上海嘉定区35岁以上首诊测压工作的回顾与展望

Objective: To understand the policy development of blood pressure test blood pressure test among residents above 35 years old at first visit in Jiading district in Shanghai in order to provide a better reference for the development of the blood pressure test. Methods: Retrospect is from the following three aspects: the policy advancement of the blood pressure measurement, the progress of the work and the next step of the development of blood pressure test to first diagnosis above 35 years old. Results: The total of policy documents related to prevention and treatment of chronic disease, published by national, Shanghai municipal and Jiading District government department are 185. There are 22 policy documents aspects of the prevention and control of hypertension among these documents, and 11 involving measurement of blood pressure test in the first diagnosis patients above 35 years old, 5.95% proportion of above total policy documents. These policy documents involving blood pressure test are technical solutions. There are 3 policy documents (1 Shanghai municipal, 2 Jiading District) involving measurement of blood pressure test published in 1999 and before; and 4 policy documents (2 national, 2 Shanghai municipal) during 2000-2008; and 4 policy documents (4 national) published after 2009. At present, the work runs well in Jiading district, and the work runs better in the community health service center than the comprehensive hospital. Conclusions: More and more documents were released from the national department, provincial department and local health department so that solid policy guarantees the work of blood pressure test for residents above 35 years old at first visit in Jiading district in Shanghai. The development and use of information software provides a powerful tool for the pressure measurement. Along with the perfect of supporting measures, the work of blood pressure test to first diagnosis above 35 years old will be further developed and improved.目的  了解上海嘉定区35岁以上首诊测压工作的发展历程，为更好地推进首诊测压工作提供参考。方法  按照政策出台时间、类别和内容，围绕国家、上海市和嘉定区三份层面，从测压政策的演变、测压工作的进展和下一步的发展三份方面对上海嘉定区35岁以上首诊测压工作的进展和走向进行了回顾与展望。结果  国家、上海市、嘉定区出台的相关慢性病政策文件共185份，其中高血压防控方面的有22份，涉及到首诊测压政策方面的有11份，占慢病政策的5.95%。在出台的首诊测压政策文件中，均为技术性的文件。1999年及以前的政策有3份（其中上海市1份、嘉定区2份）；2000～2008年期间的政策共有4份（其中国家2份、上海市2份）；2009年及以后的政策有4份（均为国家的）。目前全区的测压工作进展良好，社区卫生服务中心的测压工作相对比二级医院的发展得好。结论  国家、省市和县区级卫生部门的政策性文件的陆续出台，为35岁以上首诊测压工作提供坚实的政策性保障，信息软件的开发与使用为测压工作提供了有力的手段。 随着测压工作的各项配套措施推进，35岁以上首诊测压工作会进一步得到发展与提高

deepBase: a database for deeply annotating and mining deep sequencing data

Advances in high-throughput next-generation sequencing technology have reshaped the transcriptomic research landscape. However, exploration of these massive data remains a daunting challenge. In this study, we describe a novel database, deepBase, which we have developed to facilitate the comprehensive annotation and discovery of small RNAs from transcriptomic data. The current release of deepBase contains deep sequencing data from 185 small RNA libraries from diverse tissues and cell lines of seven organisms: human, mouse, chicken, Ciona intestinalis, Drosophila melanogaster, Caenhorhabditis elegans and Arabidopsis thaliana. By analyzing ∼14.6 million unique reads that perfectly mapped to more than 284 million genomic loci, we annotated and identified ∼380 000 unique ncRNA-associated small RNAs (nasRNAs), ∼1.5 million unique promoter-associated small RNAs (pasRNAs), ∼4.0 million unique exon-associated small RNAs (easRNAs) and ∼6 million unique repeat-associated small RNAs (rasRNAs). Furthermore, 2038 miRNA and 1889 snoRNA candidates were predicted by miRDeep and snoSeeker. All of the mapped reads can be grouped into about 1.2 million RNA clusters. For the purpose of comparative analysis, deepBase provides an integrative, interactive and versatile display. A convenient search option, related publications and other useful information are also provided for further investigation. deepBase is available at: http://deepbase.sysu.edu.cn/

Changes and Relationship of PAF and TNF in Rats with Myocardial Ischaemia and Reperfusion Injury

