63 research outputs found
First measurement of the helicity asymmetry E in eta photoproduction on the proton
Results are presented for the first measurement of the double-polarization helicity asymmetry E for the eta photoproduction reaction gamma p - \u3e eta p. Data were obtained using the FROzen Spin Target (FROST) with the CLAS spectrometer in Hall B at Jefferson Lab, covering a range of center-of-mass energy W from threshold to 2.15 GeV and a large range in center-of-mass polar angle. As an initial application of these data, the results have been incorporated into the Julich-Bonn model to examine the case for the existence of a narrow N* resonance between 1.66 and 1.70 GeV. The addition of these data to the world database results in marked changes in the predictions for the Eobservable from that model. Further comparison with several theoretical approaches indicates these data will significantly enhance our understanding of nucleon resonances. (C) 2016 Published by Elsevier B.V
Predictive Process Monitoring Methods: Which One Suits Me Best?
Predictive process monitoring has recently gained traction in academia and is
maturing also in companies. However, with the growing body of research, it
might be daunting for companies to navigate in this domain in order to find,
provided certain data, what can be predicted and what methods to use. The main
objective of this paper is developing a value-driven framework for classifying
existing work on predictive process monitoring. This objective is achieved by
systematically identifying, categorizing, and analyzing existing approaches for
predictive process monitoring. The review is then used to develop a
value-driven framework that can support organizations to navigate in the
predictive process monitoring field and help them to find value and exploit the
opportunities enabled by these analysis techniques
First Results from The GlueX Experiment
The GlueX experiment at Jefferson Lab ran with its first commissioning beam
in late 2014 and the spring of 2015. Data were collected on both plastic and
liquid hydrogen targets, and much of the detector has been commissioned. All of
the detector systems are now performing at or near design specifications and
events are being fully reconstructed, including exclusive production of
, and mesons. Linearly-polarized photons were
successfully produced through coherent bremsstrahlung and polarization transfer
to the has been observed.Comment: 8 pages, 6 figures, Invited contribution to the Hadron 2015
Conference, Newport News VA, September 201
ΠΡΡΠ°ΡΠΈΠΈ ΠΈΠ·ΠΎΡΠΈΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π· 1 ΠΈ 2 ΠΈ ΠΌΠ΅ ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅Π½Π° MGMT Π² Π³Π»ΠΈΠΎΠΌΠ°Ρ
Gliomas are the most common brain tumors. It is difficult to detect them at early stages of disease and there is a few available therapies providingΒ significant improvement in survival. Mutations of isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) play significant role in gliomogenesis,Β diagnostics and selection of patient therapy. We tested the distribution of IDH1 and IDH2 mutations in gliomas of different histologicalΒ types and grades of malignancy by DNA melting analysis using our protocol with a sensitivity of 5 %. The results of this assay wereΒ confirmed by conventional Sanger sequencing. IDH1/2 mutations were detected in 74 % of lower grade gliomas (II and III, World HealthΒ Organization) and in 14 % of glioblastomas (IV, World Health Organization). Mutation rate in gliomas with oligodendroglioma componentΒ were significantly higher then in other glioma types (Ρ = 0.014). The IDH1 mutations was the most common (79 % of general mutation number).