SYNTHESIS AND X-RAY CRYSTALLOGRAPHY OF 2,4,6-TRIMETHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER

The biologically active 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester has been prepared and characterized by X-ray crystallography. The 1,4-dihydro-pyridine ring is in a flattened boat form, with atoms C3, and N1 being the bow and stern of the boat. Atoms C3 and N1 being 0.1346(12)A and 0.0970(12)A above the mean plane of the 1,4-dihydro-pyridine ring. One of the ethyl ester groups were found to be disordered in two positions at occupancies of 0.517 (19) and 0.483 (19) respectively. There are four molecules of 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester, in the unit cell. Inter­molecular N—H···O hydrogen bonding inter­actions were observed in the crystal lattice which connected the molecules into chain running along b-axis

14-Bromo-12-chloro-2,16-dioxapentacyclohenicosa-3(8),10,12,14-tetraene-7,20-dione

In the title compound, C19H16BrClO4, both the fused xanthene rings and one of the cyclohexane rings adopt envelope conformations, while the other cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by C-H...O hydrogen bonds, forming infinite chains running along [10-1] incorporating R22(16) ring motifs. In addition, C-H...[pi] interactions and weak [pi]-[pi] stacking interactions [centroid-centroid distance = 3.768 (3) Å] help to consolidate the packing

Revolucionando la educación especial del inglés como lengua extranjera: cómo ChatGPT está transformando la forma en que los profesores abordan el aprendizaje de idiomas

This mixed-methods study explored the attitudes of 199 English as a Foreign Language (EFL) special education teachers towards using ChatGPT for language learning. The survey questionnaire, consisting of 21 items, examined attitudes, effectiveness, barriers, and the future use of ChatGPT. The results revealed that participants held moderate attitudes, perceiving ChatGPT as moderately effective with moderate barriers. While no significant differences were found between male and female teachers in attitudes and effectiveness, significant gender differences emerged in the future use of ChatGPT, with female teachers exhibiting a greater willingness to embrace it. Follow-up email interviews with five participants provided valuable insights into strategies, effectiveness, challenges, and inclusivity when using ChatGPT in language instruction for special education students. These findings contribute to implementing and developing ChatGPT as a language learning tool for EFL special education students, emphasizing the importance of gender-inclusive approaches and practical considerations to enhance its efficacy.Este estudio de métodos mixtos exploró las actitudes de 199 profesores de educación especial de inglés como lengua extranjera (EFL) hacia el uso de ChatGPT para el aprendizaje del idioma. El cuestionario de encuesta, compuesto por 21 ítems, examinó las actitudes, la efectividad, las barreras y el uso futuro de ChatGPT. Los resultados revelaron que los participantes tenían actitudes moderadas, percibiendo a ChatGPT como moderadamente efectivo con barreras moderadas. Si bien no se encontraron diferencias significativas entre los profesores hombres y mujeres en cuanto a actitudes y efectividad, surgieron diferencias de género significativas en el uso futuro de ChatGPT, siendo las profesoras mujeres las que mostraron una mayor disposición a adoptarlo. Entrevistas de seguimiento por correo electrónico con cinco participantes proporcionaron información valiosa sobre estrategias, efectividad, desafíos e inclusión al usar ChatGPT en la enseñanza del idioma para estudiantes de educación especial. Estos hallazgos contribuyen a implementar y desarrollar ChatGPT como herramienta de aprendizaje de idiomas para estudiantes de educación especial de EFL, enfatizando la importancia de enfoques inclusivos de género y consideraciones prácticas para mejorar su eficacia

2,2′-[(E,E)-cis-(Cyclo­hexane-1,4-di­yl)bis­(nitrilo­methanylyl­idene)]diphenol

In the title compound, C20H22N2O2, the asymmetric unit contains two independent half-mol­ecules, which are both completed by crystallographic inversion symmetry. The cyclo­hexane rings of both mol­ecules adopt chair conformations; the N atoms are in equatorial orientations in one mol­ecule and in axial orientations in the other. Both mol­ecules feature two intra­molecular O—H⋯N hydrogen bonds, which generate S(6) rings

