Summary -- Reducing Market and Appropriation Uncertainty: The Twin Organizational Tasks of Entrepreneurship

One of the reasons entrepreneurs are motivated to action is their assessment of the potential profit associated with a particular opportunity to recombine resources from the factor market into a product (or service) that will be demanded in the product market. Entrepreneurial firm survival often depends on the creation and appropriation of this profit. However, this profit is uncertain ex ante as it depends on the ex post difference between the costs that must be paid for the factors of production and the prices that will be realized for the finished product. This paper explores the relationship between uncertainty and the creation and appropriation of profit by entrepreneurial firms

Poster Summary -- Alliances Between Newcomer Firms and Established Firms: A Sense Making Response Mechanism for Entrepreneurial Firms in Uncertain Environments

This study is organized around two basic research questions. First, how do entrepreneurial firms use their alliances with large firms to make sense of their world? Second, how does sensemaking in entrepreneurial firms impact their alliance success and ultimately firm success? In the tradition of a sensemaking perspective this paper seeks to understand how particular cues are singled out from other experiences (Weick 1979), how the interpretations and meanings of these cues result in certain behaviors leading to new firm success or failure

Firm‐specific human capital investments as a signal of general value: Revisiting assumptions about human capital and how it is managed

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136278/1/smj2521.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136278/2/smj2521_am.pd

Occurrence of OsHV-1 in Crassostrea gigas cultured in Ireland during an exceptionally warm summer. Selection of less susceptible oysters

The occurrence of OsHV-1, a herpes virus causing mass mortality in the Pacific oyster Crassostrea gigas was investigated with the aim to select individuals with different susceptibility to the infection. Naïve spat transferred to infected areas and juveniles currently being grown at those sites were analyzed using molecular and histology approaches. The survey period distinguishes itself by very warm temperatures reaching up to 3.5°C above the average. The virus was not detected in the virus free area although a spread of the disease could be expected due to high temperatures. Overall mortality, prevalence of infection and viral load was higher in spat confirming the higher susceptibility in early life stages. OsHV-1 and oyster mortality were detected in naïve spat after 15 days of cohabitation with infected animals. Although, infection was associated with mortality in spat, the high seawater temperatures could also be the direct cause of mortality at the warmest site. One stock of juveniles suffered an event of abnormal mortality that was significantly associated with OsHV-1 infection. Those animals were infected with a previously undescribed microvariant whereas the other stocks were infected with OsHV-1 μVar. Cell lesions due to the infection were observed by histology and true infections were corroborated by in situ hybridization. Survivors from the natural outbreak were exposed to OsHV-1 μVar by intramuscular injection and were compared to naïve animals. The survival rate in previously exposed animals was significantly higher than in naïve oysters. Results derived from this study allowed the selection of animals that might possess interesting characteristics for future analysis on OsHV-1 resistance

