Enhancing the Approach to Forecasting the Dynamics of Socio-Economic Development during the COVID-19 Pandemic

This study reveals the approach to scaling socio-economic indicators to ensure economic security through regional budget expenditures to the GRP ratio example. Indicator choice is conditioned by the necessity to determine the degree of the federal center's rational influence on the regional strategic goals of sustainable development. The study aims to develop and test the system for assessing the dynamics of Russian socio-economic development based on the authors' interpretation of the scaling factor values. The main research method is scaling, which provides additional perspectives reflected by preserving proportions when changing the target parameters. The new method's effectiveness is confirmed by calculating the scaling factor. Its value interpretation gives a tool for assessing the effectiveness of the strategy development system and its economic security. The study's relevance is due to adaptation to global transformations based on the management system's capability to act under various crisis scenarios and make anti-crisis decisions important for the Russian economy. The findings improve the basis for implementing a sustainable strategic planning system and strengthening national security in the COVID-19 pandemic. The findings make it possible to predict the further evolution of the relationships between indicator groups in order to increase the role of per capita budgetary expenditures in GRP. Doi: 10.28991/esj-2022-SPER-08 Full Text: PD

Migration processes and socio-economic development of the regions

Migration processes management is an important public administration element. Migration affects many aspects of society — economics, public safety, and culture. Without a competent migration policy, a conflict between residents and migrants is inevitable in society. The problem of the relationship between migration flows and the level of socio-economic development of territories is considered herein. The data from the RIA Rating Agency and the Federal State Statistics Service of Russia are used in this study. The main research method is the correlation-regression analysis. As part of the study, the hypothesis that migration flows tend to the regions that are strong in terms of socioeconomic status has not been confirmed

Algorithm for J-Integral Measurements by Digital Image Correlation

The work is devoted to the testing of the algorithm for calculating J-integral based on the construction of vector fields by digital image correlation (DIC) method. A comparative analysis of J-integral values calculated using DIC and instrumental data obtained in accordance with ASTM E 1820 "Standard Test Method for Measurement of Fracture Toughness" has made. It is shown that this approach can be used for cases when the standard technique for measuring the J-integral cannot be applied, or the standard technique does not allow achieving the required accuracy for the integral determination in local areas of the loaded material

Structure-related bandgap of hybrid lead halide perovskites and close-packed APbX3 family of phases

Metal halide perovskites APbX3 (A+ = FA+ (formamidinium), MA+ (methylammonium) or Cs+, X- = I-, Br-) are considered as prominent innovative components in nowadays perovskite solar cells. Crystallization of these materials is often complicated by the formation of various phases with the same stoichiometry but structural types deviating from perovskites such as well-known the hexagonal delta FAPbI3 polytype. Such phases are rarely placed in the focus of device engineering due to their unattractive optoelectronic properties while they are, indeed, highly important because they influence on the optoelectronic properties and efficiency of final devices. However, the total number of such phases has not been yet discovered and the complete configurational space of the polytypes and their band structures have not been studied systematically. In this work, we predicted and described all possible hexagonal polytypes of hybrid lead halides with the APbI3 composition using the group theory approach, also we analyzed theoretically the relationship between the configuration of close-packed layers in polytypes and their band gap using DFT calculations. Two main factors affecting the bandgap were found including the ratio of cubic (c) and hexagonal (h) close-packed layers and the thickness of blocks of cubic layers in the structures. We also show that the dependence of the band gap on the ratio of cubic (c) and hexagonal (h) layers in these structures are non-linear. We believe that the presence of such polytypes in the perovskite matrix might be a reason for a decrease in the charge carrier mobility and therefore it would be an obstacle for efficient charge transport causing negative consequences for the efficiency of solar cell devices

Temperature- and field-induced transformation of the magnetic state in Co2.5Ge0.5BO5

