Preventing and improving interactions between autistic individuals and the criminal justice system: A roadmap for research

Researchers have identified that autistic individuals are encountering the criminal justice system as victims, offenders, and witnesses at high rates. The prevalence of autism spectrum disorder (ASD) is increasing and generating a comprehensive approach to addressing criminal justice system involvement among autistic individuals is a timely and urgent need. Revisions to an established framework generated for use among individuals with mental health diagnoses, the sequential Intercept Model (SIM), were produced by an international consortium of interdisciplinary stakeholders presenting a new opportunity to identify gaps in ASD research and generate preventive solutions across the criminal justice system. The revised SIM maps each criminal justice system component, or Intercept, and includes paths for the experiences of autistic individuals as victims or witnesses to crimes as well as offenders to catalyze new and interdisciplinary research, policy, and practice efforts. As the field of ASD research continues to grow, the revised SIM is a promising pathway to avoiding siloed research approaches, including diverse autistic voices, and contributing to international dialogue about criminal justice reform at a critical juncture. LAY SUMMARY: Autistic individuals are encountering the criminal justice system as victims, offenders, and witnesses at high rates. A revised version of the SIM generated by an international consortium provides a cohesive framework to ensure research focused on this topic extends across the criminal justice system. Preventing and improving interactions between autistic individuals and the criminal justice system is an urgent research, policy, and practice need

7. Habitat Use and Home Range of Eastern Box Turtle (Terrapene carolina carolina) in North Georgia Piedmont

The Eastern Box Turtle (Terrapene carolina carolina) is a terrestrial species native to the eastern United States. Eastern Box Turtles are experiencing range-wide population decline and are classified as vulnerable by the International Union for the Conservation of Nature. Despite this, little research has been conducted regarding home range and habitat use in the Southeastern US. Therefore, since May 2013, we have conducted a radiotelemetry study to investigate factors that influence Box Turtle movement, habitat use, and survival in the Northeastern Piedmont region of Georgia. The study site is composed of mixed hardwood-pine uplands primarily comprised of oaks and maples, mesic and upland areas dominated by Chinese privet (Ligustrum sinense), beaver-created wetland, and maintained utility line areas. Our research includes 21 radio-transmitted turtles that are tracked on foot by homing 1-2 times a week. From spring 2013 to winter 2017, an average of 74 radiolocations (range: 6 to 166) per turtle were collected. Home ranges (100% minimum convex polygon) varied from less than 1 to over 6 ha. Radiotracked turtles primarily used mixed-upland areas and areas dominated by Chinese privet. The assessment of habitat use and home ranges will continue throughout 2017 with tracking and further data analysis. Keywords: Terrapene carolina carolina, radiotelemetry, home range, habitat use, Ligustrum sinens

Let’s talk about seagrasses! A front-end evaluation to improve messaging strategies for seagrass conservation in Indian River Lagoon visitor centers

In the most recent decades, there has been extensive loss of seagrasses within the Indian River Lagoon estuary on the eastern coast of Florida. This decline poses a significant threat to the ecological function of the ecosystem, as well as to the social and economic wellbeing of the surrounding communities. Stakeholder buy-in and engagement with conservation initiatives is a critical component of lagoon-wide seagrass restoration and management efforts. Visitor centers, such as zoos, aquarium, and nature centers, can play a key role in increasing knowledge of environmental issues and facilitating behavior change among stakeholders. This capstone project included a 2-phase front-end evaluation to provide recommendations for the network of visitor centers within the region to increase messaging impact and buy-in for seagrass conservation efforts. The first phase involved a content analysis conducted at 11 facilities to understand current messaging strategies. The second phase was a visitor survey conducted at Brevard Zoo in Melbourne, Florida that sought to understand visitors’ beliefs and prior knowledge about seagrasses, as well as conduct a pilot-study to compare the impact of various messaging approaches. Combined, these two evaluation efforts helped to inform a set of recommendations to improve future messaging. While this project served as an important first step in improving messaging impact, continued and on-going evaluation efforts will undoubtedly be needed to help leverage the impact of visitor centers in their efforts to help secure a more sustainable future for seagrasses in the Indian River Lagoon

