Inhibition of Pro-inflammatory Cytokines by Ethyl Acetate Extract of Scrophularia striata

Purpose: To investigate the effect of ethyl acetate extract of S. striata on pro-inflammatory production by macrophages.Methods: Mouse peritoneal macrophages were cultured in solvent either alone or with 2 ìg/ml lipopolysaccaride (LPS) with/without different doses of ethyl acetate extract of S. striata. Production of pro-inflammatory cytokines including interleukin 1â (IL-1â), tumor necrosis factor - á (TNF-á) andprostaglandin E2 (PGE2) were examined using ELISA.Results: Ethyl acetate fraction of S. striata in doses of 10, 50, 100 and 200 ìg/ml significantly (p < 0.05) inhibited pro-inflammatory mediators (IL-1â, TNF-á, and PGE2) production by LPS stimulated peritoneal macrophages.Conclusion: The anti-inflammatory effect of the extract on pro-inflammatory cytokines may ameliorate inflammatory diseases, possibly via an immunomodulatory mechanism.Keywords: Pro-inflammatory, Cytokines, Ethyl acetate extract, Scrophularia striat

Load mitigation of a class of 5-MW wind turbine with RBF neural network based fractional-order PID controller

Copyright © 2019 ISA. All rights reserved.Peer reviewedPostprin

Perceptions of body size, obesity threat and the willingness to lose weight among black South African adults: a qualitative study

BACKGROUND: The obesity epidemic is associated with rising rates of cardiovascular disease (CVD) among adults, particularly in countries undergoing rapid urbanisation and nutrition transition. This study explored the perceptions of body size, obesity risk awareness, and the willingness to lose weight among adults in a resource-limited urban community to inform appropriate community-based interventions for the prevention of obesity. METHOD: This is a descriptive qualitative study. Semi-structured focus group discussions were conducted with purposively selected black men and women aged 35–70 years living in an urban South African township. Weight and height measurements were taken, and the participants were classified into optimal weight, overweight and obese groups based on their body mass index (Kg/m2). Participants were asked to discuss on perceived obesity threat and risk of cardiovascular disease. Information on body image perceptions and the willingness to lose excess body weight were also discussed. Discussions were conducted in the local language (isiXhosa), transcribed and translated into English. Data was analysed using the thematic analysis approach. RESULTS: Participants generally believed that obesity could lead to health conditions such as heart attack, stroke, diabetes, and hypertension. However, severity of obesity was perceived differently in the groups. Men in all groups and women in the obese and optimal weight groups perceived obesity to be a serious threat to their health, whereas the overweight women did not. Obese participants who had experienced chronic disease conditions indicated strong perceptions of risk of obesity and cardiovascular disease. Obese participants, particularly men, expressed willingness to lose weight, compared to the men and women who were overweight. The belief that overweight is ‘normal’ and not a disease, subjective norms, and inaccessibility to physical activity facilities, negatively influenced participants’ readiness to lose weight. CONCLUSION: Low perception of threat of obesity to health particularly among overweight women in this community indicates a considerable challenge to obesity control. Community health education and promotion programmes that increase awareness about the risk associated with overweight, and improve the motivation for physical activity and maintenance of optimal body weight are needed.IS

Estimation of Government Health Expenditures in Iran during 2006 to 2011, Using Panel Data

The status of public resources in health has a positive and direct impact on this sector's outcomes because of its effect on the increase of social services. The government's ability to manage health expenditures greatly depends on identifying the determinants of these expenditures. Therefore, this study aimed to determine factors affecting the government health expenditures and estimate the related function in Iran during 2006-2011 using panel data. This was a cross-sectional and time-series study that was conducted using panel data analysis. In this study, the data were collected and categorized separately for each province from documents in the Ministry of Health and the Statistical Center of Iran. The results showed that there were positive associations between health expenditures and some factors including age group of 20 to 39 years (P =.04), the number of women (P =.001), the number of physicians, the number of hospital beds, and annual budget (P <.001). According to the results, it seems that allocating a part of health subsidies for increasing the insurance coverage of the age group of 20 to 39 years and also starting saving accounts can have an important effect on reducing health expenditures of this age group. © 2019 Wolters Kluwer Health, Inc. All rights reserved

Initial studies on proton computed tomography using a silicon strip detector telescope”, Nucl Instr Meth A 514

Abstract We report initial results of a feasibility study of Proton Computed Tomography (PCT) and Proton Transmission Radiography (PTR) for applications in proton therapy treatment planning and patient positioning. The aim of the study is to explore experimentally if PCT, which is based on the measurement of the specific energy loss of protons traversing tissues of different density, may be preferred to X-ray Computed Tomography (CT) and X-ray radiography, which are presently used for radiation treatment planning and patient positioning in proton treatment centers. We present first data from proton transmission studies through a hollow aluminum cylinder taken with a telescope of silicon detectors with very high spatial and good energy resolution. In addition, we report the results of GEANT4 simulations of proton transport through the same object, which show good agreement with experimental results and explain the observed features of the proton transmission image