Exploitation of social IoT for recommendation services

International audienceInternet of Things (IoT) applications are generally developed in a vertical manner, i.e., each IoT application is developed for a certain scenario which generally does not share data with IoT applications for recommendation services. This leads to an inefficient exploitation of other IoT service applications. In fact, such recommendation services can be achieved with the help of Social IoT (SIoT) by using data generated by various IoT applications. SIoT builds a profile of objects based on IoT applications data that can be exchanged with SIoT network for accessible to other IoT applications. In this manner, the SIoT network provides recommendation services for reusability of IoT applications' data among various IoT applications, as well as adapting IoT services according to users' needs which improve user experience. Additionally, the profiles built by a SIoT network can also help a single IoT application by looking for similar conditions that have been addressed in the past for the same IoT application. We propose a concept for exploiting the SIoT for recommendation services among various IoT applications with the help of a sample application scenario that highlights how the SIoT can help by providing recommendations. We also provide some implementation challenges for this concep

Preparation, structure determination, and in silico and in vitro Elastase inhibitory properties of substituted N-([1,1′-Biphenyl]-2-ylcarbamothioyl)- Aryl/Alkyl benzamide Derivatives

The preparation of a set of eight closely related biphenyl-thiourea conjugates with aromatic and aliphatic side chains (3a-3h) using a one-pot three-component strategy is reported. All the novel compounds were characterized by spectroscopic techniques (FTIR, 1H and 13C NMR) and elemental analysis. Moreover, the crystal structure of compounds 3f and 3h have been determined by X-ray diffraction. The common molecular skeleton can be closely superposed to each other and the 1-acyl thiourea groups show a nearly planar conformation favored by an intramolecular N–H•••O=C bond. In-vitro studies were carried out to test the elastase inhibition activity of the newly synthesized biphenyl-thiourea hybrid derivatives. Among the series, compound 3c (IC50 = 0.26 ± 0.05 μM) exhibited the maximum inhibition against elastase. The higher activity of aryl substituents over alkyl chains is evidenced, as well as the importance of electron withdrawing groups, as nitro (3b and 3c) and bromo (3d) to enhance the enzyme inhibitory activity. The compound 3c inhibits the enzyme in a competitive manner, with dissociation constant Ki = 0.84 µM. Molecular docking was also carried out within the enzyme active site to study enzyme-inhibitor interactions. Docking results correlate with experimental inhibition studies and show that compound 3c exhibits the highest binding energy (-7.70 kcal/mol) as compared with other compounds. The results of this study might help to develop new elastase inhibitors.Fil: Ilyas, Sara. Quaid-i-azam University; PakistánFil: Saeed, Aamer. Quaid-i-azam University; PakistánFil: Abbas, Qamar. University of Bahrain; BahréinFil: Ujan, Rabail. Universidad Quaid-i-azam; PakistánFil: Channar, Pervaiz Ali. Universidad Quaid-i-azam; PakistánFil: Shaikh, Izhar Ahmed. Ministry of Science and Technology; PakistánFil: Hassan, Mubashir. University of Lahore; PakistánFil: Raza, Hussain. Kongju National University; Corea del SurFil: Seo, Sung Yum. Kongju National University; Corea del SurFil: Echeverría, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; ArgentinaFil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; ArgentinaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentin