Conductor's analysis: John Mackey's Wine-Dark Sea: symphony for band, A

2020 Spring.Includes bibliographical references.This thesis provides a study of the composer John Mackey and his music. In the last twelve years, Mackey has become internationally renowned and one of the most widely performed composers in the band world. Mackey has received numerous awards and honors for his musical contributions. His unique compositional style is distinguishable in his works regardless of the genre. Audiences, conductors, and performers alike continue to find enjoyment in his music due to his creative, rhythmic, and unique scoring for winds and percussion. This document includes biographical information on the composer, provides insight into his compositional style, and thoroughly analyzes the symphony for band, Wine-Dark Sea. Wine- Dark Sea was commissioned in 2014 by Jerry Junkin and the University of Texas Wind Ensemble, in celebration of the 100th anniversary of the Sarah and Ernest Butler School of Music. The symphony is a programmatic piece that tells the story of Odysseus, Homer's hero from The Odyssey, through three exciting and dramatic movements. Distinctive characteristics of this piece include Mackey's unique use of meter changes, extended techniques in winds and percussion, and recurring programmatic themes. Wine-Dark Sea is Mackey's longest work to date, one of his most challenging works for performers and conductor, and is especially captivating for the audience

Enhanced co-solubilities of Ca and Si in YAG (Y3Al5O12)

General garnet structure (Ia3-d) is a forgiving host and can accommodate cations of varying sizes and valence states. Studies on highly yttrium doped alumina ceramics with Ca and Si contamination indicated that YAG precipitates in the ceramic had a propensity to allow simultaneous incorporation of small amounts of Ca and Si impurities in their structure. In this study, using chemical synthesis techniques it was shown that YAG can accommodate up to approximately 8 cation % Ca+2 and Si+4 (i.e. Ca+2/Y+3 and Si+4/Y+3) if they are incorporated together. Equilibrium conditions are established by calcining samples at 900 C for 2 hours and cooling the samples to room temperature in the furnace. Disappearing-phase method and energy dispersive X-ray spectroscopy (EDS) were used to determine solubility and co-solubility limits. Beyond the solubility limit phase separation occurred and three crystalline yttrium aluminate phases (YAG, YAP (yttrium aluminate perovskite, YAlO3), YAM (yttrium aluminate monoclinic, Y4Al2O9)) were observed. It is believed that the excess Ca and Si above co-solubility limit precipitate out in the form of an x-ray amorphous anorthite-like glass in the system

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.

3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases. Blockade of this enzyme by atorvastatin (AT) inhibits the destructive proinflammatory T helper cell (Th)1 response during experimental autoimmune encephalomyelitis and may be beneficial in the treatment of multiple sclerosis and other Th1-mediated autoimmune diseases. Here we present evidence linking specific isoprenoid intermediates of the mevalonate pathway to signaling pathways that regulate T cell autoimmunity. We demonstrate that the isoprenoid geranylgeranyl-pyrophosphate (GGPP) mediates proliferation, whereas both GGPP and its precursor, farnesyl-PP, regulate the Th1 differentiation of myelin-reactive T cells. Depletion of these isoprenoid intermediates in vivo via oral AT administration hindered these T cell responses by decreasing geranylgeranylated RhoA and farnesylated Ras at the plasma membrane. This was associated with reduced extracellular signal-regulated kinase (ERK) and p38 phosphorylation and DNA binding of their cotarget c-fos in response to T cell receptor activation. Inhibition of ERK and p38 mimicked the effects of AT and induced a Th2 cytokine shift. Thus, by connecting isoprenoid availability to regulation of Th1/Th2 fate, we have elucidated a mechanism by which AT may suppress Th1-mediated central nervous system autoimmune disease

Asymmetric speed modulation of a rotary blood pump affects ventricular unloading

OBJECTIVES Rotary blood pumps (RBPs) running at a constant speed are routinely used for the mechanical support of the heart in various clinical applications, from short-term use in heart-lung machines to long-term support of a failing heart. Their operating range is delineated by suction and regurgitation events, leaving limited control on the cardiac workload. This study investigates whether different ratios of systolic/diastolic support are advantageous over a constant-speed operation. METHODS In order to effectively control the load on the heart, this study aimed at developing a pulsatile control algorithm for rotary pumps to investigate the impact of pump speed modulation during systole and diastole on the left ventricle unloading. The CentriMagTM RBP with a modified controller was implanted in four sheep via a left thoracotomy and cannulated from the ventricular apex to the descending aorta. To modulate the pump speed synchronized with the heartbeat, custom-made real-time software detected the QRS complex of the electrocardiogram and controlled the pump speed during systole and diastole. Four different speed modulations with the same average speed but different systolic and diastolic speeds were compared with the baseline and the constant speed support. Left ventricular (LV) pressure and volume, coronary flow and pump flow were analysed to examine the influence of the pump speed modulation. RESULTS Pulsatile setting reduces the cardiac workload to 64% of the baseline and 72% of the constant speed value. Maximum unloading is obtained with the highest speed during diastole and high-pulse amplitude. End-diastolic volume in the pulsatile modes varied from 85 to 94% of the baseline and 96 to 107% of the constant speed value. Consequently, the mechanical load on the heart can be adjusted to provide assuagement, which may lead to myocardial recovery. The higher pump speed during systole results in an increase in the pulse pressure up to 140% compared with the constant speed. CONCLUSIONS The present study is an initial step to more accurate speed modulation of RBPs to optimize the cardiac load control. To develop future control algorithms, the concept of high speed during diastole having a maximal unloading effect on the LV and high speed during systole increasing the pulse pressure is worth considerin

Quality Rating Improvement System (QRIS)

With funding from the Race-to-the-Top grant, we are working with Oregon State University researchers to conduct a validation study to support the state’s Quality Rating Improvement System (QRIS). The QRIS provides technical assistance to child care facilities to improve quality, as well as ratings for child care facilities to help parents in decision-making. Center staff are collecting standardized observational measures of child care quality statewide to assess the extent to which QRIS ratings correspond to observed quality

Mysteries of the Underground River

Have you ever heard of a river that that flows backwards? Mammoth Cave, the longest cave system in the world, has an underground river exhibiting reverse fl ow patterns since at least the 1960’s and most likely earlier. Beginning in 2009, 7th graders from T.K. Stone Middle School in Elizabethtown, Kentucky have been teaming with WKU researchers to study and conduct research about this phenomenon

Family–Teacher Relationships and Child Engagement in Early Care and Education

Young children’s positive interactions with teachers and peers in early care and education (ECE) settings support the development of their social and academic skills. Identifying malleable factors that contribute to children’s positive engagement in these interactions is important in supporting early development. The current study examines one potential malleable factor that could be bolstered through supports for families and teachers alike: family–teacher relationships. We investigate associations between three specific domains of family–teacher relationships and children’s engagement in ECE, so that findings are specific and relevant to intervention. We examine data from Oregon’s Quality Rating Improvement System Validation Study; a diverse sample of 492 preschool-aged children in center-based ECE participated. Children’s engagement was directly observed; parents reported their perception of family–teacher relationships. Multilevel models examined the associations between family–teacher relationships and children’s positive engagement with teachers and peers in ECE classrooms. Results indicate a positive significant relationship between practices and children’s positive engagement with teachers. Although this association was not causal, it suggests that teachers who collaborate and communicate with families, respond to family feedback and cultural values, and demonstrate a family-focused concern may help children engage more positively with teachers. Findings are discussed, limitations addressed, and future directions provided