Optimization and Numerical Simulation of Multi-layer Microchannel Heat Sink

AbstractThe configuration sizes of multi-layer microchannel heat sink is optimized in order to enhance the performance of the high flux chip, which is 556W/cm2. Taking the thermal resistance and the pressure drop as goal functions, a double-objective optimization model was proposed based on the thermal resistance network model. The opimized microchannel heat sink is numerically simulated by computational fluid dynamics (CFD) software. The number of microchannel in width n1 and that in height n2 are 24 and 2, the width of optimized optimized microchannel and fin are 196 and 50μm, respectively, and the corresponding total thermal resistance of the whole microchannel heat sink is 0.4025°C/W. The highest temperature is less than 98°C, which can satisfy the requirement of chip to temperature. The maximum temperature difference is 77.8673°C, and the transferred power of heat flux is 200W, so the total thermal resistance is 0.3893°C/W, which agrees well with the analysis result of thermal resistance network model

Study on the Cooling Capacity of Different Quenchant

AbstractHeat treatment is one method to improve mechanical properties of metal, but each heat treatment method has its advantages and disadvantages, therefore, different requirements regarding size, shape, and properties with respect to different heat treatment processes should be considered. The traditional liquid quenchant are clear water and quench oil. Gas quenching is a relatively new process with several important advantages, such as minimal environmental impact, clean products, and ability to control the cooling locally and temporally for best product properties. To meet the high cooling rates required for quenching, the cooling gas must flow at very high velocities, but still the cooling capacity of gas is weakness. In order to increase the cooling capacity of gas, the spray water is added during gas quenching. In this paper, the GCr15 steel is as the research object, the cooling capacity of clear water, quench oil, nitrogen and nitrogen-spray water are studied through comparison of temperature difference and cooling velocity of the specimen

Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors

Chemotherapy-induced thrombocytopenia (CIT) is a common complication in cancer patients, especially after multiple cycles of chemotherapy, which leads to the delayed treatment or reduced dosage. The treatment of CIT is limited for refractory and severe cases. Herein we reported a single-center study of avatrombopag, a type of thrombopoietin receptor agonist (TPO-RA), for the treatment of severe and refractory (S/R) CIT who failed from multi-line treatments. A total of 13 cancer patients with S/R CIT were enrolled at the First Affiliated Hospital of Zhejiang Chinese Medical University from September 2020 to February 2021. All the patients were administered oral avatrombopag at an initial dose of 60 mg/day, which could be decreased as needed, over a period of 8 weeks. Eight (8/13, 61.5%) patients responded to avatrombopag (with a platelet count ≥50 × 109/L and transfusion independent), with a median response time of 27.5 (11–50) days, and the median cumulative day of platelet response was 79 (20–167). Ten of 13 patients (76.9%) no longer required platelet transfusion at the study endpoint. The predictor of response was the level of hemoglobin (HB) at study entry, patients with an HB over 90 g/L achieved a response rate of 88.9%. In addition, platelet count showed 87.5% sensitivity and 100% specificity to predict the treatment response at a cutoff value of 25.5× 109/L at the end of the third week management. No drug-related side effects were noticed during administration. Our study showed that avatrombopag could be a novel and effective drug for the treatment of severe and refractory CIT, especially for those with hemoglobin above 90 g/L. This study was registered at chictr.org.cn as # ChiCTR2100050646