The Control Method for Wavelength-Based CCT of Natural Light Using Warm/Cool White LED

Reproducing circadian patterns of natural light through lighting requires technology that can control correlated color temperature (CCT) and short wavelength ratio (SWR) simultaneously. This study proposes a method for controlling wavelength-based CCT of natural light using LED light sources. First, the spectral power distribution (SPD) of each channel of the test lighting (two-channel LED lighting with warm white and cool white) is identified through actual measurement. Next, CCT and SWR are calculated based on the additive mixing of SPD using the mixing ratio from the measured SPD. Finally, the regression equations for mixing ratio-CCT and mixing ratio-SWR are derived through regression analysis. These equations are then utilized to implement a wavelength-based CCT control algorithm. For performance and evaluation purposes, natural light reproduction experiments were conducted, achieving a mean error of 94.5K for CCT and 1.5% for SWR

Fade Lighting Control Method for Visual Comfort and Energy Saving

This study proposes a fade lighting control method to ensure the visual comfort of indoor occupants through gradual illuminance control while saving energy. The illuminance sensor measures the indoor illuminance and calculates the required illuminance for achieving a reference illuminance of 500 Lux. The control illuminance for each lighting is derived based on the required illuminance, and it is confirmed to fall within the threshold range of 20%. The illuminance values and time intervals for fade lighting control are calculated, ensuring that the amount of illuminance adjustment is divided by the size of the threshold range or less. In the performance evaluation, the proposed method (experimental group) was compared with the influence-based control method (control group). The result shows that this fade lighting control method minimizes the visual discomfort of occupants caused by sudden changes in lighting, and the same energy-saving of 11-42% is achieved as the control group

Effects of Body Mass Index on Ankle Joint Muscle Function and Dynamic Proprioceptive Control

PURPOSE Increased body mass index (BMI) increases ankle instability and adversely affects human movement. This study aims to compare and analyze the muscle function and proprioception of the ankle joint based on Body Mass Index (BMI) to determine potential differences. METHODS Twenty-eight healthy male and female college students were categorized into overweight (≥ BMI 23) and normal (< BMI 23) groups. Measurements included BMI, isokinetic strength of dorsiflexion, plantarflexion, eversion, inversion, ankle joint range of motion, and ankle joint proprioception. RESULTS In dorsiflexion, right 30°/sec (p=.035), left 30°/sec (p=.009) and right 120°/sec (p=.011); in plantarflexion, left 30°/sec (p<.001), right 120°/sec (p=.007) and left 120°/sec (p=.006) in ankle inversion, left 30°/sec (p=.001), right 120°/sec (p=.021) and left 120°/sec (p=.007), left 30°/sec (p=.014), 120°/sec (p=.001) in ankle inversion-eversion ratio, right (p=.003) and left (p=.003) in ankle joint range of motion, right (p<.001) and left (p=.022) in total proprioception, and left (p<.001) in left-right proprioception were significantly different between the normal and overweight groups. CONCLUSIONS It was found that the overweight group had lower muscle strength, joint range of motion, and proprioceptive control function of the ankle joint than the normal group according to BMI. Therefore, exercise programs should be provided to strengthen the periarticular muscles involved in ankle movement, such as the tibialis anterior, soleus, and peroneus longus, and to control dynamic proprioception to prevent ankle injuries and function of the ankle joint according to BMI

Molecular Subgroup Analysis of Clinical Outcomes in a Phase 3 Study of Gemcitabine and Oxaliplatin with or without Erlotinib in Advanced Biliary Tract Cancer

