Building energy retrofitting in urban areas

Abstract The analysis of existing built environment shows that the critical values of the peripheral areas, together with the very poor energy performance of existing buildings and the levels of possible transformations they imply, may contribute, collectively, to formulate from light to radical proposals for urban and building retrofitting. In such urban contexts, the reading of urban spaces and the environmental evaluation of their use, both in relation to the intrinsic features of the buildings and with the outdoor spaces, take on a renewed importance. In terms of architectural structure, this importance is focused on the building shell, which can be properly re-thought by proposing new energy efficient technological solutions aimed at re-shaping the technical and formal aspect of the building. These solutions, although developed and conducted on a single building and at the building-level technology, thus contributing to re-function the spatial units, may also been conceived in order to positively affect the urban places and the surrounding environment, fostering a mending relation between the built space and the environmental boundary conditions

Nanofluid suspensions as heat carrier fluids in single U-tube borehole heat exchangers

The borehole heat exchanger (BHE) is a critical component to improve energy efficiency and decreasing environmental impact of ground-source heat pump systems. The lower thermal resistance of the BHE results in the better thermal performance and/or in the lower required borehole length. In the present study, effects of employing a nanofluid suspension as a heat carrier fluid on the borehole thermal resistance are examined. A 3D transient finite element code is adopted to evaluate thermal comportment of nanofluids with various concentrations in single U-tube borehole heat exchangers and to compare their performance with the conventional circuit fluid. The results show, in presence of nanoparticles, the borehole thermal resistance is reduced to some extent and the BHE renders a better thermal performance. It is also revealed that employing nanoparticle fractions between 0.5% and 2 % are advantageous in order to have an optimal decrement percentage of the thermal resistance

Early invasive strategy (< 24 hours) in patients with acute coronary syndromes: Weighing the evidence

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Numerical Analysis on the Optimisation of Thermal Comfort Levels in an Office Located inside a Historical Building

The present study examines the possibility of thermal comfort optimisation inside an office room where, due to historical heritage, it is possible to modify neither the energetic characteristic of the envelope nor the position of the inlet air vents. The distribution of global and local thermal comfort indices is evaluated in both heating and cooling conditions by establishing a computational fluid dynamics (CFD) model validated against experimental data. The obtained results demonstrate a striking asymmetry of the air velocity and temperature distribution due to the low energy efficiency of the building. In heating mode, the predicted mean vote (PMV) values were improved if the discharged air from the fan coil was at its maximal velocity. However, at the same time, the vertical air temperature gradient increased by around 0.5 C in each working station. In the cooling condition, in the absence of the solar radiation, the minimal air-flow rate satisfied the acceptable range of the draught rate (DR), whereas in the presence of a solar load, it could not meet the required cooling load in all positions, leading to higher floor temperature. The findings of this study allow for identifying and rearranging the optimal position of working stations in terms of thermal comfort

Evaluation of dental demands and needs of people experiencing homelessness in the city of Rome, Italy

Objective: poor oral health and oral diseases are common among people experiencing homelessness. The aim of this study was to evaluate the dental demands and needs of a population of homeless persons in the city of Rome, Italy. Patients and methods: the clinical records of 165 homeless patients admitted between October 2020 and October 2021 to the dental service of the Primary Care Services of the Eleemosynaria Apostolica, Vatican City, were retrospectively reviewed. The service employed dentists to evaluate dental needs and oral conditions in patients experiencing homelessness. The main dental and oral pathological conditions were noted. Results: one hundred and sixty-five records of homeless patients were included in the study. The sample consisted in 138 males (76.97%) and 27 females (23.03%) with a mean age of 46.9 years (range 7-85 years). Acute tooth pain was reported by 132 (80%) patients, 42 (25.45%) had edentulism or missing teeth and 18 (10.91%) patients had oral lesions. Both dental and oral pathologies were intercepted and managed in secondary healthcare facilities. Conclusions: given the specific peculiarities of this vulnerable population, it is important to implement strategies that facilitate the access of persons experiencing homelessness to dental evaluation with a preventive and curative perspective

A Multi-Channel Low-Power System-on-Chip for in Vivo Recording and Wireless Transmission of Neural Spikes

This paper reports a multi-channel neural spike recording system-on-chip with digital data compression and wireless telemetry. The circuit consists of 16 amplifiers, an analog time-division multiplexer, a single 8 bit analog-to-digital converter, a digital signal compression unit and a wireless transmitter. Although only 16 amplifiers are integrated in our current die version, the whole system is designed to work with 64, demonstrating the feasibility of a digital processing and narrowband wireless transmission of 64 neural recording channels. Compression of the raw data is achieved by detecting the action potentials (APs) and storing 20 samples for each spike waveform. This compression method retains sufficiently high data quality to allow for single neuron identification (spike sorting). The 400 MHz transmitter employs a Manchester-Coded Frequency Shift Keying (MC-FSK) modulator with low modulation index. In this way, a 1.25 Mbit/s data rate is delivered within a limited band of about 3 MHz. The chip is realized in a 0.35 um AMS CMOS process featuring a 3 V power supply with an area of 3.1x 2.7 mm2. The achieved transmission range is over 10 m with an overall power consumption for 64 channels of 17.2 mW. This figure translates into a power budget of 269uW per channel, in line with published results but allowing a larger transmission distance and more efficient bandwidth occupation of the wireless link. The integrated circuit was mounted on a small and light board to be used during neuroscience experiments with freely-behaving rats. Powered by 2 AAA batteries, the system can continuously work for more than 100 hours allowing for long-lasting neural spike recordings

