Analycity and smoothing effect for the coupled system of equations of Korteweg - de Vries type with a single point singularity

We study that a solution of the initial value problem associated for the coupled system of equations of Korteweg - de Vries type which appears as a model to describe the strong interaction of weakly nonlinear long waves, has analyticity in time and smoothing effect up to real analyticity if the initial data only has a single point singularity at $x=0.

Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children

BACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the risk of developing specific malaria clinical complications. Nevertheless, susceptibility to experimental CM in the mouse has been linked to host genes including Transforming Growth Factor Beta 2 (TGFB2) and Heme oxygenase-1 (HMOX1). Here, we tested whether those genes were governing the risk of progressing to CM in patients with severe malaria syndromes. METHODOLOGY/PRINCIPAL FINDINGS: We report that the clinical outcome of P. falciparum infection in a cohort of Angolan children (n = 430) correlated with nine TGFB2 SNPs that modify the risk of progression to CM as compared to other severe forms of malaria. This genetic effect was explained by two haplotypes harboring the CM-associated SNPs (Pcorrec. = 0.035 and 0.036). In addition, one HMOX1 haplotype composed of five CM-associated SNPs increased the risk of developing the CM syndrome (Pcorrec. = 0.002) and was under-transmitted to children with uncomplicated malaria (P = 0.036). Notably, the HMOX1-associated haplotype conferred increased HMOX1 mRNA expression in peripheral blood cells of CM patients (P = 0.012). CONCLUSIONS/SIGNIFICANCE: These results represent the first report on CM genetic risk factors in Angolan children and suggest the novel hypothesis that genetic variants of the TGFB2 and HMOX1 genes may contribute to confer a specific risk of developing the CM syndrome in patients with severe P. falciparum malaria. This work may provide motivation for future studies aiming to replicate our findings in larger populations and to confirm a role for these genes in determining the clinical course of malaria

Fully adaptive multiresolution schemes for strongly degenerate parabolic equations with discontinuous flux

A fully adaptive finite volume multiresolution scheme for one-dimensional strongly degenerate parabolic equations with discontinuous flux is presented. The numerical scheme is based on a finite volume discretization using the Engquist--Osher approximation for the flux and explicit time--stepping. An adaptivemultiresolution scheme with cell averages is then used to speed up CPU time and meet memory requirements. A particular feature of our scheme is the storage of the multiresolution representation of the solution in a dynamic graded tree, for the sake of data compression and to facilitate navigation. Applications to traffic flow with driver reaction and a clarifier--thickener model illustrate the efficiency of this method

Intensive parenting and the ethics of care: The discourses of low-income children and adults from Santiago, Chile

Las parentalidades desplegadas en los sectores más pobres han sido, históricamente, objeto de sospecha de parte del Estado y de la sociedad en general. Este artículo describe los resultados relativos al estrato socioeconómico bajo de una investigación orientada a comprender los discursos de niños y adultos acerca de la relación padres e hijos en Chile hoy. La investigación se basa en los Estudios Sociales de la Infancia, en los Estudios sobre Culturas Parentales, y el Análisis Crítico de Discursos, y fue desarrollada a través de entrevistas grupales abiertas y semiestructuradas. Los niños muestran a la parentalidad como una tarea sacrificial y solitaria, y dan cuenta de una búsqueda de formas de aliviar las vidas de sus padres; los padres, por su parte, enfatizan la temática de una presencia permanente, además de intentar contrarrestar los estereotipos que presentan a las parentalidades de sectores pobres como violentas o negligentes. En las conclusiones se destaca el carácter recíproco del cuidado entre padres e hijos, así como la intensificación de las demandas relacionadas con la parentalidades y la condición de ser hijos en contextos neoliberales, y se relacionan estos aspectos con las condiciones de existencia del estrato bajo.Parenting practiced by low-income families have historically been object of suspicion on behalf of State and of society in general. This article describes the results related to this social class of a research study which aimed to understand the discourses of children and adults about the parent-child relationship in Chile. The research is based on Childhood Studies, on Parenting Culture Studies, and Critical Discourse Analysis, developed through open and semi-structured group interviews. Children show parenting as a self-sacrificing and solitary task, and give account of the different ways they seek in order to ease their parent’s lives; parents, on the other hand, emphasize their constant presence as a relevant topic, besides trying to counteract the stereotypes that portray low strata parenting as violent or negligent. Conclusions highlight the reciprocal character of care between parents and children, as well as the intensification of the demands related to parenting and the status of children in neoliberal contexts, and relate these aspects to the conditions of existence of the low-income class

