Ruolo dell’imaging TC nella valutazione post-mortem dei soggetti deceduti per caduta da altezze elevate: nostra esperienza

The CT-v can therefore be considered an effective method as an aid in the autopsy evaluation of individuals who died for various causes; in particular, in the case of deaths due to accidental falls from high altitudes, is able to identify the primary cause of death and all the epiphenomena due to precipitation

SHOT-DEAD CT-VIRTOPSY: OUR EXPERIENCE

To illustrate the potential of CT-virtopsy (CT-v) as a valid help in post-mortem evaluation in gunshot-dead people. To explain as it can support, complete and, in some special cases, be a substitute of body-opening autopsy. To stress its role in establishing cause of death, in dating the succession of lethal events occurred in the body and, possibly, in identifying the corpse

THE ROLE OF DWI SEQUENCES IN PRECLINICAL INVESTIGATIONS OF THE SACROILIAC JOINTS ANOMALIES IN PATIENTS WITH CROHN'S DISEASE. OUR EXPERIENCE

The purpose of this study is to establish the role to confer to diffusion weighted sequences (DWI) in the detection of early stage of sacroileitis in patients with Crohn's Disease (CD)

MRI DEFECOGRAPHY: TECHNIQUE, INDICATIONS AND CLINICAL FINDINGS NOT ONLY IN OBSTRUCTED DEFECATION SYNDROME

This education poster aims to share our personal experience about the MRI defecography, even though there is no general agreement about the technical and methodical details of the exam, also to improve knowledge about when and how is important to suggest MRI

Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: A pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Background: This study evaluated whether demographics, pre-diagnosis lifestyle habits and clinical data are associated with the overall survival (OS) and head and neck cancer (HNC)-specific survival in patients with HNC. Patients and methods: We conducted a pooled analysis, including 4759 HNC patients from five studies within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Cox proportional hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated including terms reported significantly associated with the survival in the univariate analysis. Results: Five-year OS was 51.4% for all HNC sites combined: 50.3% for oral cavity, 41.1% for oropharynx, 35.0% for hypopharynx and 63.9% for larynx. When we considered HNC-specific survival, 5-year survival rates were 57.4% for all HNC combined: 54.6% for oral cavity, 45.4% for oropharynx, 37.1% for hypopharynx and 72.3% for larynx. Older ages at diagnosis and advanced tumour staging were unfavourable predictors of OS and HNC-specific survival. In laryngeal cancer, low educational level was an unfavourable prognostic factor for OS (HR=2.54, 95% CI 1.01-6.38, for high school or lower versus college graduate), and status and intensity of alcohol drinking were prognostic factors both of the OS (current drinkers HR=1.73, 95% CI 1.16-2.58) and HNC-specific survival (current drinkers HR=2.11, 95% CI 1.22-3.66). In oropharyngeal cancer, smoking status was an independent prognostic factors for OS. Smoking intensity ( > 20 cigarettes/day HR=1.41, 95% CI 1.03-1.92) was also an independent prognostic factor for OS in patients with cancer of the oral cavity. Conclusions: OS and HNC-specific survival differ among HNC sites. Pre-diagnosis cigarette smoking is a prognostic factor of the OS for patients with cancer of the oral cavity and oropharynx, whereas pre-diagnosis alcohol drinking is a prognostic factor of OS and HNC-specific survival for patients with cancer of the larynx. Low educational level is an unfavourable prognostic factor for OS in laryngeal cancer patients

The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract

Acknowledgments: The authors thank all of the participants who took part in this research and the funders and support and technical staff who made this study possible. We also acknowledge and thank The Cancer Genome Atlas initiative whose data contributed heavily to this study. Funding: Funding for study coordination, genotyping of replication studies and statistical analysis was provided by the US National Institutes of Health (R01 CA092039 05/05S1) and the National Institute of Dental and Craniofacial Research (1R03DE020116). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Patterns, trends and sex differences in HIV/AIDS reported mortality in Latin American countries: 1996-2007

<p>Abstract</p> <p>Background</p> <p>International cohort studies have shown that antiretroviral treatment (ART) has improved survival of HIV-infected individuals. National population based studies of HIV mortality exist in industrialized settings but few have been presented from developing countries. Our objective was to investigate on a population basis, the regional situation regarding HIV mortality and trends in Latin America (LA) in the context of adoption of public ART policies and gender differences.</p> <p>Methods</p> <p>Cause of death data from vital statistics registries from 1996 to 2007 with "good" or "average" quality of mortality data were examined. Standardized mortality rates and Poisson regression models by country were developed and differences among countries assessed to identify patterns of HIV mortality over time occurring in Latin America.</p> <p>Results</p> <p>Standardized HIV mortality following the adoption of public ART policies was highest in Panama and El Salvador and lowest in Chile. During the study period, three overall patterns were identified in HIV mortality trends- following the adoption of the free ART public policies; a remarkable decrement, a remarkable increment and a slight increment. HIV mortality was consistently higher in males compared to females. Mean age of death attributable to HIV increased in the majority of countries over the study period.</p> <p>Conclusions</p> <p>Vital statistics registries provide valuable information on HIV mortality in LA. While the introduction of national policies for free ART provision has coincided with declines in population-level HIV mortality and increasing age of death in some countries, in others HIV mortality has increased. Barriers to effective ART implementation and uptake in the context of free ART public provision policies should be further investigated.</p

Diffusion weighted magnetic resonance imaging at 1.5 Tesla in paediatric patients with Crohn's disease

Aim of our study was to investigate role of ADC values at b=0, 500, 800, and at multi-b in the evaluation of PC

Indicatori di dose e di effetto nell\u2019esposizione a sevoflurano

Abstract The aim of this study was to determine the relationship between exposure biomarkers and renal and liver effect indicators in subjects exposed to sevoflurane. Many of the subjects show exposure to sevoflurane below the environmental threshold limit of 2 ppm established by NIOSH for halogenate compounds (mean: 0.161 ppm; median: 0.027 ppm; range: 0.007-2.71 ppm); urinary excretion of sevoflurane appeared to be influenced by exposure peaks, so that the metabolite hexafluoroisopropanol (HFIP) seemed to be more reliable as an exposure indicator. Statistically significant correlations were found between HFIP and renal biomarkers (N-acetyl-\u3b2-D-glucosaminidase and glutamine-synthetase); no differences between controls and exposed subjects in D-glucaric acid excretion were found for sevoflurane alone, but there was a significant difference with respect to the control group in combined exposure to N2O and sevoflurane

Confronto tra differenti metodi di valutazione dell\u2019esposizione occupazionale a benzene

Abstract The aim of the study was to assess the benzene exposure of workers in a large petrochemical plant and to determine which biological exposure index, urinary benzene, trans,trans-muconic acid (t,t-MA) or S-phenylmercapturic acid (S-PMA), showed a better correlation with the individual exposure. The environmental and biological monitoring data show that benzene exposure is low (means: benzene in air 0.022 mg/m3; urinary benzene 1.22 \u3bcg/L; t,t-MA: 81.9 \u3bcg/g creat.; S-PMA: 2.80 \u3bcg/g creat.). Significant correlations have been found between exposure to benzene and biomarkers, but with significant scattering of the data. For such low levels of benzene in the air, environmental monitoring seems to be the best method of evaluating individual exposure