A tetravalent-substituted cobalt ludwigite Co2.5Ge0.5BO5 has been synthesized using the flux method. The compound undergoes two magnetic transitions: a long-range antiferromagnetic transition at TN1 = 84 K and a metamagnetic one at TN2 = 36 K. The sample-oriented magnetization measurements revealed a fully compensated magnetic moment along the a- and c-axes and an uncompensated one along the b-axis leading to high uniaxial anisotropy. A field-induced enhancement of the ferromagnetic correlations at TN2 is observed in specific heat measurements. The DFT+GGA calculation predicts the spin configuration of (↑↓↓↑) as a ground state with a magnetic moment of 1.37 μB/f.u. The strong hybridization of Ge(4s, 4p) with O (2p) orbitals resulting from the high electronegativity of Ge4+ is assumed to cause an increase in the interlayer interaction, contributing to the long-range magnetic order. The effect of two super–superexchange pathways Co2+-O-B-O-Co2+ and Co2+-O-M4-O-Co2+ on the magnetic state is discussed.This work has been financed by the Russian Foundation for Basic Research (project no. 20-02-00559). The authors acknowledge financial support from the Spanish Agencia Estatal de Investigación, through projects MAT2017-83468-R (AEI/FEDER, UE) and PID2020-115159GB-I00/AEI/10.13039/501100011033, the Aragonese project RASMIA E12_20R (co-funded by Fondo Social Europeo), and of the European Union FEDER (ES).Peer reviewe

Механизация в технологиях семеноводства корнеплодов

Abstract. The sugar beet seed production is currently employing a non-planting-and-transplant technology with the use of steklings. Planting units of the machines available on the market feature a number of drawbacks: low productivity, possible injuring of root crops, and increased labor intensity of operators. (Research purpose) To develop a universal design and parameters of an increased-productivity unit for planting steklings of sugar beet and other root crops. (Materials and methods) The design scheme and type of a planting unit have been chosen according to the requirements of applicability and versatility. Its preferred design parameters have been calculated as well. A prototype machine with a universal planting unit in the form of a cellular disk has been developed and manufactured in test production. (Results and discussion) The conducted field experiments proved the versatility of a planting machine with a disc-type unit used for planting root crops, including dimensional characteristics corresponding to those of steklings. The authors have found that when replacing a disk with a different number of cells of different sizes, the machine is suitable for planting a number of similar crops. A removable disk with 12-16 cells has been installed, with its angular speed decreased to 0.393-1.180 radian per second, which is lower as compared to the existing machines. Satisfactory agrotechnical tolerances have been provided for carrot planting in the soil at a depth of 12 cm, a step of 30 cm, and a deviation from the vertical of 110. The intensity of root crop laying in the cells of a seeding disk has been increased to 1-3 pcs. per second. (Conclusions) It has been found that the machine and the planting unit can increase the working speed up to 1.0 meter per second and reduce the labor intensity of operators to the level of safety requirements. The use of universal machines in the breeding and seed production of root crops will reduce the range of the applied machines and operating costs of farm enterprises.Реферат. В семеноводстве сахарной свеклы набирает популярность эффективная безвысадочно-пересадочная технология с использованием штеклингов. Высаживающие аппараты, предлагаемые на рынке машин, имеют ряд недостатков: невысокую производительность, возможность травмирования корнеплодов, повышенную напряженность труда операторов. (Цель исследования) Разработать универсальную конструкцию и параметры аппарата повышенной производительности для высадки штеклингов сахарной свеклы и корнеплодов других культур. (Материалы и методы) По условиям применимости и универсальности выбрали конструктивную схему и тип высаживающего аппарата. Рассчитали его предпочтительные конструктивные параметры. Разработали и изготовили в опытном производстве макетный образец машины с универсальным высаживающим аппаратом в виде ячеистого диска. (Результаты и обсуждение) В полевых экспериментах подтвердили универсальность посадочной машины с высаживающим аппаратом дискового типа на высадке корнеплодов, в том числе с размерными характеристиками, соответствующими штеклингам. Выявили, что при замене диска с разным количеством ячеек различного размера машина пригодна для высадки целого ряда аналогичных культур. Установили сменный диск с 12-16 ячейками, снизив его угловую скорость до 0,393-1,180 радиан в секунду, что ниже по сравнению с параметрами высаживающего аппарата существующих машин. Обеспечили удовлетворительные агротехнические допуски по размещению корнеплодов моркови в почве на глубину 12 см при шаге посадки 30 см и отклонении от вертикали на 11 градусов. Повысили интенсивность укладки корнеплодов в ячейки высевающего диска до 1-3 штук в секунду. (Выводы) Установили, что машина и высаживающий аппарат позволят повысить рабочую скорость до 1 м в секунду и снизить напряженность труда операторов до уровня требований техники безопасности. Применение универсальных машин в селекции и семеноводстве корнеплодных культур снизит номенклатуру машин и эксплуатационные затраты хозяйств