Strategies to Automatically Derive a Process Model from a Configurable Process Model Based on Event Data

Configurable process models are frequently used to represent business workflows and other discrete event systems among different branches of large organizations: they unify commonalities shared by all branches and describe their differences, at the same time. The configuration of such models is usually done manually, which is challenging. On the one hand, when the number of configurable nodes in the configurable process model grows, the size of the search space increases exponentially. On the other hand, the person performing the configuration may lack the holistic perspective to make the right choice for all configurable nodes at the same time, since choices influence each other. Nowadays, information systems that support the execution of business processes create event data reflecting how processes are performed. In this article, we propose three strategies (based on exhaustive search, genetic algorithms and a greedy heuristic) that use event data to automatically derive a process model from a configurable process model that better represents the characteristics of the process in a specific branch. These strategies have been implemented in our proposed framework and tested in both business-like event logs as recorded in a higher educational enterprise resource planning system and a real case scenario involving a set of Dutch municipalities

TUMORES ANEXIALES Y EMBARAZO

Objetivo: Evaluar la frecuencia de tumores anexiales en el embarazo, la histología tumoral y los resultados perinatales. Pacientes y método: Análisis retrospectivo de 33 pacientes con diagnóstico de tumor anexial y embarazo atendidas en el Servicio de Obstetricia del Hospital San Juan de Dios entre febrero de 2001 a julio de 2004. Resultados: La asociación tumor anexial y embarazo fue 1 en 424 embarazos. El tipo histológico más frecuente fue el cistoadenoma seroso (19,2%). La cirugía no alteró el pronóstico perinatal. Conclusión: Recomendamos la resolución quirúrgica de las masas anexiales complejas durante el embarazo sobre las 12 semanas, período que da un margen de seguridad bastante amplio sin afectar la evolución del embarazo o los resultados perinatale

ARIA 2016: Resumen ejecutivo vías de atención integradas para una medicina preventiva a lo largo del ciclo vital

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization (WHO) workshop in 1999. The initial goals were (i) to propose a new allergic rhinitis classification, (ii) to promote the concept of multi-morbidity in asthma and rhinitis and (iii) to develop guidelines with all stakeholders for global use in all countries and populations. ARIA - disseminated and implemented in over 70 countries globally - is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK (MACVIA (Contre les MAladies Chroniques pour un VIeillissement Actif)-ARIA Sentinel NetworK) uses mobile technology to develop care pathways in order to enable the management of rhinitis and asthma by a multi-disciplinary group or by patients themselves. An App (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing

The experience of the fundacion valle del lili in Cali, Colombia with combined liver and kidney transplantation

Introduction: Combined liver and kidney transplantation (CLK) has been shown to be a good alternative for patients with concomitant diagnosis of chronic kidney disease (CKD) and end-stage liver disease. Some studies have also shown immunological benefits from combined transplantation with decreased rates of kidney graft rejection. Introducción: el trasplante combinado de hígado y riñón (CLK) ha mostrado ser una buena alternativa para pacientes con diagnóstico concomitante de enfermedad renal crónica (ERC) y enfermedad hepática terminal. Algunos estudios han mostrado además un beneficio inmunológico del trasplante combinado, con disminución de la tasa de rechazo del injerto renal.Introducción: el trasplante combinado de hígado y riñón (CLK) ha mostrado ser una buena alternativa para pacientes con diagnóstico concomitante de enfermedad renal crónica (ERC) y enfermedad hepática terminal. Algunos estudios han mostrado además un beneficio inmunológico del trasplante combinado, con disminución de la tasa de rechazo del injerto renal