A packaged mindset:How elongated packages induce healthy mindsets

Product packaging is an important instrument for marketers to draw consumer attention to specific product information and influence product perceptions. The purpose of this research is to investigate whether exposure to a product's packaging can also activate specific mindsets that, once activated, alter consumers' food perceptions. The results of three experiments demonstrate that elongated containers activate a health mindset that influences both consumers' perception of the packaged food product but also their health perceptions of subsequently encountered food. Specifically, foods in elongated containers lead consumers to think of concepts related to healthiness, which have differentiable effects on subsequent healthy and unhealthy food products

An Analysis of Repeated High Intensity Efforts (RHIE) across Different Competition Levels in Elite Rugby Union

The current investigation aimed to understand the differing positional demands across two elite rugby union competitions, with special reference to high-intensity effort (HIE) and repeated high-intensity effort (RHIE) activity. Four hundred and forty-one (n = 441) individual game files from thirty-five competitive games from the European Rugby Champions Cup (tier 1; n = 8) and PRO12 League (tier 2; n = 24) were analysed. Players’ locomotor profiles were recorded using wearable global positioning system microtechnology (10 Hz Catapult S5, Catapult Innovations, Australia). Locomotor activities were classified as running (4.4 ms1), high-speed running (5.5 ms1), accelerations (2 ms2) and decelerations (2 ms2). Data was gathered on collisions (4 g1), high-intensity efforts (HIE), repeated high-intensity efforts (RHIE), average number of efforts within a RHIE bout (n) and maximal number of efforts within a RHIE bout (n). Overall locomotor differences between competitions were trivial to small in nature, with tier 1 competition associated with a larger number of RHIE bouts (6.5 1.4 vs. 5.7 1.5, effect size, ES = 0.55) and efforts per bout (3.0 1.1 vs. 2.4 1.2, ES = 0.52). Collisions comprised a greater proportion of total HIE for forwards within tier 1 competition compared to tier 2 competition. The hooker (mean difference: 4 [10 to 14]; ES = 0.30, small), lock (mean difference: 5 [12 to 23]; ES = 0.36, small) and backrow (mean difference: 8 [10 to 15]; ES = 0.54, small) positions engaged in more collisions during tier 1 competition compared to tier 2 competition. These findings can be used by athletic performance staff to design game-specific drills and recovery strategies during different competition weeks to ensure players are appropriately prepared for the differing demands of elite rugby competitio

Keeping ubiquitous computing to yourself: a practical model for user control of privacy

As with all the major advances in information and communication technology, ubiquitous computing (ubicomp) introduces new risks to individual privacy. Our analysis of privacy protection in ubicomp has identified four layers through which users must navigate: the regulatory regime they are currently in, the type of ubicomp service required, the type of data being disclosed, and their personal privacy policy. We illustrate and compare the protection afforded by regulation and by some major models for user control of privacy. We identify the shortcomings of each and propose a model which allows user control of privacy levels in a ubicomp environment. Our model balances the user's privacy preferences against the applicable privacy regulations and incorporates five types of user controlled 'noise' to protect location privacy by introducing ambiguities. We also incorporate an economics-based approach to assist users in balancing the trade-offs between giving up privacy and receiving ubicomp services. We conclude with a scenario and heuristic evaluation which suggests that regulation can have both positive and negative influences on privacy interfaces in ubicomp and that social translucence is an important heuristic for ubicomp privacy interface functionality

ALMA Discovery of a Disk around the Planetary-Mass Companion Sr 12 C

We report an Atacama Large Millimeter/submillimeter Array 0.88 mm (Band 7) continuum detection of the accretion disk around SR 12 c, an ∼11 M Jup planetary-mass companion (PMC) orbiting its host binary at 980 au. This is the first submillimeter detection of a circumplanetary disk around a wide PMC. The disk has a flux density of 127 ± 14 μJy and is not resolved by the ∼0.″1 beam, so the dust disk radius is likely less than 5 au and can be much smaller if the dust continuum is optically thick. If, however, the dust emission is optically thin, then the SR 12 c disk has a comparable dust mass to the circumplanetary disk around PDS 70 c but is about five times lower than that of the ∼12 M Jup free-floating OTS 44. This suggests that disks around bound and unbound planetary-mass objects can span a wide range of masses. The gas mass estimated with an accretion rate of 10-11 M ⊙ yr-1 implies a gas-to-dust ratio higher than 100. If cloud absorption is not significant, a nondetection of 12CO(3-2) implies a compact gas disk around SR 12 c. Future sensitive observations may detect more PMC disks at 0.88 mm flux densities of ≲ 100 μJy

