Whose book is this [and does it matter]? How shared print programs are redefining our understanding of local collections

Shared print initiatives such as the Eastern Academic Scholars’ Trust [EAST] and the HathiTrust Shared Print Program are beginning to redefine collection ownership in academic and research libraries and offer opportunities for new forms of cooperation and collaboration. These large-scale programs effectively create mega-collections of scholarly materials that have been designated for retention or preservation and can be loaned to partner libraries. This panel will report on the results of these ground-breaking shared print programs, discuss plans for growth and posit ways in which such programs may impact collection development, resource sharing, and library collaboration at scale. EAST has completed a collection analysis across more than 16 million holdings from its 40 retention partner libraries and committed to retain over 6 million items on behalf of the members. In addition, important work was done to validate presence and condition of over 240,000 items with further statistical analysis of this data likely to influence retention modeling in the future. The HathiTrust program builds on the commitments its members have made to digital preservation by working with libraries to extend commitments to the print equivalents. These programs focus on protecting print and digital collections in ways that reduce the costs of collection management and storage as well as provide models of ways in which shared print is changing the landscape for the ownership of scholarly titles. As more and more academic and research libraries commit to participate in such programs, it sets the stage for rethinking collection development and resource sharing. The panelists will provide an update of the status of EAST and HathiTrust, and discuss the impact of such large-scale initiatives on their member libraries. Potential opportunities for further collaboration across shared print programs will be considered as will ways in which these initiatives can drive new forms of library cooperation and act as further catalysts for collective management of library collections. Presenters: Lorraine Huddy, CTW Consortium, Connecticut Matthew Sheehy, Brandeis University Lizanne Payne, Hathi Trus

The effect of the addition of resistance training to a dietary education intervention on apolipoproteins and diet quality in overweight and obese older adults

Objectives: The aim of the study was to examine the additive effect of resistance training (RT) to a dietary education (DE) intervention on emerging coronary heart disease (CHD) risk factors, concentration of apolipoproteins B (apoB) and A-I (apoA-I), and Dietary Approaches to Stop Hypertension (DASH) Diet Index scores in overweight and obese older adults. Patients and Methods: This was an ancillary study of a randomized clinical trial held in the Fall of 2008 at the University of Rhode Island. Participants were overweight or obese subjects (mean body mass index [BMI] of 31.7 kg/m2) randomized into two groups, one participating in DE only (n = 12) and the other participating in DE plus RT (DERT) (n = 15). The intervention involved all subjects participating in 30 minutes of DE per week for 10 weeks. Subjects in the DERT group participated in an additional 40 minutes of RT three times per week for 10 weeks. Measurements taken were anthropometric (height, weight, waist circumference, and body composition using the BOD POD® [Body Composition System, v 2.14; Life Measurement Instruments, Concord, CA]), clinical (blood pressure), and biochemical (lipid profile and apoB and apoA-I concentrations), and the DASH Diet Index was used to measure diet quality. Results: 27 subjects (11 males, 16 females), with a mean age of 66.6 ± 4.3 years, were included in analyses. The DERT subjects had significantly better triacylglycerol and apoB concentrations and DASH Diet Index scores than the DE subjects post-intervention. Improvements were seen within the DE group in energy intake, fat-free mass, and systolic blood pressure and within the DERT group in body weight, percentage of body fat, BMI, diastolic blood pressure, and oxidized low-density lipoprotein (all P \u3c 0.05). Conclusion: The addition of RT effectively reduced CHD risk factors, body composition, and diet quality in overweight and obese older adults; DERT was more effective than DE alone in improving DASH Diet Index scores and lowering apoB concentrations but was not more effective in increasing apoA-I concentrations. Future research is needed to determine if apolipoproteins are superior to lipoprotein cholesterol concentrations in predicting CHD risk

HathiTrust Print Monographs Archive Planning Task Force: Final Report

Following the approval of a 2011 ballot initiative calling for the development of a distributed print monographs archive, HathiTrust charged a Print Monographs Archive Planning Task Force in the spring of 2014 to make initial recommendations for a print monograph retention program that would serve both members and the broader scholarly community. After working extensively between June 2014 and March 2015, the Task Force submitted a report that summarizes its recommendations with respect to the composition, phased construction, operating systems, business model, and governance of the HathiTrust Shared Print Monograph Program (HTSPMP). In supporting appendices, the report offers greater detail that implementation teams may find useful.Ope

Automatic approach-avoidance tendency toward physical activity, sedentary, and neutral stimuli as a function of age, explicit affective attitude, and intention to be active

