On the performance of routing algorithms in wormhole-switched multicomputer networks

This paper presents a comparative performance study of adaptive and deterministic routing algorithms in wormhole-switched hypercubes and investigates the performance vicissitudes of these routing schemes under a variety of network operating conditions. Despite the previously reported results, our results show that the adaptive routing does not consistently outperform the deterministic routing even for high dimensional networks. In fact, it appears that the superiority of adaptive routing is highly dependent to the broadcast traffic rate generated at each node and it begins to deteriorate by growing the broadcast rate of generated message

A performance model of communication in the quarc NoC

Networks on-chip (NoC) emerged as a promising communication medium for future MPSoC development. To serve this purpose, the NoCs have to be able to efficiently exchange all types of traffic including the collective communications at a reasonable cost. The Quarc NoC is introduced as a NOC which is highly efficient in performing collective communication operations such as broadcast and multicast. This paper presents an introduction to the Quarc scheme and an analytical model to compute the average message latency in the architecture. To validate the model we compare the model latency prediction against the results obtained from discrete-event simulations

Quarc: a novel network-on-chip architecture

This paper introduces the Quarc NoC, a novel NoC architecture inspired by the Spidergon NoC. The Quarc scheme significantly outperforms the Spidergon NoC through balancing the traffic which is the result of the modifications applied to the topology and the routing elements.The proposed architecture is highly efficient in performing collective communication operations including broadcast and multicast. We present the topology, routing discipline and switch architecture for the Quarc NoC and demonstrate the performance with the results obtained from discrete event simulations

Fuzzy based load and energy aware multipath routing for mobile ad hoc networks

Routing is a challenging task in Mobile Ad hoc Networks (MANET) due to their dynamic topology and lack of central administration. As a consequence of un-predictable topology changes of such networks, routing protocols employed need to accurately capture the delay, load, available bandwidth and residual node energy at various locations of the network for effective energy and load balancing. This paper presents a fuzzy logic based scheme that ensures delay, load and energy aware routing to avoid congestion and minimise end-to-end delay in MANETs. In the proposed approach, forwarding delay, average load, available bandwidth and residual battery energy at a mobile node are given as inputs to a fuzzy inference engine to determine the traffic distribution possibility from that node based on the given fuzzy rules. Based on the output from the fuzzy system, traffic is distributed over fail-safe multiple routes to reduce the load at a congested node. Through simulation results, we show that our approach reduces end-to-end delay, packet drop and average energy consumption and increases packet delivery ratio for constant bit rate (CBR) traffic when compared with the popular Ad hoc On-demand Multipath Distance Vector (AOMDV) routing protocol

Changes in the resistance to corrosion of thermally passivated titanium aluminide during exposure to sodium chloride solution

In this study the surface of Ti-47Al-2Cr (at. %) was modified by heating and exposure to nitrogen gas flow to form a predominantly oxide layer on the surface. Samples were then immersed in Ringer's solution and 3.5 wt. % sodium chloride solution and electrochemical impedance spectroscopy tests were performed at regular intervals. The results showed that the layer is highly resistant to corrosion. The equivalent circuit proposed for the impedance curves includes a Warburg element, because diffusion is controlling charge transfer through the passive surface layer. The resistance of the layer was not significantly reduced even after 300 h exposure to solutions and scanning electron micrographs showed the surface was not damaged. © 2013 Springer Science+Business Media Dordrecht

Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas

Neuropilins (NRP) are cell surface receptors for VEGF and SEMA3 family members. The role of NRP in neurons and endothelial cells has been investigated, but the expression and role of NRP in epithelial cells is much less clear. Herein, the expression and localization of neuropilin 1 (NRP1) was investigated in human and mouse skin and squamous cell carcinomas (SCC). Results indicated that NRP1 mRNA and protein was expressed in the suprabasal epithelial layers of skin sections. NRP1 staining did not overlap with that of keratin 14 (K14) or proliferating cell nuclear antigen, but did colocalize with staining for keratin 1, indicating that differentiated keratinocytes express NRP1. Similar to the expression of NRP1, VEGF-A was expressed in suprabasal epithelial cells, whereas Nrp2 and VEGFR2 were not detectable in the epidermis. The expression of NRP1 correlated with a high degree of differentiation in human SCC specimens, human SCC xenografts, and mouse K14-HPV16 transgenic SCC. UVB irradiation of mouse skin induced Nrp1 upregulation. In vitro, Nrp1 was upregulated in primary keratinocytes in response to differentiating media or EGF-family growth factors. In conclusion, the expression of NRP1 is regulated in the skin and is selectively produced in differentiated epithelial cells. NRP1 may function as a reservoir to sequester VEGF ligand within the epithelial compartment, thereby modulating its bioactivity

iPSC-based modeling of RAG2 severe combined immunodeficiency reveals multiple T cell developmental arrests

