CERATOCISTO ODONTOGÊNICO UMA REVISÃO DE LITERATURA

O Ceratocisto veio à tona pela primeira vez na década de 50, sendo utilizado para descrever uma lesão cística de características histopatológicas e comportamento diferente, que posteriormente em 1972 foi denominada pela OMS cisto odontogênico de desenvolvimento. Por ser uma lesão de características diferentes dos outros cistos de desenvolvimento alguns patologistas em 2005 junto com a OMS alteraram o cisto para tumor benigno odontogênico sendo denominado tumor odontogênico queratocisto, mas em 2017 essa lesão foi reclassificada para cisto em razão da falta de evidências científicas relacionadas às suas características clínicas, histopatológicas e moleculares que dessem suporte a uma possível origem neoplásica. Foi realizado uma busca a descritores na base de dados wwww.decs.bvs.br a fim de padronizar as palavras chaves. Os descritores "epidemiology, keratocyst, head and neck anatomy" foram inseridos no (https://pubmed.ncbi.nlm.nih.gov/), Sclielo, utilizando o filtro humanos. Foram considerados os artigos relacionados ao tema, a base de dados ofereceu cento e oitenta e oito artigos no qual vinte e nove foram utilizados como forma de pesquisa. O ceratocisto é um cisto radiolucido, unilocular ou multilocular, muitas vezes com o crescimento de antero-posterior, que tem preferência pelo ramo e corpo mandibular. O ceratocisto é um cisto que pode tomar grandes proporções e recidivante, quanto mais precoce seu diagnóstico melhor será seu tratamento e prognóstico

ANÁLISE EPIDEMIÓLOGICA DO CISTO DENTÍGERO

O cisto dentígero é o tipo mais comum dos cistos odontogênicos de desenvolvimento e o segundo mais comum dos cistos dos maxilares, representando cerca de 20% de todos os cistos revestidos por epitélio nos ossos gnáticos. Foi realizado uma busca a descritores na base de dados wwww.decs.bvs.br a fim de padronizar as palavras chaves. Os descritores "epidemiology, dentist cyst" foram inseridos no (https://pubmed.ncbi.nlm.nih.gov/), Sclielo, utilizando o filtro humanos. Foram considerados os artigos relacionados ao tema, a base de dados ofereceu cento e sessenta e dois artigos no qual trinta e três foram utilizados como forma de pesquisa. O cisto dentígero é um cisto que radiograficamente é radiolucido com margens radiopacas, que se envolve à coroa um dente incluso, sendo na maioria das vezes o terceiro molar inferior, tendo 3 variantes. O cisto dentígero é diagnosticado inicialmente através do atraso de um dente não erupcionado, imagens radiográficas e posteriormente exame histopatológica, seu tratamento se resume a enuncleação e se for um cisto extenso, marsupialização/descompressão seguida de enuncleação, quanto mais precoce melhor o prognóstico

Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis : a preliminary study

Actinic Cheilitis (AC) is a pathological condition of the labial mucosa considered potentially malignant. The aim of this study was to investigate the effect of treatment of AC with daily use of a vitamin-based barrier cream. For this clinical study, 36 participants with lower-lip AC were recruited from three oral medicine services. At baseline, participants were evaluated by clinical examination and clinical severity of AC was classified as grade I to IV. All participants were dispensed a tube of a barrier cream containing vitamins A, D, E and ZnO to apply once nightly for 90 consecutive days. Monthly follow-up was performed to reclassify AC clinial severity. The primary outcome of interest was clinical remission of AC at 90-day follow-up compared to baseline. Progressive remission of AC lesions was observed as early as the first month and throughout the assessment period (p = 0.000). The 3-month period was insufficient for remission of lesions, especially among male participants (p = 0.002) and with a longer sun exposure in years (p = 0.007). Daily use of the vitamin-based barrier cream had a promissing positive impact on the severity of actinic cheilitis. However, a 90-day course of treatment was not sufficient to achieve lesions remission. The findings of this study suggest a promising new avenue for the treatment of lower-lip AC