Механизация в технологиях семеноводства корнеплодов

Abstract. The sugar beet seed production is currently employing a non-planting-and-transplant technology with the use of steklings. Planting units of the machines available on the market feature a number of drawbacks: low productivity, possible injuring of root crops, and increased labor intensity of operators. (Research purpose) To develop a universal design and parameters of an increased-productivity unit for planting steklings of sugar beet and other root crops. (Materials and methods) The design scheme and type of a planting unit have been chosen according to the requirements of applicability and versatility. Its preferred design parameters have been calculated as well. A prototype machine with a universal planting unit in the form of a cellular disk has been developed and manufactured in test production. (Results and discussion) The conducted field experiments proved the versatility of a planting machine with a disc-type unit used for planting root crops, including dimensional characteristics corresponding to those of steklings. The authors have found that when replacing a disk with a different number of cells of different sizes, the machine is suitable for planting a number of similar crops. A removable disk with 12-16 cells has been installed, with its angular speed decreased to 0.393-1.180 radian per second, which is lower as compared to the existing machines. Satisfactory agrotechnical tolerances have been provided for carrot planting in the soil at a depth of 12 cm, a step of 30 cm, and a deviation from the vertical of 110. The intensity of root crop laying in the cells of a seeding disk has been increased to 1-3 pcs. per second. (Conclusions) It has been found that the machine and the planting unit can increase the working speed up to 1.0 meter per second and reduce the labor intensity of operators to the level of safety requirements. The use of universal machines in the breeding and seed production of root crops will reduce the range of the applied machines and operating costs of farm enterprises.Реферат. В семеноводстве сахарной свеклы набирает популярность эффективная безвысадочно-пересадочная технология с использованием штеклингов. Высаживающие аппараты, предлагаемые на рынке машин, имеют ряд недостатков: невысокую производительность, возможность травмирования корнеплодов, повышенную напряженность труда операторов. (Цель исследования) Разработать универсальную конструкцию и параметры аппарата повышенной производительности для высадки штеклингов сахарной свеклы и корнеплодов других культур. (Материалы и методы) По условиям применимости и универсальности выбрали конструктивную схему и тип высаживающего аппарата. Рассчитали его предпочтительные конструктивные параметры. Разработали и изготовили в опытном производстве макетный образец машины с универсальным высаживающим аппаратом в виде ячеистого диска. (Результаты и обсуждение) В полевых экспериментах подтвердили универсальность посадочной машины с высаживающим аппаратом дискового типа на высадке корнеплодов, в том числе с размерными характеристиками, соответствующими штеклингам. Выявили, что при замене диска с разным количеством ячеек различного размера машина пригодна для высадки целого ряда аналогичных культур. Установили сменный диск с 12-16 ячейками, снизив его угловую скорость до 0,393-1,180 радиан в секунду, что ниже по сравнению с параметрами высаживающего аппарата существующих машин. Обеспечили удовлетворительные агротехнические допуски по размещению корнеплодов моркови в почве на глубину 12 см при шаге посадки 30 см и отклонении от вертикали на 11 градусов. Повысили интенсивность укладки корнеплодов в ячейки высевающего диска до 1-3 штук в секунду. (Выводы) Установили, что машина и высаживающий аппарат позволят повысить рабочую скорость до 1 м в секунду и снизить напряженность труда операторов до уровня требований техники безопасности. Применение универсальных машин в селекции и семеноводстве корнеплодных культур снизит номенклатуру машин и эксплуатационные затраты хозяйств