Análise psicométrica e dados normativos da UWES em adolescentes peruanos

Academic engagement is a relevant characteristic to predict successful academic trajectories and school performance; however, there is a lack of validated instruments in Peru for its evaluation. Therefore, the objective of this study was to analyze the psychometric properties of the Utrecht Work Engagement Scale – 9S (UWES-9S) in Peruvian adolescents: internal structure, measurement invariance, association with academic self-efficacy, reliability, and norms. A total of 868 school adolescents (51.728% women; Mage = 14.263; SDage = 1.430) from six schools in the Constitutional Province of Callao (central coast of Peru) were evaluated. In addition to the UWES-9S, the Specific Perceived Self-Efficacy Scale for Academic Situations was used as a measure of self-efficacy. The results show that the UWES-9S is unidimensional and invariant between men and women, although three items were eliminated, resulting in a new version: UWES-6S. Likewise, the association with academic self-efficacy was moderate (r > .50) and norms were obtained for men and women separately. In addition, the reliability indices were satisfactory for both the scores (alpha coefficient and average inter-item correlation) and the construct (omega coefficient > .80). It is concluded that the UWES-6S has adequate psychometric properties for its application in Peruvian adolescents.El engagement académico es una característica relevante para predecir las trayectorias académicas exitosas y el rendimiento escolar; sin embargo, existe una carencia de instrumentos validados en Perú para su evaluación. Por ello, el objetivo de esta investigación fue analizar las propiedades psicométricas de la Utrech Work Engagement Scale – 9S (UWES-9S) en adolescentes peruanos: estructura interna, invarianza de medición, asociación con la autoeficacia académica, confiabilidad y normas. Fueron evaluados 868 adolescentes escolares (51.728% mujeres; Medad = 14.263; DEedad = 1.430) procedentes de seis colegios de la Provincia Constitucional del Callao (costa central del Perú). Además de la UWES-9S se utilizó la Escala de Autoeficacia Percibida Específica para Situaciones Académicas como medida de autoeficacia. Los resultados indican que la UWES-9S es unidimensional e invariante entre hombres y mujeres, aunque se eliminaron tres ítems derivando en una nueva versión: UWES-6S. Asimismo, la asociación con la medida de autoeficacia académica fue moderada (r > .50) y se obtuvo normas para hombres y mujeres por separado. Los indicadores de confiabilidad fueron satisfactorios tanto para las puntuaciones (coeficiente alfa y correlación inter-ítem promedio) como para el constructo (coeficiente omega > .80). Se concluye que la UWES-6S cuenta con propiedades psicométricas adecuadas para su aplicación en adolescentes peruanos.O engagement académico é uma característica relevante para prever trajetórias académicas bem-sucedidas e o desempenho escolar, no entanto, faltam instrumentos validados no Perú para a sua avaliação. Portanto, o objetivo deste estudo foi analisar as propriedades psicométricas da Utrecht Work Engagement Scale – 9S (UWES-9S) em adolescentes peruanos: estrutura interna, invariância de medidas, associação com a autoeficácia académica, confiabilidade e normas. Foram avaliados 868 adolescentes escolares (51.728% mulheres; Midade = 14.263; DPidade = 1.430) de seis colégios da Província Constitucional de Callao (costa central do Perú). Além da UWES-9S, foi utilizada a Escala de Autoeficácia Percebida Específica para Situações Académicas como medida de autoeficácia. Os resultados mostram que a UWES-9S é unidimensional e invariável entre homens e mulheres, embora três itens tenham sido eliminados, resultando numa nova versão: UWES-6S. A associação com a autoeficácia académica foi moderada (r > 0,50) e as normas foram obtidas para homens e mulheres separadamente. Além disso, os índices de confiabilidade foram satisfatórios tanto para as pontuações (coeficiente alfa e correlação média entre itens) quanto para o constructo (coeficiente ómega > .80). Conclui-se que a UWES-6S possui propriedades psicométricas adequadas para sua aplicação em adolescentes peruanos

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor

Background and Purpose Flecainide is a use-dependent blocker of cardiac Na+ channels. Mechanistic analysis of this block showed that the cationic form of flecainide enters the cytosolic vestibule of the open Na+ channel. Flecainide is also effective in the treatment of catecholaminergic polymorphic ventricular tachycardia but, in this condition, its mechanism of action is contentious. We investigated how flecainide derivatives influence Ca2+-release from the sarcoplasmic reticulum through the ryanodine receptor channel (RyR2) and whether this correlates with their effectiveness as blockers of Na+ and/or RyR2 channels. Experimental Approach We compared the ability of fully charged (QX-FL) and neutral (NU-FL) derivatives of flecainide to block individual recombinant human RyR2 channels incorporated into planar phospholipid bilayers, and their effects on the properties of Ca2+ sparks in intact adult rat cardiac myocytes. Key Results Both QX-FL and NU-FL were partial blockers of the non-physiological cytosolic to luminal flux of cations through RyR2 channels but were significantly less effective than flecainide. None of the compounds influenced the physiologically relevant luminal to cytosol cation flux through RyR2 channels. Intracellular flecainide or QX-FL, but not NU-FL, reduced Ca2+ spark frequency. Conclusions and Implications Given its inability to block physiologically relevant cation flux through RyR2 channels, and its lack of efficacy in blocking the cytosolic-to-luminal current, the effect of QX-FL on Ca2+ sparks is likely, by analogy with flecainide, to result from Na+ channel block. Our data reveal important differences in the interaction of flecainide with sites in the cytosolic vestibules of Na+ and RyR2 channels