Monitoring Waste to Minimize Waste at the University of Massachusetts Amherst

The University of Massachusetts Amherst is committed to sustainability, however, the campus could further reduce its costs and save energy by optimizing the current method of waste removal. The Intergovernmental Panel on Climate Change predicts that by the end of the century, Earth’s average temperature will rise by 11 degrees Fahrenheit unless society takes action to reduce greenhouse gas emissions. According to the EPA, about one-third of carbon emissions in the U.S. come from transportation. Campus garbage bins are collected by carbon-emitting trucks daily, and large truckable waste compactors are collected about three times per week. The amount of harmful carbon emissions released by trucking all of the compactors to their disposal sites totals 9,600 pounds of CO2 (the weight of 12 grand pianos) every week. In this analysis, the current waste removal system is investigated and a method is proposed to save UMass money and energy by reducing the number of waste collections. Initial research focused on how traditional bins could be replaced with solar-powered compactors from Bigbelly Solar Inc. to reduce pickup frequency and generate revenue from separating waste. Findings indicate that solar compactors alone would not have a worthwhile impact on the energy consumption of the UMass campus. Alternatively, a monitoring system that reduces how frequently waste compactors are hauled from campus would have greater impact, saving $1,000 every two weeks, reducing harmful carbon emissions, and using less diesel fuel. Due to the current environmental crisis, UMass should take action to reduce its carbon footprint through this economically favorable system

Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production

Precise regulation of the kinetics and magnitude of Ca2+ signaling enables this signal to mediate diverse responses, such as cell migration, differentiation, vesicular trafficking, and cell death. Here, we showed that the Ca2+-binding protein calmodulin (CaM) acted in a positive feedback loop to potentiate Ca2+ signaling downstream of the Tec kinase family member Itk. Using NMR (nuclear magnetic resonance), we mapped CaM binding to two loops adjacent to the lipid-binding pocket within the Itk pleckstrin homology (PH) domain. The Itk PH domain bound synergistically to Ca2+/CaM and the lipid phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3], such that binding to Ca2+/CaM enhanced the binding to PI(3,4,5)P3 and vice versa. Disruption of CaM binding attenuated Itk recruitment to the membrane and diminished release of Ca2+ from the endoplasmic reticulum. Moreover, disruption of this feedback loop abrogated Itk-dependent production of the proinflammatory cytokine IL-17A (interleukin-17A) by CD4+ T cells. Additionally, we found that CaM associated with PH domains from other proteins, indicating that CaM may regulate other PH domain–containing proteins

Clustered nuclei maintain autonomy and nucleocytoplasmic ratio control in a syncytium

© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 27 (2016): 2000-2007, doi:10.1091/mbc.E16-02-0129.Nuclei in syncytia found in fungi, muscles, and tumors can behave independently despite cytoplasmic translation and the homogenizing potential of diffusion. We use a dynactin mutant strain of the multinucleate fungus Ashbya gossypii with highly clustered nuclei to assess the relative contributions of nucleus and cytoplasm to nuclear autonomy. Remarkably, clustered nuclei maintain cell cycle and transcriptional autonomy; therefore some sources of nuclear independence function even with minimal cytosol insulating nuclei. In both nuclear clusters and among evenly spaced nuclei, a nucleus’ transcriptional activity dictates local cytoplasmic contents, as assessed by the localization of several cyclin mRNAs. Thus nuclear activity is a central determinant of the local cytoplasm in syncytia. Of note, we found that the number of nuclei per unit cytoplasm was identical in the mutant to that in wild-type cells, despite clustered nuclei. This work demonstrates that nuclei maintain autonomy at a submicrometer scale and simultaneously maintain a normal nucleocytoplasmic ratio across a syncytium up to the centimeter scale.his work was supported by National Institutes of Health R01-GM081506 (A.S.G., S.E.R., and P.O.), the National Science Foundation GK-12 Program and the Neukom Institute at Dartmouth College (S.E.R.), the Alfred P. Sloan Foundation and National Science Foundation DMS-1351860 (M.R. and S.-S.C.), a National Institutes of Health Ruth L. Kirschstein National Research Service Award (T32-GM008185; S.-S.C.), and the Intramural Research Programs of the National Institutes of Health National Institute of Biomedical Imaging and Bioengineering Whitman Investigator and Grass Foundation Programs at the Marine Biological Laboratory at Woods Hole (A.K. and H.S.