ACORN (A Clinically-Oriented Antimicrobial Resistance Surveillance Network) II: protocol for case based antimicrobial resistance surveillance

Background: Antimicrobial resistance surveillance is essential for empiric antibiotic prescribing, infection prevention and control policies and to drive novel antibiotic discovery. However, most existing surveillance systems are isolate-based without supporting patient-based clinical data, and not widely implemented especially in low- and middle-income countries (LMICs). Methods: A Clinically-Oriented Antimicrobial Resistance Surveillance Network (ACORN) II is a large-scale multicentre protocol which builds on the WHO Global Antimicrobial Resistance and Use Surveillance System to estimate syndromic and pathogen outcomes along with associated health economic costs. ACORN-healthcare associated infection (ACORN-HAI) is an extension study which focuses on healthcare-associated bloodstream infections and ventilator-associated pneumonia. Our main aim is to implement an efficient clinically-oriented antimicrobial resistance surveillance system, which can be incorporated as part of routine workflow in hospitals in LMICs. These surveillance systems include hospitalised patients of any age with clinically compatible acute community-acquired or healthcare-associated bacterial infection syndromes, and who were prescribed parenteral antibiotics. Diagnostic stewardship activities will be implemented to optimise microbiology culture specimen collection practices. Basic patient characteristics, clinician diagnosis, empiric treatment, infection severity and risk factors for HAI are recorded on enrolment and during 28-day follow-up. An R Shiny application can be used offline and online for merging clinical and microbiology data, and generating collated reports to inform local antibiotic stewardship and infection control policies. Discussion: ACORN II is a comprehensive antimicrobial resistance surveillance activity which advocates pragmatic implementation and prioritises improving local diagnostic and antibiotic prescribing practices through patient-centred data collection. These data can be rapidly communicated to local physicians and infection prevention and control teams. Relative ease of data collection promotes sustainability and maximises participation and scalability. With ACORN-HAI as an example, ACORN II has the capacity to accommodate extensions to investigate further specific questions of interest