Relationship between anemia and oral cancer : a case-control study

The aim of this study was to investigate the occurrence, type and severity of anemia at the time of diagnosis of oral cancer, and its potential association with the degree of tumor cell differentiation. This case-control study used 366 medical records of patients treated at two referral centers for oral cancer diagnosis, specifically: cases (n=70) with a histopathological diagnosis of oral squamous cell carcinoma (OSCC) of the oral cavity, and controls (n=296) with benign oral lesions. Sociodemographic, behavioral, and clinical variables of both groups, as well as complete blood count values, were analyzed by descriptive statistics and crude/adjusted logistic regression. Anemia was detected in 15.7% of the cases and 11.8% of the controls. The presence of anemia had an OR=1.64 (odds ratio) (95%CI 0.54–5.00) for OSCC, with no significantly statistical association. Normocytic anemia was the most prevalent form of anemia when oral cancer was diagnosed (91.4% of the controls and 72.7% of the cases), and moderate to severely low hemoglobin levels were associated with OSCC diagnosis (OR 6.49; 95%CI 1.18–35.24), albeit data on hematological examinations were missing

Evaluation of Aquaporins 1 and 5 Expression in Rat Parotid Glands After Volumetric Modulated Arc Radiotherapy and Use of Low-Level Laser Therapy at Different Times

Introduction: This experimental study investigated the mRNA expression of aquaporins (AQPs) 1 and 5 in the parotid glands of rats irradiated with volumetric modulated arc therapy (VMAT) and subjected to low-level laser therapy (LLLT) at different time points.Methods: The sample consisted of 30 Wistar rats (Rattus norvegicus) divided into the following groups: control, LLLT alone (LG), radiotherapy alone (RG), and experimental groups that received LLLT at 24 hours (early experimental group [EEG], n=12) and 120 hours (late experimental group [LEG], n=12) after radiotherapy. VMAT was delivered at a single dose (12 Gy) and LLLT was performed with an aluminium-gallium-arsenide diode laser (660 nm, 100 mW), spot area of 0.0028 cm2, energy of 2 J/cm2 applied to 3 spots in the region corresponding to the right parotid gland, for 10 consecutive days. The right parotid gland was resected and prepared for RNA extraction. The gene expression of AQPs was evaluated by quantitative polymerase chain reaction (qPCR) using specific TaqMan probes, with the HPRT gene as an internal control.Results: The lowest AQP1 gene expression was 0.83 (0.27) with the use of LLLT 24 hours after radiotherapy (EEG), and the highest was 1.56 (0.80) with the use of LLLT alone (LG). Likewise, the lowest AQP5 gene expression was found in the EEG (mean = 0.88; SD = 0.49) and the highest in the LG (mean = 1.29; SD = 0.33).Conclusion: The use of LLLT after radiotherapy may contribute to the maintenance and an increase of these proteins, even when used at a later time point after radiotherapy

Effect of Radiotherapy and Low-Level Laser Therapy on Circulating Blood Cells of Rats: LLLT and Radiotherapy on Circulating Blood Cells

Introduction: This study aimed to investigate the effect of low-level laser therapy (LLLT) on the blood cell count when applied to parotid glands of rats irradiated by volumetric modular arc therapy (VMAT).Methods: Thirty-two adult male Wistar rats were used in this study. Samples were randomly assigned to three groups: control group (CG, n = 8), immediate laser group (24 hours) (ILG, n=12), and late laser group (120 hours) (LLG, n=12). The two laser groups were previously subjected to VMAT radiotherapy in a single dose of 12 Gy. LLLT with an AsGaAl laser (660 nm, 100 mW) was applied at three points in the region of the parotid glands, right side, with the energy of 2 J per point (20s, 70 J/cm2) and a spot size of 0.0028 cm2 for 10 consecutive days. In euthanasia, blood samples were obtained by cardiac puncture. The samples from each group were processed by an automatic method and analyzed for erythrogram, leukogram, and platelet count values. The data were analyzed by ANOVA and each LLLT time point was analyzed in relation to the control group,with a significance level less than 0.05.Results: Groups using LLLT had higher red blood cell counts, being higher in the LLG (p = 0.000). The hematimetric indices MCV (P=0.002) and MCH (P=0.009) were lower than the control group, especially when compared to the group using LLLT 120h after radiotherapy (LLG). White blood cell counts were lower in the groups with radiotherapy and immediate use of LLLT (ILG) (P=0.011), mainly at the expense of lymphocytes (P=0.002).Conclusion: The results suggest a potential systemic effect of LLLT, especially on circulating red blood cell counts, regardless of their time of immediate or late use of radiotherapy. ِDOI: 10.34172/jlms.2021.4