Besides this “European” fatwa, two other fatwas were issued respectively in the UK by the Muslim Law (Shariah) Council in 1995 and in the Netherlands by the Moroccan religious scholar Muṣṭafā Ben Ḥamza during a conference on “Islam and Organ Donation” held in March 2006. The three fatwas show that a great number of Muslim religious scholars permit organ donation and this holds true for donating organs to non-Muslims as well. Further, they demonstrate that transnationalism is one of the main characteristics of contemporary Islamic bioethics. In a bid to develop their own standpoints towards organ donation, Muslims living in the West rely heavily on fatwas imported from the Muslim world