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of IDO in a murine model of gingivitis: predictive and therapeutic potentials Babak Baban, Jun Yao Liu, Xu Qin, Tailing Wang, Mahmood S. Mozaffari A6 Specific diets for personalised treatment of diabetes type 2 Viktoriia V. Bati, Tamara V. Meleshko, Olga B. Levchuk, Nadiya V. Boyko A7 Towards personalized physiotherapeutic approach Joanna Bauer, Ewa Boerner, Halina Podbielska A8 Cells, animal, SHIME and in silico models for detection and verification of specific biomarkers of non-communicable chronic diseases Alojz Bomba, Viktor O. Petrov, Volodymyr G. Drobnych, Rostyslav V. Bubnov, Oksana M. Bykova, Nadiya V. Boyko A9 INTERACT-chronic care model: Self-treatment by patients with decision support e-Health solution Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu A10 PPPM in cardiovascular medicine in 2015 Hans-Peter Brunner-La Rocca A11 Magnetic resonance imaging of nanoparticles in mice, potential for theranostic and contrast media development – pilot results Rostyslav V. Bubnov, Sergiy A. Grabovetskyi, Olena M. Mykhalchenko, Natalia O. Tymoshok, Oleksandr B. Shcherbakov, Igor P. Semeniv, Mykola Y. Spivak A12 Ultrasound diagnosis for diabetic neuropathy - comparative study Rostyslav V. Bubnov, Tetyana V. Ostapenko A13 Ultrasound for stratification patients with diabetic foot ulcers for prevention and personalized treatment - pilot results Rostyslav V. Bubnov, Nazarii M. Kobyliak, Nadiya M. Zholobak, Mykola Ya. Spivak A14 Project ImaGenX – designing and executing a questionnaire on environment and lifestyle risk of breast cancer John Paul Cauchi A15 Genomics – a new structural brand of predictive, preventive and personalized medicine or the new driver as well? Dmitrii Cherepakhin, Marina Bakay, Artem Borovikov, Sergey Suchkov A16 Survey of questionnaires for evaluation of the quality of life in various medical fields Barbara Cieślik, Agnieszka Migasiewicz, Maria-Luiza Podbielska, Markus Pelleter, Agnieszka Giemza, Halina Podbielska A17 Personalized molecular treatment for muscular dystrophies Sebahattin Cirak A18 Secondary mutations in circulating tumour DNA for acquired drug resistance in patients with advanced ALK + NSCLC Marzia Del Re, Paola Bordi, Valentina Citi, Marta Palombi, Carmine Pinto, Marcello Tiseo, Romano Danesi A19 Recombinant species-specific FcεRI alpha proteins for diagnosis of IgE-mediated allergies in dogs, cats and horses Lukas Einhorn, Judit Fazekas, Martina Muhr, Alexandra Schoos, Lucia Panakova, Ina Herrmann, Krisztina Manzano-Szalai, Kumiko Oida, Edda Fiebiger, Josef Singer, Erika Jensen-Jarolim A20 Global methodology for developmental neurotoxicity testing in humans and animals early and chronically exposed to chemical contaminants Arpiné A. Elnar, Nadia Ouamara, Nadiya Boyko, Xavier Coumoul, Jean-Philippe Antignac, Bruno Le Bizec, Gauthier Eppe, Jenny Renaut, Torsten Bonn, Cédric Guignard, Margherita Ferrante, Maria Liusa Chiusano, Salvatore Cuzzocrea, Gerard O'Keeffe, John Cryan, Michelle Bisson, Amina Barakat, Ihsane Hmamouchi, Nasser Zawia, Anumantha Kanthasamy, Glen E. Kisby, Rui Alves, Oscar Villacañas Pérez, Kim Burgard, Peter Spencer, Norbert Bomba, Martin Haranta, Nina Zaitseva, Irina May, Stéphanie Grojean, Mathilde Body-Malapel, Florencia Harari, Raul Harari, Kristina Yeghiazaryan, Olga Golubnitschaja, Vittorio Calabrese, Christophe Nemos, Rachid Soulimani A21 Mental indicators at young people with attributes hypertension and pre-hypertension Maria E. Evsevyeva, Elena A. Mishenko, Zurida V. Kumukova, Evgeniy V. Chudnovsky, Tatyana A. Smirnova A22 On the approaches to the early diagnosis of stress-induced hypertension in young employees of State law enforcement agencies Maria E. Evsevyeva, Ludmila V. Ivanova, Michail V. Eremin, Maria V. Rostovtseva A23 Сentral aortic pressure and indexes of augmentation in young persons in view of risk factors Maria E. Evsevyeva, Michail V. Eremin, Vladimir I. Koshel, Oksana V. Sergeeva, Nadesgda M. Konovalova A24 Breast cancer prediction and prevention: Are reliable biomarkers in horizon? Shantanu Girotra, Olga Golubnitschaja A25 Flammer Syndrome and potential formation of pre-metastatic niches: A multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease Olga Golubnitschaja, Manuel