481 research outputs found
Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells
Testosterone by promoting different metabolic pathways contributes to short-term homeostasis of skeletal muscle, the largest insulin-sensitive tissue and the primary site for insulin-stimulated glucose utilization. Despite evidences indicate a close relationship between testosterone and glucose metabolism, the molecular mechanisms responsible for a possible testosterone-mediated insulin-like effects on skeletal muscle are still unknown
Reading a GEM with a VLSI pixel ASIC used as a direct charge collecting anode
In MicroPattern Gas Detectors (MPGD) when the pixel size is below 100 micron
and the number of pixels is large (above 1000) it is virtually impossible to
use the conventional PCB read-out approach to bring the signal charge from the
individual pixel to the external electronics chain. For this reason a custom
CMOS array of 2101 active pixels with 80 micron pitch, directly used as the
charge collecting anode of a GEM amplifying structure, has been developed and
built. Each charge collecting pad, hexagonally shaped, realized using the top
metal layer of a deep submicron VLSI technology is individually connected to a
full electronics chain (pre-amplifier, shaping-amplifier, sample and hold,
multiplexer) which is built immediately below it by using the remaining five
active layers. The GEM and the drift electrode window are assembled directly
over the chip so the ASIC itself becomes the pixelized anode of a MicroPattern
Gas Detector. With this approach, for the first time, gas detectors have
reached the level of integration and resolution typical of solid state pixel
detectors. Results from the first tests of this new read-out concept are
presented. An Astronomical X-Ray Polarimetry application is also discussed.Comment: 11 pages, 14 figures, presented at the Xth Vienna Conference on
Instrumentation (Vienna, February 16-21 2004). For a higher resolution paper
contact [email protected]
Opening a New Window to Fundamental Physics and Astrophysics: X-ray Polarimetry
An extensive theoretical literature predicts that X-ray Polarimetry can
directly determine relevant physical and geometrical parameters of
astrophysical sources, and discriminate between models further than allowed by
spectral and timing data only. X-ray Polarimetry can also provide tests of
Fundamental Physics. A high sensitivity polarimeter in the focal plane of a New
Generation X-ray telescope could open this new window in the High Energy Sky.Comment: 8 pages 1 table 14 figure
On possible interpretations of the high energy electron-positron spectrum measured by the Fermi Large Area Telescope
The Fermi-LAT experiment recently reported high precision measurements of the
spectrum of cosmic-ray electrons-plus-positrons (CRE) between 20 GeV and 1 TeV.
The spectrum shows no prominent spectral features, and is significantly harder
than that inferred from several previous experiments. Here we discuss several
interpretations of the Fermi results based either on a single large scale
Galactic CRE component or by invoking additional electron-positron primary
sources, e.g. nearby pulsars or particle Dark Matter annihilation. We show that
while the reported Fermi-LAT data alone can be interpreted in terms of a single
component scenario, when combined with other complementary experimental
results, specifically the CRE spectrum measured by H.E.S.S. and especially the
positron fraction reported by PAMELA between 1 and 100 GeV, that class of
models fails to provide a consistent interpretation. Rather, we find that
several combinations of parameters, involving both the pulsar and dark matter
scenarios, allow a consistent description of those results. We also briefly
discuss the possibility of discriminating between the pulsar and dark matter
interpretations by looking for a possible anisotropy in the CRE flux.Comment: 29 pages, 12 figures. Final version accepted for publication in
Astroparticle Physic
Gas Pixel Detectors for X-ray Polarimetry applications
We discuss a new class of Micro Pattern Gas Detectors, the Gas Pixel Detector
(GPD), in which a complete integration between the gas amplification structure
and the read-out electronics has been reached. An Application-Specific
Integrated Circuit (ASIC) built in deep sub-micron technology has been
developed to realize a monolithic device that is, at the same time, the
pixelized charge collecting electrode and the amplifying, shaping and charge
measuring front-end electronics. The CMOS chip has the top metal layer
patterned in a matrix of 80 micron pitch hexagonal pixels, each of them
directly connected to the underneath electronics chain which has been realized
in the remaining five layers of the 0.35 micron VLSI technology. Results from
tests of a first prototype of such detector with 2k pixels and a full scale
version with 22k pixels are presented. The application of this device for
Astronomical X-Ray Polarimetry is discussed. The experimental detector response
to polarized and unpolarized X-ray radiation is shown. Results from a full
MonteCarlo simulation for two astronomical sources, the Crab Nebula and the
Hercules X1, are also reported.Comment: 16 pages, 20 figures, accepted for publication in Nuclear Instruments
and Methods in Physics Research Section
Fermi observations of TeV-selected AGN
We report on observations of TeV-selected AGN made during the first 5.5
months of observations with the Large Area Telescope (LAT) on-board the Fermi
Gamma-ray Space Telescope (Fermi). In total, 96 AGN were selected for study,
each being either (i) a source detected at TeV energies (28 sources) or (ii) an
object that has been studied with TeV instruments and for which an upper-limit
has been reported (68 objects). The Fermi observations show clear detections of
38 of these TeV-selected objects, of which 21 are joint GeV-TeV sources and 29
were not in the third EGRET catalog. For each of the 38 Fermi-detected sources,
spectra and light curves are presented. Most can be described with a power law
of spectral index harder than 2.0, with a spectral break generally required to
accommodate the TeV measurements. Based on an extrapolation of the Fermi
spectrum, we identify sources, not previously detected at TeV energies, which
are promising targets for TeV instruments. Evidence for systematic evolution of
the -ray spectrum with redshift is presented and discussed in the
context of interaction with the EBL.Comment: 51 pages, 6 figures, accepted for The Astronomical Journa
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