86 research outputs found

    Change and persistence in an independent nonprofit college: A case study

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    Private independent nonprofit colleges and universities serve millions of students annually, yet very little is written about this group. Most of the literature and research concern large public institutions of higher learning. Davenport College, a private independent nonprofit college system in Michigan and northern Indiana, serving 15,000 students, was the focus of the case study that offers a historical view of how the college evolved and changed over the institution’s 134-year history. The study highlights the influence of the five leaders and significant environmental events that that led to change and persistence in Davenport College from its inception on January 25, 1866, to May 18, 2000. Further, an examination of the interactions between the influences of the environment at the institutional level, governance activities at the managerial level, and core activities at the technical level contributes to development of a system of explanation for organizational change at Davenport College. Sources of primary and secondary data included personal interviews, historical documents, newspaper accounts, financial statements, annual reports, accreditation reports, and board reports, as well as college catalogs, brochures, and minutes of academic and executive leadership meetings. Many documents were collected that provided national, state, and local environmental data about economics, education, employment and training needs, and policies and statutes relevant to the college. From the industrial revolution to the information age, through wars and depression, government support and regulation, technical advances and competition, Davenport leaders maintained the institution’s mission and identity while adapting to a changing environment

    The tensions between state control and local autonomy: can collaborative planning practice align local with regional strategic planning outcomes?

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    University of Technology Sydney. Faculty of Design, Architecture and Building.This research explores the factors that facilitate or impede local strategic planning outcomes making their way up to, and having influence on, regional strategic plans. In particular the research investigates how collaborative planning practice can contribute to reaching agreements about alignment of local and regional strategic planning outcomes. Case studies of practice in preparing and aligning local and regional plans in two comparable city-regions, Vancouver BC Canada and Sydney NSW Australia, provide empirical evidence to fill an identified gap in theoretical and practical understanding of the shifting variables that have made different configurations of collaboration and governance work well or not, in different places at different times. A set of anticipated explanatory factors is developed, the manifestation of which, in different configurations in the two case study cities, may explain how local strategic planning outcomes have made their way up to, and had influence on, regional strategic planning outcomes, or not. A thematic, interpretive analysis of documentary and interview data is undertaken against these factors, and the findings from the case study cities compared. This approach provides situated and contextualised explanations of practice to answer three key questions: 1. Why is it important to ensure local strategic concerns are reflected in regional strategies? 2. What factors facilitate or impede local strategic concerns being aligned with regional strategies? 3. Under what circumstances can collaborative planning practice align local strategic planning outcomes with regional strategic planning outcomes? This is exploratory, comparative case study research about planning practice in the case study cities. It does not seek to adjust the theoretical framework, rather analyses the case study data to identify areas where practice indicates theory may need more grounding, where claims made for collaborative planning are less well grounded, and where claims are more solidly reflected in practice. In the context of ongoing neoliberal planning system reform, the research provides useful comparison of two jurisdictions facing similar planning problems, and addressing them through similar planning legislation, producing similar planning documents. They occupy similar political-economic positions and have experienced similar growth (and growth tensions) as they have each consolidated their position as second-ranked global centres on the Pacific Rim. Nevertheless, significant differences emerge in their approaches to planning for similar challenges, and these are reflected in the different roles for and manifestation of collaborative planning processes. This comparison identifies approaches that might strengthen the consonance between local and regional strategic planning, providing opportunities for governments and institutions to combine some measure of local democracy and autonomy with coherent and deliverable metropolitan and regional planning frameworks. Areas of further research to enrich our understanding of the circumstances under which collaborative planning practice can be effective in aligning local with regional strategic planning outcomes are suggested

    Primary peripheral arterial stenoses and restenoses excised by transluminal atherectomy: A histopathologic study

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    Atherectomy is a new therapeutic intervention for the treatment of peripheral arterial disease, and permits the controlled excision and retrieval of portions of stenosing lesions. The gross and light microscopic features of 218 peripheral arterial stenoses resected from 100 patients by atherectomy were studied. One hundred seventy of these lesions were primary stenoses and 48 were restenoses subsequent to prior angioplasty or atherectomy. Microscopically, primary stenoses were composed of atherosclerotic plaque (150 lesions), fibrous intimai thickening (15 lesions) or thrombus alone (5 lesions). Atherosclerotic plaques had a variable morphology and, in one-third of cases, were accompanied by abundant surface thrombus that probably added to the severity of stenosis. Most patients with fibrous intimai thickening or thrombus alone had typical atherosclerotic plaque removed elsewhere from within the same artery.Intimai hyperplasia, with or without underlying residual plaque, was found at 36 sites of restenosis, the remaining 12 consisting of plaque only. Intimai hyperplasia had a distinctive histologic appearance and was due to smooth muscle cell proliferation within a loosely fibrous stroma. Superimposed thrombus may have contributed to arterial narrowing in 25% of hyperplastic and 8% of atherosclerotic restenoses (p = 0.41). Pathologic examination of tissues recovered by peripheral atherectomy is an important adjunct that may provide insight into the efficacy of vascular interventions and the phenomenon of postintervention restenosis

    Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implants

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    Additive manufacturing technologies have been utilised in healthcare to create patient-specific implants. This study demonstrates the potential to add new implant functionality by further exploiting the design flexibility of these technologies. Selective laser melting was used to manufacture titanium-based (Ti-6Al-4V) implants containing a reservoir. Pore channels, connecting the implant surface to the reservoir, were incorporated to facilitate antibiotic delivery. An injectable brushite, calcium phosphate cement, was formulated as a carrier vehicle for gentamicin. Incorporation of the antibiotic significantly (p=0.01) improved the compressive strength (5.8±0.7MPa) of the cement compared to non-antibiotic samples. The controlled release of gentamicin sulphate from the calcium phosphate cement injected into the implant reservoir was demonstrated in short term elution studies using ultraviolet-visible spectroscopy. Orientation of the implant pore channels were shown, using micro-computed tomography, to impact design reproducibility and the back-pressure generated during cement injection which ultimately altered porosity. The amount of antibiotic released from all implant designs over a 6hour period (<28% of the total amount) were found to exceed the minimum inhibitory concentrations of Staphylococcus aureus (16μg/mL) and Staphylococcus epidermidis (1μg/mL); two bacterial species commonly associated with periprosthetic infections. Antibacterial efficacy was confirmed against both bacterial cultures using an agar diffusion assay. Interestingly, pore channel orientation was shown to influence the directionality of inhibition zones. Promisingly, this work demonstrates the potential to additively manufacture a titanium-based antibiotic eluting implant, which is an attractive alternative to current treatment strategies of periprosthetic infections

    Comparative distribution of dopamine D-1 and D-2 receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys

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    The distribution and density of dopamine D-1 and D-2 receptors were studied in the basal ganglia of adult turtles, pigeons, rats, cats, and monkeys. Dopamine receptors were measured in vitro by quantitative autoradiography in alternate sections processed for D-1 and D-2 receptor subtypes and compared to adjacent sections stained for acetylcholinesterase (AChE) activity. [ 3 H]-SCH 23390 and [ 3 H]-spiroperidol were used to label the D-1 and D-2 dopamine receptor subtypes, respectively. The anatomic distribution of both D-1 and D-2 receptors in the basal ganglia was remarkably similar across all species examined. Whereas the absolute number of D-1 and D-2 receptors in the basal ganglia varied between species, the percentage of D-1 and D-2 receptors in a region was quite similar among species. The pattern of binding to the D-1 and D-2 receptor varied among the different species. The adult turtles, pigeons, and rats demonstrated non-patchy D-1 and D-2 receptor binding in the striatum and pallidum. The adult cat and monkey caudate nucleus and putamen demonstrated mildly heterogeneous receptor binding in a pattern that differed from that seen with AChE staining, but did occasionally demonstrate similar patterns of the D-1 and D-2 receptor subtypes, The immature cat striatum was characterized by heterogeneous D-1 receptor binding that corresponded to heterogeneous AChE rich patches, whereas D-2 receptor binding was homogeneous. Heterogeneous binding was seen in other basal ganglia structures including the nucleus accumbens, olfactory tubercle, and substantia nigra pars compacta and reticulata. Complementary D-1 and D-2 receptor binding patterns were seen in the pallidum and substantia nigra of the mammals. The results of this study indicate that both D-1 and D-2 dopamine receptors are present in the basal ganglia of five different vertebrates. A common feature of dopamine receptors in the basal ganglia is their heterogeneity in distribution and density. The heterogeneity of dopamine receptors has similarities to and differences from the distribution of presynaptic dopamine and other neurotransmitter markers of the basal ganglia.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50037/1/902620308_ftp.pd

    Freehand Drawing, Head

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    Pencil/white paper; 11 1/2" x 17 1/2"Part of the Archives' Visual Materials collectionIn the original record this name was followed by a question mark
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