Malacofauna continental holocena (Región Pampeana, Argentina)

In this study the molluscan fauna recovered from six archaeological sites of the Interserrana Bonaerense area is analyzed. Three geographical sectors were studied in this area: I) Middle river basin of Quequén Grande river; II) Southwest of the Interserrana area, and III) Upper river basin of the Tapalqué stream. The systematic review of the continental mollusks recovered was complemented with quantitative, stratigraphical and chronological data for each site since the early Holocene until the present. Additionally, ecological requirements and modern distribution patterns of the taxa recorded were considered in order to search for eventual palaeoenvironmental variations in space and time. A total of 15 taxa (14 Gastropoda and one Bivalvia) were identified in the Luján Formation deposits from southeastern Buenos Aires Province. The first Holocene records for “Aplexa” minor (d’Orbigny), Drepanotrema kermatoides (d’Orbigny), Antillorbis nordestensis (Lucena), Omalonyx unguis d’Orbigny and Pisidium sp. are reported in the Bonaerese Interserrana area. Overall, the mollusks suggest palustrine habitats at the beginning of the early Holocene. During the middle Holocene, they suggest higher humidity (increase of the precipitation pattern) ca. 4.9 kyrs BP and ca. 4.7 kyrs BP. At the beginning of the late Holocene they indicate a general arid trend interrupted by brief humid episodes registered ca. 2.5 kyrs BP and ca. 2.2 kyrs BP. The integration and correlation of molluscan records in spatial and temporal scales allowed recognizing geographical displacements (i.e. Retidiscus reticulatus Fonseca & Thomé) which represent biotic responses to Holocene climate variations as well as local environmental differences for stratigraphical sequences of similar chronologies.Facultad de Ciencias Naturales y Muse

Malacofauna continental holocena (Región Pampeana, Argentina)

In this study the molluscan fauna recovered from six archaeological sites of the Interserrana Bonaerense area is analyzed. Three geographical sectors were studied in this area: I) Middle river basin of Quequén Grande river; II) Southwest of the Interserrana area, and III) Upper river basin of the Tapalqué stream. The systematic review of the continental mollusks recovered was complemented with quantitative, stratigraphical and chronological data for each site since the early Holocene until the present. Additionally, ecological requirements and modern distribution patterns of the taxa recorded were considered in order to search for eventual palaeoenvironmental variations in space and time. A total of 15 taxa (14 Gastropoda and one Bivalvia) were identified in the Luján Formation deposits from southeastern Buenos Aires Province. The first Holocene records for “Aplexa” minor (d’Orbigny), Drepanotrema kermatoides (d’Orbigny), Antillorbis nordestensis (Lucena), Omalonyx unguis d’Orbigny and Pisidium sp. are reported in the Bonaerese Interserrana area. Overall, the mollusks suggest palustrine habitats at the beginning of the early Holocene. During the middle Holocene, they suggest higher humidity (increase of the precipitation pattern) ca. 4.9 kyrs BP and ca. 4.7 kyrs BP. At the beginning of the late Holocene they indicate a general arid trend interrupted by brief humid episodes registered ca. 2.5 kyrs BP and ca. 2.2 kyrs BP. The integration and correlation of molluscan records in spatial and temporal scales allowed recognizing geographical displacements (i.e. Retidiscus reticulatus Fonseca & Thomé) which represent biotic responses to Holocene climate variations as well as local environmental differences for stratigraphical sequences of similar chronologies.Facultad de Ciencias Naturales y Muse

Malacofauna continental holocena (Región Pampeana, Argentina)

In this study the molluscan fauna recovered from six archaeological sites of the Interserrana Bonaerense area is analyzed. Three geographical sectors were studied in this area: I) Middle river basin of Quequén Grande river; II) Southwest of the Interserrana area, and III) Upper river basin of the Tapalqué stream. The systematic review of the continental mollusks recovered was complemented with quantitative, stratigraphical and chronological data for each site since the early Holocene until the present. Additionally, ecological requirements and modern distribution patterns of the taxa recorded were considered in order to search for eventual palaeoenvironmental variations in space and time. A total of 15 taxa (14 Gastropoda and one Bivalvia) were identified in the Luján Formation deposits from southeastern Buenos Aires Province. The first Holocene records for “Aplexa” minor (d’Orbigny), Drepanotrema kermatoides (d’Orbigny), Antillorbis nordestensis (Lucena), Omalonyx unguis d’Orbigny and Pisidium sp. are reported in the Bonaerese Interserrana area. Overall, the mollusks suggest palustrine habitats at the beginning of the early Holocene. During the middle Holocene, they suggest higher humidity (increase of the precipitation pattern) ca. 4.9 kyrs BP and ca. 4.7 kyrs BP. At the beginning of the late Holocene they indicate a general arid trend interrupted by brief humid episodes registered ca. 2.5 kyrs BP and ca. 2.2 kyrs BP. The integration and correlation of molluscan records in spatial and temporal scales allowed recognizing geographical displacements (i.e. Retidiscus reticulatus Fonseca & Thomé) which represent biotic responses to Holocene climate variations as well as local environmental differences for stratigraphical sequences of similar chronologies.Facultad de Ciencias Naturales y Muse