Synthesis of New Potential Chemotherapeutic Agents Incorporating Naproxen Sub-Structure

A Series Of Potential Biologically Active Compounds Have Been Synthesized Through The Derivatization of Carboxyl Group In Naproxen Core Structure Involving The Conversion The Naproxen To Its Methyl Ester Then To TheAcid Hydrazide. The Acid Hydrazide Of Naproxen Was Incorporated With Hydrazones, Diamide Linkage, Oxadiazole, Pyrazolone, Triazole, Quinazoline And Indole Containing Motifs. The Targeted Compounds Have Been Achieved In A Very Good Yield Under Conventional Heat And Irradiation Conditions. All Compounds Have Been Characterized By Ir, 1h-Nmr, 13c-Nmr And Mass Spectra.Keywords: Naproxen; Anti-Inflammatory; Nsaid's

7-Bromo-9-(2-hy­droxy-4,4-dimethyl-6-oxocyclo­hex-1-en-1-yl)-3,3-dimethyl-2,3,4,9-tetra­hydro-1H-xanthen-1-one

In the xanthene ring system of the title compound, C23H25BrO4, the 4H-pyran ring is almost planar [maximum deviation = 0.040 (3) Å] and the cyclo­hexene ring adopts a sofa conformation. The cyclo­hexene ring attached to the xanthene system is puckered [Q T = 0.427 (3) Å, θ = 55.0 (4) ° and ϕ = 164.4 (6) °]. In the crystal, mol­ecules are linked to each other by O—H⋯O and C—H⋯O hydrogen bonds

(6Z)-4-Bromo-6-{[(2-hy­droxy­eth­yl)amino]­methyl­idene}cyclo­hexa-2,4-dien-1-one

The title mol­ecule, C9H10BrNO2, excluding methyl­ene H atoms and the C—OH group, is essentially planar, with a maximum deviation of 0.037 (2) Å for the N atom. The N—C—C—O torsion angle is −63.1 (3)°. The mol­ecular structure is stabilized by a weak intra­molecular N—H⋯O(carbonyl) hydrogen bond, forming an S(6) motif. In the crystal, mol­ecules are linked by O—H⋯O and C—H⋯O hydrogen bonds, forming a three-dimensional network

2-((E)-{[4-(Hy­droxy­meth­yl)phen­yl]imino}­meth­yl)phenol

The title compound, C14H13NO2, adopts the enol–imine tautomeric form, with an intra­molecular O—H⋯N hydrogen bond which generates an S(6) ring motif. The dihedral angle between the aromatic rings is 7.85 (7)°. The crystal structure is stabilized by O—H⋯O, O—H⋯N and C—H⋯O hydrogen bonds, forming a two-dimensional array that stacks along the a axis. In addition, a C—H⋯π inter­action contributes to the stabilization of the crystal packing

2-Anilino-3-(2-hy­droxy­prop­yl)-4-methyl-1,3-thia­zol-3-ium chloride

In the title compound, C13H17N2OS+·Cl−, the thia­zolium ring mean plane makes a dihedral angle of 55.46 (9)° with the benzene ring. In the propanol group, the N—C—C—C and N—C—C—O torsion angles are 172.58 (15) and 52.9 (2)°, respectively, and the S—C—C—C torsion angle is 178.99 (18)°. In the crystal, mol­ecules are linked by O—H⋯Cl and N—H⋯Cl hydrogen bonds, forming zigzag chains along [001]. There is also a C—H⋯Cl inter­action present

Crystal structure of ethyl 2-[2-((1E)-{(1E)-2-[2-(2-ethoxy-2-oxoethoxy)benzyl-idene]hydrazin-1-ylidene}methyl)phen-oxy]acetate

NSF–MRI grant No. 1228232 for the purchase of the diffractometer and Tulane University for support of the Tulane Crystallography Laboratory are gratefully acknowledged.Peer reviewedPublisher PD