RAG2 severe combined immune deficiency (RAG2-SCID) is a lethal disorder caused by the absence of functional T and B cells due to a differentiation block. Here, we generated induced pluripotent stem cells (iPSCs) from a RAG2-SCID patient to study the nature of the T cell developmental blockade. We observed a strongly reduced capacity to differentiate at every investigated stage of T cell development, from early CD7(-)CD5(-) to CD4(+)CD8(+). The impaired differentiation was accompanied by an increase in CD7(-)CD56(+)CD33(+) natural killer (NK) cell-like cells. T cell receptor D rearrangements were completely absent in RAG2SCID cells, whereas the rare T cell receptor B rearrangements were likely the result of illegitimate rearrangements. Repair of RAG2 restored the capacity to induce T cell receptor rearrangements, normalized T cell development, and corrected the NK cell-like phenotype. In conclusion, we succeeded in generating an iPSC-based RAG2-SCID model, which enabled the identification of previously unrecognized disorder-related T cell developmental roadblocks

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests

RAG2 severe combined immune deficiency (RAG2-SCID) is a lethal disorder caused by the absence of functional T and B cells due to a differentiation block. Here, we generated induced pluripotent stem cells (iPSCs) from a RAG2-SCID patient to study the nature of the T cell developmental blockade. We observed a strongly reduced capacity to differentiate at every investigated stage of T cell development, from early CD7−CD5− to CD4+CD8+. The impaired differentiation was accompanied by an increase in CD7−CD56+CD33+ natural killer (NK) cell-like cells. T cell receptor D rearrangements were completely absent in RAG2SCID cells, whereas the rare T cell receptor B rearrangements were likely the result of illegitimate rearrangements. Repair of RAG2 restored the capacity to induce T cell receptor rearrangements, normalized T cell development, and corrected the NK cell-like phenotype. In conclusion, we succeeded in generating an iPSC-based RAG2-SCID model, which enabled the identification of previously unrecognized disorder-related T cell developmental roadblocks.In this article, Mikkers

Epistatic interaction between adiponectin and survivin gene polymorphisms in endometrial carcinoma

Adiponectin appears to play an important role in the development and progression of several obesity-related malignancies. Also, overexpression of survivin, an inhibitor of apoptosis protein, is associated with increased risk of cancers. The aim of this study was to investigate the association between two polymorphisms in the adiponectin gene and endometrial cancer (EC) risk. We also investigated whether epistasis between surviving and adiponectin gene polymorphisms are associated with EC risk in an Iranian population.The samples comprised formalin-fixed, paraffin-embedded tissue sections obtained from the archive of the pathology department, Imam-Khomeini Hospital and Firouzgar hospital. After DNA extraction the genotyping was performed using PCR-RFLP technique.Single nucleotide polymorphisms (SNPs) in adiponectin (rs1063539, rs2241766) and survivin (rs9904341) gene were evaluated in the study. The increased frequency of ADIPOQ rs1063539C allele (CC. +. CG genotype) was associated with decreased EC risk OR: 0.39(0.17-0.90). Survivin rs9904341C allele (CC. +. CG genotype) was associated with increased EC risk crude OR: 2.75(1.27-5.95), adjusted OR: 2.93(1.27-6.76). We observed an epistatic interaction between survivin rs9904341 CC. +. CG genotype and ADIPOQ rs1063539 GG genotype increasing the risk of EC compared to those with other genotypes OR: 4.86(1.88-12.54), P=0.001.Our findings indicate that adiponectin might have a modulatory effect on survivin role and function in EC, which requires further investigation. © 2014 Elsevier GmbH

Computational Cancer Biology: An Evolutionary Perspective

ISSN:1553-734XISSN:1553-735