Gravitational Geons in 1+1 Dimensions

It is well known that general relativity does not admit gravitational geons that are stationary, asymptotically flat, singularity free and topologically trivial. However, it is likely that general relativity will receive corrections at large curvatures and the modified field equations may admit solutions corresponding to this type of geon. If geons are produced in the early universe and survive until today they could account for some of the dark matter that has been "observed" in galaxies and galactic clusters. In this paper I consider gravitational geons in 1+1 dimensional theories of gravity. I show that the Jackiw-Teitelboim theory with corrections proportional to $R^2$ and $\Box R$ admits gravitational geons. I also show that gravitational geons exist in a class of theories that includes Lagrangians proportional to $R^{2/3}$.Comment: 8 pages, a comment added, two references corrected, to appear in Classical and Quantum Gravit

Int J Tuberc Lung Dis

BackgroundTherapeutic effects of antiretroviral therapy (ART) in patients with multidrug resistant tuberculosis (MDR-TB) and HIV infection have not been established.ObjectiveThe objective of this study was to assess therapeutic outcomes of ART integration with MDR-TB treatment.DesignA subgroup of MDR-TB patients from the SAPiT study, a randomized controlled trial, conducted in an out-patient clinic in Durban, South Africa from 2008\u20132012MethodsClinical outcomes at 18 months were compared in patients randomized to receive ART within 12 weeks of standard first-line tuberculosis treatment initiation with those who commenced ART after completing tuberculosis treatment.ResultsMycobacterium tuberculosis drug susceptibility was available in 489 (76%) of 642 SAPiT patients; 23 had MDR-TB, 14 in the integrated treatment arm and 9 in the sequential treatment arm. At 18 months, the mortality rate was 11.9/100 person-years (95% confidence interval (CI): 1.4\u201342.8) in the combined integrated treatment arm and 56.0/100 person-years (95%CI: 18.2\u2013130.8) in the sequential treatment arm, (Hazard Ratio adjusted for baseline CD4 count and whether MDR-TB treatment was initiated: 0.14; 95% CI: 0.02\u20130.94; P=0.04).ConclusionDespite the small sample size, the 86% reduction in mortality due to early initiation of ART in MDR-TB patients was statistically significant.D43TW00231/TW/FIC NIH HHS/United StatesD43 TW000231/TW/FIC NIH HHS/United States5U26PS001350/PS/NCHHSTP CDC HHS/United StatesU19 AI051794/AI/NIAID NIH HHS/United StatesU2G PS001350/PS/NCHHSTP CDC HHS/United StatesPEPFAR/United States2016-02-29T00:00:00Z24429305PMC47700138583vault:1580

Gravitational Geons on the Brane

In this paper, we examine the possibility of static, spherically symmetric gravitational geons on a 3 dimensional brane embedded in a 4+1 dimensional space-time. We choose a specific g_tt for the brane-world space-time metric. We then calculate g_rr analytically in the weak field limit and numerically for stronger fields. We show that the induced field equations on the brane do admit gravitational geon solutions.Comment: 14 pages with 9 figures. To appear in General Relativity and Gravitatio

FLUKA cross sections for cosmic-ray interactions with the DRAGON2 code

Secondary particles produced in spallation reactions of cosmic rays with the interstellar gas provide valuable information that allow us to investigate the injection and transport of charged particles in the Galaxy. A good understanding of the cross sections of production of these particles is crucial to correctly interpret our models, although the existing experimental data is very scarce and uncertain. We have developed a new set of cross sections, both inelastic and inclusive, computed with the FLUKA Monte Carlo nuclear code and tested its compatibility with CR data. Inelastic and inclusive cross sections have been compared to the most up-to-date data and parameterisations finding a general good agreement. Then, these cross sections have been implemented in the DRAGON2 code to characterize the spectra of CR nuclei up to Z = 26 and the secondary-to-primary ratios of B, Be and Li. Interestingly, we find that the FLUKA cross sections allow us to predict an energy-dependence of the B, Be and Li flux ratios which is compatible with AMS-02 data and to reproduce simultaneously these flux ratios with a scaling lower than 20%. Finally, we implement the cross sections of production of gamma rays, calculated with FLUKA, in the Gammasky code and compute diffuse gamma-ray sky maps and the local HI emissivity spectrum, finding a very good agreement with Fermi Large Area Telescope data