A Novel Method for Vibrotactile Proprioceptive Feedback Using Spatial Encoding and Gaussian Interpolation

Objective: The bidirectional communication between the user and the prosthesis is an important requirement when developing prosthetic hands. Proprioceptive feedback is fundamental to perceiving prosthesis movement without the need for constant visual attention. We propose a novel solution to encode wrist rotation using a vibromotor array and Gaussian interpolation of vibration intensity. The approach generates tactile sensation that smoothly rotates around the forearm congruently with prosthetic wrist rotation. The performance of this scheme was systematically assessed for a range of parameter values (number of motors and Gaussian standard deviation). Methods: Fifteen able-bodied subjects and one individual with congenital limb deficiency used vibrational feedback to control the virtual hand in the target-achievement test. Performance was assessed by end-point error and efficiency as well as subjective impressions. Results: The results showed a preference for smooth feedback and a higher number of motors (8 and 6 versus 4). With 8 and 6 motors, the standard deviation, determining the sensation spread and continuity, could be modulated through a broad range of values (0.1 - 2) without a significant performance loss (error: ∼ 10%; efficiency: ∼ 30%). For low values of standard deviation (0.1-0.5), the number of motors could be reduced to 4 without a significant performance decrease. Conclusion: The study demonstrated that the developed strategy provided meaningful rotation feedback. Moreover, the Gaussian standard deviation can be used as an independent parameter to encode an additional feedback variable. Significance: The proposed method is a flexible and effective approach to providing proprioceptive feedback while adjusting the trade-off between sensation quality and the number of vibromotors

Prognostic value of high-sensitivity cardiac troponin I early after coronary artery bypass graft surgery

Background: The diagnosis of periprocedural myocardial infarction (PMI) after coronary artery bypass graft (CABG) is based on biochemical markers along with clinical and instrumental findings. However, there is not a clear cutoff value of high-sensitivity cardiac troponin (hs-cTn) to identify PMI. We hypothesized that isolated hs-cTn concentrations in the first 24&nbsp;h following CABG could predict cardiac adverse events (in-hospital death and PMI) and/or left ventricular ejection fraction (LVEF) decrease. Methods: We retrospectively enrolled all consecutive adult patients undergoing CABG, alone or in association with other cardiac surgery procedures, over 1&nbsp;year. Hs-cTn I concentrations (Access, Beckman Coulter) were serially measured in the post-operative period and analyzed according to post-operative outcomes. Results: 300 patients were enrolled; 71.3% underwent CABG alone, 33.7% for acute coronary syndrome. Most patients showed hs-cTn I values superior to the limit required by the latest guidelines for the diagnosis of PMI. Five patients (1.7%) died, 8% developed a PMI, 10.6% showed a LVEF decrease ≥ 10%. Hs-cTn I concentrations did not significantly differ with respect to death and/or PMI whereas they were associated with LVEF decrease ≥ 10% (p value &lt; 0.005 at any time interval), in particular hs-cTn I values at 9–12&nbsp;h post-operatively. A hs-cTn I cutoff of 5556&nbsp;ng/L, a value 281 (for males) and 479 (for females) times higher than the URL, at 9–12&nbsp;h post-operatively was identified, representing the best balance between sensitivity (55%) and specificity (79%) in predicting LVEF decrease ≥ 10%. Conclusions: Hs-cTn I at 9–12&nbsp;h post-CABG may be useful to early identify patients at risk for LVEF decrease and to guide early investigation and management of possible post-operative complications

Virus-like Particle (VLP) Vaccines for Cancer Immunotherapy

Cancer vaccines are increasingly being studied as a possible strategy to prevent and treat cancers. While several prophylactic vaccines for virus-caused cancers are approved and efficiently used worldwide, the development of therapeutic cancer vaccines needs to be further implemented. Virus-like particles (VLPs) are self-assembled protein structures that mimic native viruses or bacteriophages but lack the replicative material. VLP platforms are designed to display single or multiple antigens with a high-density pattern, which can trigger both cellular and humoral responses. The aim of this review is to provide a comprehensive overview of preventive VLP-based vaccines currently approved worldwide against HBV and HPV infections or under evaluation to prevent virus-caused cancers. Furthermore, preclinical and early clinical data on prophylactic and therapeutic VLP-based cancer vaccines were summarized with a focus on HER-2-positive breast cancer