Dark energy survey year 1 results: The lensing imprint of cosmic voids on the cosmic microwave background

Cosmic voids gravitationally lens the cosmic microwave background (CMB) radiation, resulting in a distinct imprint on degree scales. We use the simulated CMB lensing convergence map from the Marenostrum Institut de Ciencias de l’Espai (MICE) N-body simulation to calibrate our detection strategy for a given void definition and galaxy tracer density. We then identify cosmic voids in Dark Energy Survey (DES) Year 1 data and stack the Planck 2015 lensing convergence map on their locations, probing the consistency of simulated and observed void lensing signals. When fixing the shape of the stacked convergence profile to that calibrated from simulations, we find imprints at the 3σ significance level for various analysis choices. The best measurement strategies based on the MICE calibration process yield S/N ≈ 4 for DES Y1, and the best-fitting amplitude recovered from the data is consistent with expectations from MICE (A ≈ 1). Given these results as well as the agreement between them and N-body simulations, we conclude that the previously reported excess integrated Sachs–Wolfe (ISW) signal associated with cosmic voids in DES Y1 has no counterpart in the Planck CMB lensing map.This work has made use of CosmoHub (see Carretero et al. 2017). CosmoHub has been developed by the Port d’Informacio Cient ´ ´ıfica (PIC), maintained through a collaboration of the Institut de F´ısica d’Altes Energies (IFAE) and the Centro de Investigaciones Energeticas, Medioambientales y Tecnol ´ ogicas (CIEMAT), and was ´ partially funded by the ‘Plan Estatal de Investigacion Cient ´ ´ıfica y Tecnica y de Innovaci ´ on’ program of the Spanish government. ´ Funding for the DES Projects has been provided by the US Department of Energy, the US National Science Foundation, the Ministry of Science and Education of Spain, the Science and Technology Facilities Council of the United Kingdom, the Higher Education Funding Council for England, the National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign, the Kavli Institute of Cosmological Physics at the University of Chicago, the Center for Cosmology and Astro-Particle Physics at the Ohio State University, the Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University, Financiadora de Estudos e Projetos, Fundac¸ao Carlos Chagas Filho de Amparo ˜ a Pesquisa do ` Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnologico and the Minist ´ erio da Ci ´ encia, Tecnologia ˆ e Inovac¸ao, the Deutsche Forschungsgemeinschaft, and the Collab- ˜ orating Institutions in the Dark Energy Survey. The Collaborating Institutions are Argonne National Laboratory, the University of California at Santa Cruz, the University of Cambridge, Centro de Investigaciones Energeticas, Medioambien- ´ tales y Tecnologicas-Madrid, the University of Chicago, Univer- ´ sity College London, the DES-Brazil Consortium, the University of Edinburgh, the Eidgenossische Technische Hochschule (ETH) ¨ Zurich, Fermi National Accelerator Laboratory, the University of ¨ Illinois at Urbana-Champaign, the Institut de Ciencies de l’Espai ` (IEEC/CSIC), the Institut de F´ısica d’Altes Energies, Lawrence Berkeley National Laboratory, the Ludwig-Maximilians Universitat¨ Munchen and the associated Excellence Cluster Universe, the Uni- ¨ versity of Michigan, the National Optical Astronomy Observatory, the University of Nottingham, The Ohio State University, the University of Pennsylvania, the University of Portsmouth, SLAC National Accelerator Laboratory, Stanford University, the University of Sussex, Texas A&M University, and the OzDES Membership Consortium. This paper is based in part on observations at Cerro Tololo InterAmerican Observatory, National Optical Astronomy Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. The DES data management system is supported by the National Science Foundation under Grant Numbers AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MINECO under grants AYA2015- 71825, ESP2015-66861, FPA2015-68048, SEV-2016-0588, SEV2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007-2013) including ERC grant agreements 240672, 291329, 306478, and 615929. We acknowledge support from the Brazilian Instituto Nacional de Cienciae Tecnologia ˆ (INCT) e-Universe (CNPq grant 465376/2014-2). This paper has been authored by Fermi Research Alliance, LLC under Contract No. DE-AC02-07CH11359 with the US Department of Energy, Office of Science, Office of High Energy Physics. PV acknowledges the support from the grant MIUR PRIN 2015 ‘Cosmology and Fundamental Physics: illuminating the Dark Universe with Euclid’. AK has been supported by a Juan de la Cierva fellowship from MINECO with project number IJC2018-037730-I. Funding for this project was also available in part through SEV-2015-0548 and AYA2017-89891-P. This project has also received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754558.Peer reviewe