FLUKA cross sections for cosmic-ray interactions with the DRAGON2 code

Secondary particles produced in spallation reactions of cosmic rays with the interstellar gas provide valuable information that allow us to investigate the injection and transport of charged particles in the Galaxy. A good understanding of the cross sections of production of these particles is crucial to correctly interpret our models, although the existing experimental data is very scarce and uncertain. We have developed a new set of cross sections, both inelastic and inclusive, computed with the FLUKA Monte Carlo nuclear code and tested its compatibility with CR data. Inelastic and inclusive cross sections have been compared to the most up-to-date data and parameterisations finding a general good agreement. Then, these cross sections have been implemented in the DRAGON2 code to characterize the spectra of CR nuclei up to Z = 26 and the secondary-to-primary ratios of B, Be and Li. Interestingly, we find that the FLUKA cross sections allow us to predict an energy-dependence of the B, Be and Li flux ratios which is compatible with AMS-02 data and to reproduce simultaneously these flux ratios with a scaling lower than 20%. Finally, we implement the cross sections of production of gamma rays, calculated with FLUKA, in the Gammasky code and compute diffuse gamma-ray sky maps and the local HI emissivity spectrum, finding a very good agreement with Fermi Large Area Telescope data

Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment

Different strategies have been investigated for a more satisfactory treatment of advanced breast cancer, including the adjuvant use of omega-3 polyunsaturated fatty acids (PUFAs). These nutritional compounds have been shown to possess potent anti-inflammatory and antiangiogenic activities, the capacity to affect transduction pathways/receptors involved in cell growth and to reprogram tumor microenvironment. Omega-3 PUFA-containing nanoformulations designed for drug delivery in breast cancer were shown to potentiate the effects of enclosed drugs, enhance drug delivery to target sites, and minimize drug-induced side effects. We have critically analyzed here the results of the most recent studies investigating the effects of omega-3 PUFA-containing nanoformulations in breast cancer. The anti-neoplastic efficacy of omega-3 PUFAs has also been convincingly demonstrated by using preclinical in vivo models of ovarian cancer. The results obtained are critically analyzed here and seem to provide a sufficient rationale to move to still lacking interventional clinical trials, as well as to evaluate possible advantages of enclosing omega-3 PUFAs to drug-delivery nanosystems for ovarian cancer. Future perspectives in this area are also provided

Percolation, Morphogenesis, and Burgers Dynamics in Blood Vessels Formation

Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that both the model and the real system exhibit a fractal behavior at small scales, due to the process of migration and dynamical aggregation, followed at large scale by a random percolation behavior due to the coalescence of aggregates. The results are in good agreement with the analysis performed on the experimental data.Comment: 4 pages, 11 eps figure

Cosmic-ray interactions with the Sun

The solar disk is a bright gamma-ray source in the sky. The interactions of cosmic rays with the solar atmosphere produce secondary particles which can reach the Earth. In this work we present a comprehensive calculation of the yields of secondary particles such as gamma-rays, electrons, positrons, neutrons and neutrinos, performed with the FLUKA code. We also estimate the intensity at the Sun and the fluxes at the Earth of these secondary particles by folding their yields with the intensities of cosmic rays impinging on the solar surface. The results are sensitive to the assumptions on the magnetic field near the Sun and to the cosmic-ray transport in the magnetic field in the inner solar system

ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3

An interactive crosstalk between tumor and stroma cells is essential for metastatic melanoma progression. We evidenced that ESDN/DCBLD2/CLCP1 plays a crucial role in endothelial cells during the spread of melanoma. Precisely, increased extravasation and metastasis formation were revealed in ESDN-null mice injected with melanoma cells, even if the primary tumor growth, vessel permeability, and angiogenesis were not enhanced. Interestingly, improved adhesion of melanoma cells to ESDN-depleted endothelial cells was observed, due to the presence of higher levels of E-selectin transcripts/proteins in ESDN-defective cells. In accordance with these results, anticorrelation was observed between ESDN and E-selectin in human endothelial cells. Most importantly, our data revealed that cimetidine, an E-selectin inhibitor, was able to block cell adhesion, extravasation, and metastasis formation in ESDN-null mice, underlying a major role of ESDN in E-selectin transcription upregulation, which according to our data, may presumably be linked to STAT3. Based on our results, we propose a protective role for ESDN during the spread of melanoma and reveal its therapeutic potential