Análisis psicométrico y datos normativos de la UWES en adolescentes peruanos

El engagement académico es una característica relevante para predecir las trayectorias académicas exitosas y el rendimiento escolar; sin embargo, existe una carencia de instrumentos validados en Perú para su evaluación. Por ello, el objetivo de esta investigación fue analizar las propiedades psicométricas de la Utrech Work Engagement Scale – 9S (UWES-9S) en adolescentes peruanos: estructura interna, invarianza de medición, asociación con la autoeficacia académica, confiabilidad y normas. Fueron evaluados 868 adolescentes escolares (51.728% mujeres; Medad = 14.263; DEedad = 1.430) procedentes de seis colegios de la Provincia Constitucional del Callao (costa central del Perú). Además de la UWES-9S se utilizó la Escala de Autoeficacia Percibida Específica para Situaciones Académicas como medida de autoeficacia. Los resultados indican que la UWES-9S es unidimensional e invariante entre hombres y mujeres, aunque se eliminaron tres ítems derivando en una nueva versión: UWES-6S. Asimismo, la asociación con la medida de autoeficacia académica fue moderada (r > .50) y se obtuvo normas para hombres y mujeres por separado. Los indicadores de confiabilidad fueron satisfactorios tanto para las puntuaciones (coeficiente alfa y correlación inter-ítem promedio) como para el constructo (coeficiente omega > .80). Se concluye que la UWES-6S cuenta con propiedades psicométricas adecuadas para su aplicación en adolescentes peruanos

Genomic features of bacterial adaptation to plants

Author(s): Levy, A; Salas Gonzalez, I; Mittelviefhaus, M; Clingenpeel, S; Herrera Paredes, S; Miao, J; Wang, K; Devescovi, G; Stillman, K; Monteiro, F; Rangel Alvarez, B; Lundberg, DS; Lu, TY; Lebeis, S; Jin, Z; McDonald, M; Klein, AP; Feltcher, ME; Rio, TG; Grant, SR; Doty, SL; Ley, RE; Zhao, B; Venturi, V; Pelletier, DA; Vorholt, JA; Tringe, SG; Woyke, T; Dangl, JL | Abstract: © 2017 The Author(s). Plants intimately associate with diverse bacteria. Plant-associated bacteria have ostensibly evolved genes that enable them to adapt to plant environments. However, the identities of such genes are mostly unknown, and their functions are poorly characterized. We sequenced 484 genomes of bacterial isolates from roots of Brassicaceae, poplar, and maize. We then compared 3,837 bacterial genomes to identify thousands of plant-associated gene clusters. Genomes of plant-associated bacteria encode more carbohydrate metabolism functions and fewer mobile elements than related non-plant-associated genomes do. We experimentally validated candidates from two sets of plant-associated genes: one involved in plant colonization, and the other serving in microbe-microbe competition between plant-associated bacteria. We also identified 64 plant-associated protein domains that potentially mimic plant domains; some are shared with plant-associated fungi and oomycetes. This work expands the genome-based understanding of plant-microbe interactions and provides potential leads for efficient and sustainable agriculture through microbiome engineering

Experiences, challenges and looking to the future in a clinical tuberculosis cohort in the time of COVID-19 in the Philippines.

A cohort study of Filipino tuberculosis patients is currently undergoing data collection amidst the coronavirus disease 2019 pandemic. In this article we present the current experiences, challenges and obstacles of our team during this period as we attempt to fulfil our roles and responsibilities in Metro Manila, Cebu and Negros Occidental in the Philippines. Each site had different lockdown restrictions and experienced problems to different degrees. The underlying themes were similar, covering the supply chain, mobility, communication, physical and mental health and disruption of health services due to reallocation of staff. While we maximized the use of mobile devices, logistical challenges remained. Institutional support for the field teams, creative problem solving and resilience are required to adapt in a rapidly changing environment

Discovery and Creation: Alternative Theories of Entrepreneurial Action

As oportunidades empreendedoras existem, independentemente, das percepções dos empreendedores, esperando apenas para serem descobertas? Ou, estas oportunidades são criadas pelas ações dos empreendedores? Duas teorias, internamente, consistentes com as oportunidades empreendedoras são: teoria da criação e teoria da descoberta- as quais serão descritas. Enquanto, será sempre possível, descrever a formação de uma oportunidade particular, como exemplo, de um processo da descoberta ou da criação de oportunidade, estas duas teorias têm implicações importantes para a eficácia de uma variedade ampla de ações empreendedoras em contextos diferentes. As implicações destas teorias para sete destas ações serão descritas, acompanhadas de uma discussão sobre algumas das implicações teóricas mais amplas destas duas teorias para os campos do empreendimento e do gerenciamento estratégico