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Friedrich Jacobi: Only Madman Can Be Follower of Kant!

Friedrich Jacobi (1743-1819) is known mainly as a representative of the “philosophy of feeling and faith” and as one of the first critics of Kant, who drew attention to the fundamental contradiction in his system: without the concept of “thing in itself” (or “thing in oneself”) it is impossible to enter into his “Critique of Pure Reason”, but it is equally impossible to remain in it with this concept. The consistent development of the transcendental philosophy system leads to the elimination of its own initial, fundamental premise. The discovery of this contradiction and the indication of its significance for the evaluation of critical philosophy was often seen as almost the only contribution of Jacobi to world philosophy. In the historical and philosophical literature, the opinion prevails is that Jacobi, by and large, simply did not understand Kant and was in comparison with him, just a “grumpy scoundrel” (Heinrich Heine) and a “lower monad” (Kuno Fischer). This pejorative assessment significantly simplifies and distorts both Jacobi’s philosophy and Jacobi’s actual attitude towards Kant, which was not so unambiguous. It should be considered in a much broader historical and problematic context. The study briefly examines the history of the long and difficult relationship between the “privileged heretic” and the “gray eminence” of the German philosophical classics with the creator of the transcendental philosophy system. The main directions of a deeply thought-out and well-founded serious criticism of Kant’s philosophy (i.e. its inconsistency, idealism, rational intellectualism, subjectivism, “speculative egoism”, etc.) are outlined and analyzed from the positions of radical realism, common sense, Christian faith, metaphysical “sense of the supersensible”, direct knowledge of the most important truths for a person, the absolute values of life, moral intuition, freedom, and dignity of the individual

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury.

BackgroundMechanical pain hypersensitivity associated with physical trauma to peripheral nerve depends on T-helper (Th) cells expressing the algesic cytokine, interleukin (IL)-17A. Fibronectin (FN) isoform alternatively spliced within the IIICS region encoding the 25-residue-long connecting segment 1 (CS1) regulates T cell recruitment to the sites of inflammation. Herein, we analyzed the role of CS1-containing FN (FN-CS1) in IL-17A expression and pain after peripheral nerve damage.MethodsMass spectrometry, immunoblotting, and FN-CS1-specific immunofluorescence analyses were employed to examine FN expression after chronic constriction injury (CCI) in rat sciatic nerves. The acute intra-sciatic nerve injection of the synthetic CS1 peptide (a competitive inhibitor of the FN-CS1/α4 integrin binding) was used to elucidate the functional significance of FN-CS1 in mechanical and thermal pain hypersensitivity and IL-17A expression (by quantitative Taqman RT-PCR) after CCI. The CS1 peptide effects were analyzed in cultured primary Schwann cells, the major source of FN-CS1 in CCI nerves.ResultsFollowing CCI, FN expression in sciatic nerve increased with the dominant FN-CS1 deposition in endothelial cells, Schwann cells, and macrophages. Acute CS1 therapy attenuated mechanical allodynia (pain from innocuous stimulation) but not thermal hyperalgesia and reduced the levels of IL-17A expression in the injured nerve. CS1 peptide inhibited the LPS- or starvation-stimulated activation of the stress ERK/MAPK pathway in cultured Schwann cells.ConclusionsAfter physical trauma to the peripheral nerve, FN-CS1 contributes to mechanical pain hypersensitivity by increasing the number of IL-17A-expressing (presumably, Th17) cells. CS1 peptide therapy can be developed for pharmacological control of neuropathic pain

Mobility of edge dislocations in stressed iron crystals during irradiation

The behavior of a/2(111){110} edge dislocations in iron in shear loading and irradiation conditions was studied by means of molecular dynamics simulation. Edge dislocations were exposed to shock waves formed by atomic displacement cascades of different energies. It was shown that starting from a certain threshold amplitude shock waves cause displacement of edge dislocations in the loaded samples. Calculations showed that the larger the shear load and the amplitude of the shock wave, the greater the displacement of dislocations in the crystallite

Organization and Usage of Learning Objects within Personal Computers

Research report of the ProLearn Network of Excellence (IST 507310), Deliverable 7.6To promote the integration of Desktop related Knowledge Management and Technology Enhanced Learning this deliverable aims at increasing the awareness of Desktop research within the Professional Learning community and at familiarizing the e-Learning researchers with the state-of-the-art in the relevant areas of Personal Information Management (PIM), as well as with the currently on-going activities and some of the regular PIM publication venues