AbstractBACKGROUND: We previously reported that the addition of erlotinib to gemcitabine and oxaliplatin (GEMOX) resulted in greater antitumor activity and might be a treatment option for patients with biliary tract cancers (BTCs). Molecular subgroup analysis of treatment outcomes in patients who had specimens available for analysis was undertaken. METHODS: Epidermal growth factor receptor (EGFR), KRAS, and PIK3CA mutations were evaluated using peptide nucleic acid–locked nucleic acid polymerase chain reaction clamp reactions. Survival and response rates (RRs) were analyzed according to the mutational status. Sixty-four patients (48.1%) were available for mutational analysis in the chemotherapy alone group and 61 (45.1%) in the chemotherapy plus erlotinib group. RESULTS: 1.6% (2/116) harbored an EGFR mutation (2 patients; exon 20), 9.6% (12/121) harbored a KRAS mutation (12 patients; exon 2), and 9.6% (12/118) harbored a PIK3CA mutation (10 patients, exon 9 and 2 patients, exon 20). The addition of erlotinib to GEMOX in patients with KRAS wild-type disease (n = 109) resulted in significant improvements in overall response compared with GEMOX alone (30.2% vs 12.5%, P = .024). In 95 patients with both wild-type KRAS and PIK3CA, there was evidence of a benefit associated with the addition of erlotinib to GEMOX with respect to RR as compared with GEMOX alone (P = .04). CONCLUSION: This study demonstrates that KRAS mutational status might be considered a predictive biomarker for the response to erlotinib in BTCs. Additionally, the mutation status of PIK3CA may be a determinant for adding erlotinib to chemotherapy in KRAS wild-type BTCs

Effects of physical activity participation on cognitive impairment in older adults population with disabilities

BackgroundExisting research on the association between cognitive function and physical activity in the older adults population with disabilities is limited. Additionally, there is a need to explore avenues for enhancing the longevity and quality of life among these individuals.ObjectiveThis study aimed to investigate the independent and joint associations between cognitive function and levels of physical activity in the older adults population with disabilities.MethodsA total of 315 older adults adults (men = 182, women = 133), identified with disabilities based on medical evaluation, were recruited from the first survey of the Korean Longitudinal Study of Aging (KLoSA). Participants underwent assessments for cognitive function, physical activity (PA), activities of daily living (ADLs), instrumental activities of daily living (IADLs), and grip strength.ResultsADLs (p &lt; 0.001) and IADLs (p &lt; 0.001) scores were significantly higher in the male normal cognitive group compared to both the male and female cognitive impairment groups. In an unadjusted model, disabled older adults individuals who did not meet the recommended PA guidelines showed an increased odds ratio for cognitive dysfunction (OR = 2.29, 95% CI = 1.32–3.97). Those participating in PA at least 1 day per week also demonstrated an elevated odds ratio (OR = 1.22, 95% CI = 1.08–1.38) for cognitive dysfunction compared to those who engaged in regular PA. A negative correlation was observed between K-MMSE scores and grip strength (r = 0.448, p &lt; 0.001).ConclusionThis study provides robust evidence that disabled older adults individuals who do not meet the recommended guidelines for PA or who do not participate in PA at least once a week have an increased likelihood of cognitive impairment compared to those who are regularly active

Urachal Actinomycosis Mimicking a Urachal Tumor

A 26-year-old man presented with lower abdominal discomfort and a palpable mass in the right lower quadrant. An abdominal computed tomography (CT) scan revealed an abdominal wall mass that extended from the dome of the bladder. Fluorine-18 fluorodeoxyglucose (FDG) positron-emission tomography/CT (PET/CT) showed hypermetabolic wall thickening around the bladder dome area that extended to the abdominal wall and hypermetabolic mesenteric infiltration. Differential diagnosis included a urachal tumor with invasion into adjacent organs and chronic inflammatory disease. Partial cystectomy with abdominal wall mass excision was performed, and the final pathologic report was consistent with urachal actinomycosis

Induced neural stem cells from distinct genetic backgrounds exhibit different reprogramming status

Somatic cells could be directly converted into induced neural stem cells (iNSCs) by ectopic expression of defined transcription factors. However, the underlying mechanism of direct lineage transition into iNSCs is largely unknown. In this study, we examined the effect of genetic background on the direct conversion process into an iNSC state. The iNSCs from two different mouse strains exhibited the distinct efficiency of lineage conversion as well as clonal expansion. Furthermore, the expression levels of endogenous NSC markers, silencing of transgenes, and in vitro differentiation potential were also different between iNSC lines from different strains. Therefore, our data suggest that the genetic background of starting cells influences the conversion efficiency as well as reprogramming status of directly converted iNSCs.ope

Efficacy, Tolerability, and Biomarker Analyses of Once-Every-2-Weeks Cetuximab Plus First-Line FOLFOX or FOLFIRI in Patients With KRAS or All RAS Wild-Type Metastatic Colorectal Cancer: The Phase 2 APEC Study

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