Β IDH1/2 mutations can induce aberrant gene methylation. Detection of methylation rate of the gene encoding for O6-methylguanine-DNA-methyltransferase (MGMT), predictive biomarker for treatment of gliomas with the alkylating agents, has demonstrated a partial associationΒ with IDH1/2 mutations. In 73 % of IDH1/2-mutant tumors MGMT promoter methylation were observed. At the same time IDH1/2Β mutations were not revealed in 67 % tumors with MGMT promoter methylation. These results indicate existence of another mechanismΒ of MGMT methylation in gliomas. Our data strong support for necessity of both markers testing when patient therapy is selected.ΠΠ»ΠΈΠΎΠΌΡ β Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, ΡΡΡΠ΄Π½ΠΎ ΠΏΠΎΠ΄Π΄Π°ΡΡΠΈΠ΅ΡΡ ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΡΡΠ°ΡΠΈΠΈΒ Π² Π³Π΅Π½Π°Ρ
ΠΈΠ·ΠΎΡΠΈΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π· 1 ΠΈ 2 (IDH1 ΠΈ IDH2) ΠΈΠ³ΡΠ°ΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΡΠΎΠ»Ρ Π² Π³Π»ΠΈΠΎΠΌΠΎΠ³Π΅Π½Π΅Π·Π΅, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π²ΡΠ±ΠΎΡΠ΅ ΡΠ΅ΡΠ°ΠΏΠΈΠΈΒ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΠ»ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΌΡΡΠ°ΡΠΈΠΉ IDH1 / 2 Π² Π³Π»ΠΈΠΎΠΌΠ°Ρ
ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΠΏΠΎΠ² ΠΈ ΡΡΠ΅ΠΏΠ΅Π½Π΅ΠΉ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΡΠΈΠ²ΡΡ
ΠΏΠ»Π°Π²Π»Π΅Π½ΠΈΡ ΠΠΠ Ρ Π·ΠΎΠ½Π΄Π°ΠΌΠΈ TaqMan ΠΏΠΎ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΌΡ Π½Π°ΠΌΠΈ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Ρ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ΅ΠΌΡΒ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ ΠΌΡΡΠ°ΡΠΈΠΈ Ρ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ 5 %. Π‘ΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΌΡΡΠ°ΡΠΈΠΉ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° ΡΠ΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠΎ Π‘ΡΠ½Π³Π΅ΡΡ. Π Π³Π»ΠΈΠΎΠΌΠ°Ρ
II ΠΈ III ΡΡΠ΅ΠΏΠ΅Π½Π΅ΠΉ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΡΠ΅ΠΌΠΈΡΠ½ΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ ΡΠ°ΡΡΠΎΡΠ° ΠΌΡΡΠ°ΡΠΈΠΉ IDH1 / 2 ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 74 %, Π² Π³Π»ΠΈΠΎΠ±Π»Π°ΡΡΠΎΠΌΠ°Ρ
(IV ΡΡΠ΅ΠΏΠ΅Π½Ρ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ) β 14 %. ΠΠ»ΠΈΠΎΠΌΡ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ Ρ ΠΎΠ»ΠΈΠ³ΠΎΠ΄Π΅Π½Π΄ΡΠΎΡΠΈΡΠ°ΡΠ½ΡΠΌ ΡΠΈΠΏΠΎΠΌ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ, Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ°ΡΠ΅ ΠΈΠΌΠ΅Π»ΠΈ ΠΌΡΡΠ°ΡΠΈΠΈ IDH1 / 2, ΡΠ΅ΠΌ Π΄ΡΡΠ³ΠΈΠ΅ ΡΠΈΠΏΡ Π³Π»ΠΈΠΎΠΌ (Ρ = 0,014).Β ΠΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΠΌ ΡΠΈΠΏΠΎΠΌ ΠΌΡΡΠ°ΡΠΈΠΉ ΡΠ²Π»ΡΡΡΡΡ ΠΌΡΡΠ°ΡΠΈΠΈ IDH1 (79 % ΠΎΡ ΠΎΠ±ΡΠ΅Π³ΠΎ ΡΠΈΡΠ»Π° ΠΌΡΡΠ°ΡΠΈΠΉ). ΠΠ΄Π½ΠΎ ΠΈΠ· ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΉ ΠΌΡΡΠ°ΡΠΈΠΉΒ IDH1 / 2 β ΠΈΠ½Π΄ΡΠΊΡΠΈΡ Π°Π±Π΅ΡΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π½ΠΎΠ². ΠΠ½Π°Π»ΠΈΠ· ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ° Π³Π΅Π½Π° Π6βΠΌΠ΅ΡΠΈΠ»Π³ΡΠ°Π½ΠΈΠ½-ΠΠΠ-ΠΌΠ΅ΡΠΈΠ»-ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ (MGMT, O6βmethylguanine-DNA-methyltransferase), ΠΏΡΠ΅Π΄ΡΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π³Π»ΠΈΠΎΠΌ ΠΊ ΡΠ΅ΡΠ°ΠΏΠΈΠΈΒ Π°Π»ΠΊΠΈΠ»ΠΈΡΡΡΡΠΈΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ Ρ ΡΠ΅Ρ
ΠΆΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΏΠΎΠΊΠ°Π·Π°Π» ΡΠ°ΡΡΠΈΡΠ½ΡΡ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΡ Ρ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈ IDH1 / 2. Π 73 % ΡΠ»ΡΡΠ°Π΅Π² Ρ ΠΌΡΡΠ°ΡΠΈΡΠΌΠΈΒ IDH1 / 2 Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ MGMT. Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ Π² 67 % ΡΠ»ΡΡΠ°Π΅Π² Ρ ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ MGMT ΠΎΡΡΡΡΡΡΠ²ΠΎΠ²Π°Π»ΠΈ ΠΌΡΡΠ°ΡΠΈΠΈΒ IDH1 / 2, ΡΡΠΎ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΡΡΠ³ΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ MGMT Π² Π³Π»ΠΈΠΎΠΌΠ°Ρ
. ΠΠ°Π½Π½ΡΠ΅ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ Π² ΠΏΠΎΠ»ΡΠ·Ρ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ 2 Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΏΡΠΈ Π²ΡΠ±ΠΎΡΠ΅ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²
Π€Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΈΜ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ
Introduction. Metastatic melanoma is characterized by clinical and morphological heterogeneity and plasticity. Rare cases of metastatic melanoma are known, that have no visual expression of melanocytic markers. Contradictory histology of such melanomas requires a differential diagnosis from morphologically similar non- melanocytic tumors, sarcoma or lymphoma. objective is to describe the extraordinary cases of metastatic melanomas with low expression of differentiation markers. material and methods. 15 melanoma cases with unusual clinical and morphological characteristics were included in the study. These tumors were examined by pathologist and cytologist, by immunohistochemical and FISH analyses, mutations in BRAF, NRAS and KIT genes were detected by PCR. results. Some primary tumors were amelanotic, therefore, they were difficult for differential tumor diagnosis. Most frequently, primary tumors were located on the back, shin or head. In 4 patients the primary focuses were not detected. Metastatic lesions were as large nodular tumors in soft tissues of the back or lower limb. Most tumors belong to mixed or spindle-cell histological types. Spindle-shaped cells were also revealed by cytological analysis. BRAF gene mutations were identified by genetic analysis in 27 % of tumors, NRAS and KIT gene mutations were not detected. In 4 cases FISH analysis was performed to detect EWSR1 gene rearrangements, but it did not confirm the diagnosis of sarcoma. conclusion. The results indicate the presence of a heterogeneous group of melanoma cases, which have a number of morphological and molecular features that bring them closer to sarcomas.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΠ° ΠΎΡΠ»ΠΈΡΠ°Π΅ΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΈΜ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡΡ ΠΈ ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡΡ. ΠΡΡΡΠ΅ΡΠ°ΡΡΡΡ ΡΠ΅Π΄ΠΊΠΈΠ΅ ΡΠ»ΡΡΠ°ΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΈΜ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΡΡ ΠΌΠ΅Π»Π°Π½ΠΎΡΠΈΡΠ°ΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ². ΠΠΈcΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΠ°ΠΊΠΈΠ΅ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ ΡΡΠ΅Π±ΡΡΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΈΜ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΎΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΡ
ΠΎΠ΄Π½ΡΡ
Π½Π΅ΠΌΠ΅Π»Π°Π½ΠΎΡΠΈΡΠ°ΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΈΜ, ΡΠ°ΡΠΊΠΎΠΌΡ ΠΈΠ»ΠΈ Π»ΠΈΠΌΡΠΎΠΌΡ. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΎΡΠ΄ΠΈΠ½Π°ΡΠ½ΡΡ