The complex influence of ENSO on droughts in Ecuador

48 Pags.- 1 Tabl.- 18 Figs. The definitive version is available at: http://link.springer.com/journal/382In this study, we analyzed the influence of El Niño–Southern Oscillation (ENSO) on the spatio-temporal variability of droughts in Ecuador for a 48-year period (1965–2012). Droughts were quantified from 22 high-quality and homogenized time series of precipitation and air temperature by means of the Standardized Precipitation Evapotranspiration Index. In addition, the propagation of two different ENSO indices (El Niño 3.4 and El Niño 1 + 2 indices) and other atmospheric circulation processes (e.g., vertical velocity) on different time-scales of drought severity were investigated. The results showed a very complex influence of ENSO on drought behavior across Ecuador, with two regional patterns in the evolution of droughts: (1) the Andean chain with no changes in drought severity, and (2) the Western plains with less severe and frequent droughts. We also detected that drought variability in the Andes mountains is explained by the El Niño 3.4 index [sea surface temperature (SST) anomalies in the central Pacific], whereas the Western plains are much more driven by El Niño 1 + 2 index (SST anomalies in the eastern Pacific). Moreover, it was also observed that El Niño and La Niña phases enhance droughts in the Andes and Western plains regions, respectively. The results of this work could be crucial for predicting and monitoring drought variability and intensity in Ecuador.This work was supported by the EPhysLab (UVIGO-CSIC Associated Unit) and the research projects I-COOP H2O 2013CD0006: “Test multisectorial y actividades demostrativa sobre el potencial desarrollo de sistemas de monitorización de sequías en tiempo real en la región del oeste de Sudamérica” financed by the Spanish National Research Council, CGL2011-27574-CO2-02, CGL2014-52135-C03-01 and Red de variabilidad y cambio climático RECLIM (CGL2014-517221-REDT), financed by the Spanish Commission of Science and Technology and FEDER, and “LIFE12 ENV/ES/000536-Demonstration and validation of innovative methodology for regional climate change adaptation in the Mediterranean area (LIFE MEDACC)” financed by the LIFE programme of the European Commission. Cesar Azorin-Molina was supported by the JCI-2011-10263 Grant. Arturo Sanchez-Lorenzo was supported by the JCI-2012-12508 Grant. Miquel Tomas-Burguera was supported by a doctoral grant by the Ministry of Economy and Competitiveness and Natalia Martin-Hernandez was supported by a doctoral grant by the Aragón Regional Government. E. Aguilar was funded by the Grant CCI-009-ATN/OC-12439-RG-2012 from the Banco Iberoamericano de Desarrollo.Peer reviewe

Cognitive-behaviour therapy for patients with Abridged Somatization Disorder (SSI 4,6) in primary care: a randomized, controlled study

Abstract Background Somatoform disorders are characterized by the presence of multiple somatic symptoms without an organic cause that completely explains their symptoms. These patients generate a high cost in health services. We aim to evaluate the effectiveness and feasibility of a cognitive-behaviour therapy (CBT) programme, administered in group and individual formats in primary care for patients who are diagnosed with abridged somatization disorder. Method/design Design: Multicentre, randomized, controlled trial involving 3 groups, one of which is the control group consisting of standardized recommended treatment for somatization disorder in primary care (Smith's norms) and the 2 others, the intervention groups, consisting of cognitive-behavioural therapy (10 sessions) administered in individual format (intervention group 1) or in group format (intervention group 2). Setting: 29 primary care health centres in the province of Zaragoza and 3 primary care health centres in the province of Mallorca, Spain. Sample: N = 204 patients, (68 in each of the three groups), aged 18–65 years, able to understand and read Spanish, who fulfil Escobar's criteria of Abridgged Somatization Disorder (SSI 4,6), stable with pharmacotherapy over the previous month, and who will remain stable for the next 3 months in the doctor's opinion, having signed informed consent. Intervention: Control group: Standardized recommended treatment for somatization disorder in primary care (Smith's norms). Intervention group: 10 weekly sessions of CBT, following a protocol designed by Prof. Escobar's group at UMDNJ, USA. There are 2 different treatment conditions: individual and group format. Measurements: Survey on the use of health services, number and severity of somatic symptoms, anxiety, depression, quality of life and clinical global impression. The interviewers will not know which group the patient belongs to (blind). The assessments will be carried out at baseline, post-treatment, 6 months and 12 post-treatment. Main variables: Utilization of health services, number and severity of somatic symptoms. Analysis: The analysis will be per intent to treat. We will use the general linear models of the SPSS v.15 statistical package, to analyse the effect of treatment on the result variable (utilization of health services, number and severity of somatic symptoms). Discussion It is necessary to develop more effective psychological treatments for somatoform disorders. This randomised clinical trial will determine whether cognitive behaviour therapy, both in group or in individual format, is effective for the treatment of these patients. Trial registration Current controlled trials ISRCTN69944771</p

Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1G93A mutation display a decreased mitochondrial respiratory capacity associated to phenotypic changes that cause them to induce motor neuron death. Astrocyte-mediated toxicity can be prevented by mitochondria-targeted antioxidants, indicating a critical role of mitochondria in the neurotoxic phenotype. However, it is presently unknown whether drugs currently used to stimulate mitochondrial metabolism can also modulate ALS progression. Here, we tested the disease-modifying effect of dichloroacetate (DCA), an orphan drug that improves the functional status of mitochondria through the stimulation of the pyruvate dehydrogenase complex activity (PDH). Applied to astrocyte cultures isolated from rats expressing the SOD1G93A mutation, DCA reduced phosphorylation of PDH and improved mitochondrial coupling as expressed by the respiratory control ratio (RCR). Notably, DCA completely prevented the toxicity of SOD1G93A astrocytes to motor neurons in coculture conditions. Chronic administration of DCA (500 mg/L) in the drinking water of mice expressing the SOD1G93A mutation increased survival by 2 weeks compared to untreated mice. Systemic DCA also normalized the reduced RCR value measured in lumbar spinal cord tissue of diseased SOD1G93A mice. A remarkable effect of DCA was the improvement of grip strength performance at the end stage of the disease, which correlated with a recovery of the neuromuscular junction area in extensor digitorum longus muscles. Systemic DCA also decreased astrocyte reactivity and prevented motor neuron loss in SOD1G93A mice. Taken together, our results indicate that improvement of the mitochondrial redox status by DCA leads to a disease-modifying effect, further supporting the therapeutic potential of mitochondria-targeted drugs in ALS

Architecture and performance of the KM3NeT front-end firmware

The KM3NeT infrastructure consists of two deep-sea neutrino telescopes being deployed in the Mediterranean Sea. The telescopes will detect extraterrestrial and atmospheric neutrinos by means of the incident photons induced by the passage of relativistic charged particles through the seawater as a consequence of a neutrino interaction. The telescopes are configured in a three-dimensional grid of digital optical modules, each hosting 31 photomultipliers. The photomultiplier signals produced by the incident Cherenkov photons are converted into digital information consisting of the integrated pulse duration and the time at which it surpasses a chosen threshold. The digitization is done by means of time to digital converters (TDCs) embedded in the field programmable gate array of the central logic board. Subsequently, a state machine formats the acquired data for its transmission to shore. We present the architecture and performance of the front-end firmware consisting of the TDCs and the state machine

Population dynamics and genetic connectivity in recent chimpanzee history

The European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 864203) (to T.M.-B.). BFU2017-86471-P (MINECO/FEDER, UE) (to T.M.-B.). “Unidad de Excelencia María de Maeztu”, funded by the AEI (CEX2018-000792-M) (to T.M.-B.). Howard Hughes International Early Career (to T.M.-B.). NIH 1R01HG010898-01A1 (to T.M.-B.). Secretaria d’Universitats i Recerca and CERCA Program del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880) (to T.M.-B.). UCL’s Wellcome Trust ISSF3 award 204841/Z/16/Z (to A.M.A. and J.M.S.). Generalitat de Catalunya (2017 SGR-1040) (to M. Llorente). Wellcome Trust Investigator Award 202802/Z/16/Z (to D.A.H.). The Pan African Program: The Cultured Chimpanzee (PanAf) is generously funded by the Max Planck Society, the Max Planck Society Innovation Fund, and the Heinz L. Krekeler Foundation.Knowledge on the population history of endangered species is critical for conservation, but whole-genome data on chimpanzees (Pan troglodytes) is geographically sparse. Here, we produced the first non-invasive geolocalized catalog of genomic diversity by capturing chromosome 21 from 828 non-invasive samples collected at 48 sampling sites across Africa. The four recognized subspecies show clear genetic differentiation correlating with known barriers, while previously undescribed genetic exchange suggests that these have been permeable on a local scale. We obtained a detailed reconstruction of population stratification and fine-scale patterns of isolation, migration, and connectivity, including a comprehensive picture of admixture with bonobos (Pan paniscus). Unlike humans, chimpanzees did not experience extended episodes of long-distance migrations, which might have limited cultural transmission. Finally, based on local rare variation, we implement a fine-grained geolocalization approach demonstrating improved precision in determining the origin of confiscated chimpanzees.Publisher PDFPeer reviewe