Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

Adrian V. S. Hill; Alexandra J. Spencer; Anthony Gilbert; Berthoud; Breathnach; Caitlin Mullarkey; CDC; Christopher J. A. Duncan; Donnelly; Epstein; Epstein; Forrest; He; John Oxford; Kresse; Laddy; Laddy; Lee; Makedonas; Marie-Eve Blais; Matthew Hamill; McMichael; Osterholm; Patrick J. Lillie; Rob Lambkin Williams; Sarah C. Gilbert; Saul N. Faust; Susanne H. Sheehy; Tamara K. Berthoud; Tao Dong; Teresa Lambe; Timothy J. Powell; Tom Havelock; Wesley; Yanchun Peng

Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

Authors: Adrian V. S. Hill
Alexandra J. Spencer
Anthony Gilbert
Berthoud
Breathnach
Caitlin Mullarkey
CDC
Christopher J. A. Duncan
Donnelly
Epstein
Epstein
Forrest
He
John Oxford
Kresse
Laddy
Laddy
Lee
Makedonas
Marie-Eve Blais
Matthew Hamill
McMichael
Osterholm
Patrick J. Lillie
Rob Lambkin Williams
Sarah C. Gilbert
Saul N. Faust
Susanne H. Sheehy
Tamara K. Berthoud
Tao Dong
Teresa Lambe
Timothy J. Powell
Tom Havelock
Wesley
Yanchun Peng
Publication date: 1 July 2012
Publisher: Oxford University Press
Doi

Abstract

A single vaccination with MVA-NP+M1 boosts T-cell responses to conserved influenza antigens in humans. Protection against influenza disease and virus shedding was demonstrated in an influenza virus challenge study

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