Overheating in Scotland: contributing factors in occupied homes

There is growing awareness of the overheating risks in new-build properties in the UK. However, this tends to be considered a problem principally for the southern regions in the UK, only becoming a serious issue in the north of England in the medium-term and in the long-term for Scotland. This notion tends to be largely predicated upon climate change predictions, differences in latitude and summer air temperatures. This paper describes the results from Building Performance Evaluation (BPE) studies over a two-year period from 26 occupied new-build homes across Scotland which demonstrated incidences of overheating. Results suggest that low-energy buildings are susceptible to overheating despite northerly latitudes, with 54% of houses studied overheating for more than six months annually, and 27% of homes overheating for less than 10% of the year. Evidence indicated that commonly used prediction tools do not appear to anticipate overheating adequately. This paper maps common overheating causes due to design and the role of occupants, identifying the risks due to the regulatory system, prediction and procurement processes, and design and construction. A common finding was that design and occupancy factors appear to have a greater impact on overheating more than location and climatic factors

An assessment of environmental conditions in bedrooms of contemporary low energy houses in Scotland

This paper describes the monitored environmental conditions in the bedrooms of 26 low energy houses in Scotland, include both naturally ventilation and houses with MVHR systems. The context of the paper is the performance gap that is emerging between design predictions and actual performance of housing, and this paper focuses on the environmental performance of bedrooms. Bedrooms are of particular interest as they are the spaces in which occupants have the greatest exposure to the indoor environment, and in which conditions are relatively constant. The study indicates that ventilation is generally poor in these spaces and that both temperature and humidity frequently exceed accepted parameters for comfort and health. Increased window opening is a mitigating factor, but effects are limited by overall ventilation strategies

The nucleon's strange electromagnetic and scalar matrix elements

Quenched lattice QCD simulations and quenched chiral perturbation theory are used together for this study of strangeness in the nucleon. Dependences of the matrix elements on strange quark mass, valence quark mass and momentum transfer are discussed in both the lattice and chiral frameworks. The combined results of this study are in good agreement with existing experimental data and predictions are made for upcoming experiments. Possible future refinements of the theoretical method are suggested.Comment: 24 pages, 9 figure

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials

Environmental Assessment of Domestic Laundering

Environmental Assessment of Domestic Laundering EPSRC Contract: EP/G00028X/1 . TECHNICAL REPORT PROJECT MODULE 1: PART A EXECUTIVE SUMMARY OF FINDINGS OF MEARU HOUSING SURVEY 22 case studies monitored over 2 weeks, drawn from survey total of 100 households PREFACE The underlying aim of PM 1 was to explore the range of environmental impacts arising from domestic laundering, the initial survey of 100 households yielding at least 20 volunteers for more in-depth monitoring over a 2-week period, and both providing an adequate range of demography and house type, as well as facilities and habits relative to their washing, drying and ironing. Parallel with PM 1, PM 2 has been conducting a series of laboratory tests on common existing finishing materials found within housing, specifically in order to define moisture buffering potential for passive drying (as well as other ‘wet’ activities), this information adding to the modelling capability of PM 3. PM 3 is also able to draw on typical laundering scenarios from PM1 using a limited range of house types, with iterative modelling to explore the influence of key variables for whole-house ‘as found’ and ‘improved’ situations, as well as for ‘quarantined’ drying cupboards. The findings summarised below are elaborated in Parts C and D relative to the survey findings, in particular the in-depth data from the 22 specific case studies detailed in Part B. This is the technical data which helped inform the publication:Design Guide: Healthy Low Energy Home Laundering, MEARU, 2011,ISBN: 978-0-9571595-0-

Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling

Cellular Ca2+ signals are crucial in the control of most physiological processes, cell injury and programmed cell death through the regulation of a number of Ca2+-dependent enzymes such as phospholipases, proteases, and nucleases. Mitochondria along with the endoplasmic reticulum play pivotal roles in regulating intracellular Ca2+ content. Mitochondria are endowed with multiple Ca2+ transport mechanisms by which they take up and release Ca2+ across their inner membrane. During cellular Ca2+ overload, mitochondria take up cytosolic Ca2+, which in turn induces opening of permeability transition pores and disrupts the mitochondrial membrane potential (<FONT FACE=Symbol>Dy</FONT>m). The collapse of <FONT FACE=Symbol>Dy</FONT>m along with the release of cytochrome c from mitochondria is followed by the activation of caspases, nuclear fragmentation and cell death. Members of the Bcl-2 family are a group of proteins that play important roles in apoptosis regulation. Members of this family appear to differentially regulate intracellular Ca2+ level. Translocation of Bax, an apoptotic signaling protein, from the cytosol to the mitochondrial membrane is another step in this apoptosis signaling pathway