LI-Detector:a Method for Curating Ordered Gene-Replacement Libraries

In recent years the availability of genome sequence information has grown logarithmically resulting in the identification of a plethora of uncharacterized genes. To address this gap in functional annotation, many high-throughput screens have been devised to uncover novel gene functions. Gene-replacement libraries are one such tool that can be screened in a high-throughput way to link genotype and phenotype and are key community resources. However, for a phenotype to be attributed to a specific gene, there needs to be confidence in the genotype. Construction of large libraries can be laborious and occasionally errors will arise. Here, we present a rapid and accurate method for the validation of any ordered library where a gene has been replaced or disrupted by a uniform linear insertion (LI). We applied our method (LI-detector) to the well-known Keio library of Escherichia coli gene-deletion mutants. Our method identified 3,718 constructed mutants out of a total of 3,728 confirmed isolates, with a success rate of 99.7% for identifying the correct kanamycin cassette position. This data set provides a benchmark for the purity of the Keio mutants and a screening method for mapping the position of any linear insertion, such as an antibiotic resistance cassette in any ordered library. IMPORTANCE The construction of ordered gene replacement libraries requires significant investment of time and resources to create a valuable community resource. During construction, technical errors may result in a limited number of incorrect mutants being made. Such mutants may confound the output of subsequent experiments. Here, using the remarkable E. coli Keio knockout library, we describe a method to rapidly validate the construction of every mutant.</p

Learning from Lives and Deaths - People with a learning disability and autistic people (LeDeR) report for 2022

The seventh annual report of 'Learning from lives and deaths - People with a learning disability and autistic people' (LeDeR) focuses on reviews of deaths of people with a learning disability and autistic people that occurred in 2022. Comparison data from reviews of deaths in 2018 to 2021 is used to identify trends over time. Introduced by a foreword from the 'Staying Alive and Well' group, the report explores the demographics of people who died, circumstances and causes of death, factors associated with age at death, issues in quality of care and avoidable and excess deaths. Deaths of autistic people without a learning disability are included in the report for the first time in an important step towards understanding the unique challenges faced by autistic people

How do you choose a book for a pre-arrival shared reading scheme within a University? A case study

This paper continues the exploration of Kingston University’s pre-arrival shared reading scheme, the Kingston University Big Read (KUBR), this time considering action research into how best to choose a common book. After a review of methods used to choose books both specifically in American universities and generally within large shared reading groups, the method used for the KUBR is described. A key objective of the KUBR is to promote inclusion, so the longlist of titles considered was produced by inviting the entire community to submit suggestions. Since the list was extensive, time to make a choice was short, and there was a strong desire for the methodology to be as objective as possible, it was decided to identify the key criteria relevant to choosing a suitable book and then use a simple algorithm—essentially a weighted scoring system—to score each book using readily available data in order to make a shortlist of six books. These were then read by a panel of students and administrative and academic staff. The book finally chosen was Matt Haig’s The Humans. This paper details each step of the method and finishes with an appraisal and lessons learnt for next time.</jats:p

Stage-specific proteomes from onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle

Despite 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected. The etiological agent, Onchocerca volvulus, is a filarial nematode with a complex lifecycle involving several distinct stages in the definitive host and blackfly vector. The challenges of obtaining sufficient material have prevented high-throughput studies and the development of novel strategies for disease control and diagnosis. Here, we utilize the closest relative of O. volvulus, the bovine parasite Onchocerca ochengi, to compare stage-specific proteomes and host-parasite interactions within the secretome. We identified a total of 4260 unique O. ochengi proteins from adult males and females, infective larvae, intrauterine microfilariae, and fluid from intradermal nodules. In addition, 135 proteins were detected from the obligate Wolbachia symbiont. Observed protein families that were enriched in all whole body extracts relative to the complete search database included immunoglobulin-domain proteins, whereas redox and detoxification enzymes and proteins involved in intracellular transport displayed stage-specific overrepresentation. Unexpectedly, the larval stages exhibited enrichment for several mitochondrial-related protein families, including members of peptidase family M16 and proteins which mediate mitochondrial fission and fusion. Quantification of proteins across the lifecycle using the Hi-3 approach supported these qualitative analyses. In nodule fluid, we identified 94 O. ochengi secreted proteins, including homologs of transforming growth factor-β and a second member of a novel 6-ShK toxin domain family, which was originally described from a model filarial nematode (Litomosoides sigmodontis). Strikingly, the 498 bovine proteins identified in nodule fluid were strongly dominated by antimicrobial proteins, especially cathelicidins. This first high-throughput analysis of an Onchocerca spp. proteome across the lifecycle highlights its profound complexity and emphasizes the extremely close relationship between O. ochengi and O. volvulus The insights presented here provide new candidates for vaccine development, drug targeting and diagnostic biomarkers

Dative constructions in Romance and beyond

This book offers a comprehensive account of dative structures across languages –with an important, though not exclusive, focus on the Romance family. As is well-known, datives play a central role in a variety of structures, ranging from ditransitive constructions to cliticization of indirect objects and differentially marked direct objects, and including also psychological predicates, possessor or causative constructions, among many others. As interest in all these topics has increased significantly over the past three decades, this volume provides an overdue update on the state of the art. Accordingly, the chapters in this volume account for both widely discussed patterns of dative constructions as well as those that are relatively unknown

Dative constructions in Romance and beyond

This book offers a comprehensive account of dative structures across languages –with an important, though not exclusive, focus on the Romance family. As is well-known, datives play a central role in a variety of structures, ranging from ditransitive constructions to cliticization of indirect objects and differentially marked direct objects, and including also psychological predicates, possessor or causative constructions, among many others. As interest in all these topics has increased significantly over the past three decades, this volume provides an overdue update on the state of the art. Accordingly, the chapters in this volume account for both widely discussed patterns of dative constructions as well as those that are relatively unknown