THE CITY AND ITS IMAGE: DISCOURSES OF THEORETICAL UNDERSTANDING

The article is devoted to understanding the ideas that influence the understanding of the essence of the city and its image in the process of historical development. Through historical and comparative analysis, key changes are illuminated, including the shift from the ideal of social justice to individualism. The research is relevant in the context of the impact of technology on urban life; it can become the basis for developing strategies for sustainable urban development and creating favorable social conditions. Aspects that influence the perception of residents and researchers of the urban image are identified for subsequent analysis of the modern city

ОЦЕНКА ТЯЖЕСТИ БОЛЕЗНИ И ПОДБОРАДЕКВАТНОЙ ДОЗЫ БАЗИСНОЙ ТЕРАПИИМЕТОТРЕКСАТОМ У РЕБЕНКА С ЮВЕНИЛЬНЫМ ПОЛИАРТРИТОМ

The article presents a short review of the current notion of the leading role methotrexate in treatment of most clinical variants ofjuvenile idiopathic arthritis. The authors demonstrate that methotrexate is a “gold standard” of antirheumatic therapy and the key disease-modifying drug of pediatric rheumatology. The emphasis is laid on safety profile and advantages of parenteral administration thereof. The article presents follow-up of a clinical case involving use of dosage form of methotrexate in the dose of 15 mg/m per week for subcutaneous administration in a patient with polyarticular juvenile idiopathic arthritis featuring insufficient effectiveness and low tolerance of the oral drug. Prescription of methotrexate for subcutaneous administration helped to terminate progression of the disease and pain syndrome and improve function of the affected joints and the patient’s quality of life. В статье дан краткий обзор современных представлений о ведущем месте метотрексата в лечении большинства клинических вариантов ювенильного идиопатического артрита. Показано, что метотрексат ― «золотой стандарт» противоревматической терапии, ключевой болезньмодифицирующий препарат в педиатрической ревматологии. Сделан акцент на профиль его безопасности и преимущества парентерального способа введения. В статье представлено наблюдение клинического случая использования дозированной формы метотрексата в дозе 15 мг/м2 в нед для подкожного введения у пациента с полиартикулярным вариантом ювенильного идиопатического артрита с недостаточной эффективностью и плохой переносимостью перорального препарата. Назначение метотрексата для подкожного введения позволило остановить прогрессирование заболевания, купировать болевой синдром, улучшить функцию пораженных суставов и повысить качество жизни пациента.

NOVOSIBIRSK REGION PROGRAM OF THE LIVER TRANSPLANTATION IN CHILDREN

The aim of the study was to analyze the early and late outcomes of pediatric liver transplantation (LTx) program in the Novosibirsk region. Material and Methods. The retrospective study included 24 patients aged 72 ± 74.8 months (from 4 to 212 months, median – 20 months) with a body weight of 21.7 ± 18.1 kg (from 4.5 to 55 kg, median – 12.5 kg). Two (8.3 %) cadaveric whole liver grafts, 19 (79.2 %) living donor liver grafts, and 3 (12.5 %) cadaveric liver fragments (reduced-size or split-liver) were transplanted. Results. The features of vascular and biliary reconstruction in different types of LTx are discussed. The incidence of vascular and biliary complications was 8.3 and 20.8%, respectively. The patients stayed in the intensive care unit for 9 ± 5.1 days (from 4 to 22 days, median 8 days) and total length of hospital stay was for 40 ± 25.4 days (from 19 to 136 days, median 32 days). Two (8.3 %) recipients had early graft dysfunction. Perioperative mortality (up to 90 days) was absent. The overall 5-year patient and graft survival rates were 95 and 88 %, respectively. Conclusion. The Novosibirsk region has a pediatric LTx program with outcomes comparable to the data of the leading world and Russian centers

ТРАНСПЛАНТАЦИЯ ПЕЧЕНИ ПРИ ЭПИТЕЛИОИДНОЙ ГЕМАНГИОЭНДОТЕЛИОМЕ С КАНЦЕРОМАТОЗОМ БРЮШНОЙ ПОЛОСТИ: КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ

We report the case of a young woman who underwent liver transplantation for epithelioid hemangioendothe- lioma with diffuse intraperitoneal metastases. We observe the 1-year survival without tumor progression on everolimus-based immunosuppression. The different therapies and the results of surgery for this disease are discussed in short literature review. В статье представлен клинической случай трансплантации печени у молодой пациентки со злокачественной эпителиоидной гемангиоэндотелиомой печени и канцероматозом брюшной полости. Мы наблюдаем 1-летнюю выживаемость без признаков опухолевой прогрессии на фоне иммуносупрессии эверолимусом. В кратком литературном обзоре рассмотрены лечебные опции и результаты операций при данном заболевании.

The Communicative lntent of Text as a Problem of Translation

In any information addressed to some recipient, there is always a communicative intent, something that determines the communicative structure of the sentence and may necessitate a restructuring of text in translation. The subject of this paper is comparison between the communicative structure (CS) of sentences in the Russian and ltalian languages, in order to see what kind of text transformations result from the differences found, and to identify the more common restructuring patterns, primarily when translating from Russian into ltalian. The study is based on works by Anton ehekhov, Konstantin Paustovsky and Mikhail Sholokhov, translated into ltalian, and a story by the modern ltalian writer Seppe Fenoglio, translated into Russian. l will not go deeply into the history and theory of the issue which is covered by ampie literature. l will only quote this statement by V. Mathesius, one of the earlier students of the subject who underscored the linguistic nature of es and linked it to word order as its basic means of expression

Pre-conditions of development of ideas about health and healthy way of life.

Directions of development of ideas are examined about a health and healthy method of life on the basic stages of development of human civilization. The deposit of prominent philosophers, teachers, enlighteners in development of ideas of healthy method of life is analysed. It becomes firmly established that on the different stages of development of human society a problem of maintainance and strengthening of health and healthy way of life always were in the highlight of public and state figures. Characteristic for domestic pedagogics was attention to the problem of health from the side of teachers, psychologists, doctors. Directions of forming of health and healthy way of life are selected. The necessity of scientific researches is marked on perfection of methods, facilities and form of physical education

Investing in international corporate innovations

Выпускная квалификационная работа (магистерская диссертация) посвящена исследованию аспектов ведения инновационной деятельности в реальном секторе экономики и принципам ее финансирования. Предметом исследования выступают. Основной целью магистерской диссертации является формулирование алгоритма реализации и финансирования инновационного проекта на примере международной корпорации и разработка рекомендаций для повышения его эффективности.Final qualifying work (master's thesis) is devoted to the study of aspects of innovations in the manufacturing sector of economy and methods of investing in it. The subject of the study are aspects of investing in innovative activities of an international corporation, analysis of its effectiveness. The main purpose of the master's thesis is to develop a comprehensive concept of systematization of costs for the production and sale of formulate algorithm of innovation project realization and investing process and to develop a set of recommendations on its efficiency increase