In this study it is reported that: (1) the levels of blood platelet-activating factor and serum tumour necrosis factor significantly increased after coronary ligation and reperfusion, compared with sham-ligated controls, in an anaesthetized rat model; (2) compared with vehicle controls, pretreatment with the PAF antagonist BN 50739 (10 mg/kg, i.v.) produced significant decreases in infarct size (from 29.6 ± 4.0% to 22.4 ± 2.1%, p < 0.05 after 3 h ligation, and from 28.5 ± 9.5% to 10.5 ± 4.5%, p < 0.01 after 4 h reperfusion) and the level of serum TNF (from 10.4 ± 7.7 U/ml to 3.9 ± 4.8 U/ml, p < 0.05); and (3) a significan positive correlation was found between the level of blood PAF or serum TNF and infarct size. The present results indicate that PAF and TNF may be important mediators involved in myocardial ischaemia and reperfusion injury, and that PAF antagonists may exert a protective effect on ischaemic or reperfused myocardium by inhibiting the interaction of PAF and TNF

Reactivation of hypersaline aerobic granular sludge after low-temperature storage

Chen, Y., Zhu, J. Y., Qin, Y., Zhang, Z. M., & Yuan, S. C.  (March-April, 2017). Reactivation of hypersaline aerobic  granular sludge after low-temperature storage.  Water  Technology and Sciences (in Spanish),  8 (2), 61-70.    Reactivation of hypersaline aerobic granular sludge after  low-temperature storage was studied by slowly increasing  the organic loading. Results indicated that the basic external  features of thawed hypersaline aerobic granules were still  largely intact after a six-week low temperature storage, but  the colors and internal structure changed greatly. Aerobic  granules experienced a process of particle disintegration,  fragmentary particles, filamentous bacteria-like particles,  and dense granules during the recovery process. After  more than one-month re-cultivation, the settling property,  dehydrogenase activity, and nitrification properties of  hypersaline aerobic granules returned to normal. During  the re-cultivated process, the decentralized growth pattern  of particles can be effectively controlled, and granules can  grow compactly by controlling water alkalinity, aeration rate  and reactor settling time

Polyethyleneimine-coated MXene quantum dots improve cotton tolerance to Verticillium dahliae by maintaining ROS homeostasis

Verticillium dahliae is a soil-borne hemibiotrophic fungal pathogen that threatens cotton production worldwide. In this study, we assemble the genomes of two V. dahliae isolates: the more virulence and defoliating isolate V991 and nondefoliating isolate 1cd3-2. Transcriptome and comparative genomics analyses show that genes associated with pathogen virulence are mostly induced at the late stage of infection (Stage II), accompanied by a burst of reactive oxygen species (ROS), with upregulation of more genes involved in defense response in cotton. We identify the V991-specific virulence gene SP3 that is highly expressed during the infection Stage II. V. dahliae SP3 knock-out strain shows attenuated virulence and triggers less ROS production in cotton plants. To control the disease, we employ polyethyleneimine-coated MXene quantum dots (PEI-MQDs) that possess the ability to remove ROS. Cotton seedlings treated with PEI-MQDs are capable of maintaining ROS homeostasis with enhanced peroxidase, catalase, and glutathione peroxidase activities and exhibit improved tolerance to V. dahliae. These results suggest that V. dahliae trigger ROS production to promote infection and scavenging ROS is an effective way to manage this disease. This study reveals a virulence mechanism of V. dahliae and provides a means for V. dahliae resistance that benefits cotton production

Fabrication of Densely Packed AlN Nanowires by a Chemical Conversion of Al2O3Nanowires Based on Porous Anodic Alumina Film

Porous alumina film on aluminum with gel-like pore wall was prepared by a two-step anodization of aluminum, and the corresponding gel-like porous film was etched in diluted NaOH solution to produce alumina nanowires in the form of densely packed alignment. The resultant alumina nanowires were reacted with NH3and evaporated aluminum at an elevated temperature to be converted into densely packed aluminum nitride (AlN) nanowires. The AlN nanowires have a diameter of 15–20 nm larger than that of the alumina nanowires due to the supplement of the additional evaporated aluminum. The results suggest that it might be possible to prepare other aluminum compound nanowires through similar process