New Operators for Spin Net Gravity: Definitions and Consequences

Two operators for quantum gravity, angle and quasilocal energy, are briefly reviewed. The requirements to model semi-classical angles are discussed. To model semi-classical angles it is shown that the internal spins of the vertex must be very large, ~10^20.Comment: 7 pages, 2 figures, a talk at the MG9 Meeting, Rome, July 2-8, 200

Quantum Geometry Phenomenology: Angle and Semiclassical States

The phenomenology for the deep spatial geometry of loop quantum gravity is discussed. In the context of a simple model of an atom of space, it is shown how purely combinatorial structures can affect observations. The angle operator is used to develop a model of angular corrections to local, continuum flat-space 3-geometries. The physical effects involve neither breaking of local Lorentz invariance nor Planck scale suppression, but rather reply on only the combinatorics of SU(2) recouping theory. Bhabha scattering is discussed as an example of how the effects might be observationally accessible.Comment: 5 pages, slightly extended version of the contribution to the Loops'11 conference proceeding

On Modified Dispersion Relations and the Chandrasekhar Mass Limit

Modified dispersion relations from effective field theory are shown to alter the Chandrasekhar mass limit. At exceptionally high densities, the modifications affect the pressure of a degenerate electron gas and can increase or decrease the mass limit, depending on the sign of the modifications. These changes to the mass limit are unlikely to be relevant for the astrophysics of white dwarf or neutron stars due to well-known dynamical instabilities that occur at lower densities. Generalizations to frameworks other than effective field theory are discussed.Comment: 14 pages, 2 figures; v2: version accepted for publication, minor changes; v3: note added correcting comments on the applicability of the calculation to the DSR context, references added, results unchange

On the Universality of the Entropy-Area Relation

We present an argument that, for a large class of possible dynamics, a canonical quantization of gravity will satisfy the Bekenstein-Hawking entropy-area relation. This result holds for temperatures low compared to the Planck temperature and for boundaries with areas large compared to Planck area. We also relate our description, in terms of a grand canonical ensemble, to previous geometric entropy calculations using area ensembles.Comment: 6 page

Towards Loop Quantization of Plane Gravitational Waves

The polarized Gowdy model in terms of Ashtekar-Barbero variables is further reduced by including the Killing equations for plane-fronted parallel gravitational waves with parallel rays. The resulting constraint algebra, including one constraint derived from the Killing equations in addition to the standard ones of General Relativity, are shown to form a set of first-class constraints. Using earlier work by Banerjee and Date the constraints are expressed in terms of classical quantities that have an operator equivalent in Loop Quantum Gravity, making space-times with pp-waves accessible to loop quantization techniques.Comment: 14 page

Shape in an Atom of Space: Exploring quantum geometry phenomenology

A phenomenology for the deep spatial geometry of loop quantum gravity is introduced. In the context of a simple model, an atom of space, it is shown how purely combinatorial structures can affect observations. The angle operator is used to develop a model of angular corrections to local, continuum flat-space 3-geometries. The physical effects involve neither breaking of local Lorentz invariance nor Planck scale suppression, but rather reply on only the combinatorics of SU(2) recoupling. Bhabha scattering is discussed as an example of how the effects might be observationally accessible.Comment: 14 pages, 7 figures; v2 references adde

Spatial Hypersurfaces in Causal Set Cosmology

Within the causal set approach to quantum gravity, a discrete analog of a spacelike region is a set of unrelated elements, or an antichain. In the continuum approximation of the theory, a moment-of-time hypersurface is well represented by an inextendible antichain. We construct a richer structure corresponding to a thickening of this antichain containing non-trivial geometric and topological information. We find that covariant observables can be associated with such thickened antichains and transitions between them, in classical stochastic growth models of causal sets. This construction highlights the difference between the covariant measure on causal set cosmology and the standard sum-over-histories approach: the measure is assigned to completed histories rather than to histories on a restricted spacetime region. The resulting re-phrasing of the sum-over-histories may be fruitful in other approaches to quantum gravity.Comment: Revtex, 12 pages, 2 figure

Embedded graph invariants in Chern-Simons theory

Chern-Simons gauge theory, since its inception as a topological quantum field theory, has proved to be a rich source of understanding for knot invariants. In this work the theory is used to explore the definition of the expectation value of a network of Wilson lines - an embedded graph invariant. Using a slight generalization of the variational method, lowest-order results for invariants for arbitrary valence graphs are derived; gauge invariant operators are introduced; and some higher order results are found. The method used here provides a Vassiliev-type definition of graph invariants which depend on both the embedding of the graph and the group structure of the gauge theory. It is found that one need not frame individual vertices. Though, without a global projection of the graph, there is an ambiguity in the relation of the decomposition of distinct vertices. It is suggested that framing may be seen as arising from this ambiguity - as a way of relating frames at distinct vertices.Comment: 20 pages; RevTex; with approx 50 ps figures; References added, introduction rewritten, version to be published in Nuc. Phys.

Cosmological Histories for the New Variables

Histories and measures for quantum cosmology are investigated through a quantization of the Bianchi IX cosmology using path integral techniques. The result, derived in the context of Ashtekar variables, is compared with earlier work. A non-trivial correction to the measure is found, which may dominate the classical potential for universes on the Planck scale.Comment: 14, CGPG-94/2-

Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53

DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful elimination of cancer cells. However, cancer cells often evolve to evade the cytotoxicity induced by DNA DSBs, thereby forming the basis for treatment resistance. As such, a better understanding of the DSB DNA damage response (DSB–DDR) pathway will facilitate the design of more effective strategies to overcome chemo- and radioresistance. To identify novel mechanisms that protect cells from the cytotoxic effects of DNA DSBs, we performed a forward genetic screen in zebrafish for recessive mutations that enhance the IR–induced apoptotic response. Here, we describe radiosensitizing mutation 7 (rs7), which causes a severe sensitivity of zebrafish embryonic neurons to IR–induced apoptosis and is required for the proper development of the central nervous system. The rs7 mutation disrupts the coding sequence of ccdc94, a highly conserved gene that has no previous links to the DSB–DDR pathway. We demonstrate that Ccdc94 is a functional member of the Prp19 complex and that genetic knockdown of core members of this complex causes increased sensitivity to IR–induced apoptosis. We further show that Ccdc94 and the Prp19 complex protect cells from IR–induced apoptosis by repressing the expression of p53 mRNA. In summary, we have identified a new gene regulating a dosage-sensitive response to DNA DSBs during embryonic development. Future studies in human cancer cells will determine whether pharmacological inactivation of CCDC94 reduces the threshold of the cancer cell apoptotic response