The Schizoid Dialectic Theses on winning the Union back

Bringing together Anderson's work as a cultural activist in performance (the Institute for the Art and Practice of Dissent at Home (www.twoaddthree.org)) and his role as Branch Chair of his institution's union for teaching staff (University and College Union), this performative paper will argue that a dialectical, agonistic blurring of boundaries across the borders of conflicting identities and interests is not only productive and desirable, but also liberatory and could constitute a small act of social justice. From lived experience the paper stages a series of arguments - in dialogue form - between Gary the anarchist art-activist and Gary the reformist trade unionist branch chair. Whilst both would agree that social justice is the 'bottom line' neither would agree that the task of institutional transformation is in part to recognise the dialectical flux inherent in their (Gary's) conflicting identities. Yet, this is what emerges when these identities are juxtaposed to engage in agonistic debate. The dialogues focus on the institutional context of higher education in particular, and suggests that agonistically robust debate produces not a winner and a loser, but a dialectical schizoid (Deleuze and Guattari, 2004 Deleuze, Gilles, and Félix Guattari (2004) A Thousand Plateaus: Capitalism and schizophrenia, London: Continuum Impacts. [Google Scholar]) who occupies both positions, more or less, simultaneously. The dialogues deploys two texts: Karl Marx's Theses on Feuerbach (1845) - of which the union chair is enamoured - and the rewritten Theses on Winning the Union Back - which the art-activist performance artist has vandalised. The paper contains the full text of the rewritten Theses on Winning the Union Back

Potential of pre-contrast T1 mapping as a marker of interstitial fibrosis in severe aortic stenosis

International audiencen.

Non-invasive assessment of interstitial myocardial fibrosis in pressure-overload left ventricular hypertrophy

International audiencen.

On the relational dynamics of caring: a psychotherapeutic approach to emotional and power dimensions of women’s care work

Care is double-edged and paradoxical, inspiring a vast range of strong feelings in both care-givers and care-recipients. This paper draws on ideas about psychotherapeutic relationships to offer a theorisation of the complex emotional and power dynamics and imaginative geographies of care. Examining the humanistic approach developed by Carl Rogers as well as the psychoanalytic tradition, I advance an interpretation of psychotherapeutic practices that foregrounds the fundamental importance of the emotional and power-inflected relationship between practitioners and those with whom they work. I show how different traditions offer conceptualisations of the shape of therapeutic relationships that are highly relevant to consideration of the emotional and power dynamics of giving and receiving care. Against this background I discuss current debates about care, emotions and power, drawing especially on feminist and disability perspectives and arguing that psychotherapeutic approaches offer a powerful lens through which to understand the emotional and power dynamics of caring relationships. I conclude by emphasising how this theorisation helps to illuminate ubiquitous features of women’s care work

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Ängeln

Affisch för en dramatisk representation på Åbo Svenska Teater 18.8.1858, innehållande bl.a. teaterföreställningarna 1. Carl IX:s dröm, 2. Eric XIV:s kärleksförklaring till Catharina Månsdotter, 3. Carl XII:s död wid Fredrikshall, 4. Lennart Torstensons fångenskap i Ingolstadt och 5. Othello eller Mohren i Venedig, samt sång

Lo! Here the gentle lark, weary of rest, from his moist cabinet [first line of chorus]

Performance Medium: Piano, Voice and Chord