Using computerized reaction-time tasks assessing automatic attitudes, studies have shown that healthy young adults have faster reaction times when approaching physical activity stimuli than when avoiding them. The opposite has been observed for sedentary stimuli. However, it is unclear whether these results hold across the lifespan and when error rates and a possible generic approach-avoidance tendency are accounted for. Here, reaction times and errors in online approach-avoidance tasks of 130 participants aged 21 to 77 years were analyzed using mixed-effects models. Automatic approach-avoidance tendencies were tested using physical activity, sedentary, and neutral stimuli. Explicit attitudes toward physical activity and intention to be physically active were self-reported. Results accounting for age, sex, gender, level of physical activity, body mass index, and chronic health condition confirmed a main tendency to approach physical activity stimuli (i.e., faster reaction to approach vs. avoid; p = .001) and to avoid sedentary stimuli (i.e., faster reaction to avoid vs. approach; p < .001). Results based on neutral stimuli revealed a generic approach tendency in early adulthood (i.e., faster approach before age 53 and fewer errors before age 36) and a generic avoidance tendency in older adults (i.e., more errors after age 60). When accounting for these generic tendencies, results showed a greater tendency (i.e., fewer errors) to avoid than approach sedentary stimuli after aged 50, but not before (p = .026). Exploratory analyses showed that irrespective of age, participants were faster at approaching physical activity (p = .028) and avoiding sedentary stimuli (p = .041) when they considered physical activity as pleasant and enjoyable (explicit attitude). However, results showed no evidence of an association between approach-avoidance tendencies and the intention to be physically active. Taken together, these results suggest that both age and explicit attitudes can affect the general tendency to approach physical activity stimuli and to avoid sedentary stimuli

Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

A single vaccination with MVA-NP+M1 boosts T-cell responses to conserved influenza antigens in humans. Protection against influenza disease and virus shedding was demonstrated in an influenza virus challenge study

Phase Ia Clinical Evaluation of the Safety and Immunogenicity of the Plasmodium falciparum Blood-Stage Antigen AMA1 in ChAd63 and MVA Vaccine Vectors

Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order to induce high-titer growth-inhibitory antibody responses. However, to date no such vaccine encoding a blood-stage antigen(s) alone has induced significant protective efficacy against erythrocytic-stage infection in a pre-specified primary endpoint of a Phase IIa/b clinical trial designed to assess vaccine efficacy. Cell-mediated responses, acting in conjunction with functional antibodies, may be necessary for immunity against blood-stage P. falciparum. The development of a vaccine that could induce both cell-mediated and humoral immune responses would enable important proof-of-concept efficacy studies to be undertaken to address this question

Expression and Cellular Immunogenicity of a Transgenic Antigen Driven by Endogenous Poxviral Early Promoters at Their Authentic Loci in MVA

CD8+ T cell responses to vaccinia virus are directed almost exclusively against early gene products. The attenuated strain modified vaccinia virus Ankara (MVA) is under evaluation in clinical trials of new vaccines designed to elicit cellular immune responses against pathogens including Plasmodium spp., M. tuberculosis and HIV-1. All of these recombinant MVAs (rMVA) utilize the well-established method of linking the gene of interest to a cloned poxviral promoter prior to insertion into the viral genome at a suitable locus by homologous recombination in infected cells. Using BAC recombineering, we show that potent early promoters that drive expression of non-functional or non-essential MVA open reading frames (ORFs) can be harnessed for immunogenic expression of recombinant antigen. Precise replacement of the MVA orthologs of C11R, F11L, A44L and B8R with a model antigen positioned to use the same translation initiation codon allowed early transgene expression similar to or slightly greater than that achieved by the commonly-used p7.5 or short synthetic promoters. The frequency of antigen-specific CD8+ T cells induced in mice by single shot or adenovirus-prime, rMVA-boost vaccination were similarly equal or marginally enhanced using endogenous promoters at their authentic genomic loci compared to the traditional constructs. The enhancement in immunogenicity observed using the C11R or F11L promoters compared with p7.5 was similar to that obtained with the mH5 promoter compared with p7.5. Furthermore, the growth rates of the viruses were unimpaired and the insertions were genetically stable. Insertion of a transgenic ORF in place of a viral ORF by BAC recombineering can thus provide not only a potent promoter, but also, concomitantly, a suitable insertion site, potentially facilitating development of MVA vaccines expressing multiple recombinant antigens

BICEP2/SPUD: searching for inflation with degree scale polarimetry from the South Pole

BICEP2/SPUD is the new powerful upgrade of the existing BICEP1 experiment, a bolometric receiver to study the polarization of the cosmic microwave background radiation, which has been in operation at the South Pole since January 2006. BICEP2 will provide an improvement up to 10 times mapping speed at 150 GHz compared to BICEP1, using the same BICEP telescope mount. SPUD, a series of compact, mechanically-cooled receivers deployed on the DASI mount at the Pole, will provide similar mapping speed in to BICEP2 in three bands, 100, 150, and 220 GHz. The new system will use large TES focal plane arrays to provide unprecedented sensitivity and excellent control of foreground contamination.Astronom