Debald, Walther Kuhn, Kristina Yeghiazaryan, Rostyslav V. Bubnov, Vadym M. Goncharenko, Ulyana Lushchyk, Godfrey Grech, Katarzyna Konieczka A26 Innovative tools for prenatal diagnostics and monitoring: improving individual pregnancy outcomes and health-economy in EU Olga Golubnitschaja, Jan Jaap Erwich, Vincenzo Costigliola, Kristina Yeghiazaryan, Ulrich Gembruch A27 Immunohistochemical assessment of APUD cells in endometriosis Vadym M. Goncharenko, Vasyl O. Beniuk, Olga V. Kalenska, Rostyslav V. Bubnov A28 Updating personalized management algorithm of endometrial hyperplasia in pre-menopause women Vadym M. Goncharenko, Vasyl O. Beniuk, Rostyslav V. Bubnov, Olga Melnychuk A29 The personified treatment approach of polimorbid patients with periodontal inflammatory diseases Irina A. Gorbacheva, Lyudmila Y. Orekhova, Vadim V. Tachalov A30 Ukrainian experience in hybrid war – the challenge to update algorithms for personalized care and early prevention of different military injuries Olena I. Grechanyk, Rizvan Ya. Abdullaiev, Rostyslav V. Bubnov A31 Tear fluid biomarkers: a comparison of tear fluid sampling and storage protocols Suzanne Hagan, Eilidh Martin, Ian Pearce, Katherine Oliver A32 The correlation of dietary habits with gingival problems during menstruation Cenk Haytac, Fariz Salimov, Servin Yoksul, Anatoly A. Kunin, Natalia S. Moiseeva A33 Genomic medicine in a contemporary Spanish population of prostate cancer: our experience Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, Antonia Angulo, Francisco Javier Machuca Santa-Cruz A34 Challenges, opportunities and collaborations for personalized medicine applicability in uro-oncological disease Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara A35 Metabolic hallmarks of cancer as targets for a personalized therapy John Ionescu A36 Influence of genetic polymorphism as a predictor of the development of periodontal disease in patients with gastric ulcer and 12 duodenal ulcer Alfiya Z. Isamulaeva, Anatoly A. Kunin, Shamil Sh. Magomedov, Aida I. Isamulaeva A37 Challenges in diabetic macular edema Tatjana Josifova A38 Overview of the EPMA strategies in laboratory medicine relevant for PPPM Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, Vincenzo Costigliola A39 EPMA initiative for effective organization of medical travel: European concepts and criteria Vincenzo Costigliola, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja A40 Design and innovation in e-textiles: implications for PPPM Anthony Kent, Tom Fisher, Tilak Dias A41 Biobank in Pilsen as a member of national node BBMRI_CZ Judita Kinkorová, Ondřej Topolčan A42 Big data in personalized medicine: hype and hope Matthias Kohl A43 The 3P approach as the platform of the European Dentistry Department (DPPPD) Anatoly A. Kunin, Natalia S. Moiseeva A44 The endometrium cytokine patterns for predictive diagnosis of proliferation severity and cancer prevention Andrii I. Kurchenko, Vasyl A. Beniuk, Vadym M. Goncharenko, Rostyslav V. Bubnov, Nadiya V. Boyko, Andriy M. Strokan A45 A monocyte-based in-vitro system for testing individual responses to the implanted material: future for personalized implant construction Julia Kzhyshkowska, Alexandru Gudima, Ksenia S. Stankevich, Victor D. Filimonov4, Harald Klüter, Evgeniya M. Mamontova, Sergei I. Tverdokhlebov A46 Prediction and prevention of adverse health effects by meteorological factors: Biomarker patterns and creation of a device for self-monitoring and integrated care Ulyana B. Lushchyk, Viktor V. Novytskyy, Igor P. Babii, Nadiya G. Lushchyk, Lyudmyla S. Riabets, Ivanna I. Legka A47 Targeting "disease signatures" towards personalized healthcare Mira Marcus-Kalish, Alexis Mitelpunkt, Tal Galili, Neta Shachar, Yoav Benjamini A48 Influence of the skin imperfection on the personal quality of life and possible tools for objective diagnosis Agnieszka Migasiewicz, Markus Pelleter, Joanna Bauer, Ewelina Dereń, Halina Podbielska A49 The new direction in caries prevention based on the ultrastructure of dental hard tissues and filling materials Natalia S. Moiseeva, Anatoly A. Kunin, Dmitry A. Kunin A50 The use of LED radiation in prevention of dental diseases Natalia S. Moiseeva, Yury A. Ippolitov, Dmitry A. Kunin, Alexei N. Morozov, Natalia