Total and Differential Phylloquinone (Vitamin K1) Intakes of Preterm Infants from All Sources during the Neonatal Period.

All newborns require phylloquinone after birth to prevent vitamin K deficiency bleeding. Babies born prematurely may be at particular risk of deficiency without adequate supplementation during infancy. The main sources of phylloquinone in preterm babies during the neonatal period are the prophylactic dose of phylloquinone given at birth, and that derived from parenteral and/or enteral feeding. This observational study formed part of a prospective, multicentre, randomised, controlled trial that examined the vitamin K status of preterm infants after random allocation to one of three phylloquinone prophylactic regimens at birth (0.5 or 0.2 mg intramuscularly or 0.2 mg intravenously). In this nutritional sub-study we quantified the proportional and total phylloquinone intakes of preterm infants within the neonatal period from all sources. Almost all infants had average daily phylloquinone intakes that were in excess of the currently recommended amounts. In infants who did not receive parenteral nutrition, the bolus dose of phylloquinone given at birth was the major source of phylloquinone intake, whereas in infants who received parenteral nutrition, the intake from the parenteral preparation exceeded that from the bolus dose by a ratio of approximately 3:1. Our study supports the concern of others that preterm infants who receive current parenteral nutrition formulations may be receiving excessive vitamin K

Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers

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Optical Pulse-Phased Photopolarimetry of PSR B0656+14

We have observed the optical pulse profile of PSR B0656+14 in 10 phase bins at a high signal-to-noise ratio, and have measured the linear polarization profile over 30% of the pulsar period with some significance. The pulse profile is double-peaked, with a bridge of emission between the two peaks, similar to gamma-ray profiles observed in other pulsars. There is no detectable unpulsed flux, to a 1-sigma limit of 16% of the pulse-averaged flux. The emission in the bridge is highly (~ 100%) polarized, with a position angle sweep in excellent agreement with the prediction of the Rotating Vector Model as determined from radio polarization observations. We are able to account for the gross features of the optical light curve (i.e., the phase separation of the peaks) using both polar cap and outer gap models. Using the polar cap model, we are also able to estimate the height of the optical emission regions.Comment: 27 pages, 11 figures, accepted by ApJ (scheduled v597 n2, November 10, 2003

Minerals and vitamins in bone health: the potential value of dietary enhancement

Nutrition is important to bone health, and a number of minerals and vitamins have been identified as playing a potential role in the prevention of bone diseases, particularly osteoporosis. Despite this, there is currently no consensus on maximum levels to allow in food or as dietary supplements. The benefits of supplementation of populations at risk of osteoporosis with Ca and vitamin D are well established. Prolonged supplementation of Ca and vitamin D in elderly has been shown to prevent bone loss, and in some intervention studies to prevent fragility fractures. Although P is essential to bone health, the average intake is considered to be more than sufficient and supplementation could raise intake to adverse levels. The role of vitamin K in bone health is less well defined, though it may enhance the actions of Ca and vitamin D. Sr administered in pharmacological doses as the ranelate salt was shown to prevent fragility fractures in postmenopausal osteoporosis. However, there is no hard evidence that supplementation with Sr salts would be beneficial in the general population. Mg is a nutrient implicated in bone quality, but the benefit of supplementation via foodstuffs remains to be established. A consensus on dietary supplementation for bone health should balance the risks, for example, exposure of vulnerable populations to values close to maximal tolerated doses, against evidence for benefits from randomised clinical trials, such as those for Ca and vitamin D. Feedback from community studies should direct further investigations and help formulate a consensus on dietary supplementation for bone healt

Simultaneous Absolute Timing of the Crab Pulsar at Radio and Optical Wavelengths

The Crab pulsar emits across a large part of the electromagnetic spectrum. Determining the time delay between the emission at different wavelengths will allow to better constrain the site and mechanism of the emission. We have simultaneously observed the Crab Pulsar in the optical with S-Cam, an instrument based on Superconducting Tunneling Junctions (STJs) with $\mu$s time resolution and at 2 GHz using the Nan\c{c}ay radio telescope with an instrument doing coherent dedispersion and able to record giant pulses data. We have studied the delay between the radio and optical pulse using simultaneously obtained data therefore reducing possible uncertainties present in previous observations. We determined the arrival times of the (mean) optical and radio pulse and compared them using the tempo2 software package. We present the most accurate value for the optical-radio lag of 255 $\pm$ 21 $\mu$s and suggest the likelihood of a spectral dependence to the excess optical emission asociated with giant radio pulses.Comment: 8 pages; accepted for publication in Astronomy and Astrophysic

Optical spectroscopy of the radio pulsar PSR B0656+14

We have obtained the spectrum of a middle-aged PSR B0656+14 in the 4300-9000 AA range with the ESO/VLT/FORS2. Preliminary results show that at 4600-7000 AA the spectrum is almost featureless and flat with a spectral index $\alpha_nu ~ -0.2 that undergoes a change to a positive value at longer wavelengths. Combining with available multiwavelength data suggests two wide, red and blue, flux depressions whose frequency ratio is about 2 and which could be the 1st and 2nd harmonics of electron/positron cyclotron absorption formed at magnetic fields ~10^8G in upper magnetosphere of the pulsar.Comment: 4 pages, 4 figures, To appear in Astrophysics and Space Science, Proceedings of "Isolated Neutron Stars: from the Interior to the Surface", eds. D. Page, R. Turolla and S. Zan

Report from the “What is Open?” Workgroup

The scholarly community’s current definition of “open” captures only some of the attributes of openness that exist across different publishing models and content types. Open is not an end in itself, but a means for achieving the most effective dissemination of scholarship and research. We suggest that the different attributes of open exist along a broad spectrum and propose an alternative way of describing and evaluating openness based on four attributes: discoverable, accessible, reusable, and transparent. These four attributes of openness, taken together, form the draft “DART Framework for Open Access.” This framework can be applied to both research artifacts as well as research processes. We welcome input from the broader scholarly community about this framework

A Bio-Based Pro-Antimicrobial Polymer Network Via Degradable Acetal Linkages

The synthesis of a fully degradable, bio-based, sustained release, pro-antimicrobial polymer network comprised of degradable acetals (PANDA) is reported. The active antimicrobial agent – p-anisaldehyde (pA) (an extract from star anise) – was converted into a UV curable acetal containing pro-antimicrobial monomer and subsequently photopolymerized into a homogenous thiol-ene network. Under neutral to acidic conditions (pH \u3c 8), the PANDAs undergo surface erosion and exhibit sustained release of pA over 38 days. The release of pA from PANDAs was shown to be effective against both bacterial and fungal pathogens. From a combination of confocal microscopy and transmission electron microscopy, we observed that the released pA disrupts the cell membrane. Additionally, we demonstrated that PANDAs have minimal cytotoxicity towards both epithelial cells and macrophages. Although a model platform, these results point to promising pathways for the design of fully degradable sustained-release antimicrobial systems with potential applications in agriculture, pharmaceuticals, cosmetics, household/personal care, and food industries

Late onset vitamin K deficiency bleeding, extreme prematurity and a human milk based diet

An extremely preterm female infant (born at 23+5 weeks; weight 555g) received 0.4mg/kg IM Vitamin K1 (VK). She received an exclusively human milk-based diet and was commenced on a commercially available human-milk fortifier