Policy Gaps and Opportunities: A Systematic Review of Autism Spectrum Disorder and Criminal Justice Intersections

LAY ABSTRACT: The number of people with autism spectrum disorder has increased, and as this population ages, research is showing high rates of contact with the criminal justice system among this group. Social and communication differences that autistic individuals experience can act as a risk factor during these interactions, as shown by public reports of negative and violent encounters between autistic individuals and the law enforcement. There is a clear need for evidence-based strategies to reduce high rates of contact and to improve outcomes when an interaction occurs. This article provides a systematic review of research on autism spectrum disorder and criminal justice system to compile this evidence base. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis structure was used to identify 89 articles after searching six databases. The Sequential Intercept Model describes the criminal justice system as different stages, or intercepts, that are connected, and the Sequential Intercept Model serves as an overall framework to organize the included articles. Articles were analyzed to identify research themes at each intercept, which offer guidance for policy and program changes that support equitable justice for autistic individuals

Circadian rhythm of cortisol and neighborhood characteristics in a population-based sample: The Multi-Ethnic Study of Atherosclerosis

Although stress is often hypothesized to contribute to the effects of neighborhoods on health, very few studies have investigated associations of neighborhood characteristics with stress biomarkers. This study helps address the gap in the literature by examining whether neighborhood characteristics are associated with cortisol profiles. Analyses were based on data from the Multi-Ethnic Study of Atherosclerosis Stress study which collected multiple measures of salivary cortisol over three days on a population based sample of approximately 800 adults. Multilevel models with splines were used to examine associations of cortisol with neighborhood poverty, violence, disorder, and social cohesion. Neighborhood violence was significantly associated with lower cortisol values at wakeup and with a slower decline in cortisol over the earlier part of the day, after sociodemographic controls. Associations were weaker and less consistent for neighborhood poverty, social cohesion, and disorder. Results revealed suggestive, though limited, evidence linking neighborhood contexts to cortisol circadian rhythms

Racial differences in cumulative disadvantage among women and its relation to health: Development and preliminary validation of the CSI-WE

Background: Cumulative disadvantage (CD) is a measure of accumulated social, economic, and person-related stressors due to unequal access to resources and opportunities, which increases a person's biological risk for disease. The purpose of this research was to develop an instrument tailored to women's experiences that had intervention and translational potential. In addition, we explored whether CD contributed to racial health disparities among black and white women. Methods: In-depth life course interviews were used to assess stressful experiences of 15 black and 15 white women. Using information from the interviews, we developed the Cumulative Stress Inventory of Women's Experiences (CSI-WE) as a quantitative instrument to measure stressful life experiences from childhood to adulthood. The CSI-WE was then administered to the original 30 women for validation and feedback. Results: Qualitative and quantitative assessments were highly correlated, which suggested that the CSI-WE reliably captured the experiences of the interviewed women. Black participants reported significantly higher numbers of childhood and adult stressors, more acute adulthood and lifetime stressors, and worse adult physical self-rated health. Conclusions: This study supports the preliminary validity of an instrument that once fully validated may be used in future studies to elucidate the experiences of CD among black and white women and examines how these experiences relate to perceived and objective health status

Optimizing management of invasions in an uncertain world using dynamic spatial models

Dispersal drives invasion dynamics of nonnative species and pathogens. Applying knowledge of dispersal to optimize the management of invasions can mean the difference between a failed and a successful control program and dramatically improve the return on investment of control efforts. A common approach to identifying optimal management solutions for invasions is to optimize dynamic spatial models that incorporate dispersal. Optimizing these spatial models can be very challenging because the interaction of time, space, and uncertainty rapidly amplifies the number of dimensions being considered. Addressing such problems requires advances in and the integration of techniques from multiple fields, including ecology, decision analysis, bioeconomics, natural resource management, and optimization. By synthesizing recent advances from these diverse fields, we provide a workflow for applying ecological theory to advance optimal management science and highlight priorities for optimizing the control of invasions. One of the striking gaps we identify is the extremely limited consideration of dispersal uncertainty in optimal management frameworks, even though dispersal estimates are highly uncertain and greatly influence invasion outcomes. In addition, optimization frameworks rarely consider multiple types of uncertainty (we describe five major types) and their interrelationships. Thus, feedbacks from management or other sources that could magnify uncertainty in dispersal are rarely considered. Incorporating uncertainty is crucial for improving transparency in decision risks and identifying optimal management strategies. We discuss gaps and solutions to the challenges of optimization using dynamic spatial models to increase the practical application of these important tools and improve the consistency and robustness of management recommendations for invasions