V. Chirkova, Nakhid T. Aliev A51 Status of endothelial progenitor cells in diabetic nephropathy: predictive and preventive potentials Mahmood S. Mozaffari, Jun Yao Liu, Babak Baban A52 The status of glucocorticoid-induced leucine zipper protein in salivary gland in Sjögren’s syndrome: predictive and personalized treatment potentials Mahmood S. Mozaffari, Jun Yao Liu, Rafik Abdelsayed, Xing-Ming Shi, Babak Baban A53 Maximal aerobic capacity - important quality marker of health Jaroslav Novák, Milan Štork, Václav Zeman A54 The EMPOWER project: laboratory medicine and Horizon 2020 Wytze P. Oosterhuis, Elvar Theodorsson A55 Personality profile manifestations in patient’s attitude to oral care and adherence to doctor’s prescriptions Lyudmila Y. Orekhova, Tatyana V. Kudryavtseva, Elena R. Isaeva, Vadim V. Tachalov, Ekaterina S. Loboda A56 Results of an European survey on personalized medicine addressed to directions of laboratory medicine Mario Pazzagli, Francesca Malentacchi, Irene Mancini, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc, Ron H.N. van Schaik, Gerard Siest, Elvar Theodorsson, Chiara Di Resta A57 MCI or early dementia predictive speech based diagnosis techniques Matus Pleva, Jozef Juhar A58 Personalized speech based mobile application for eHealth Matus Pleva, Jozef Juhar A59 Circulating tumor cell-free DNA as the biomarker in the management of cancer patients Jiří Polívka jr., Filip Janků, Martin Pešta, Jan Doležal, Milena Králíčková, Jiří Polívka A60 Complex stroke care – educational programme in Stroke Centre University Hospital Plzen Jiří Polívka, Alena Lukešová, Nina Müllerová, Petr Ševčík, Vladimír Rohan A61 Sleep apnea and sleep fragmentation contribute to brain aging Kneginja Richter, Lence Miloseva, Günter Niklewski A62 Personalised approach for sleep disturbances in shift workers Kneginja Richter, Jens Acker, Guenter Niklewski A63 Medical travel and innovative PPPM clusters: new concept of integration Olga Safonicheva, Vincenzo Costigliola A64 Medical travel and women health Olga Safonicheva A65 Continuity of generations in the training of specialists in the field of reconstructive microsurgery Maxim Sautin, Janna Sinelnikova, Sergey Suchkov A66 Telemonitoring of stroke patients – empirical evidence of individual risk management results from an observational study in Germany Songül Secer, Stephan von Bandemer A67 Women’s increasing breast cancer risk with n-6 fatty acid intake explained by estrogen-fatty acid interactive effect on DNA damage: implications for gender-specific nutrition within personalized medicine Niva Shapira A68 Cytobacterioscopy of the gingival crevicular fluid as a method for preventive diagnosis of periodontal diseases Aleksandr Shcherbakov, Anatoly A. 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Blood indicators of dry cows before and after administration of a drug STEMB

Objective: To determine the effect of a drug STEMB, which is a biostimulating tissue preparation based on chicken embryos, on the morpho-biochemical blood values of dry cows. Methods: The study was conducted on 60 Holstein cows, which were divided into three groups (group 1, group 2, and group 3), with 20 cows in each group. During the experiment, all animals in each group were subjected to the same condition of feeding and maintenance. The experimental animals were administered with the STEMB drug three times subcutaneously at an interval of 7 d within 30 d before calving. Group 1 were given 0.050 mL/kg body weight; group 2 were given 0.075 mL/kg body weight; group 3 were given 0.100 mL/kg body weight. Results: STEMB at 0.075 mL/kg body weight improved the blood cell composition, increasing the erythrocytes, hemoglobin, leukocytes, hemoglobin content, the total protein, albumins, alpha globulins, and gamma globulins. It reduced the beta-globulin index and provided a threshold level for the enzymes alanine aminotransferase, aspartate aminotransferase, and A, M, G immunoglobulins. Conclusions: Use of the STEMB drug with a dose of 0.075 mL/kg body weight given subcutaneously three times at an interval of 7 d within 30 d before delivery is optimal for the prevention of complications during calving and postpartum periods, thereby providing an improvement in the blood cell composition