ΡΠ»ΡΡΠ°Π΅Π² ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΈΜ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ Ρ Π½ΠΈΠ·ΠΊΠΎΠΈΜ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΈΜ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΎΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ². ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΏΠΈΡΠ°Π½Ρ 15 ΡΠ»ΡΡΠ°Π΅Π² ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ Ρ Π½Π΅ΠΎΠ±ΡΡΠ½ΡΠΌΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ. ΠΠΏΡΡ
ΠΎΠ»ΠΈ ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π»ΠΈΡΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ, ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΠΈ FISH-Π°Π½Π°Π»ΠΈΠ·Ρ, Π±ΡΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΌΡΡΠ°ΡΠΈΠΈ Π² Π³Π΅Π½Π°Ρ
BRAF, NRAS ΠΈ KIT. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ΅ΡΠ²ΠΈΡΠ½ΡΠ΅ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ ΡΠ°ΡΡΠΎ Π½Π΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π»ΠΈ ΠΏΠΈΠ³ΠΌΠ΅Π½ΡΠ°, ΡΡΠΎ Π·Π°ΡΡΡΠ΄Π½ΡΠ»ΠΎ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. ΠΠΏΡΡ
ΠΎΠ»ΠΈ ΡΠ°ΡΠΏΠΎΠ»Π°Π³Π°Π»ΠΈΡΡ ΡΠ°ΡΠ΅ Π²ΡΠ΅Π³ΠΎ Π½Π° ΡΠΏΠΈΠ½Π΅, Π³ΠΎΠ»Π΅Π½ΠΈ ΠΈΠ»ΠΈ Π³ΠΎΠ»ΠΎΠ²Π΅, Ρ 4 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠ΅ ΠΎΡΠ°Π³ΠΈ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½Ρ. ΠΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ»ΠΈ ΡΠΎΠ±ΠΎΠΈΜ ΠΊΡΡΠΏΠ½ΡΠ΅ ΡΠ·Π»ΠΎΠ²ΡΠ΅ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΌΡΠ³ΠΊΠΈΡ
ΡΠΊΠ°Π½ΡΡ
Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΏΠΈΠ½Ρ Π»ΠΈΠ±ΠΎ Π½ΠΈΠΆΠ½Π΅ΠΈΜ ΠΊΠΎΠ½Π΅ΡΠ½ΠΎΡΡΠΈ. ΠΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΈΜ ΠΎΡΠ½ΠΎΡΠΈΠ»ΠΈΡΡ ΠΊ ΡΠΌΠ΅ΡΠ°Π½Π½ΠΎΠΌΡ ΠΈΠ»ΠΈ Π²Π΅ΡΠ΅ΡΠ΅Π½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΌΡ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΈΠΏΠ°ΠΌ. ΠΠ΅ΡΠ΅ΡΠ΅Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ ΠΈ ΠΏΡΠΈ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
. ΠΡΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ Π°Π½Π°Π»ΠΈΠ·Π΅ ΠΌΡΡΠ°ΡΠΈΠΈ Π² Π³Π΅Π½Π΅ BRAF Π²ΡΡΠ²Π»Π΅Π½Ρ Π² 27 % ΠΌΠ΅Π»Π°Π½ΠΎΠΌ, ΠΌΡΡΠ°ΡΠΈΠΈ Π² Π³Π΅Π½Π°Ρ
NRAS ΠΈ KIT Π½Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ. Π 4 ΡΠ»ΡΡΠ°ΡΡ
Ρ ΠΏΠΎΠΌΠΎΡΡΡ FISH ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π½Π° Π½Π°Π»ΠΈΡΠΈΠ΅ ΡΠ΅Π°ΡΠ°Π½ΠΆΠΈΡΠΎΠ²ΠΊΠΈ Π³Π΅Π½Π° EWSR1, ΠΏΡΠΈ ΡΡΠΎΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ· ΡΠ°ΡΠΊΠΎΠΌΡ Π½Π΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΡΡ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΊΠ°Π·ΡΠ²Π°ΡΡ Π½Π° Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ Π½Π΅ΠΎΠ΄Π½ΠΎΡΠΎΠ΄Π½ΠΎΡΡΡ ΠΈ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΡΡ ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ΅Π»Π°Π½ΠΎΠΌ. Π ΡΠ΄ Π²ΡΡΠ²Π»Π΅Π½Π½ΡΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΈΜ ΡΠ±Π»ΠΈΠΆΠ°Π΅Ρ ΡΡΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Ρ ΡΠ°ΡΠΊΠΎΠΌΠ°ΠΌΠΈ
Analysis of the spatio-temporal distribution of large earthquakes
The investigation on the spatio-temporal distribution of large earthquakes is still a controversial issue in geophysics and many works in scientific literature have been devoted to this topic. The importance of understanding the statistical distribution of large events is aimed not only to extract information on the physics of the earthquakes occurrence process, but also to make reliable earthquake forecasting. As far as theoretical aspects are concerned, a satisfactory modelling may allow, at least in principle, to test a variety of hypotheses, such as the presence of any regularity in time, and the in uence of di erent tectonic/physical factors that regulate the spatial occurrence of earthquakes. At the same time, a reliable earthquake forecasting has undoubtedly a huge social impact because it may mitigate the seismic risk
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